Page last updated: 2024-10-31

midazolam and Chronic Insomnia

midazolam has been researched along with Chronic Insomnia in 44 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"To compare the safety and efficacy of midazolam and estazolam in hypertensive patients with chronic insomnia."9.12[Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. ( Ke, YN; Wang, XL, 2006)
"Methods are described for a five-center study of flurazepam and midazolam, in which 107 patients with histories of benzodiazepine use for chronic insomnia were enrolled."9.06Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology. ( Chernik, DA; Johnson, LC; Kanitra, L, 1990)
"This article contains the sleep results of the efficacy study of flurazepam 30 mg and 15 mg, midazolam 15 mg, and placebo in the 99 chronic insomniacs studied as part of this multicenter study."9.06Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Ancoli-Israel, S; Hauri, P; Kripke, DF; Roth, T, 1990)
"Four skills performance (psychomotor) tasks, including simple and choice reaction time, divided attention, and vigilance, were given to 99 chronic insomniacs to determine whether the use of midazolam 15 mg, or of flurazepam 15 or 30 mg, compared with placebo would produce next-day impairment throughout a 14-day treatment period."9.06Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Linnoila, M; Moskowitz, H; Roehrs, T, 1990)
"The 99 chronic insomniacs examined in the present multicenter study were given three cognitive tasks (reading comprehension, addition, and digit symbol substitution test [DSST]) as well as the Hopkins Symptom Checklist (HSCL) and the Profile of Mood States (POMS) in order to evaluate the effects of flurazepam (Dalmane) 15 and 30 mg, midazolam 15 mg, and placebo on cognitive performance and mood."9.06Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam. ( Ellinwood, E; Judd, LL; McAdams, LA, 1990)
"One hundred seven chronic insomniacs (41 men, 66 women; mean age, 37."6.67Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam. ( Judd, LL; Linnoila, M; Roehrs, T; Roth, T, 1990)
" No marked adverse reactions were found in any area for any group."6.67Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs. ( Hauri, P; Kripke, D; Roehrs, T; Sateia, MJ, 1990)
" Irrespective of the dosage sleep was almost exclusively increased at the expense of NREM sleep."6.66Short-term sleep laboratory evaluation of midazolam in chronic insomniacs. Preliminary results. ( Alterwain, P; Altier, H; Debellis, J; Monti, D; Monti, JM; Pellejero, T, 1987)
"To compare the safety and efficacy of midazolam and estazolam in hypertensive patients with chronic insomnia."5.12[Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. ( Ke, YN; Wang, XL, 2006)
"Methods are described for a five-center study of flurazepam and midazolam, in which 107 patients with histories of benzodiazepine use for chronic insomnia were enrolled."5.06Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology. ( Chernik, DA; Johnson, LC; Kanitra, L, 1990)
"This article contains the sleep results of the efficacy study of flurazepam 30 mg and 15 mg, midazolam 15 mg, and placebo in the 99 chronic insomniacs studied as part of this multicenter study."5.06Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Ancoli-Israel, S; Hauri, P; Kripke, DF; Roth, T, 1990)
"Four skills performance (psychomotor) tasks, including simple and choice reaction time, divided attention, and vigilance, were given to 99 chronic insomniacs to determine whether the use of midazolam 15 mg, or of flurazepam 15 or 30 mg, compared with placebo would produce next-day impairment throughout a 14-day treatment period."5.06Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam. ( Linnoila, M; Moskowitz, H; Roehrs, T, 1990)
"The 99 chronic insomniacs examined in the present multicenter study were given three cognitive tasks (reading comprehension, addition, and digit symbol substitution test [DSST]) as well as the Hopkins Symptom Checklist (HSCL) and the Profile of Mood States (POMS) in order to evaluate the effects of flurazepam (Dalmane) 15 and 30 mg, midazolam 15 mg, and placebo on cognitive performance and mood."5.06Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam. ( Ellinwood, E; Judd, LL; McAdams, LA, 1990)
" The author calls the attention to the importance of the observance of the dosage and administration of the drug which may prevent the development of a great number of side-effects."2.67Placebo-controlled clinical trial of Dormicum 15-mg tablet. ( Köves, P, 1993)
"Midazolam or placebo were given double-blind immediately before turning off the lights."2.67The effect of midazolam on transient insomnia. ( Alvariño, F; Boussard, M; Labraga, P; Monti, JM; Olivera, S, 1993)
