midazolam has been researched along with Cerebral Palsy in 9 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate how effective a combination of rectally administered midazolam and racemic ketamine was for reducing pain in paediatric cerebral palsy patients receiving intramuscular injections of botulinum neurotoxin A." | 9.24 | A rectally administered combination of midazolam and ketamine was easy, effective and feasible for procedural pain in children with cerebral palsy. ( Askljung, B; Brunsson, I; Himmelmann, K; Nilsson, S; Påhlman, M, 2017) |
| " This study describes our institution's experience with ketamine-based PSA in terms of safety and efficacy in children with cerebral palsy receiving BoNT-A injections." | 7.83 | Ketamine-based procedural sedation and analgesia for botulinum toxin A injections in children with cerebral palsy. ( Choong, CT; Chow, C, 2016) |
| "The aim of this study was to investigate how effective a combination of rectally administered midazolam and racemic ketamine was for reducing pain in paediatric cerebral palsy patients receiving intramuscular injections of botulinum neurotoxin A." | 5.24 | A rectally administered combination of midazolam and ketamine was easy, effective and feasible for procedural pain in children with cerebral palsy. ( Askljung, B; Brunsson, I; Himmelmann, K; Nilsson, S; Påhlman, M, 2017) |
| "This randomized, double-blind, placebo-controlled study compared the efficacy of inhaled nitrous oxide (N(2)O) with enteral midazolam for sedation of children with cerebral palsy (CP) undergoing botulinum toxin A (BoNT-A) injections." | 5.13 | Effectiveness of sedation using nitrous oxide compared with enteral midazolam for botulinum toxin A injections in children. ( Krach, LE; Rivard, PF; Wendorf, HR; Zier, JL, 2008) |
| " This study describes our institution's experience with ketamine-based PSA in terms of safety and efficacy in children with cerebral palsy receiving BoNT-A injections." | 3.83 | Ketamine-based procedural sedation and analgesia for botulinum toxin A injections in children with cerebral palsy. ( Choong, CT; Chow, C, 2016) |
| " A significant odds ratio related to decreased SpO2 was observed for age, sex, midazolam and propofol levels, concurrent use of nitrous oxide, cerebral palsy, Down syndrome, and mental retardation." | 3.79 | Risk factors with intravenous sedation for patients with disabilities. ( Fukayama, H; Ishikawa, M; Jinno, S; Kohase, H; Kunimori, H; Miwa, Z; Nakamura, Z; Okumura, H; Shimoyama, K; Tamaki, Y; Yoshikawa, F, 2013) |
| " For management of postoperative muscle spasm, an intravenous benzodiazepine was used (diazepam 0." | 3.69 | Pain management for children following selective dorsal rhizotomy. ( Geiduschek, JM; Haberkern, CM; Hays, RM; Jacobson, LE; McLaughlin, JF; Roberts, TS, 1994) |
| "Midazolam was used in approximately 47% in the MC group." | 1.40 | Survey on choice of intravenous sedative agent at department of dental anesthesiology, Tokyo Dental College Chiba Hospital between 2010 and 2011. ( Ichinohe, T; Kasahara, M; Matsuki, Y; Matsuura, N; Okamura, T; Shiozaki, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshikawa, F | 1 |
| Tamaki, Y | 1 |
| Okumura, H | 1 |
| Miwa, Z | 1 |
| Ishikawa, M | 1 |
| Shimoyama, K | 1 |
| Nakamura, Z | 1 |
| Kunimori, H | 1 |
| Jinno, S | 1 |
| Kohase, H | 1 |
| Fukayama, H | 1 |
| Matsuki, Y | 1 |
| Okamura, T | 1 |
| Shiozaki, K | 1 |
| Matsuura, N | 1 |
| Kasahara, M | 1 |
| Ichinohe, T | 1 |
| Chow, C | 1 |
| Choong, CT | 1 |
| Nilsson, S | 1 |
| Brunsson, I | 1 |
| Askljung, B | 1 |
| Påhlman, M | 1 |
| Himmelmann, K | 1 |
| Zier, JL | 1 |
| Rivard, PF | 1 |
| Krach, LE | 1 |
| Wendorf, HR | 1 |
| Gubbay, A | 1 |
| Langdon, K | 1 |
| Kumar, R | 1 |
| Sneade, C | 1 |
| Littler, K | 1 |
| Hansen, CR | 1 |
| Gooch, JL | 1 |
| Such-Neibar, T | 1 |
| Geiduschek, JM | 1 |
| Haberkern, CM | 1 |
| McLaughlin, JF | 1 |
| Jacobson, LE | 1 |
| Hays, RM | 1 |
| Roberts, TS | 1 |
3 trials available for midazolam and Cerebral Palsy
| Article | Year |
|---|---|
A rectally administered combination of midazolam and ketamine was easy, effective and feasible for procedural pain in children with cerebral palsy.
Topics: Administration, Rectal; Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Child, Preschoo | 2017 |
Effectiveness of sedation using nitrous oxide compared with enteral midazolam for botulinum toxin A injections in children.
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Child, Preschool; Double-Blind Method; | 2008 |
Effectiveness of sedation using nitrous oxide compared with enteral midazolam for botulinum toxin A injections in children.
Topics: Adolescent; Anesthetics, Inhalation; Anesthetics, Intravenous; Botulinum Toxins, Type A; Cerebral Pa | 2009 |
6 other studies available for midazolam and Cerebral Palsy
| Article | Year |
|---|---|
Risk factors with intravenous sedation for patients with disabilities.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Dental; Anesthes | 2013 |
Survey on choice of intravenous sedative agent at department of dental anesthesiology, Tokyo Dental College Chiba Hospital between 2010 and 2011.
Topics: Administration, Intravenous; Adult; Aged; Anesthesia, Dental; Anesthetics, Intravenous; Cerebral Pal | 2014 |
Ketamine-based procedural sedation and analgesia for botulinum toxin A injections in children with cerebral palsy.
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Child, Preschool; Conscious Sedation; F | 2016 |
'Effectiveness of sedation using nitrous oxide compared with enteral midazolam for botulinum toxin A injections in children'.
Topics: Botulinum Toxins, Type A; Cerebral Palsy; Child; Conscious Sedation; Female; Humans; Hypnotics and S | 2009 |
Prolonged, severe intrathecal baclofen withdrawal syndrome: a case report.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Critical Care; Cross Infection; Device Removal; Dose-Re | 2007 |
Pain management for children following selective dorsal rhizotomy.
Topics: Adolescent; Adult; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Bupiva | 1994 |