midazolam has been researched along with Chronic Liver Failure in 2 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An abnormal liver function test likely gives the clinician a hint about dosage adjustment." | 1.42 | Serum alanine transaminase total bilirubin concentrations predict CYP3A activity as measured by midazolam and 1'-hydroxylation. ( He, R; Li, Y; Ruan, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, YH | 1 |
| He, R | 2 |
| Ruan, JG | 1 |
| Li, Y | 1 |
| Ruan, J | 1 |
2 other studies available for midazolam and Chronic Liver Failure
| Article | Year |
|---|---|
Effect of hepatic function on the EC50 of midazolam and the BIS50 at the time of loss of consciousness.
Topics: Adult; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; Cholelithiasis; Electroencephalograp | 2014 |
Serum alanine transaminase total bilirubin concentrations predict CYP3A activity as measured by midazolam and 1'-hydroxylation.
Topics: Alanine Transaminase; Analysis of Variance; Bilirubin; Biomarkers; Cytochrome P-450 CYP3A; End Stage | 2015 |