midazolam has been researched along with Chronic Insomnia in 44 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Excerpt | Relevance | Reference |
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"To compare the safety and efficacy of midazolam and estazolam in hypertensive patients with chronic insomnia." | 9.12 | [Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. ( Ke, YN; Wang, XL, 2006) |
"Methods are described for a five-center study of flurazepam and midazolam, in which 107 patients with histories of benzodiazepine use for chronic insomnia were enrolled." | 9.06 | Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology. ( Chernik, DA; Johnson, LC; Kanitra, L, 1990) |
"This article contains the sleep results of the efficacy study of flurazepam 30 mg and 15 mg, midazolam 15 mg, and placebo in the 99 chronic insomniacs studied as part of this multicenter study." | 9.06 | Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Ancoli-Israel, S; Hauri, P; Kripke, DF; Roth, T, 1990) |
"Four skills performance (psychomotor) tasks, including simple and choice reaction time, divided attention, and vigilance, were given to 99 chronic insomniacs to determine whether the use of midazolam 15 mg, or of flurazepam 15 or 30 mg, compared with placebo would produce next-day impairment throughout a 14-day treatment period." | 9.06 | Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Linnoila, M; Moskowitz, H; Roehrs, T, 1990) |
"The 99 chronic insomniacs examined in the present multicenter study were given three cognitive tasks (reading comprehension, addition, and digit symbol substitution test [DSST]) as well as the Hopkins Symptom Checklist (HSCL) and the Profile of Mood States (POMS) in order to evaluate the effects of flurazepam (Dalmane) 15 and 30 mg, midazolam 15 mg, and placebo on cognitive performance and mood." | 9.06 | Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam. ( Ellinwood, E; Judd, LL; McAdams, LA, 1990) |
"One hundred seven chronic insomniacs (41 men, 66 women; mean age, 37." | 6.67 | Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam. ( Judd, LL; Linnoila, M; Roehrs, T; Roth, T, 1990) |
" No marked adverse reactions were found in any area for any group." | 6.67 | Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs. ( Hauri, P; Kripke, D; Roehrs, T; Sateia, MJ, 1990) |
" Irrespective of the dosage sleep was almost exclusively increased at the expense of NREM sleep." | 6.66 | Short-term sleep laboratory evaluation of midazolam in chronic insomniacs. Preliminary results. ( Alterwain, P; Altier, H; Debellis, J; Monti, D; Monti, JM; Pellejero, T, 1987) |
"To compare the safety and efficacy of midazolam and estazolam in hypertensive patients with chronic insomnia." | 5.12 | [Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. ( Ke, YN; Wang, XL, 2006) |
"Methods are described for a five-center study of flurazepam and midazolam, in which 107 patients with histories of benzodiazepine use for chronic insomnia were enrolled." | 5.06 | Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology. ( Chernik, DA; Johnson, LC; Kanitra, L, 1990) |
"This article contains the sleep results of the efficacy study of flurazepam 30 mg and 15 mg, midazolam 15 mg, and placebo in the 99 chronic insomniacs studied as part of this multicenter study." | 5.06 | Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Ancoli-Israel, S; Hauri, P; Kripke, DF; Roth, T, 1990) |
"Four skills performance (psychomotor) tasks, including simple and choice reaction time, divided attention, and vigilance, were given to 99 chronic insomniacs to determine whether the use of midazolam 15 mg, or of flurazepam 15 or 30 mg, compared with placebo would produce next-day impairment throughout a 14-day treatment period." | 5.06 | Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Linnoila, M; Moskowitz, H; Roehrs, T, 1990) |
"The 99 chronic insomniacs examined in the present multicenter study were given three cognitive tasks (reading comprehension, addition, and digit symbol substitution test [DSST]) as well as the Hopkins Symptom Checklist (HSCL) and the Profile of Mood States (POMS) in order to evaluate the effects of flurazepam (Dalmane) 15 and 30 mg, midazolam 15 mg, and placebo on cognitive performance and mood." | 5.06 | Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam. ( Ellinwood, E; Judd, LL; McAdams, LA, 1990) |
