Page last updated: 2024-10-31

midazolam and Chronic Disease

midazolam has been researched along with Chronic Disease in 21 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"The analgesic effect of the N-methyl-D-aspartate (NMDA) receptor blocker ketamine in 17 patients (13 females and four males, age 32-88 years) who had suffered neuropathic orofacial pain for time periods ranging from 6 months to 28 years was examined."9.09Interindividual differences in the analgesic response to ketamine in chronic orofacial pain. ( Rabben, T; Øye, I, 2001)
"To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group."9.08[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998)
"Patients with moderate to severe chronic plaque psoriasis (n = 21) received single oral doses of sensitive probe substrates for CYP1A2 (caffeine 100 mg), CYP2C9 (warfarin 10 mg), CYP2C19 (omeprazole 20 mg), CYP2D6 (metoprolol 50 mg), and CYP3A (midazolam 2 mg) on day 1, followed by 12 weeks of subcutaneous risankizumab treatment of 150 mg once every 4 weeks from day 8 to day 92, and again the same cocktail of substrates on day 98."5.30Lack of Effect of 12-Week Treatment with Risankizumab on the Pharmacokinetics of Cytochrome P450 Probe Substrates in Patients with Moderate to Severe Chronic Plaque Psoriasis. ( Camez, A; Cheng, L; Ignatenko, S; Khatri, A; Othman, AA; Pang, Y, 2019)
"A group of 44 patients undergoing FESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or midazolam as preoperative premedication."5.17Premedication with clonidine before TIVA optimizes surgical field visualization and shortens duration of endoscopic sinus surgery - results of a clinical trial. ( Burduk, PK; Cywinski, JB; Kazmierczak, W; Kusza, K; Wawrzyniak, K, 2013)
"The analgesic effect of the N-methyl-D-aspartate (NMDA) receptor blocker ketamine in 17 patients (13 females and four males, age 32-88 years) who had suffered neuropathic orofacial pain for time periods ranging from 6 months to 28 years was examined."5.09Interindividual differences in the analgesic response to ketamine in chronic orofacial pain. ( Rabben, T; Øye, I, 2001)
"To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group."5.08[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998)
" At the initial surgery, children were assigned (no parental intervention) to receive oral midazolam (n = 13), or parental presence during the induction of anesthesia (PPIA, n = 27), or PPIA + midazolam (n = 10) or no intervention (n = 33)."3.72Parental intervention choices for children undergoing repeated surgeries. ( Caldwell-Andrews, AA; Kain, ZN; Krivutza, DM; Mayes, LC; Wang, SM; Weinberg, ME, 2003)
"Ketamine infusion was associated with significant and rapid reduction in PTSD symptom severity, compared with midazolam, when assessed 24 hours after infusion (mean difference in Impact of Event Scale-Revised score, 12."2.79Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. ( Aan Het Rot, M; Charney, DS; Feder, A; Iosifescu, D; Kirkwood, K; Lapidus, KA; Morgan, JE; Murrough, JW; Parides, MK; Perez, AM; Saxena, S; Wan, LB, 2014)
" altered renal and hepatic function, catecholamine-related circulatory changes, altered drug volume of distribution, enteral versus parenteral feeding and morbid obesity, along with concomitant multiple drug regimens may account for the wide inter-individual variability in drug exposure and response in critically ill patients and for the high risk for drug-drug interactions to occur."2.45Mini-series: II. clinical aspects. clinically relevant CYP450-mediated drug interactions in the ICU. ( de Hoon, J; Meersseman, W; Spriet, I; von Winckelmann, S; Willems, L; Wilmer, A, 2009)
"Chronic anal fissure is the main cause of anal pain and is very common."1.31Open lateral sphincterotomy is still the best treatment for chronic anal fissure. ( Argov, S; Levandovsky, O, 2000)
"Fentanyl and midazolam is a combination that is effective and convenient to use because both agents are relatively short acting, have little cardiovascular depression and are easily reversible (with naloxone and flumazenil)."1.29Analgesia and sedation in interventional radiological procedures. ( Hart, GK; Hennessy, OF; Hiew, CY; Thomson, KR, 1995)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (28.57)18.2507
2000's11 (52.38)29.6817
2010's4 (19.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Khatri, A1
Cheng, L1
Camez, A1
Ignatenko, S1
Pang, Y1
Othman, AA1
Wawrzyniak, K1
Kusza, K1
Cywinski, JB1
Burduk, PK1
Kazmierczak, W1
Feder, A1
Parides, MK1
Murrough, JW1
Perez, AM1
Morgan, JE1
Saxena, S1
Kirkwood, K1
Aan Het Rot, M1
Lapidus, KA1
Wan, LB1
Iosifescu, D1
Charney, DS1
Shrot, S1
Ramaty, E1
Biala, Y1
Bar-Klein, G1
Daninos, M1
Kamintsky, L1
Makarovsky, I1
Statlender, L1
Rosman, Y1
Krivoy, A1
Lavon, O1
Kassirer, M1
Friedman, A1
Yaari, Y1
Spriet, I1
Meersseman, W1
de Hoon, J1
von Winckelmann, S1
Wilmer, A1
Willems, L1
Jevtovic-Todorovic, V1
Hartman, RE1
Izumi, Y1
Benshoff, ND1
Dikranian, K1
Zorumski, CF1
Olney, JW1
Wozniak, DF1
Kain, ZN1
Caldwell-Andrews, AA1
Wang, SM1
Krivutza, DM1
Weinberg, ME1
Mayes, LC1
Weston, BR1
Chadalawada, V1
Chalasani, N1
Kwo, P1
Overley, CA1
Symms, M1
Strahl, E1
Rex, DK1
White, SM1
Hunt, T1
Mitchell, AR1
Spurrell, PA1
Gerritse, BE1
Sulke, N1
Figurska, M1
Płocnarska, E1
Stankiewicz, A1
Rybicki, Z1
Rekas, M1
Walker, M1
Manchikanti, L1
Manchikanti, KN1
Manchukonda, R1
Pampati, V1
Cash, KA1
Hiew, CY1
Hart, GK1
Thomson, KR1
Hennessy, OF1
Ammer, R1
Alt, E1
Ayers, G1
Lehmann, G1
Schmitt, C1
Pasquantonio, J1
Pütter, K1
Schmidt, M1
Schömig, A1
Garcia, J1
Roure, P1
Hayem, C1
Dupont, D1
Argov, S1
Levandovsky, O1
Rabben, T1
Øye, I1
Baktai, G1
Székely, E1
Márialigeti, T1
Kovács, L1
Johnson, LC2
Chernik, DA2
Sateia, MJ1
Chen, D1
Ellinwood, E1
Hauri, P1
Judd, LL1
Kripke, DF1
Linnoila, M1
Moskowitz, H1
Roth, T1

