midazolam and Burns
midazolam has been researched along with Burns in 25 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Midazolam, S+ ketamine, placebo, or clonidine was used for the anesthesia." | 9.19 | Clonidine for reduction of hemodynamic and psychological effects of S+ ketamine anesthesia for dressing changes in patients with major burns: an RCT. ( Pretto, G; Silva, E; Westphal, GA, 2014) |
| "A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population." | 9.13 | Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008) |
| "Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children." | 9.11 | Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004) |
| "The metabolism of morphine and ketamine was studied in a 14 month old child with extensive burns, who received infusions of both drugs for more than 30 days." | 7.68 | Long term high dose morphine, ketamine and midazolam infusion in a child with burns. ( Bengtsson, M; Björkman, S; Cederholm, I; Choonara, I; Rane, A, 1990) |
| " Midazolam, S+ ketamine, placebo, or clonidine was used for the anesthesia." | 5.19 | Clonidine for reduction of hemodynamic and psychological effects of S+ ketamine anesthesia for dressing changes in patients with major burns: an RCT. ( Pretto, G; Silva, E; Westphal, GA, 2014) |
| "The aim of this study was to compare the efficacy of oral midazolam and ketamine with oral midazolam, acetaminophen, and codeine in providing sedation and analgesia for wound care procedures in children with burns." | 5.17 | Oral ketamine and midazolam for pediatric burn patients: a prospective, randomized, double-blind study. ( Carrasco, P; Flores, V; Norambuena, C; Puentes, P; Villena, R; Yañez, J, 2013) |
| "A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population." | 5.13 | Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings. ( MacPherson, RD; Penfold, J; Woods, D, 2008) |
| "Conscious sedation with rectally applied S(+)-ketamine and Midazolam allows safe and painless dressing changes after heat injuries in children." | 5.11 | Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries. ( Heinrich, M; Muensterer, OJ; Till, H; Wetzstein, V, 2004) |
| "Ketamine and midazolam have been used safely by anaesthetists in paediatric burns and have a good safety profile." | 3.80 | A 2 year experience of nurse led conscious sedation in paediatric burns. ( Ganeshalingam, K; Gerrish, H; O'Hara, D; Richardson, P, 2014) |
| "The metabolism of morphine and ketamine was studied in a 14 month old child with extensive burns, who received infusions of both drugs for more than 30 days." | 3.68 | Long term high dose morphine, ketamine and midazolam infusion in a child with burns. ( Bengtsson, M; Björkman, S; Cederholm, I; Choonara, I; Rane, A, 1990) |
| "IV midazolam was administered in almost all cases (98%) at a median dose of 3." | 1.51 | Intravenous Ketamine as an Adjunct to Procedural Sedation During Burn Wound Care and Dressing Changes. ( Brennan, PG; Kahn, SA; Landry, JK; Lintner, AC; McGinn, KA; Miles, MVP, 2019) |
| " For both experiments, cumulative morphine anti-nociceptive dose-response (ED50) was tested and hyperactive behaviors such as jumping and scratching were recorded." | 1.40 | Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury. ( Chen, L; Mao, J; Martyn, JA; Song, L; Wang, S; Zuo, Y, 2014) |
| "Mice treated with midazolam had significantly lower serum IL-1β (p=0." | 1.38 | The burn wound inflammatory response is influenced by midazolam. ( Babcock, GF; Dugan, A; Hernandez, L; Schwemberger, S; Yadav, E, 2012) |
| "Posttraumatic stress disorder PTSD is based on memory of a traumatic event." | 1.35 | The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers. ( Black, IH; DeSocio, PA; Garza, TH; Gaylord, KM; Maani, CV; McGhee, LL, 2009) |
