midazolam has been researched along with Brain Neoplasms in 16 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas." | 7.91 | Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019) |
| "Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells." | 7.88 | Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018) |
| " This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas." | 3.91 | Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019) |
| "Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells." | 3.88 | Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018) |
| " Acute seizures were treated with intranasal midazolam." | 3.83 | Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study. ( Heimans, JJ; Koekkoek, JA; Postma, TJ; Reijneveld, JC; Taphoorn, MJ, 2016) |
| " Furthermore, total drug dosage requirements were measured and compared." | 2.67 | [Infusion or repetitive bolus injection? A clinical study of midazolam/fentanyl and diazepam/fentanyl combination anesthesia in neurosurgical operations]. ( Luger, TJ; Mair, P; Morawetz, R; Mutz, N; Stroschneider, E, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Isherwood, R | 1 |
| Forsyth, A | 1 |
| Wilson, A | 1 |
| Yan, N | 1 |
| Zheng, Y | 1 |
| Yang, C | 1 |
| Wang, C | 1 |
| Datoo, T | 1 |
| Zhao, H | 1 |
| Wu, L | 1 |
| Date, A | 1 |
| Jiang, C | 1 |
| Sanders, RD | 1 |
| Wang, G | 1 |
| Bevan, C | 1 |
| Ma, D | 1 |
| Lin, N | 1 |
| Han, R | 1 |
| Hui, X | 1 |
| Zhang, K | 1 |
| Gelb, AW | 1 |
| Koekkoek, JA | 1 |
| Postma, TJ | 1 |
| Heimans, JJ | 1 |
| Reijneveld, JC | 1 |
| Taphoorn, MJ | 1 |
| Weise, LM | 1 |
| Bruder, M | 1 |
| Eibach, S | 1 |
| Seifert, V | 1 |
| Byhahn, C | 1 |
| Marquardt, G | 1 |
| Setzer, M | 1 |
| Vitaz, TW | 1 |
| Marx, W | 1 |
| Victor, JD | 1 |
| Gutin, PH | 1 |
| Khan, RB | 1 |
| Schmidt, JE | 1 |
| Tamburro, RF | 1 |
| Postovsky, S | 1 |
| Moaed, B | 1 |
| Krivoy, E | 1 |
| Ofir, R | 1 |
| Ben Arush, MW | 1 |
| Giffin, JP | 1 |
| Cottrell, JE | 1 |
| Shwiry, B | 1 |
| Hartung, J | 1 |
| Epstein, J | 1 |
| Lim, K | 1 |
| Weiss, FR | 1 |
| Schwartz, R | 1 |
| Thal, GD | 1 |
| Szabo, MD | 1 |
| Lopez-Bresnahan, M | 1 |
| Crosby, G | 1 |
| Knudsen, L | 2 |
| Cold, GE | 2 |
| Holdgård, HO | 2 |
| Johansen, UT | 2 |
| Jensen, S | 2 |
| Mair, P | 1 |
| Mutz, N | 1 |
| Stroschneider, E | 1 |
| Luger, TJ | 1 |
| Morawetz, R | 1 |
| Massei, R | 1 |
| Baratta, P | 1 |
| Beretta, L | 1 |
| de Silva, E | 1 |
| Tomei, G | 1 |
| Gaini, SM | 1 |
| Rampini, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Remimazolam Tosilate for General Anesthesia on Prognosis After Bladder Cancer Surgery: a Randomized Controlled Trial[NCT04532606] | Phase 4 | 1,128 participants (Anticipated) | Interventional | 2021-02-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for midazolam and Brain Neoplasms
| Article | Year |
|---|---|
Efficacy and safety of local versus general anesthesia in stereotactic biopsies: a matched-pairs cohort study.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Algorithms; Anesthesia, Gener | 2013 |
Intracranial pressure, mean arterial pressure, and heart rate following midazolam or thiopental in humans with brain tumors.
Topics: Adult; Anesthesia, Intravenous; Benzodiazepines; Blood Pressure; Brain Neoplasms; Clinical Trials as | 1984 |
Effects of flumazenil on cerebral blood flow and oxygen consumption after midazolam anaesthesia for craniotomy.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Intravenous; Brain Neoplas | 1991 |
[Infusion or repetitive bolus injection? A clinical study of midazolam/fentanyl and diazepam/fentanyl combination anesthesia in neurosurgical operations].
Topics: Adult; Anesthesia, Intravenous; Brain Neoplasms; Craniotomy; Diazepam; Fentanyl; Hemodynamics; Human | 1990 |
The effects of midazolam on cerebral blood flow and oxygen consumption. Interaction with nitrous oxide in patients undergoing craniotomy for supratentorial cerebral tumours.
Topics: Adult; Aged; Anesthesia, General; Brain; Brain Neoplasms; Cerebrovascular Circulation; Craniotomy; D | 1990 |
11 other studies available for midazolam and Brain Neoplasms
| Article | Year |
|---|---|
Subcutaneous Dihydrocodeine Tartrate: Compatibility in a Syringe Pump With Other Drugs Frequently Prescribed for the Management of Symptoms Associated With Brain Tumors.
Topics: Brain Neoplasms; Cyclizine; Humans; Midazolam; Scopolamine; Sodium Chloride; Syringes; Tartrates; Wa | 2023 |
Functional and morphological effects of diazepam and midazolam on tumor vasculature in the 9L gliosarcoma brain tumor model using dynamic susceptibility contrast MRI: a comparative study.
Topics: Angiogenesis Inhibitors; Animals; Brain; Brain Neoplasms; Cerebrovascular Circulation; Contrast Medi | 2017 |
Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dexmedetom | 2018 |
Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas.
Topics: Adult; Brain Neoplasms; Female; Flumazenil; GABA Modulators; Glioma; Humans; Hypnotics and Sedatives | 2019 |
Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study.
Topics: Administration, Buccal; Administration, Intranasal; Aged; Brain Neoplasms; Clonazepam; Feasibility S | 2016 |
Comparison of conscious sedation and general anesthesia for motor mapping and resection of tumors located near motor cortex.
Topics: Adenocarcinoma; Anesthesia, General; Brain Mapping; Brain Neoplasms; Conscious Sedation; Craniotomy; | 2003 |
A reversible generalized movement disorder in critically ill children with cancer.
Topics: Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Critical Illness; Dystonic Disorders; Fema | 2005 |
Practice of palliative sedation in children with brain tumors and sarcomas at the end of life.
Topics: Adolescent; Bone Neoplasms; Brain Neoplasms; Child; Combined Modality Therapy; Consciousness; Glioma | 2007 |
Anaesthesia for awake craniotomy.
Topics: Adult; Anesthesia, Intravenous; Awareness; Brain Mapping; Brain Neoplasms; Cerebral Cortex; Cranioto | 1993 |
Exacerbation or unmasking of focal neurologic deficits by sedatives.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Brain Neoplasms; Endarterectomy, Carotid; | 1996 |
[Variations of intracranial pressure during induction with midazolam].
Topics: Adenoma; Adult; Anesthetics; Benzodiazepines; Brain Neoplasms; Cranial Nerve Neoplasms; Craniopharyn | 1985 |