Clinical Trials (17)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Multiple Subcutaneous Doses of Risankizumab on the Single Dose Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) Administered Orally in an Open-label, One-sequence Trial in Patients Wit[NCT02772601]Phase 121 participants (Actual)Interventional2016-09-15Completed
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder[NCT00749203]Phase 241 participants (Actual)Interventional2009-01-31Completed
Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain Patients[NCT04322968]Phase 341 participants (Actual)Interventional2018-01-09Completed
A Single Ketamine Infusion Combined With Music for Suicidal Ideation During a Depressive Episode: A Randomized Open Label Clinical Trial[NCT04658420]Phase 2200 participants (Anticipated)Interventional2021-07-01Not yet recruiting
Music as a Potential Intervention to Improve Hemodynamic Tolerability of Repetitive Sub-Anesthetic IV Ketamine Infusions in Bipolar and Unipolar Depression: A Pilot Study[NCT04701866]32 participants (Actual)Interventional2021-01-11Completed
A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885]Phase 26 participants (Anticipated)Interventional2022-08-26Recruiting
Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department[NCT04260607]Phase 32 participants (Actual)Interventional2020-01-14Terminated (stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.)
Assessing a Combined Ketamine and Online Cognitive Behavioural Therapy Intervention for Treatment Resistant Post-Traumatic Stress Disorder[NCT04771767]Phase 216 participants (Anticipated)Interventional2021-08-01Recruiting
The Effect of Therapeutic Ketamine Infusions on the Symptoms of Post-Traumatic Stress Disorder in Combat Veterans[NCT03088384]30 participants (Actual)Observational2016-11-28Completed
Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency in Intensive Care Unit- A Randomized Controlled Trial.[NCT02868827]Phase 2/Phase 3127 participants (Actual)Interventional2017-08-27Terminated (stopped due to The initial plan was 2 years but due to slow recruitment. We were able to screen 635 patients in 4 years and recruited only 127 patients.)
The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial[NCT05936853]16 participants (Anticipated)Interventional2023-07-31Not yet recruiting
Anesthesia Exposure and Neurodevelopment in Infants and Children: Pediatric Anesthesia & NeuroDevelopment (PANDA) Study[NCT00881764]369 participants (Actual)Observational2009-05-31Completed
Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial[NCT02559102]Phase 3104 participants (Actual)Interventional2015-07-31Completed
Randomized Controlled Trial of Nitrous Oxide Analgesia in External Cephalic Version (ECV)[NCT03502915]Phase 348 participants (Actual)Interventional2017-01-30Completed
Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development: 10-year Study[NCT05759351]30 participants (Actual)Observational2006-01-01Completed
A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics[NCT01229514]30 participants (Actual)Observational2008-10-31Completed
Use of Handheld Audiovisual Devices to Treat Pediatric Preoperative Anxiety: A Randomized Control Trial.[NCT02286674]200 participants (Actual)Interventional2014-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinician-Administered PTSD Scale (CAPS)

