midazolam has been researched along with Cancer of Liver in 10 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, the impact of microRNAs (miRNAs) has been identified in hepatocellular carcinoma (HCC), this study was designed to assess the effects of miR-124-3p and midazolam (MDZ) in HCC with the involvement of PIM-1." | 7.96 | Midazolam inhibits proliferation and accelerates apoptosis of hepatocellular carcinoma cells by elevating microRNA-124-3p and suppressing PIM-1. ( Du, X; Qi, Y; Yao, X, 2020) |
| "Recently, the impact of microRNAs (miRNAs) has been identified in hepatocellular carcinoma (HCC), this study was designed to assess the effects of miR-124-3p and midazolam (MDZ) in HCC with the involvement of PIM-1." | 3.96 | Midazolam inhibits proliferation and accelerates apoptosis of hepatocellular carcinoma cells by elevating microRNA-124-3p and suppressing PIM-1. ( Du, X; Qi, Y; Yao, X, 2020) |
| "Compared to propofol and general anesthesia, midazolam/fentanyl sedation was associated with an increased periprocedural perception of pain and lower local tumor progression-free survival." | 3.91 | Propofol Compared to Midazolam Sedation and to General Anesthesia for Percutaneous Microwave Ablation in Patients with Hepatic Malignancies: A Single-Center Comparative Analysis of Three Historical Cohorts. ( de Jong, MC; de Vries, JJJ; Geboers, B; Gerçek, CC; Hoedemaker-Boon, CJ; Meijerink, MR; Nieuwenhuizen, S; Puijk, RS; Ruarus, AH; Scheffer, HJ; Thöne-Passchier, DH; van den Tol, PMP; Vroomen, LGPH; Ziedses des Plantes, V, 2019) |
| " Based on clearance of CYP isoform-specific substrates at the microsomal level (CLM), microsomal protein per gram of liver (MPPGL), liver weight, hepatic blood flow, hepatic clearance values (CLH) for 10 CYPs in HCC patients (n=102) were extrapolated using a predictive bottom-up pharmacokinetic model." | 1.43 | Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach. ( Fang, Y; Gao, J; Gao, N; He, XP; Jia, LJ; Jin, H; Qiao, HL; Tian, X; Wen, Q; Zhang, YF; Zhou, J, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, D | 1 |
| Soh, CK | 1 |
| Goh, WH | 1 |
| Wang, H | 1 |
| Parhar, D | 2 |
| Baum, RA | 2 |
| Spouge, R | 2 |
| Yan, T | 2 |
| Ho, S | 2 |
| Hadjivassiliou, A | 2 |
| Machan, L | 2 |
| Legiehn, G | 2 |
| Klass, D | 2 |
| Dhatt, R | 2 |
| Boucher, LM | 2 |
| Liu, DM | 2 |
| Qi, Y | 1 |
| Yao, X | 1 |
| Du, X | 1 |
| Puijk, RS | 1 |
| Ziedses des Plantes, V | 1 |
| Nieuwenhuizen, S | 1 |
| Ruarus, AH | 1 |
| Vroomen, LGPH | 1 |
| de Jong, MC | 1 |
| Geboers, B | 1 |
| Hoedemaker-Boon, CJ | 1 |
| Thöne-Passchier, DH | 1 |
| Gerçek, CC | 1 |
| de Vries, JJJ | 1 |
| van den Tol, PMP | 1 |
| Scheffer, HJ | 1 |
| Meijerink, MR | 1 |
| Gao, J | 1 |
| Zhou, J | 1 |
| He, XP | 1 |
| Zhang, YF | 1 |
| Gao, N | 1 |
| Tian, X | 1 |
| Fang, Y | 1 |
| Wen, Q | 1 |
| Jia, LJ | 1 |
| Jin, H | 1 |
| Qiao, HL | 1 |
| Vrzal, R | 1 |
| Kubesova, K | 1 |
| Pavek, P | 1 |
| Dvorak, Z | 1 |
| Jabbour-Khoury, S | 1 |
| Dabbous, A | 1 |
| al-Jazzar, M | 1 |
| Rizk, M | 1 |
| Chahine, M | 1 |
| Khalife, M | 1 |
| Ayoub, C | 1 |
| Baraka, A | 1 |
| Thomas, P | 1 |
| de Sousa, G | 1 |
| Nicolas, F | 1 |
| Le Treut, YP | 1 |
| Delpero, JR | 1 |
| Fuentes, P | 1 |
| Placidi, M | 1 |
| Rahmani, R | 1 |
| Wandel, C | 1 |
| Böcker, RH | 1 |
| Böhrer, H | 1 |
| deVries, JX | 1 |
| Hofmann, W | 1 |
| Walter, K | 1 |
| Kleingeist, B | 1 |
| Neff, S | 1 |
| Ding, R | 1 |
| Walter-Sack, I | 1 |
| Martin, E | 1 |
| Benvenuti, D | 1 |
10 other studies available for midazolam and Cancer of Liver
| Article | Year |
|---|---|
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterografts | 2018 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
Midazolam inhibits proliferation and accelerates apoptosis of hepatocellular carcinoma cells by elevating microRNA-124-3p and suppressing PIM-1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell M | 2020 |
Propofol Compared to Midazolam Sedation and to General Anesthesia for Percutaneous Microwave Ablation in Patients with Hepatic Malignancies: A Single-Center Comparative Analysis of Three Historical Cohorts.
Topics: Ablation Techniques; Aged; Anesthesia, General; Cohort Studies; Female; Humans; Hypnotics and Sedati | 2019 |
Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach.
Topics: Algorithms; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; GABA Modulators; Humans; Isoe | 2016 |
Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.
Topics: Anti-Anxiety Agents; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome | 2010 |
Anesthetic management of a patient having a carcinoid syndrome.
Topics: Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Atracurium; Carcinoid Tumor; Fema | 2003 |
In vitro evaluation of donor liver preservation fluids on human hepatocyte function.
Topics: Antimetabolites; Biotransformation; Cell Division; Cell Hypoxia; Cold Temperature; Diazepam; GABA Mo | 1995 |
Relationship between hepatic cytochrome P450 3A content and activity and the disposition of midazolam administered orally.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; | 1998 |
Novel uses for Zyderm and Versed.
Topics: Collagen; Embolization, Therapeutic; Humans; Liver Neoplasms; Midazolam | 1988 |