Page last updated: 2024-10-31

midazolam and Colicky Pain

midazolam has been researched along with Colicky Pain in 11 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"Propofol was titrated to a level of deep sedation and propofol combined with midazolam was used for moderate sedation."2.74CO2 insufflation during colonoscopy decreases post-interventional pain in deeply sedated patients: a randomized controlled trial. ( Akan, B; Dirlea, D; Karner-Hanusch, J; Mikola, B; Mittlböck, M; Rieder, E; Riss, S; Weiser, FA, 2009)
"Preoperatively, 95% of the patients received morphine versus 100% postoperatively, with a median dosage of 10."1.43Infants Operated on for Necrotizing Enterocolitis: Towards Evidence-Based Pain Guidelines. ( Keyzer-Dekker, CM; Knibbe, CA; Meesters, NJ; Simons, SH; Tibboel, D; van Dijk, M, 2016)
"Meperidine and midazolam were most commonly used."1.37Ileoscopy via stoma after diverting ileostomy: a safe and effective tool to evaluate for Crohn's recurrence of neoterminal ileum. ( Alkhouri, N; Lopez, R; Mahajan, L; Shen, B; Vadlamudi, N, 2011)
" Extrapyramidal side effects like tardive dyskinesia are known to develop with chronic use of metoclopramide, while acute akathisia is a lesser known side effect following IV administration."1.37Case of acute akathisia from intravenous metoclopramide. ( Lim, BL; Qiu, LM, 2011)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (54.55)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ball, AJ1
Rees, CJ1
Corfe, BM1
Riley, SA2
Meesters, NJ1
van Dijk, M1
Knibbe, CA1
Keyzer-Dekker, CM1
Tibboel, D1
Simons, SH1
Cadoni, S1
Falt, P1
Gallittu, P1
Liggi, M1
Smajstrla, V1
Leung, FW1
Elphick, DA1
Donnelly, MT1
Smith, KS1
Riss, S1
Akan, B1
Mikola, B1
Rieder, E1
Karner-Hanusch, J1
Dirlea, D1
Mittlböck, M1
Weiser, FA1
Vadlamudi, N1
Alkhouri, N1
Mahajan, L1
Lopez, R1
Shen, B1
Qiu, LM1
Lim, BL1
Pineau, BC1
Vining, DJ1
Iyilikci, L1
Akarsu, M1
Kocaayan, E1
Topalak, O1
Cacho, G1
Dueñas, C1
Pérez de las Vacas, J1
Robledo, P1
Rosado, JL1
Fazel, A1
Burton, FR1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Carbon Dioxide Insufflation and Water Exchange on Post-Colonoscopy Outcomes: A Randomized Controlled Trial[NCT02409979]246 participants (Actual)Interventional2015-04-30Completed
Is End Tidal CO2 Level Elevation During Upper Endoscopy With CO2 Gas Insufflation Physiologically Significant[NCT04541667]200 participants (Actual)Interventional2019-11-18Completed
Water Exchange Versus Carbon Dioxide Insufflation to Improve Colonoscopy Screening - a Randomized Controlled Trial[NCT01633333]473 participants (Actual)Interventional2012-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Reporting Abdominal Pain

Pain rating scales using FLACC and VAS will be used to assess self reported pain before and after the procedure (NCT04541667)
Timeframe: This will be assessed before and after the procedure

Interventionparticipants (Number)
Air for Luminal Inflation14
Carbon Dioxide for Luminal Inflation15

Number of Procedures With Elevated End-tidal CO2 Levels

Compare the peak end-tidal CO2 levels (>/= 60 mmHg) observed during endoscopy in children managed with endotracheal intubation or laryngeal mask airway using CO2 versus air (NCT04541667)
Timeframe: Measured from time of procedure start to time of procedure conclusion this lasts usually from 1-2.5 hours.

