midazolam has been researched along with Chemical Dependence in 39 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found that ketamine leads to significantly greater mystical-type effects (by Hood Mysticism Scale) and dissociation (by Clinician Administered Dissociative States Scale) compared to the active control." | 5.41 | Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial. ( Azhari, N; Dakwar, E; Haug, NA; Rothberg, RL, 2021) |
| "Myocardial infarction is a rare and lethal event during pregnancy with an incidence of 1 in 10,000 pregnancies." | 5.28 | Anaesthetic management of a parturient with myocardial infarction related to cocaine use. ( Chen, K; Forrester, RM; Glassenberg, R; Liu, SS; Murphy, GS, 1992) |
| " The mechanism of action analysis revealed that ketamine directly targets multiple CUD-associated genes (BDNF, CNR1, DRD2, GABRA2, GABRB3, GAD1, OPRK1, OPRM1, SLC6A3, SLC6A4) and pathways implicated in neuroactive ligand-receptor interaction, cAMP signaling and cocaine abuse/dependence." | 4.31 | Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses. ( Davis, PB; Gao, Z; Ghitza, UE; Gorenflo, M; Kaelber, DC; Winhusen, TJ; Xu, R, 2023) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| "Propofol is an addictive drug, and the problem of its abuse and dependence has occurred." | 1.42 | Increased use in propofol and reported patterns of adverse events among anesthetics in Korea. ( Kim, MH; Park, BJ; Park, HJ; Shin, JY, 2015) |
| " Compared with the alcohol and control groups, the opioid group used a statistically higher mean medication dosage to achieve sedation." | 1.42 | Chronic Opioid Users Are More Difficult to Sedate than Alcoholics and Controls. ( Clayton, S; Gill, J; Patel, R; Quintero, E, 2015) |
| "Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together." | 1.39 | Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. ( Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM, 2013) |
| "Midazolam was the most commonly used BZD." | 1.34 | Concomitant use of midazolam and buprenorphine and its implications among drug users in Singapore. ( Chan, YH; Mythily, S; Ng, WL; Song, G; Winslow, M, 2007) |
| "Ramelteon did not produce benzodiazepine-like discriminative stimulus effects at doses up to 10 mg/kg." | 1.33 | Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies. ( Cruź, CM; France, CP; Koek, W; McMahon, LR; Weltman, RH, 2006) |
| " The switch to oral agents must take into consideration the differences in potency, half-life, and oral bioavailability between the agents." | 1.29 | Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit. ( Deshpande, JK; Gregory, DF; Tobias, JD, 1994) |
| "Myocardial infarction is a rare and lethal event during pregnancy with an incidence of 1 in 10,000 pregnancies." | 1.28 | Anaesthetic management of a parturient with myocardial infarction related to cocaine use. ( Chen, K; Forrester, RM; Glassenberg, R; Liu, SS; Murphy, GS, 1992) |
| "Zolpidem is a new, short-acting hypnotic of imidazopyridine structure which binds selectively to a subpopulation of receptors involved in the action of benzodiazepines [omega 1 (BZ1) sites of the gamma-aminobutyric acidA receptors]." | 1.28 | Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1992) |
| " Using a cumulative dosing procedure, PTZ substituted for PTZ, and MDZ, chlordiazepoxide and diazepam (DZP) substituted for MDZ, in a dose-dependent manner." | 1.28 | Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam. ( Boone, MS; Emmett-Oglesby, MW; Pugh, SL, 1992) |
