Page last updated: 2024-10-31

midazolam and Burns

midazolam has been researched along with Burns in 25 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Research Excerpts

ExcerptRelevanceReference
" Midazolam, S+ ketamine, placebo, or clonidine was used for the anesthesia."9.19Clonidine for reduction of hemodynamic and psychological effects of S+ ketamine anesthesia for dressing changes in patients with major burns: an RCT. ( Pretto, G; Silva, E; Westphal, GA, 2014)
"A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population."9.13Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008)
"Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children."9.11Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004)
"The metabolism of morphine and ketamine was studied in a 14 month old child with extensive burns, who received infusions of both drugs for more than 30 days."7.68Long term high dose morphine, ketamine and midazolam infusion in a child with burns. ( Bengtsson, M; Björkman, S; Cederholm, I; Choonara, I; Rane, A, 1990)
" Midazolam, S+ ketamine, placebo, or clonidine was used for the anesthesia."5.19Clonidine for reduction of hemodynamic and psychological effects of S+ ketamine anesthesia for dressing changes in patients with major burns: an RCT. ( Pretto, G; Silva, E; Westphal, GA, 2014)
"The aim of this study was to compare the efficacy of oral midazolam and ketamine with oral midazolam, acetaminophen, and codeine in providing sedation and analgesia for wound care procedures in children with burns."5.17Oral ketamine and midazolam for pediatric burn patients: a prospective, randomized, double-blind study. ( Carrasco, P; Flores, V; Norambuena, C; Puentes, P; Villena, R; Yañez, J, 2013)
"A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population."5.13Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008)
"Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children."5.11Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004)
"Ketamine and midazolam have been used safely by anaesthetists in paediatric burns and have a good safety profile."3.80A 2 year experience of nurse led conscious sedation in paediatric burns. ( Ganeshalingam, K; Gerrish, H; O'Hara, D; Richardson, P, 2014)
"The metabolism of morphine and ketamine was studied in a 14 month old child with extensive burns, who received infusions of both drugs for more than 30 days."3.68Long term high dose morphine, ketamine and midazolam infusion in a child with burns. ( Bengtsson, M; Björkman, S; Cederholm, I; Choonara, I; Rane, A, 1990)
"IV midazolam was administered in almost all cases (98%) at a median dose of 3."1.51Intravenous Ketamine as an Adjunct to Procedural Sedation During Burn Wound Care and Dressing Changes. ( Brennan, PG; Kahn, SA; Landry, JK; Lintner, AC; McGinn, KA; Miles, MVP, 2019)
" For both experiments, cumulative morphine anti-nociceptive dose-response (ED50) was tested and hyperactive behaviors such as jumping and scratching were recorded."1.40Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury. ( Chen, L; Mao, J; Martyn, JA; Song, L; Wang, S; Zuo, Y, 2014)
"Mice treated with midazolam had significantly lower serum IL-1β (p=0."1.38The burn wound inflammatory response is influenced by midazolam. ( Babcock, GF; Dugan, A; Hernandez, L; Schwemberger, S; Yadav, E, 2012)
"Posttraumatic stress disorder PTSD is based on memory of a traumatic event."1.35The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers. ( Black, IH; DeSocio, PA; Garza, TH; Gaylord, KM; Maani, CV; McGhee, LL, 2009)
"Ketamine has not elicited the HSR in this model of experimental burns and, therefore, its protective effects were not shown to be mediated through this mechanism."1.32Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. ( Lázaro Da Silva, A; Neder Meyer, T, 2004)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's3 (12.00)18.2507
2000's5 (20.00)29.6817
2010's13 (52.00)24.3611
2020's3 (12.00)2.80