Clinician-administered structured interview measuring PTSD symptoms. frequency score - scale 0 = none of the time to 4 = most or all of the time intensity score - scale 0 = none to 4 = extreme To meet criteria for a symptom, a patient must meet criteria in both frequency and intensity score for each item. Frequency and intensity and then combined to form a single severity score. 30 questions scale, with total score ranging from 0 to 240. (NCT00749203)
Timeframe: 7 days after first infusion

Interventionunits on a scale (Mean)
Ketamine54
Midazolam65.69

Impact of Event Scale - Revised (IES-R)

"A 22-item self-report questionnaire measuring PTSD symptoms. Items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score ranging from 0 (not at all) to 88 (extremely)" (NCT00749203)
Timeframe: 7 days after first infusion

Interventionunits on a scale (Mean)
Ketamine25.76
Midazolam36.32

Montgomery-Asberg Depression Rating Scale (MADRS)

Clinician-administered questionnaire measuring depressive symptoms. The MADRS-S has 10-items which are based on mood symptoms over the past 7 days. Each items is scored 0 (normal) to 6 (severe depression) with overall score ranges from 0 (normal) to 60 (severe depression). Mean difference between baseline and 2 weeks. (NCT00749203)
Timeframe: 24 hours after first infusion

Interventionunits on a scale (Mean)
Ketamine12.6
Midazolam10.1

Quick Inventory of Depressive Symptomatology - Self Report (QIDS-SR)

Self-report questionnaire measuring depressive symptoms. Each item is rated 0 (no depression) to 3 (severe depression). The total score ranges from 0-27. (NCT00749203)
Timeframe: 24 hours after first infusion

Interventionunits on a scale (Mean)
Ketamine12.4
Midazolam11.3

Impact of Event Scale-Revised (IES-R)

"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 1 week post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion28.22
Chronic Pain With PTSD+IV Ketorolac Infusion33.66666667
Chronic Pain Without PTSD+IV Ketamine Infusion11.44
Chronic Pain Without PTSD+IV Ketorolac Infusion13.41

Impact of Event Scale-Revised (IES-R)

"Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 (not at all) to 4 (extremely). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms" (NCT04322968)
Timeframe: 24 hrs post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion36.33333333
Chronic Pain With PTSD+IV Ketorolac Infusion37
Chronic Pain Without PTSD+IV Ketamine Infusion10.44444444
Chronic Pain Without PTSD+IV Ketorolac Infusion15.64705882

Visual Analogue Scale (VAS)

"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 1 week post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion48.22
Chronic Pain With PTSD+IV Ketorolac Infusion52.88
Chronic Pain Without PTSD+IV Ketamine Infusion43.33
Chronic Pain Without PTSD+IV Ketorolac Infusion48.23

Visual Analogue Scale (VAS)

"Severity of chronic pain symptoms; using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the no pain anchor and the patient's mark, providing a range of scores from 0-100; a higher score indicates greater pain intensity." (NCT04322968)
Timeframe: 24 hrs post-infusion