| "Midazolam is a new ultra short-acting benzodiazepine whose physical dependence properties have not been well characterized." | 1.28 | Tolerance and physical dependence to a short-acting benzodiazepine, midazolam. ( Boisse, NR; Guarino, JJ; Quaglietta, N; Samoriski, GM, 1990) |
| " In naive animals, after the chronic administration of midazolam at 0." | 1.27 | [Drug dependence tests on a new anesthesia inducer, midazolam]. ( Hakkei, M; Kubota, A; Kuwahara, A; Nakamura, K, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (15.38) | 18.7374 |
| 1990's | 14 (35.90) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 4 (10.26) | 2.80 |
| Authors | Studies |
|---|---|
| Ikram, H | 1 |
| Tasneem, S | 1 |
| Perveen, S | 1 |
| Zakir, R | 1 |
| Jabeen Haleem, D | 1 |
| Gao, Z | 1 |
| Winhusen, TJ | 1 |
| Gorenflo, M | 1 |
| Ghitza, UE | 1 |
| Davis, PB | 1 |
| Kaelber, DC | 1 |
| Xu, R | 1 |
| Schippers, F | 1 |
| Pesic, M | 1 |
| Saunders, R | 1 |
| Borkett, K | 1 |
| Searle, S | 1 |
| Webster, L | 1 |
| Stoehr, T | 1 |
| Rothberg, RL | 1 |
| Azhari, N | 1 |
| Haug, NA | 1 |
| Dakwar, E | 1 |
| Soberón, JR | 1 |
| King, JJ | 1 |
| Wojcik, SM | 1 |
| Tantra, M | 1 |
| Stepniak, B | 1 |
| Man, KN | 1 |
| Müller-Ribbe, K | 1 |
| Begemann, M | 1 |
| Ju, A | 1 |
| Papiol, S | 1 |
| Ronnenberg, A | 1 |
| Gurvich, A | 1 |
| Shin, Y | 1 |
| Augustin, I | 1 |
| Brose, N | 1 |
| Ehrenreich, H | 1 |
| Shin, JY | 2 |
| Lee, SH | 1 |
| Shin, SM | 1 |
| Kim, MH | 2 |
| Park, SG | 1 |
| Park, BJ | 2 |
| Park, HJ | 1 |
| Patel, R | 1 |
| Clayton, S | 1 |
| Quintero, E | 1 |
| Gill, J | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| Asl, BH | 1 |
| Hassanzadeh, K | 1 |
| Khezri, E | 1 |
| Mohammadi, S | 1 |
| Gerak, LR | 2 |
| Isbister, GK | 1 |
| Calver, LA | 1 |
| Page, CB | 1 |
| Stokes, B | 1 |
| Bryant, JL | 1 |
| Downes, MA | 1 |
| Bai, X | 1 |
| France, CP | 2 |
| Caldicott, DG | 1 |
| Edwards, NA | 1 |
| Kruys, A | 1 |
| Kirkbride, KP | 1 |
| Sims, DN | 1 |
| Byard, RW | 1 |
| Prior, M | 1 |
| Irvine, RJ | 1 |
| Weltman, RH | 1 |
| Koek, W | 1 |
| Cruź, CM | 1 |
| McMahon, LR | 1 |
| Raffa, RB | 1 |
| Cavallo, F | 1 |
| Capasso, A | 1 |
| Ng, WL | 1 |
| Mythily, S | 1 |
| Song, G | 1 |
| Chan, YH | 1 |
| Winslow, M | 1 |
| Spain, D | 1 |
| Crilly, J | 1 |
| Whyte, I | 1 |
| Jenner, L | 1 |
| Carr, V | 1 |
| Baker, A | 1 |
| Tobias, JD | 1 |
| Deshpande, JK | 1 |
| Gregory, DF | 1 |
| Evans, EB | 1 |
| Balster, RL | 1 |
| Yaster, M | 1 |
| Kost-Byerly, S | 1 |
| Berde, C | 1 |
| Billet, C | 1 |
| Mariathasan, EA | 1 |
| Stolerman, IP | 1 |
| White, JA | 1 |
| Weerts, EM | 1 |
| Kaminski, BJ | 1 |
| Griffiths, RR | 2 |
| Perera, I | 1 |
| Lim, L | 1 |
| Augsburger, M | 1 |
| Giroud, C | 1 |
| Rivier, L | 1 |
| Tracqui, A | 1 |
| Mangin, P | 1 |
| Loeb, P | 1 |
| Adnet, P | 1 |
| Boittiaux, P | 1 |
| Forget, AP | 1 |
| Mille, FX | 1 |
| Liu, SS | 1 |
| Forrester, RM | 1 |
| Murphy, GS | 1 |
| Chen, K | 1 |
| Glassenberg, R | 1 |
| Perrault, G | 1 |
| Morel, E | 1 |
| Sanger, DJ | 1 |
| Zivkovic, B | 1 |
| Pugh, SL | 1 |
| Boone, MS | 1 |
| Emmett-Oglesby, MW | 1 |
| Vigorito, M | 1 |
| Lau, CE | 1 |
| Tang, M | 3 |
| Falk, JL | 3 |
| Sannerud, CA | 1 |
| Allen, M | 1 |
| Cook, JM | 1 |
| Boisse, NR | 1 |
| Quaglietta, N | 1 |
| Samoriski, GM | 1 |
| Guarino, JJ | 1 |