Authors

AuthorsStudies
Cinotti, R1
Besnard, N1
Desmedt, L1
Floch, RL1
Perrot, P1
Bekara, F1
Klouche, K1
Larcher, R1
Mahé, PJ1
Frasca, D1
Asehnoune, K1
Jung, B1
Roquilly, A1
Gencer, M1
Sezen, O1
Wall, SL2
Allorto, NL2
Chetty, V1
Burns-Nader, S1
Joe, L1
Pinion, K1
Brennan, PG1
Landry, JK1
Miles, MVP1
Lintner, AC1
McGinn, KA1
Kahn, SA1
Grossmann, B1
Nilsson, A1
Sjöberg, F1
Nilsson, L1
Clarke, DL1
Norambuena, C1
Yañez, J1
Flores, V1
Puentes, P1
Carrasco, P1
Villena, R1
O'Hara, D1
Ganeshalingam, K1
Gerrish, H1
Richardson, P1
Song, L1
Wang, S1
Zuo, Y1
Chen, L2
Martyn, JA1
Mao, J1
Pretto, G1
Westphal, GA1
Silva, E1
Meng, K1
Su, W1
Fu, Y1
MacPherson, RD1
Woods, D1
Penfold, J1
McGhee, LL1
Maani, CV1
Garza, TH1
DeSocio, PA1
Gaylord, KM1
Black, IH1
MacPherson, R1
Zor, F1
Ozturk, S1
Bilgin, F1
Isik, S1
Cosar, A1
Bache, SE1
Watson, SB1
Babcock, GF1
Hernandez, L1
Yadav, E1
Schwemberger, S1
Dugan, A1
Egydio, F1
Pires, GN1
Tufik, S1
Andersen, ML1
Neder Meyer, T1
Lázaro Da Silva, A1
Heinrich, M1
Wetzstein, V1
Muensterer, OJ1
Till, H1
Goepfert, A1
Schwab, A1
Weber, U1
Rice, TL1
Kyff, JV1
Cederholm, I1
Bengtsson, M1
Björkman, S1
Choonara, I1
Rane, A1
Hansbrough, JF1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226]Phase 431 participants (Actual)Interventional2023-04-01Completed
Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery[NCT01106846]22 participants (Actual)Interventional2010-03-31Terminated (stopped due to Resources not available to complete.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Quality of Recovery Score Post Operative at 24 Hours

Quality of recovery 40 score at 24 hours after the surgical procedure. 40 being a poor recovery and 200 being a good recovery. (NCT01106846)
Timeframe: 24 hours post operative

Interventionunits on scale (Mean)
Group A: Saline Group191.2
Group B: 1% Ketamine Group191.1

Reviews

1 review available for midazolam and Burns

ArticleYear
Wound-healing and benzodiazepines: does sleep play a role in this relationship?
    Clinics (Sao Paulo, Brazil), 2012, Volume: 67, Issue:7

    Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Burns; Humans; Mice; Midazolam; Rats; Sleep Depriva

2012

Trials

9 trials available for midazolam and Burns

ArticleYear
A study comparing the effect of premedication with intravenous midazolam or dexmedetomidine on ketamine-fentanyl sedoanalgesia in burn patients: A randomized clinical trial.
    Burns : journal of the International Society for Burn Injuries, 2021, Volume: 47, Issue:1

    Topics: Administration, Intravenous; Aged; Arterial Pressure; Burns; Dexmedetomidine; Double-Blind Method; F

2021
Computer tablet distraction reduces pain and anxiety in pediatric burn patients undergoing hydrotherapy: A randomized trial.
    Burns : journal of the International Society for Burn Injuries, 2017, Volume: 43, Issue:6

    Topics: Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Burns; Child; Child, Preschool; Computers, Handhel

2017
Rectal ketamine during paediatric burn wound dressing procedures: a randomised dose-finding study.
    Burns : journal of the International Society for Burn Injuries, 2019, Volume: 45, Issue:5

    Topics: Analgesics; Bandages; Burns; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method

2019
Oral ketamine and midazolam for pediatric burn patients: a prospective, randomized, double-blind study.
    Journal of pediatric surgery, 2013, Volume: 48, Issue:3

    Topics: Administration, Oral; Analgesics; Burns; Double-Blind Method; Drug Therapy, Combination; Female; Hum

2013
Clonidine for reduction of hemodynamic and psychological effects of S+ ketamine anesthesia for dressing changes in patients with major burns: an RCT.
    Burns : journal of the International Society for Burn Injuries, 2014, Volume: 40, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Anesthesia; Anesthetics, Dissociative; Anti-Anxiety Age

2014
The Effect of Continuous Sedation Therapy on Immunomodulation, Plasma Levels of Antioxidants, and Indicators of Tissue Repair in Post-Burn Sepsis Patients.
    Cell biochemistry and biophysics, 2015, Volume: 73, Issue:2

    Topics: Adult; Aged; Antioxidants; Burns; Enzyme-Linked Immunosorbent Assay; Female; Gelsolin; HSP70 Heat-Sh