" The author calls the attention to the importance of the observance of the dosage and administration of the drug which may prevent the development of a great number of side-effects." | 2.67 | Placebo-controlled clinical trial of Dormicum 15-mg tablet. ( Köves, P, 1993) |
"Midazolam or placebo were given double-blind immediately before turning off the lights." | 2.67 | The effect of midazolam on transient insomnia. ( Alvariño, F; Boussard, M; Labraga, P; Monti, JM; Olivera, S, 1993) |
"Rebound insomnia was evident in the zopiclone group in five out of 10 items of the LSEQ." | 2.67 | A comparison of efficacy and tolerance of the short acting sedatives midazolam and zopiclone. ( Begg, EJ; Campbell, JE; Frampton, CM; Robson, RA, 1992) |
"One hundred seven chronic insomniacs (41 men, 66 women; mean age, 37." | 2.67 | Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam. ( Judd, LL; Linnoila, M; Roehrs, T; Roth, T, 1990) |
" No marked adverse reactions were found in any area for any group." | 2.67 | Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs. ( Hauri, P; Kripke, D; Roehrs, T; Sateia, MJ, 1990) |
"Midazolam (15 mg) was compared with temazepam (30 mg) in a randomized, double-blind, parallel group study." | 2.66 | Efficacy without tolerance or rebound insomnia for midazolam and temazepam after use for one to three months. ( Allen, RP; Chernik, DA; Hoddes, E; Mendels, J; Nevins, DB, 1987) |
" Irrespective of the dosage sleep was almost exclusively increased at the expense of NREM sleep." | 2.66 | Short-term sleep laboratory evaluation of midazolam in chronic insomniacs. Preliminary results. ( Alterwain, P; Altier, H; Debellis, J; Monti, D; Monti, JM; Pellejero, T, 1987) |
" There was no dose-response effect for effectiveness with either initial or continued drug administration." | 2.65 | Midazolam: dose-response studies of effectiveness and rebound insomnia. ( Bixler, EO; Goff, PJ; Kales, A; Soldatos, CR; Vela-Bueno, A, 1983) |
"Forty-three outpatients with "midwinter insomnia" (an early type insomnia commonly seen north of the Polar Circle when the sun stays below the horizon) were randomly allocated to one of three treatment groups, receiving either 15 mg midazolam, 1 mg flunitrazepam, or placebo, for 5 nights, double blind, after 3 nights without drug." | 2.65 | Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway. ( Bratlid, T; Gordeladze, JO; Lingjaerde, O; Westby, OC, 1983) |
"Three different dosage studies were carried out with midazolam in 47 institutionalized geriatric patients (17 males: mean age 82." | 2.65 | Midazolam dosage studies in institutionalized geriatric patients. ( Beck, H; Holzer, J; Salom, M, 1983) |
"No within-night rebound insomnia, residual daytime effects, or rebound effects upon discontinuation appeared." | 1.28 | The chronic efficacy of midazolam. ( Fortier, J; Koshorek, G; Lamphere, J; Roehrs, T; Roth, T; Vogel, G, 1990) |
"Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop." | 1.27 | Early morning insomnia with rapidly eliminated benzodiazepines. ( Bixler, EO; Kales, A; Kales, JD; Soldatos, CR, 1983) |
"Midazolam has the lowest residual fraction of all known benzodiazepines and thus, administered in the appropriate dosage, also has the shortest duration of activity." | 1.27 | Pharmacokinetic and clinical considerations in the choice of a hypnotic. ( Amrein, R; Eckert, M; Haefeli, H; Leishman, B, 1983) |
"Efficacy (sleep--sedation) and tolerance of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) in a dosage of 10 mg to 30 mg p." | 1.26 | Evaluation of efficacy and safety of midazolam administered orally in sleep disorders. A dose-finding study. ( Buch, JP; Lupolover, R, 1981) |
"Withdrawal of midazolam was followed by rebound insomnia, in which sleep latency, total wake time and wake time after sleep onset were increased above baseline." | 1.26 | Sleep laboratory study of the effects of midazolam in insomniac patients. ( Alterwain, P; Altier, H; D'Angelo, L; Debellis, J; Gratadoux, E; Monti, JM, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 25 (56.82) | 18.7374 |
1990's | 15 (34.09) | 18.2507 |
2000's | 3 (6.82) | 29.6817 |
2010's | 1 (2.27) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kaneishi, K | 1 |
Kawabata, M | 1 |
Morita, T | 3 |
Matsuo, N | 2 |
Wang, XL | 1 |
Ke, YN | 1 |
Lupolover, R | 3 |
Buch, JP | 2 |
Helcl, I | 1 |
Amrein, R | 2 |
Kales, A | 3 |
Soldatos, CR | 3 |
Bixler, EO | 3 |
Kales, JD | 2 |
Goff, PJ | 1 |
Vela-Bueno, A | 1 |
Lingjaerde, O | 1 |
Bratlid, T | 1 |
Westby, OC | 1 |
Gordeladze, JO | 1 |
Vogel, GW | 1 |
Vogel, F | 1 |
Hauri, P | 6 |
Roth, T | 6 |
Sateia, M | 2 |
Zorick, F | 2 |