Interventionunits on a scale (Mean)
Chronic Pain With PTSD+IV Ketamine Infusion37.22222222
Chronic Pain With PTSD+IV Ketorolac Infusion49.66666667
Chronic Pain Without PTSD+IV Ketamine Infusion29.88888889
Chronic Pain Without PTSD+IV Ketorolac Infusion38.70588235

Brief Pain Inventory (Short Form)

"Severity of pain, impact of pain on daily function, location of pain, pain medications and amount of pain relief in the past 24 hours or the past week; No scoring algorithm, but worst pain or the arithmetic mean of the four severity items can be used as measures of pain severity (a range of 0-10, with 10 being worse scores); the arithmetic mean of the seven interference items can be used as a measure of pain interference (a range of 0-10, with 10 being worse scores). The total score is reported for severity items and interference items, which range from 0-40 and 0-70, respectively. Higher values represent worse outcome." (NCT04322968)
Timeframe: 1 week post-infusion

,,,
Interventionunits on a scale (Mean)
Pain interference ScalePain severity Scale
Chronic Pain With PTSD+IV Ketamine Infusion38.6220.75
Chronic Pain With PTSD+IV Ketorolac Infusion25.6614.66
Chronic Pain Without PTSD+IV Ketamine Infusion9.6212.75
Chronic Pain Without PTSD+IV Ketorolac Infusion28.3322.66

Mean Anxiety Score Experienced During Version

Anxiety scores will be collected following each version attempt using an 11 point scale (0 being not at all anxious; 10 being extremely anxious), ranging from 0 to 10. Higher scores indicate more anxiety, lower scores indicate less anxiety. If more than one attempt, anxiety scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes

Interventionscore on a scale (Mean)
Nitrous Oxide4.696
Oxygen4.253

Mean Pain Score Experienced During Version

Pain scores will be collected following each version attempt using an 11 point scale (with 0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. If more than one attempt, pain scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes

Interventionscore on a scale (Mean)
Nitrous Oxide5.486
Oxygen5.433

Mean Post-procedure Pain Score

Pain scores will be collected following completion of the version using an 11 point scale (0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt

Interventionscore on a scale (Mean)
Nitrous Oxide1
Oxygen0.88

Mean Post-procedure Patient Satisfaction Score

Satisfaction will be assessed following the procedure using an 11 point scale (0 being not at all satisfied; 10 being extremely satisfied), ranging from 0 to 10. Higher scores indicate more satisfaction, lower scores indicate less satisfaction. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt

Interventionscore on a scale (Mean)
Nitrous Oxide4.286
Oxygen6.920

Mean Post-procedure Provider Assessed Level of Difficulty Score

Following the procedure, the obstetric provider performing the procedure will rate the ease of procedure on a 1-10 scale (1 being very easy and 10 being extremely difficult), ranging from 1 to 10. Higher scores indicate more difficulty, lower scores indicate less difficulty. A 10 point scale was used for this outcome, while an 11 point scale was used for the other 4 outcome measures (pain, anxiety, post-procedure pain and satisfaction). (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt

Interventionscore on a scale (Mean)
Nitrous Oxide6.136
Oxygen6.080

Reviews

3 reviews available for midazolam and Chronic Disease

ArticleYear
Mini-series: II. clinical aspects. clinically relevant CYP450-mediated drug interactions in the ICU.
    Intensive care medicine, 2009, Volume: 35, Issue:4

    Topics: Acute Disease; Analgesics, Opioid; Anti-Bacterial Agents; Anticonvulsants; Benzodiazepines; Catechol

2009
Status epilepticus: an evidence based guide.
    BMJ (Clinical research ed.), 2005, Sep-24, Volume: 331, Issue:7518

    Topics: Anticonvulsants; Chronic Disease; Critical Care; Drug Administration Routes; Emergency Treatment; Ev

2005
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per

1990

Trials

12 trials available for midazolam and Chronic Disease

ArticleYear
Lack of Effect of 12-Week Treatment with Risankizumab on the Pharmacokinetics of Cytochrome P450 Probe Substrates in Patients with Moderate to Severe Chronic Plaque Psoriasis.
    Clinical pharmacokinetics, 2019, Volume: 58, Issue:6

    Topics: Antibodies, Monoclonal; Area Under Curve; Caffeine; Chronic Disease; Cytochrome P-450 Enzyme System;