| "Ketamine has not elicited the HSR in this model of experimental burns and, therefore, its protective effects were not shown to be mediated through this mechanism." | 1.32 | Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. ( Lázaro Da Silva, A; Neder Meyer, T, 2004) |
Research
Studies (25)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 13 (52.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Cinotti, R | 1 |
| Besnard, N | 1 |
| Desmedt, L | 1 |
| Floch, RL | 1 |
| Perrot, P | 1 |
| Bekara, F | 1 |
| Klouche, K | 1 |
| Larcher, R | 1 |
| Mahé, PJ | 1 |
| Frasca, D | 1 |
| Asehnoune, K | 1 |
| Jung, B | 1 |
| Roquilly, A | 1 |
| Gencer, M | 1 |
| Sezen, O | 1 |
| Wall, SL | 2 |
| Allorto, NL | 2 |
| Chetty, V | 1 |
| Burns-Nader, S | 1 |
| Joe, L | 1 |
| Pinion, K | 1 |
| Brennan, PG | 1 |
| Landry, JK | 1 |
| Miles, MVP | 1 |
| Lintner, AC | 1 |
| McGinn, KA | 1 |
| Kahn, SA | 1 |
| Grossmann, B | 1 |
| Nilsson, A | 1 |
| Sjöberg, F | 1 |
| Nilsson, L | 1 |
| Clarke, DL | 1 |
| Norambuena, C | 1 |
| Yañez, J | 1 |
| Flores, V | 1 |
| Puentes, P | 1 |
| Carrasco, P | 1 |
| Villena, R | 1 |
| O'Hara, D | 1 |
| Ganeshalingam, K | 1 |
| Gerrish, H | 1 |
| Richardson, P | 1 |
| Song, L | 1 |
| Wang, S | 1 |
| Zuo, Y | 1 |
| Chen, L | 2 |
| Martyn, JA | 1 |
| Mao, J | 1 |
| Pretto, G | 1 |
| Westphal, GA | 1 |
| Silva, E | 1 |
| Meng, K | 1 |
| Su, W | 1 |
| Fu, Y | 1 |
| MacPherson, RD | 1 |
| Woods, D | 1 |
| Penfold, J | 1 |
| McGhee, LL | 1 |
| Maani, CV | 1 |
| Garza, TH | 1 |
| DeSocio, PA | 1 |
| Gaylord, KM | 1 |
| Black, IH | 1 |
| MacPherson, R | 1 |
| Zor, F | 1 |
| Ozturk, S | 1 |
| Bilgin, F | 1 |
| Isik, S | 1 |
| Cosar, A | 1 |
| Bache, SE | 1 |
| Watson, SB | 1 |
| Babcock, GF | 1 |
| Hernandez, L | 1 |
| Yadav, E | 1 |
| Schwemberger, S | 1 |
| Dugan, A | 1 |
| Egydio, F | 1 |
| Pires, GN | 1 |
| Tufik, S | 1 |
| Andersen, ML | 1 |
| Neder Meyer, T | 1 |
| Lázaro Da Silva, A | 1 |
| Heinrich, M | 1 |
| Wetzstein, V | 1 |
| Muensterer, OJ | 1 |
| Till, H | 1 |
| Goepfert, A | 1 |
| Schwab, A | 1 |
| Weber, U | 1 |
| Rice, TL | 1 |
| Kyff, JV | 1 |
| Cederholm, I | 1 |
| Bengtsson, M | 1 |
| Björkman, S | 1 |
| Choonara, I | 1 |
| Rane, A | 1 |
| Hansbrough, JF | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226] | Phase 4 | 31 participants (Actual) | Interventional | 2023-04-01 | Completed | ||
| Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery[NCT01106846] | 22 participants (Actual) | Interventional | 2010-03-31 | Terminated (stopped due to Resources not available to complete.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Quality of Recovery Score Post Operative at 24 Hours
Quality of recovery 40 score at 24 hours after the surgical procedure. 40 being a poor recovery and 200 being a good recovery. (NCT01106846)
Timeframe: 24 hours post operative
| Intervention | units on scale (Mean) |
|---|---|
| Group A: Saline Group | 191.2 |
| Group B: 1% Ketamine Group | 191.1 |
Reviews
1 review available for midazolam and Burns
| Article | Year |
|---|---|
Wound-healing and benzodiazepines: does sleep play a role in this relationship?
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Burns; Humans; Mice; Midazolam; Rats; Sleep Depriva | 2012 |
Trials
9 trials available for midazolam and Burns
| Article | Year |
|---|---|
A study comparing the effect of premedication with intravenous midazolam or dexmedetomidine on ketamine-fentanyl sedoanalgesia in burn patients: A randomized clinical trial.
Topics: Administration, Intravenous; Aged; Arterial Pressure; Burns; Dexmedetomidine; Double-Blind Method; F | 2021 |
Computer tablet distraction reduces pain and anxiety in pediatric burn patients undergoing hydrotherapy: A randomized trial.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Burns; Child; Child, Preschool; Computers, Handhel | 2017 |
Rectal ketamine during paediatric burn wound dressing procedures: a randomised dose-finding study.