InterventionProcedures (Count of Units)
Air for Luminal Inflation8
Carbon Dioxide for Luminal Inflation21

Trials

3 trials available for midazolam and Colicky Pain

ArticleYear
Impact of carbon dioxide insufflation and water exchange on postcolonoscopy outcomes in patients receiving on-demand sedation: a randomized controlled trial.
    Gastrointestinal endoscopy, 2017, Volume: 85, Issue:1

    Topics: Abdominal Pain; Aged; Air; Carbon Dioxide; Colonoscopy; Conscious Sedation; Fecal Incontinence; Fema

2017
CO2 insufflation during colonoscopy decreases post-interventional pain in deeply sedated patients: a randomized controlled trial.
    Wiener klinische Wochenschrift, 2009, Volume: 121, Issue:13-14

    Topics: Abdominal Pain; Adult; Anti-Anxiety Agents; Body Mass Index; Carbon Dioxide; Colonoscopy; Colorectal

2009
CO2 insufflation during colonoscopy decreases post-interventional pain in deeply sedated patients: a randomized controlled trial.
    Wiener klinische Wochenschrift, 2009, Volume: 121, Issue:13-14

    Topics: Abdominal Pain; Adult; Anti-Anxiety Agents; Body Mass Index; Carbon Dioxide; Colonoscopy; Colorectal

2009
CO2 insufflation during colonoscopy decreases post-interventional pain in deeply sedated patients: a randomized controlled trial.
    Wiener klinische Wochenschrift, 2009, Volume: 121, Issue:13-14

    Topics: Abdominal Pain; Adult; Anti-Anxiety Agents; Body Mass Index; Carbon Dioxide; Colonoscopy; Colorectal

2009
CO2 insufflation during colonoscopy decreases post-interventional pain in deeply sedated patients: a randomized controlled trial.
    Wiener klinische Wochenschrift, 2009, Volume: 121, Issue:13-14

    Topics: Abdominal Pain; Adult; Anti-Anxiety Agents; Body Mass Index; Carbon Dioxide; Colonoscopy; Colorectal

2009
[Viability of colonoscopy without analgesia and conscious sedation].
    Gastroenterologia y hepatologia, 2000, Volume: 23, Issue:9

    Topics: Abdominal Pain; Adjuvants, Anesthesia; Analgesia; Anesthesia, Intravenous; Colonoscopy; Conscious Se

2000

Other Studies

8 other studies available for midazolam and Colicky Pain

ArticleYear
Sedation practice and comfort during colonoscopy: lessons learnt from a national screening programme.
    European journal of gastroenterology & hepatology, 2015, Volume: 27, Issue:6

    Topics: Abdominal Pain; Administration, Intravenous; Aged; Analgesics, Opioid; Anesthetics, Combined; Colono

2015
Infants Operated on for Necrotizing Enterocolitis: Towards Evidence-Based Pain Guidelines.
    Neonatology, 2016, Volume: 110, Issue:3

    Topics: Abdominal Pain; Analgesics, Opioid; Birth Weight; Enterocolitis, Necrotizing; Female; Fentanyl; Gest

2016
Factors associated with abdominal discomfort during colonoscopy: a prospective analysis.
    European journal of gastroenterology & hepatology, 2009, Volume: 21, Issue:9

    Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Analgesia; Clinical Competence; Colonoscopy; Female;

2009
Ileoscopy via stoma after diverting ileostomy: a safe and effective tool to evaluate for Crohn's recurrence of neoterminal ileum.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:3

    Topics: Abdominal Pain; Adolescent; Adult; Anesthetics, Intravenous; Crohn Disease; Endoscopy, Gastrointesti

2011
Case of acute akathisia from intravenous metoclopramide.
    Singapore medical journal, 2011, Volume: 52, Issue:1

    Topics: Abdominal Pain; Adult; Akathisia, Drug-Induced; Diphenhydramine; Emergency Service, Hospital; Female

2011
Better tolerance for colonoscopy or intolerance to virtual colonoscopy?
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:4

    Topics: Abdominal Pain; Colonic Neoplasms; Colonoscopy; Humans; Hypnotics and Sedatives; Insufflation; Mass

2002
Sedation for endoscopic retrograde cholangiopancreatography (ERCP) in a pregnant patient.
    Journal of anesthesia, 2007, Volume: 21, Issue:1

    Topics: Abdominal Pain; Adult; Anesthesia; Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Re

2007
The effect of midazolam on the normal sphincter of Oddi: a controlled study.
    Endoscopy, 2002, Volume: 34, Issue:1

    Topics: Abdominal Pain; Adult; Case-Control Studies; Cholangiopancreatography, Endoscopic Retrograde; Consci

2002