midazolam has been researched along with Brain Ischemia in 10 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 7.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
| "We investigated the effects of anesthesia with ketamine and midazolam on focal cerebral ischemia injury, and evaluated the neuroprotective properties of this combination during surgical procedures." | 7.73 | [Effects of ketamine and midazolam combination anesthesia on focal cerebral ischemia injury in rats]. ( Chen, XL; Li, J; Liu, JX; Liu, Y; Sun, JJ; Tian, YF; Zhang, PB, 2005) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 7.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "To compare the effects of ketamine, midazolam, thiopental, and propofol on brain ischemia by the model of oxygen-glucose deprivation (OGD) in rat cerebral cortical slices." | 7.72 | Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices. ( Chen, HZ; Wang, ZJ; Xue, QS; Yu, BW, 2004) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "Midazolam (MDZ) is a benzodiazepine drug that is clinically used during surgical procedures and for the treatment of insomnia, with a potential ability to treat stroke." | 5.51 | Neuroprotective effects of midazolam on focal cerebral ischemia in rats through anti‑apoptotic mechanisms. ( Chen, Z; Dai, M; Kang, F; Meng, Y; Wang, X; Yu, H, 2019) |
| " To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 3.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
| "We investigated the effects of anesthesia with ketamine and midazolam on focal cerebral ischemia injury, and evaluated the neuroprotective properties of this combination during surgical procedures." | 3.73 | [Effects of ketamine and midazolam combination anesthesia on focal cerebral ischemia injury in rats]. ( Chen, XL; Li, J; Liu, JX; Liu, Y; Sun, JJ; Tian, YF; Zhang, PB, 2005) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 3.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "To compare the effects of ketamine, midazolam, thiopental, and propofol on brain ischemia by the model of oxygen-glucose deprivation (OGD) in rat cerebral cortical slices." | 3.72 | Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices. ( Chen, HZ; Wang, ZJ; Xue, QS; Yu, BW, 2004) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "Midazolam (MDZ) is a benzodiazepine drug that is clinically used during surgical procedures and for the treatment of insomnia, with a potential ability to treat stroke." | 1.51 | Neuroprotective effects of midazolam on focal cerebral ischemia in rats through anti‑apoptotic mechanisms. ( Chen, Z; Dai, M; Kang, F; Meng, Y; Wang, X; Yu, H, 2019) |
| " Twenty-four hours after ischemia, five rats in each group were killed by injecting the above dosage of ketamine or ketamine-midazolam intraperitoneally and infarct size was measured." | 1.33 | Effects of ketamine-midazolam anesthesia on the expression of NMDA and AMPA receptor subunit in the peri-infarction of rat brain. ( Liu, Y; Qiu, SD; Tian, YF; Wang, Y; Zhang, PB; Zhang, YL, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, H | 1 |
| Wang, X | 1 |
| Kang, F | 1 |
| Chen, Z | 1 |
| Meng, Y | 1 |
| Dai, M | 1 |
| Ulbrich, F | 1 |
| Eisert, L | 1 |
| Buerkle, H | 1 |
| Goebel, U | 1 |
| Schallner, N | 1 |
| Jennekens, W | 1 |
| Dankers, F | 1 |
| Janssen, F | 1 |
| Toet, M | 1 |
| van der Aa, N | 1 |
| Niemarkt, H | 1 |
| van Pul, C | 1 |
| de Vries, L | 1 |
| Andriessen, P | 1 |
| Mayer, SA | 1 |
| Chen, L | 1 |
| Gong, Q | 1 |
| Xiao, C | 1 |
| Xue, QS | 1 |
| Yu, BW | 1 |
| Wang, ZJ | 1 |
| Chen, HZ | 1 |
| Zhang, PB | 2 |
| Liu, Y | 2 |
| Li, J | 1 |
| Chen, XL | 1 |
| Tian, YF | 2 |
| Sun, JJ | 1 |
| Liu, JX | 1 |
| Zhang, YL | 1 |
| Qiu, SD | 1 |
| Wang, Y | 1 |
| Ito, H | 1 |
| Watanabe, Y | 1 |
| Isshiki, A | 1 |
| Uchino, H | 1 |
| Roquefeuil, B | 1 |
1 trial available for midazolam and Brain Ischemia
| Article | Year |
|---|---|
Hypothermia for neuroprotection after cardiac arrest.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Fentanyl; Heart Arrest; Humans; Hypnotics and Sedatives; Hy | 2002 |
9 other studies available for midazolam and Brain Ischemia
| Article | Year |
|---|---|
Neuroprotective effects of midazolam on focal cerebral ischemia in rats through anti‑apoptotic mechanisms.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Gene Expression Regulation; Glutamic Acid; Infarction, Mi | 2019 |
Propofol, but not ketamine or midazolam, exerts neuroprotection after ischaemic injury by inhibition of Toll-like receptor 4 and nuclear factor kappa-light-chain-enhancer of activated B-cell signalling: A combined in vitro and animal study.
Topics: Analgesics; Animals; B-Lymphocytes; Brain Ischemia; Cell Line, Tumor; Dose-Response Relationship, Dr | 2016 |
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy; | 2012 |
Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acids; Male; M | 2003 |
Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.
Topics: Anesthetics, Intravenous; Animals; Brain Ischemia; Cell Hypoxia; Cerebral Cortex; Glucose; In Vitro | 2004 |
[Effects of ketamine and midazolam combination anesthesia on focal cerebral ischemia injury in rats].
Topics: Anesthesia; Anesthetics, Combined; Animals; Brain Ischemia; Ketamine; Male; Midazolam; Neuroprotecti | 2005 |
Effects of ketamine-midazolam anesthesia on the expression of NMDA and AMPA receptor subunit in the peri-infarction of rat brain.
Topics: Anesthetics, Dissociative; Animals; Brain Chemistry; Brain Infarction; Brain Ischemia; Immunohistoch | 2006 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
[Cerebral ischemia, anesthetic agents and cerebral metabolic protection].
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Barbiturates; Brain; Brain Ischemia; Diazepam; Etomidate | 1987 |