"Rebound insomnia was evident in the zopiclone group in five out of 10 items of the LSEQ."2.67A comparison of efficacy and tolerance of the short acting sedatives midazolam and zopiclone. ( Begg, EJ; Campbell, JE; Frampton, CM; Robson, RA, 1992)
"One hundred seven chronic insomniacs (41 men, 66 women; mean age, 37."2.67Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam. ( Judd, LL; Linnoila, M; Roehrs, T; Roth, T, 1990)
" No marked adverse reactions were found in any area for any group."2.67Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs. ( Hauri, P; Kripke, D; Roehrs, T; Sateia, MJ, 1990)
"Midazolam (15 mg) was compared with temazepam (30 mg) in a randomized, double-blind, parallel group study."2.66Efficacy without tolerance or rebound insomnia for midazolam and temazepam after use for one to three months. ( Allen, RP; Chernik, DA; Hoddes, E; Mendels, J; Nevins, DB, 1987)
" Irrespective of the dosage sleep was almost exclusively increased at the expense of NREM sleep."2.66Short-term sleep laboratory evaluation of midazolam in chronic insomniacs. Preliminary results. ( Alterwain, P; Altier, H; Debellis, J; Monti, D; Monti, JM; Pellejero, T, 1987)
" There was no dose-response effect for effectiveness with either initial or continued drug administration."2.65Midazolam: dose-response studies of effectiveness and rebound insomnia. ( Bixler, EO; Goff, PJ; Kales, A; Soldatos, CR; Vela-Bueno, A, 1983)
"Forty-three outpatients with "midwinter insomnia" (an early type insomnia commonly seen north of the Polar Circle when the sun stays below the horizon) were randomly allocated to one of three treatment groups, receiving either 15 mg midazolam, 1 mg flunitrazepam, or placebo, for 5 nights, double blind, after 3 nights without drug."2.65Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway. ( Bratlid, T; Gordeladze, JO; Lingjaerde, O; Westby, OC, 1983)
"Three different dosage studies were carried out with midazolam in 47 institutionalized geriatric patients (17 males: mean age 82."2.65Midazolam dosage studies in institutionalized geriatric patients. ( Beck, H; Holzer, J; Salom, M, 1983)
"No within-night rebound insomnia, residual daytime effects, or rebound effects upon discontinuation appeared."1.28The chronic efficacy of midazolam. ( Fortier, J; Koshorek, G; Lamphere, J; Roehrs, T; Roth, T; Vogel, G, 1990)
"Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop."1.27Early morning insomnia with rapidly eliminated benzodiazepines. ( Bixler, EO; Kales, A; Kales, JD; Soldatos, CR, 1983)
"Midazolam has the lowest residual fraction of all known benzodiazepines and thus, administered in the appropriate dosage, also has the shortest duration of activity."1.27Pharmacokinetic and clinical considerations in the choice of a hypnotic. ( Amrein, R; Eckert, M; Haefeli, H; Leishman, B, 1983)
"Efficacy (sleep--sedation) and tolerance of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) in a dosage of 10 mg to 30 mg p."1.26Evaluation of efficacy and safety of midazolam administered orally in sleep disorders. A dose-finding study. ( Buch, JP; Lupolover, R, 1981)
"Withdrawal of midazolam was followed by rebound insomnia, in which sleep latency, total wake time and wake time after sleep onset were increased above baseline."1.26Sleep laboratory study of the effects of midazolam in insomniac patients. ( Alterwain, P; Altier, H; D'Angelo, L; Debellis, J; Gratadoux, E; Monti, JM, 1982)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199025 (56.82)18.7374
1990's15 (34.09)18.2507
2000's3 (6.82)29.6817
2010's1 (2.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kaneishi, K1
Kawabata, M1
Morita, T3
Matsuo, N2
Wang, XL1
Ke, YN1
Lupolover, R3
Buch, JP2
Helcl, I1
Amrein, R2
Kales, A3
Soldatos, CR3
Bixler, EO3
Kales, JD2
Goff, PJ1
Vela-Bueno, A1
Lingjaerde, O1
Bratlid, T1
Westby, OC1
Gordeladze, JO1
Vogel, GW1
Vogel, F1
Hauri, P6
Roth, T6
Sateia, M2
Zorick, F2
Beck, H1
Salom, M1
Holzer, J1
Ballmer, U1
Helcl, J1
Escher, J1
Pavletic, B1
Gallais, H1
Casanova, P1
Fabregat, H1
Feldmeier, C1
Kapp, W2
Philipp, E1
Costa E Silva, JA1
Acioli, A1
Naylor, C1
Jones Da Silva, C1
Ferreira, I1
Eckert, M1
Haefeli, H1
Leishman, B1
Monti, JM4
Debellis, J3
Alterwain, P3
D'Angelo, L2
Gath, I1
Bar-On, E1
Rogowski, Z1
Bental, E1
Gratadoux, E1
Altier, H2
Köves, P1
Boussard, M1
Olivera, S1
Labraga, P1
Alvariño, F1
Begg, EJ1
Robson, RA1
Frampton, CM1
Campbell, JE1
Johnson, LC4
Chernik, DA5
Sateia, MJ2
Kanitra, L1
Roehrs, T5
Linnoila, M4
Judd, LL3
Kripke, D1
Chen, D1
Ellinwood, E3
Kripke, DF2
Moskowitz, H2
Ancoli-Israel, S1
McAdams, LA1
Marsh, G1
Lamphere, J1
Vogel, G1
Koshorek, G1
Fortier, J1
Jacoby, JA1
Kipp, J1
Allen, RP1
Mendels, J1
Nevins, DB1
Hoddes, E1
Lorizio, A1
Salsa, F1
Hegelbach-Feller, DA1
Tschopp, JM1
Christeller, S1
Fabre, J1
Nicholson, AN1
Kok, LP1
Tsoi, WF1
Pellejero, T1
Monti, D1