2019
Premedication with clonidine before TIVA optimizes surgical field visualization and shortens duration of endoscopic sinus surgery - results of a clinical trial.
    Rhinology, 2013, Volume: 51, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Blood Loss, Surgical; Chronic Disease; Clonidine;

2013
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial.
    JAMA psychiatry, 2014, Volume: 71, Issue:6

    Topics: Administration, Intravenous; Adult; Anti-Anxiety Agents; Chronic Disease; Cross-Over Studies; Depres

2014
Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients.
    The American journal of gastroenterology, 2003, Volume: 98, Issue:11

    Topics: Aged; Ambulatory Care; Chronic Disease; Conscious Sedation; Dose-Response Relationship, Drug; Drug A

2003
Improving the acceptability of the atrial defibrillator for the treatment of persistent atrial fibrillation: the atrial defibrillator sedation assessment study (ADSAS).
    International journal of cardiology, 2004, Volume: 96, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Atrial Fibrillation; Chronic Disease; Confidence Interva

2004
Evaluation of therapeutic thoracic medial branch block effectiveness in chronic thoracic pain: a prospective outcome study with minimum 1-year follow up.
    Pain physician, 2006, Volume: 9, Issue:2

    Topics: Adult; Back Pain; Chronic Disease; Disability Evaluation; Employment; Female; Fentanyl; Follow-Up St

2006
Pain threshold for low energy intracardiac cardioversion of atrial fibrillation with low or no sedation.
    Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:1 Pt 2

    Topics: Atrial Fibrillation; Chronic Disease; Conscious Sedation; Defibrillators, Implantable; Electric Coun

1997
[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination].
    Revue des maladies respiratoires, 1998, Volume: 15, Issue:2

    Topics: Adjuvants, Anesthesia; Administration, Rectal; Anesthesia, Local; Anesthetics, Inhalation; Anestheti

1998
Interindividual differences in the analgesic response to ketamine in chronic orofacial pain.
    European journal of pain (London, England), 2001, Volume: 5, Issue:3

    Topics: Adjuvants, Anesthesia; Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics

2001
Use of midazolam ('Dormicum') and flumazenil ('Anexate') in paediatric bronchology.
    Current medical research and opinion, 1992, Volume: 12, Issue:9

    Topics: Anesthesia; Atropine; Bronchoscopy; Child, Preschool; Chronic Disease; Drug Administration Schedule;

1992
Sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: an introduction.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Chronic Disease; Double-Blind Method; Flurazepam; Humans; Long-Term Care; Midazolam; Psychomotor Per

1990
A multicenter study of sleep, performance, and plasma levels in chronic insomniacs during 14-day use of flurazepam and midazolam: executive summary.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:4 Suppl

    Topics: Adult; Affect; Arousal; Chronic Disease; Double-Blind Method; Flurazepam; Humans; Midazolam; Psychom

1990

Other Studies

7 other studies available for midazolam and Chronic Disease

ArticleYear
Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
    Toxicology, 2014, Sep-02, Volume: 323

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chronic Diseas

2014
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co

2003
Parental intervention choices for children undergoing repeated surgeries.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:4

    Topics: Anesthesia; Anxiety; Anxiety, Separation; Child; Child, Preschool; Chronic Disease; Female; Humans;

2003
Anaesthesia for Homans' procedure.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:5

    Topics: Analgesics, Opioid; Anesthesia, General; Anesthetics, Intravenous; Chronic Disease; Dermatologic Sur

2004
[Monitoring of blood pressure during phacotrabeculectomy].
    Klinika oczna, 2004, Volume: 106, Issue:1-2 Suppl

    Topics: Aged; Aged, 80 and over; Anesthetics, Intravenous; Blood Pressure; Blood Pressure Determination; Car

2004
Analgesia and sedation in interventional radiological procedures.
    Australasian radiology, 1995, Volume: 39, Issue:2

    Topics: Aged; Ambulatory Care; Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics,

1995
Open lateral sphincterotomy is still the best treatment for chronic anal fissure.
    American journal of surgery, 2000, Volume: 179, Issue:3

    Topics: Ambulatory Surgical Procedures; Anal Canal; Anesthetics, Local; Bupivacaine; Chronic Disease; Fissur

2000