Topics: Analgesics; Bandages; Burns; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method | 2019 |
Oral ketamine and midazolam for pediatric burn patients: a prospective, randomized, double-blind study.
Topics: Administration, Oral; Analgesics; Burns; Double-Blind Method; Drug Therapy, Combination; Female; Hum | 2013 |
Clonidine for reduction of hemodynamic and psychological effects of S+ ketamine anesthesia for dressing changes in patients with major burns: an RCT.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Anesthesia; Anesthetics, Dissociative; Anti-Anxiety Age | 2014 |
The Effect of Continuous Sedation Therapy on Immunomodulation, Plasma Levels of Antioxidants, and Indicators of Tissue Repair in Post-Burn Sepsis Patients.
Topics: Adult; Aged; Antioxidants; Burns; Enzyme-Linked Immunosorbent Assay; Female; Gelsolin; HSP70 Heat-Sh | 2015 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2008 |
Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine.
Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Dexmedetomidine; Drug Therapy, Combination; Fema | 2010 |
Conscious sedation: Off-label use of rectal S(+)-ketamine and midazolam for wound dressing changes in paediatric heat injuries.
Topics: Adjuvants, Anesthesia; Analgesics; Bandages; Burns; Child; Child, Preschool; Conscious Sedation; Dru | 2004 |
Other Studies
15 other studies available for midazolam and Burns
| Article | Year |
|---|---|
Feasibility and impact of the implementation of a clinical scale-based sedation-analgesia protocol in severe burn patients undergoing mechanical ventilation. A before-after bi-center study.
Topics: Adult; Analgesics, Opioid; Burns; Clinical Protocols; Controlled Before-After Studies; Dose-Response | 2020 |
Reaching consensus on an analgesia protocol for paediatric burn patients in a resource-scarce South African community.
Topics: Analgesia; Burns; Child; Consensus; Humans; Midazolam; Pain Management | 2021 |
Intravenous Ketamine as an Adjunct to Procedural Sedation During Burn Wound Care and Dressing Changes.
Topics: Adult; Analgesics; Analgesics, Opioid; Bandages; Burns; Conscious Sedation; Female; Humans; Hypnotic | 2019 |
Analgesia protocols for burns dressings: Challenges with implementation.
Topics: Academic Medical Centers; Acetaminophen; Analgesics; Anesthetics, Inhalation; Bandages; Burns; Child | 2019 |
A 2 year experience of nurse led conscious sedation in paediatric burns.
Topics: Adolescent; Anesthetics, Dissociative; Bandages; Burns; Child; Child, Preschool; Cohort Studies; Con | 2014 |
Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury.
Topics: Analgesics, Opioid; Animals; Burns; Drug Tolerance; Hyperalgesia; Hyperkinesis; Hypnotics and Sedati | 2014 |
The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers.
Topics: Anti-Anxiety Agents; Brief Psychiatric Rating Scale; Burns; Case-Control Studies; Humans; Intraopera | 2009 |
Ketamine and midazolam in combination.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Bandages; Burns; Drug Therapy, C | 2009 |
Bedside application of integra after debridement of necrotising fasciitis.
Topics: Aged; Burns; Chondroitin Sulfates; Collagen; Debridement; Fasciitis, Necrotizing; Female; Humans; Hy | 2011 |
The burn wound inflammatory response is influenced by midazolam.
Topics: Animals; Burns; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Inflammation; Inter | 2012 |
Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl.
Topics: Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Burns; Disease | 2004 |
[Intranasal administration of midazolam (Dormicum) in young children in emergency medicine].
Topics: Burns; Child, Preschool; Conscious Sedation; Emergencies; Female; First Aid; Humans; Hypnotics and S | 1996 |
Intranasal administration of midazolam to a severely burned child.
Topics: Administration, Intranasal; Burns; Child, Preschool; Humans; Male; Midazolam; Pain | 1990 |
Long term high dose morphine, ketamine and midazolam infusion in a child with burns.
Topics: Burns; Burns, Inhalation; Female; Humans; Infant; Ketamine; Midazolam; Morphine; Time Factors | 1990 |
Massive doses of midazolam infusion for delirium tremens.
Topics: Alcohol Withdrawal Delirium; Burns; Ethanol; Humans; Infusions, Intravenous; Midazolam; Psychoses, A | 1989 |