Reviews

2 reviews available for midazolam and Chronic Insomnia

ArticleYear
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per

1990
Rebound insomnia and elimination half-life: assessment of individual subject response.
    Journal of clinical pharmacology, 1985, Volume: 25, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D

1985

Trials

35 trials available for midazolam and Chronic Insomnia

ArticleYear
[Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial].
    Zhonghua xin xue guan bing za zhi, 2006, Volume: 34, Issue:4

    Topics: Aged; Estazolam; Female; Humans; Hypertension; Hypnotics and Sedatives; Male; Midazolam; Middle Aged

2006
Evaluation of the efficacy and tolerance of orally administered midazolam as hypnotic agent compared with oxazepam in the treatment of insomnia of mild to moderate severity.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:12a

    Topics: Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; Humans;

1981
Midazolam: dose-response studies of effectiveness and rebound insomnia.
    Pharmacology, 1983, Volume: 26, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Electroe

1983
Effect of midazolam, flunitrazepam, and placebo against midwinter insomnia in northern Norway.
    Acta psychiatrica Scandinavica, 1983, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Female; Flunitrazepam;

1983
Effect of midazolam on sleep of insomniacs.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Electromyography; Female; Human

1983
Sleep laboratory and performance evaluation of midazolam in insomniacs.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Adult; Anti-Anxiety Agents; Attention; Benzodiazepines; Female; Humans; Male; Memory; Midazolam; Mid

1983
Midazolam dosage studies in institutionalized geriatric patients.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Aged; Anti-Anxiety Agents; Benzodiazepines; Drug Interactions; Female; Humans; Hypnotics and Sedativ

1983
Efficacy and safety of midazolam and oxazepam in insomniacs.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; Humans;

1983
Midazolam and oxazepam in the treatment of insomnia in hospitalized patients.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Hospitalization

1983
Comparative clinical studies with midazolam, oxazepam and placebo.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Dr

1983
Comparative study of midazolam and vesparax in moderate or severe insomnia in female surgical patients.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Adult; Aged; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Dreams; Drug Combinations; Female;

1983
Midazolam and triazolam in out-patients: a double-blind comparison of hypnotic efficacy.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female;

1983
Midazolam and sleep in insomniac patients.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Female; Humans; Male; Midazolam

1983
Placebo-controlled clinical trial of Dormicum 15-mg tablet.
    Therapia Hungarica (English edition), 1993, Volume: 41, Issue:3

    Topics: Adult; Analysis of Variance; Female; Humans; Male; Midazolam; Middle Aged; Polysomnography; Severity

1993
The effect of midazolam on transient insomnia.
    European journal of clinical pharmacology, 1993, Volume: 44, Issue:6

    Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Midazolam; Psych

1993
A comparison of efficacy and tolerance of the short acting sedatives midazolam and zopiclone.
    The New Zealand medical journal, 1992, Oct-28, Volume: 105, Issue:944

    Topics: Adolescent; Adult; Azabicyclo Compounds; Double-Blind Method; Female; Humans; Hypnotics and Sedative

1992
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per

1990
Effects of flurazepam and midazolam on sleep and next-day performance in chronic insomniacs: report of a multicenter study.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Flurazepam; Humans; Midazolam; Sleep; Sleep Initiation and Maintenance Disorders

1990
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: methodology.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Affect; Arousal; Attention; Electroencephalography; Female; Flurazepam; Half-Life; Humans; Ma

1990
Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Affect; Arousal; Electroencephalography; Female; Flurazepam; Humans; Male; Midazolam; Middle

1990
Clinical safety of flurazepam and midazolam during 14-day use in chronic insomniacs.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Double-Blind Method; Female; Flurazepam; Humans; Male; Midazolam; Middle Aged; Sleep Apnea Sy

1990
A multicenter study of sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: executive summary.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Affect; Arousal; Chronic Disease; Double-Blind Method; Flurazepam; Humans; Midazolam; Psychom

1990
Sleep evaluation in chronic insomniacs during 14-day use of flurazepam and midazolam.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Arousal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurazepam; Humans

