midazolam has been researched along with Cognition Disorders in 11 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five cases are reported in which confusional states and total anterograde amnesia occurred after oral intake of recommended doses of midazolam, a new ultra-short acting benzodiazepine." | 3.67 | [Confusional states following administration of the hypnotic midazolam]. ( Schneider-Helmert, D, 1985) |
| "Midazolam was also associated with significant anterograde amnesia, both postoperatively and at 48 h, for information presented in the interval between premedication and surgery." | 2.73 | A randomised placebo-controlled trial of the effects of midazolam premedication on children's postoperative cognition. ( Asbury, AJ; Bowman, AW; Hosey, MT; Martin, K; Millar, K; Musiello, T; Welbury, RR, 2007) |
| "Midazolam is a widely used sedative agent during colonoscopy, with cognitive toxicity." | 1.42 | Evident cognitive impairments in seemingly recovered patients after midazolam-based light sedation during diagnostic endoscopy. ( Hsu, YH; Hua, MS; Lin, CP; Lin, FS; Sun, WZ; Yang, CC, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsu, YH | 1 |
| Lin, FS | 1 |
| Yang, CC | 1 |
| Lin, CP | 1 |
| Hua, MS | 1 |
| Sun, WZ | 1 |
| Wang, J | 1 |
| Niu, M | 1 |
| Bai, S | 1 |
| Boscolo, A | 1 |
| Starr, JA | 1 |
| Sanchez, V | 1 |
| Lunardi, N | 1 |
| DiGruccio, MR | 1 |
| Ori, C | 1 |
| Erisir, A | 1 |
| Trimmer, P | 1 |
| Bennett, J | 1 |
| Jevtovic-Todorovic, V | 1 |
| Millar, K | 1 |
| Asbury, AJ | 1 |
| Bowman, AW | 1 |
| Hosey, MT | 1 |
| Martin, K | 1 |
| Musiello, T | 1 |
| Welbury, RR | 1 |
| Flatt, NW | 1 |
| Sackey, PV | 1 |
| Martling, CR | 1 |
| Carlswärd, C | 1 |
| Sundin, O | 1 |
| Radell, PJ | 1 |
| Suzuki, M | 1 |
| Tsueda, K | 1 |
| Lansing, PS | 1 |
| Tolan, MM | 1 |
| Fuhrman, TM | 1 |
| Sheppard, RA | 1 |
| Hurst, HE | 1 |
| Lippmann, SB | 1 |
| Dowd, NP | 1 |
| Karski, JM | 1 |
| Cheng, DC | 1 |
| Gajula, S | 1 |
| Seneviratne, P | 1 |
| Munro, JA | 1 |
| Fiducia, D | 1 |
| Grigore, AM | 1 |
| Mathew, J | 1 |
| Grocott, HP | 1 |
| Reves, JG | 1 |
| Blumenthal, JA | 1 |
| White, WD | 1 |
| Smith, PK | 1 |
| Jones, RH | 1 |
| Kirchner, JL | 1 |
| Mark, DB | 1 |
| Newman, MF | 1 |
| Sury, MR | 1 |
| Billingham, I | 1 |
| Russell, GN | 1 |
| Hopkins, CS | 1 |
| Thornington, R | 1 |
| Vivori, E | 1 |
| Schneider-Helmert, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Mirus™ for Sedation in Resuscitation[NCT02889055] | 9 participants (Actual) | Observational | 2016-01-17 | Terminated (stopped due to Safety profile was not satisfying with sevolflurane) | |||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-06-30 | Recruiting | ||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-04-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for midazolam and Cognition Disorders
| Article | Year |
|---|---|
A randomised placebo-controlled trial of the effects of midazolam premedication on children's postoperative cognition.
Topics: Anesthesia, General; Anti-Anxiety Agents; Child; Child, Preschool; Cognition Disorders; Female; Huma | 2007 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress | 2008 |
Midazolam attenuates ketamine-induced abnormal perception and thought process but not mood changes.
Topics: Adult; Affect; Anesthetics, Dissociative; Anti-Anxiety Agents; Blood Pressure; Cognition Disorders; | 2000 |
Fast-track cardiac anaesthesia in the elderly: effect of two different anaesthetic techniques on mental recovery.
Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Anti-Anxiety Agents; Cognition Disorders; Consc | 2001 |
Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.
Topics: Anesthetics, Intravenous; Cognition Disorders; Coronary Artery Bypass; Educational Status; Female; F | 2001 |
6 other studies available for midazolam and Cognition Disorders
| Article | Year |
|---|---|
Evident cognitive impairments in seemingly recovered patients after midazolam-based light sedation during diagnostic endoscopy.
Topics: Anesthetics, Intravenous; Attention; Case-Control Studies; Cognition; Cognition Disorders; Colonosco | 2015 |
Effects of long-term infusion of sedatives on the cognitive function and expression level of RAGE in hippocampus of rats.
Topics: Animals; Cognition; Cognition Disorders; Hippocampus; Hypnotics and Sedatives; Learning; Male; Memor | 2016 |
The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and mitochondrial integrity.
Topics: Age Factors; Analysis of Variance; Anesthesia, General; Animals; Animals, Newborn; Antioxidants; Ben | 2012 |
Bribery in the anaesthetic room.
Topics: Anti-Anxiety Agents; Child; Cognition Disorders; Humans; Midazolam; Postoperative Complications; Pre | 2007 |
Acute benzodiazepine withdrawal syndrome after midazolam infusions in children.
Topics: Acute Disease; Akathisia, Drug-Induced; Child; Child, Preschool; Cognition Disorders; Confusion; Fem | 1989 |
[Confusional states following administration of the hypnotic midazolam].
Topics: Adolescent; Adult; Amnesia; Benzodiazepines; Cognition Disorders; Confusion; Female; Humans; Hypnoti | 1985 |