Beck, H | 1 |
Salom, M | 1 |
Holzer, J | 1 |
Ballmer, U | 1 |
Helcl, J | 1 |
Escher, J | 1 |
Pavletic, B | 1 |
Gallais, H | 1 |
Casanova, P | 1 |
Fabregat, H | 1 |
Feldmeier, C | 1 |
Kapp, W | 2 |
Philipp, E | 1 |
Costa E Silva, JA | 1 |
Acioli, A | 1 |
Naylor, C | 1 |
Jones Da Silva, C | 1 |
Ferreira, I | 1 |
Eckert, M | 1 |
Haefeli, H | 1 |
Leishman, B | 1 |
Monti, JM | 4 |
Debellis, J | 3 |
Alterwain, P | 3 |
D'Angelo, L | 2 |
Gath, I | 1 |
Bar-On, E | 1 |
Rogowski, Z | 1 |
Bental, E | 1 |
Gratadoux, E | 1 |
Altier, H | 2 |
Köves, P | 1 |
Boussard, M | 1 |
Olivera, S | 1 |
Labraga, P | 1 |
Alvariño, F | 1 |
Begg, EJ | 1 |
Robson, RA | 1 |
Frampton, CM | 1 |
Campbell, JE | 1 |
Johnson, LC | 4 |
Chernik, DA | 5 |
Sateia, MJ | 2 |
Kanitra, L | 1 |
Roehrs, T | 5 |
Linnoila, M | 4 |
Judd, LL | 3 |
Kripke, D | 1 |
Chen, D | 1 |
Ellinwood, E | 3 |
Kripke, DF | 2 |
Moskowitz, H | 2 |
Ancoli-Israel, S | 1 |
McAdams, LA | 1 |
Marsh, G | 1 |
Lamphere, J | 1 |
Vogel, G | 1 |
Koshorek, G | 1 |
Fortier, J | 1 |
Jacoby, JA | 1 |
Kipp, J | 1 |
Allen, RP | 1 |
Mendels, J | 1 |
Nevins, DB | 1 |
Hoddes, E | 1 |
Lorizio, A | 1 |
Salsa, F | 1 |
Hegelbach-Feller, DA | 1 |
Tschopp, JM | 1 |
Christeller, S | 1 |
Fabre, J | 1 |
Nicholson, AN | 1 |
Kok, LP | 1 |
Tsoi, WF | 1 |
Pellejero, T | 1 |
Monti, D | 1 |
2 reviews available for midazolam and Chronic Insomnia
Article | Year |
---|---|
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction.
Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per | 1990 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
35 trials available for midazolam and Chronic Insomnia
Article | Year |
---|---|
[Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial].
Topics: Aged; Estazolam; Female; Humans; Hypertension; Hypnotics and Sedatives; Male; Midazolam; Middle Aged | 2006 |
Evaluation of the efficacy and tolerance of orally administered midazolam as hypnotic agent compared with oxazepam in the treatment of insomnia of mild to moderate severity.
Topics: Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; Humans; | 1981 |
Midazolam: dose-response studies of effectiveness and rebound insomnia.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Electroe | 1983 |
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Female; Flunitrazepam; | 1983 |
Effect of midazolam on sleep of insomniacs.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Electromyography; Female; Human | 1983 |
Sleep laboratory and performance evaluation of midazolam in insomniacs.
Topics: Adult; Anti-Anxiety Agents; Attention; Benzodiazepines; Female; Humans; Male; Memory; Midazolam; Mid | 1983 |
Midazolam dosage studies in institutionalized geriatric patients.
Topics: Aged; Anti-Anxiety Agents; Benzodiazepines; Drug Interactions; Female; Humans; Hypnotics and Sedativ | 1983 |
Efficacy and safety of midazolam and oxazepam in insomniacs.
Topics: Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; Humans; | 1983 |
Midazolam and oxazepam in the treatment of insomnia in hospitalized patients.
Topics: Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Hospitalization | 1983 |
Comparative clinical studies with midazolam, oxazepam and placebo.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Dr | 1983 |
Comparative study of midazolam and vesparax in moderate or severe insomnia in female surgical patients.
Topics: Adult; Aged; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Dreams; Drug Combinations; Female; | 1983 |
Midazolam and triazolam in out-patients: a double-blind comparison of hypnotic efficacy.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; | 1983 |
Midazolam and sleep in insomniac patients.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Female; Humans; Male; Midazolam | 1983 |
Placebo-controlled clinical trial of Dormicum 15-mg tablet.
Topics: Adult; Analysis of Variance; Female; Humans; Male; Midazolam; Middle Aged; Polysomnography; Severity | 1993 |
The effect of midazolam on transient insomnia.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Midazolam; Psych | 1993 |
A comparison of efficacy and tolerance of the short acting sedatives midazolam and zopiclone.
Topics: Adolescent; Adult; Azabicyclo Compounds; Double-Blind Method; Female; Humans; Hypnotics and Sedative | 1992 |
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction.
Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per | 1990 |
Effects of flurazepam and midazolam on sleep and next-day performance in chronic insomniacs: report of a multicenter study.