1990
Psychomotor performance in chronic insomniacs during 14-day use of flurazepam and midazolam.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Arousal; Attention; Dose-Response Relationship, Drug; Female; Flurazepam; Humans; Male; Midaz

1990
Cognitive performance and mood in patients with chronic insomnia during 14-day use of flurazepam and midazolam.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Affect; Arousal; Attention; Dose-Response Relationship, Drug; Drug Administration Schedule; F

1990
Plasma concentrations of flurazepam and midazolam in chronic insomniacs during 14-day use and their relationship to therapeutic effects and next-day performance and mood.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Arousal; Attention; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; F

1990
A multicenter 14-day study of flurazepam and midazolam in chronic insomniacs: general discussion and conclusions.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Arousal; Attention; Double-Blind Method; Female; Flurazepam; Humans; Male; Midazolam; Middle Aged; P

1990
Rebound insomnia and elimination half-life: assessment of individual subject response.
    Journal of clinical pharmacology, 1985, Volume: 25, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D

1985
The effects of midazolam and temazepam on sleep and performance when administered in the middle of the night.
    Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Female; Humans; Hypnotics and Sedatives; Male; Midazola

1985
Efficacy without tolerance or rebound insomnia for midazolam and temazepam after use for one to three months.
    Journal of clinical pharmacology, 1987, Volume: 27, Issue:10

    Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Drug To

1987
The effectiveness of oral midazolam as a hypnotic compared with lorazepam.
    Pharmatherapeutica, 1986, Volume: 4, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Aged; Benzodiazepines; Double-Blind Method; Drug Evaluation

1986
Comparison of the short-acting benzodiazepines midazolam and triazolam with placebo.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:3

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Dreams; Female; Humans; Male; Midazolam;

1988
Transient insomnia and rapidly eliminated hypnotics.
    Sleep, 1986, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Azepines; Half-Life; Humans; Hypnotics and Sedatives; Male; Midazolam; Posture; S

1986
Comparison of midazolam, diazepam and placebo in the treatment of insomnia.
    Singapore medical journal, 1986, Volume: 27, Issue:3

    Topics: Adult; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Humans; Male; Midazolam; Mid

1986
Short-term sleep laboratory evaluation of midazolam in chronic insomniacs. Preliminary results.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Female; Hu

1987

Other Studies

9 other studies available for midazolam and Chronic Insomnia

ArticleYear
Single-Dose Subcutaneous Benzodiazepines for Insomnia in Patients With Advanced Cancer.
    Journal of pain and symptom management, 2015, Volume: 49, Issue:6

    Topics: Aged; Aged, 80 and over; Drug Administration Schedule; Female; Flunitrazepam; Humans; Hypnotics and

2015
Intravenous infusion of midazolam and flunitrazepam for insomnia on Japanese palliative care units.
    Journal of pain and symptom management, 2005, Volume: 30, Issue:4

    Topics: Anti-Anxiety Agents; Flunitrazepam; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Japan;

2005
Efficacy, safety, and cost effectiveness of intravenous midazolam and flunitrazepam for primary insomnia in terminally ill patients with cancer: a retrospective multicenter audit study.
    Journal of palliative medicine, 2007, Volume: 10, Issue:5

    Topics: Aged; Anti-Anxiety Agents; Cost-Benefit Analysis; Female; Flunitrazepam; Humans; Japan; Male; Medica

2007
Evaluation of efficacy and safety of midazolam administered orally in sleep disorders. A dose-finding study.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:12a

    Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug Evaluation

1981
Early morning insomnia with rapidly eliminated benzodiazepines.
    Science (New York, N.Y.), 1983, Apr-01, Volume: 220, Issue:4592

    Topics: Anti-Anxiety Agents; Benzodiazepines; Flurazepam; Half-Life; Humans; Midazolam; Sleep; Sleep Initiat

1983
Pharmacokinetic and clinical considerations in the choice of a hypnotic.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Anti-Anxiety Agents; Benzodiazepines; Drug Utilization; Humans; Hypnotics and Sedatives; Kinetics; M

1983
Automatic scoring of polygraphic sleep recordings: midazolam in insomniacs.
    British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1

    Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Humans; Midazolam; Middle Aged;

1983
Sleep laboratory study of the effects of midazolam in insomniac patients.
    European journal of clinical pharmacology, 1982, Volume: 21, Issue:6

    Topics: Adult; Benzodiazepines; Drug Evaluation; Female; Headache; Humans; Male; Midazolam; Middle Aged; Sle

1982
The chronic efficacy of midazolam.
    International clinical psychopharmacology, 1990, Volume: 5, Issue:1

    Topics: Adult; Drug Tolerance; Female; Humans; Male; Midazolam; Neuropsychological Tests; Sleep Initiation a

1990