2015
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
    The Clinical journal of pain, 2008, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2008
Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine.
    Burns : journal of the International Society for Burn Injuries, 2010, Volume: 36, Issue:4

    Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Dexmedetomidine; Drug Therapy, Combination; Fema

2010
Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2004, Volume: 14, Issue:4

    Topics: Adjuvants, Anesthesia; Analgesics; Bandages; Burns; Child; Child, Preschool; Conscious Sedation; Dru

2004

Other Studies

15 other studies available for midazolam and Burns

ArticleYear
Feasibility and impact of the implementation of a clinical scale-based sedation-analgesia protocol in severe burn patients undergoing mechanical ventilation. A before-after bi-center study.
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:6

    Topics: Adult; Analgesics, Opioid; Burns; Clinical Protocols; Controlled Before-After Studies; Dose-Response

2020
Reaching consensus on an analgesia protocol for paediatric burn patients in a resource-scarce South African community.
    South African family practice : official journal of the South African Academy of Family Practice/Primary Care, 2021, 02-23, Volume: 63, Issue:1

    Topics: Analgesia; Burns; Child; Consensus; Humans; Midazolam; Pain Management

2021
Intravenous Ketamine as an Adjunct to Procedural Sedation During Burn Wound Care and Dressing Changes.
    Journal of burn care & research : official publication of the American Burn Association, 2019, 02-20, Volume: 40, Issue:2

    Topics: Adult; Analgesics; Analgesics, Opioid; Bandages; Burns; Conscious Sedation; Female; Humans; Hypnotic

2019
Analgesia protocols for burns dressings: Challenges with implementation.
    Burns : journal of the International Society for Burn Injuries, 2019, Volume: 45, Issue:7

    Topics: Academic Medical Centers; Acetaminophen; Analgesics; Anesthetics, Inhalation; Bandages; Burns; Child

2019
A 2 year experience of nurse led conscious sedation in paediatric burns.
    Burns : journal of the International Society for Burn Injuries, 2014, Volume: 40, Issue:1

    Topics: Adolescent; Anesthetics, Dissociative; Bandages; Burns; Child; Child, Preschool; Cohort Studies; Con

2014
Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury.
    Brain research, 2014, May-20, Volume: 1564

    Topics: Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hyperalgesia; Hyperkinesis; Hypnotics and Sedati

2014
The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers.
    The Journal of trauma, 2009, Volume: 66, Issue:4 Suppl

    Topics: Anti-Anxiety Agents; Brief Psychiatric Rating Scale; Burns; Case-Control Studies; Humans; Intraopera

2009
Ketamine and midazolam in combination.
    The Clinical journal of pain, 2009, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C

2009
Bedside application of integra after debridement of necrotising fasciitis.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2011, Volume: 64, Issue:4

    Topics: Aged; Burns; Chondroitin Sulfates; Collagen; Debridement; Fasciitis, Necrotizing; Female; Humans; Hy

2011
The burn wound inflammatory response is influenced by midazolam.
    Inflammation, 2012, Volume: 35, Issue:1

    Topics: Animals; Burns; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Inflammation; Inter

2012
Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl.
    Burns : journal of the International Society for Burn Injuries, 2004, Volume: 30, Issue:5

    Topics: Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Burns; Disease

2004
[Intranasal administration of midazolam (Dormicum) in young children in emergency medicine].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1996, Volume: 31, Issue:1

    Topics: Burns; Child, Preschool; Conscious Sedation; Emergencies; Female; First Aid; Humans; Hypnotics and S

1996
Intranasal administration of midazolam to a severely burned child.
    Burns : journal of the International Society for Burn Injuries, 1990, Volume: 16, Issue:4

    Topics: Administration, Intranasal; Burns; Child, Preschool; Humans; Male; Midazolam; Pain

1990
Long term high dose morphine, ketamine and midazolam infusion in a child with burns.
    British journal of clinical pharmacology, 1990, Volume: 30, Issue:6

    Topics: Burns; Burns, Inhalation; Female; Humans; Infant; Ketamine; Midazolam; Morphine; Time Factors

1990
Massive doses of midazolam infusion for delirium tremens.
    Critical care medicine, 1989, Volume: 17, Issue:6

    Topics: Alcohol Withdrawal Delirium; Burns; Ethanol; Humans; Infusions, Intravenous; Midazolam; Psychoses, A

1989