| Yutrzenka, GJ | 1 |
| Patrick, GA | 1 |
| Rosenberger, W | 1 |
| Podnos, B | 1 |
| Fraenkel, HM | 1 |
| Kubota, A | 1 |
| Kuwahara, A | 1 |
| Hakkei, M | 1 |
| Nakamura, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for midazolam and Chemical Dependence
| Article | Year |
|---|---|
The management of opioid and benzodiazepine dependence in infants, children, and adolescents.
Topics: Adolescent; Analgesia, Patient-Controlled; Anti-Anxiety Agents; Child; Child, Preschool; Drug Admini | 1996 |
Amineptine and midazolam dependence.
Topics: Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Dibenzocycloheptenes; Follow-Up Studies; Huma | 1998 |
3 trials available for midazolam and Chemical Dependence
| Article | Year |
|---|---|
Randomized Crossover Trial to Compare Abuse Liability of Intravenous Remimazolam Versus Intravenous Midazolam and Placebo in Recreational Central Nervous System Depressant Users.
Topics: Administration, Intravenous; Adolescent; Adult; Amnesia; Benzodiazepines; Central Nervous System Dep | 2020 |
Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial.
Topics: Alcohol Drinking; Behavior, Addictive; Dissociative Disorders; Double-Blind Method; Female; Hallucin | 2021 |
Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study.
Topics: Acute Disease; Adult; Aggression; Double-Blind Method; Droperidol; Drug Therapy, Combination; Emerge | 2010 |
34 other studies available for midazolam and Chemical Dependence
| Article | Year |
|---|---|
Neurochemical and behavioral effects of fluoxetine on midazolam induce dependence in an animal model of addiction.
Topics: Animals; Behavior, Animal; Drug Interactions; Fluoxetine; Hypnotics and Sedatives; Male; Midazolam; | 2021 |
Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses.
Topics: Antidepressive Agents; Artificial Intelligence; Cocaine; Cocaine-Related Disorders; Drug Repositioni | 2023 |
Substance abuse in the anesthesia block room by a patient.
Topics: Anesthesia, Intravenous; Elective Surgical Procedures; Humans; Hypnotics and Sedatives; Ketamine; Mi | 2017 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; | 2013 |
Prescribing patterns of the four most commonly used sedatives in endoscopic examination in Korea: propofol, midazolam, diazepam, and lorazepam.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diazepam; Drug Prescriptions; Drug Utilization Review; E | 2015 |
Increased use in propofol and reported patterns of adverse events among anesthetics in Korea.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Anesthetics, Intravenous; Child; C | 2015 |
Chronic Opioid Users Are More Difficult to Sedate than Alcoholics and Controls.
Topics: Adult; Case-Control Studies; Colonoscopy; Conscious Sedation; Dose-Response Relationship, Drug; Fema | 2015 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice.
Topics: Animals; Dextromethorphan; Drug Tolerance; Male; Mice; Midazolam; Morphine; Naloxone; Substance-Rela | 2008 |
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.
Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitraz | 2009 |
The discriminative stimulus effects of midazolam are resistant to modulation by morphine, amphetamine, dizocilpine, and γ-butyrolactone in rhesus monkeys.
Topics: 4-Butyrolactone; Amphetamine; Animals; Codependency, Psychological; Discrimination, Psychological; D | 2011 |
Dancing with "death": p-methoxyamphetamine overdose and its acute management.