Topics: Flurazepam; Humans; Midazolam; Sleep; Sleep Initiation and Maintenance Disorders | 1990 |
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology.
Topics: Adult; Affect; Arousal; Attention; Electroencephalography; Female; Flurazepam; Half-Life; Humans; Ma | 1990 |
Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam.
Topics: Adult; Affect; Arousal; Electroencephalography; Female; Flurazepam; Humans; Male; Midazolam; Middle | 1990 |
Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs.
Topics: Adult; Double-Blind Method; Female; Flurazepam; Humans; Male; Midazolam; Middle Aged; Sleep Apnea Sy | 1990 |
A multicenter study of sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: executive summary.
Topics: Adult; Affect; Arousal; Chronic Disease; Double-Blind Method; Flurazepam; Humans; Midazolam; Psychom | 1990 |
Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam.
Topics: Adult; Arousal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurazepam; Humans | 1990 |
Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam.
Topics: Adult; Arousal; Attention; Dose-Response Relationship, Drug; Female; Flurazepam; Humans; Male; Midaz | 1990 |
Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam.
Topics: Adult; Affect; Arousal; Attention; Dose-Response Relationship, Drug; Drug Administration Schedule; F | 1990 |
Plasma concentrations of flurazepam and midazolam in chronic insomniacs during 14-day use and their relationship to therapeutic effects and next-day performance and mood.
Topics: Adult; Arousal; Attention; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; F | 1990 |
A multicenter 14-day study of flurazepam and midazolam in chronic insomniacs: general discussion and conclusions.
Topics: Arousal; Attention; Double-Blind Method; Female; Flurazepam; Humans; Male; Midazolam; Middle Aged; P | 1990 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
The effects of midazolam and temazepam on sleep and performance when administered in the middle of the night.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Female; Humans; Hypnotics and Sedatives; Male; Midazola | 1985 |
Efficacy without tolerance or rebound insomnia for midazolam and temazepam after use for one to three months.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Drug To | 1987 |
The effectiveness of oral midazolam as a hypnotic compared with lorazepam.
Topics: Administration, Oral; Adolescent; Adult; Aged; Benzodiazepines; Double-Blind Method; Drug Evaluation | 1986 |
Comparison of the short-acting benzodiazepines midazolam and triazolam with placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Dreams; Female; Humans; Male; Midazolam; | 1988 |
Transient insomnia and rapidly eliminated hypnotics.
Topics: Adolescent; Adult; Azepines; Half-Life; Humans; Hypnotics and Sedatives; Male; Midazolam; Posture; S | 1986 |
Comparison of midazolam, diazepam and placebo in the treatment of insomnia.
Topics: Adult; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Humans; Male; Midazolam; Mid | 1986 |
Short-term sleep laboratory evaluation of midazolam in chronic insomniacs. Preliminary results.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Female; Hu | 1987 |
9 other studies available for midazolam and Chronic Insomnia
Article | Year |
---|---|
Single-Dose Subcutaneous Benzodiazepines for Insomnia in Patients With Advanced Cancer.
Topics: Aged; Aged, 80 and over; Drug Administration Schedule; Female; Flunitrazepam; Humans; Hypnotics and | 2015 |
Intravenous infusion of midazolam and flunitrazepam for insomnia on Japanese palliative care units.
Topics: Anti-Anxiety Agents; Flunitrazepam; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Japan; | 2005 |
Efficacy, safety, and cost effectiveness of intravenous midazolam and flunitrazepam for primary insomnia in terminally ill patients with cancer: a retrospective multicenter audit study.
Topics: Aged; Anti-Anxiety Agents; Cost-Benefit Analysis; Female; Flunitrazepam; Humans; Japan; Male; Medica | 2007 |
Evaluation of efficacy and safety of midazolam administered orally in sleep disorders. A dose-finding study.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug Evaluation | 1981 |
Early morning insomnia with rapidly eliminated benzodiazepines.
Topics: Anti-Anxiety Agents; Benzodiazepines; Flurazepam; Half-Life; Humans; Midazolam; Sleep; Sleep Initiat | 1983 |
Pharmacokinetic and clinical considerations in the choice of a hypnotic.
Topics: Anti-Anxiety Agents; Benzodiazepines; Drug Utilization; Humans; Hypnotics and Sedatives; Kinetics; M | 1983 |
Automatic scoring of polygraphic sleep recordings: midazolam in insomniacs.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Humans; Midazolam; Middle Aged; | 1983 |
Sleep laboratory study of the effects of midazolam in insomniac patients.
Topics: Adult; Benzodiazepines; Drug Evaluation; Female; Headache; Humans; Male; Midazolam; Middle Aged; Sle | 1982 |
The chronic efficacy of midazolam.
Topics: Adult; Drug Tolerance; Female; Humans; Male; Midazolam; Neuropsychological Tests; Sleep Initiation a | 1990 |