Topics: Acute Disease; Adult; Amphetamines; Chromatography, Gas; Drug Overdose; Female; Glasgow Coma Scale; | 2003 |
Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzodiazepines; Conditioning, Classical; Condition | 2006 |
Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists.
Topics: Analysis of Variance; Animals; Benzodiazepines; Clorazepate Dipotassium; Dose-Response Relationship, | 2007 |
Concomitant use of midazolam and buprenorphine and its implications among drug users in Singapore.
Topics: Adult; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Narcoti | 2007 |
Safety and effectiveness of high-dose midazolam for severe behavioural disturbance in an emergency department with suspected psychostimulant-affected patients.
Topics: Adult; Emergency Service, Hospital; Female; Glasgow Coma Scale; Humans; Hypnotics and Sedatives; Mal | 2008 |
Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit.
Topics: Child; Female; Fentanyl; Humans; Iatrogenic Disease; Infant; Lorazepam; Male; Methadone; Midazolam; | 1994 |
Inhaled 1,1,1-trichloroethane-produced physical dependence in mice: effects of drugs and vapors on withdrawal.
Topics: Administration, Inhalation; Animals; Chlorpromazine; Ethanol; Male; Mice; Midazolam; Pentobarbital; | 1993 |
Antagonism of AND and AND-OR drug mixture discriminations in rats.
Topics: Animals; Anti-Anxiety Agents; Association Learning; Conditioning, Operant; Discrimination Learning; | 1997 |
Stable low-rate midazolam self-injection with concurrent physical dependence under conditions of long-term continuous availability in baboons.
Topics: Animals; Anti-Anxiety Agents; Feeding Behavior; Flumazenil; Male; Midazolam; Papio; Self Administrat | 1998 |
Car crash after massive ingestion of digoxin and midazolam.
Topics: Accidents, Traffic; Adult; Alcohol Drinking; Autopsy; Cardiotonic Agents; Digoxin; Humans; Hypnotics | 1998 |
[Benzodiazepine withdrawal presenting as pseudo-surgical abdominal pain].
Topics: Abdomen, Acute; Adult; Alprazolam; Anti-Anxiety Agents; Bromazepam; Diagnosis, Differential; Headach | 1997 |
Anaesthetic management of a parturient with myocardial infarction related to cocaine use.
Topics: Adult; Anesthesia, Intravenous; Anesthesia, Obstetrical; Crack Cocaine; Female; Fentanyl; Humans; La | 1992 |
Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem.
Topics: Animals; Drug Tolerance; Electroshock; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoniaz | 1992 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug | 1992 |
Midazolam withdrawal and discriminative motor control: effects of FG 7142 and Ro 15-1788.
Topics: Animals; Brain Chemistry; Carbolines; Discrimination, Psychological; Dose-Response Relationship, Dru | 1991 |
Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Diazepam; Dose-Response Relationship, Drug; | 1991 |
Tolerance and physical dependence to a short-acting benzodiazepine, midazolam.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tole | 1990 |
Substitution of temazepam and midazolam in pentobarbital-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred St | 1989 |
Are two dead doctors enough?
Topics: Florida; Humans; Interprofessional Relations; Midazolam; Pentazocine; Physician Impairment; Substanc | 1986 |
Midazolam oral self-administration.
Topics: Administration, Oral; Animals; Benzodiazepines; Drug Evaluation, Preclinical; Humans; Male; Midazola | 1985 |
Development of physical dependence on midazolam by oral self-administration.
Topics: Administration, Oral; Animals; Male; Midazolam; Rats; Self Administration; Substance-Related Disorde | 1987 |
[Approval of midazolam as a sedative is undesirable].
Topics: Humans; Midazolam; Sleep Wake Disorders; Substance-Related Disorders | 1986 |
[Drug dependence tests on a new anesthesia inducer, midazolam].
Topics: Animals; Injections, Intravenous; Macaca fascicularis; Male; Midazolam; Pentobarbital; Self Administ | 1986 |