midazolam has been researched along with Bone Fractures in 18 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure." | 7.71 | Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002) |
| " Before fracture reduction, children 3 to 17 years of age randomly received 2% lidocaine (L) or normal saline (NS) into the hematoma of their fracture site during sedation with intravenous ketamine and midazolam." | 5.19 | Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures. ( Constantine, E; Eberson, CP; Linakis, JG; Machan, JT; Steele, DW; Tsze, DS, 2014) |
| "To compare the efficacy of sublingual midazolam with oral morphine versus that of oral morphine with placebo in a paediatric population attending an emergency department (ED) with acute long-bone fractures." | 5.15 | Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study. ( Chappuy, H; Chéron, G; Giraud, C; Tréluyer, JM; Wille-Ledon, C, 2011) |
| "The authors performed a prospective, double-blinded, randomized trial with emergency department (ED) patients requiring procedural sedation and analgesia (PSA) for repair of deep traumatic lacerations and reduction of bone fractures, to compare the ketamine/propofol (ketofol) combination with the midazolam/fentanyl (MF) combination." | 5.15 | Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial. ( Ashraf, H; Golshani, K; Labaf, A; Moharari, RS; Nejati, A, 2011) |
| " We investigate whether anxiety levels at removal of wires may be reduced using oral midazolam." | 5.14 | Oral midazolam for removal of Kirschner wires in the children's orthopaedic outpatient department: a randomized controlled trial. ( Allgar, V; Burton, D; Cullen, E; Lewis, H; Templeton, P; Wilson, R, 2010) |
| "This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure." | 3.71 | Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002) |
| "Midazolam was the sedative agent used most commonly (45%), and morphine was the most frequently used analgesic agent (36%)." | 1.42 | Emergency department procedural sedation: the London experience. ( Baker, EC; Elkhodair, SM; Freund, Y; Glasebrook, WR; Harris, TR; Pott, JD, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alimohammadi, H | 1 |
| Azizi, MR | 1 |
| Safari, S | 1 |
| Amini, A | 1 |
| Kariman, H | 1 |
| Hatamabadi, HR | 1 |
| Constantine, E | 1 |
| Tsze, DS | 1 |
| Machan, JT | 1 |
| Eberson, CP | 1 |
| Linakis, JG | 1 |
| Steele, DW | 1 |
| Elkhodair, SM | 1 |
| Baker, EC | 1 |
| Glasebrook, WR | 1 |
| Pott, JD | 1 |
| Freund, Y | 1 |
| Harris, TR | 1 |
| Majidi, A | 1 |
| Dinpanah, H | 1 |
| Ashoori, S | 1 |
| Motamed, H | 1 |
| Tabatabaey, A | 1 |
| Schmerler, BL | 1 |
| Cohen, DM | 1 |
| Leder, MS | 1 |
| Bonsu, BK | 1 |
| Templeton, P | 1 |
| Burton, D | 1 |
| Cullen, E | 1 |
| Lewis, H | 1 |
| Allgar, V | 1 |
| Wilson, R | 1 |
| Wille-Ledon, C | 1 |
| Chappuy, H | 1 |
| Giraud, C | 1 |
| Tréluyer, JM | 1 |
| Chéron, G | 2 |
| Nejati, A | 1 |
| Moharari, RS | 1 |
| Ashraf, H | 1 |
| Labaf, A | 1 |
| Golshani, K | 1 |
| Jamal, SM | 1 |
| Fathil, SM | 1 |
| Nidzwani, MM | 1 |
| Ismail, AK | 1 |
| Yatim, FM | 1 |
| Cevik, E | 1 |
| Bilgic, S | 1 |
| Kilic, E | 1 |
| Cinar, O | 1 |
| Hasman, H | 1 |
| Acar, AY | 1 |
| Eroglu, M | 1 |
| Migita, RT | 1 |
| Klein, EJ | 1 |
| Garrison, MM | 1 |
| Wissler, M | 1 |
| Tomaske, M | 1 |
| Stutz, K | 1 |
| Schmitz, A | 1 |
| Gerber, A | 1 |
| Weiss, M | 1 |
| Ozkalkanli, MY | 1 |
| Katircioglu, K | 1 |
| Duzenli, VE | 1 |
| Unal, I | 1 |
| Savaci, S | 1 |
| Graff, KJ | 1 |
| Kennedy, RM | 2 |
| Jaffe, DM | 2 |
| Porter, FL | 1 |
| Miller, JP | 1 |
| Vas, L | 1 |
| Sawyer, RJ | 1 |
| von Schroeder, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Randomized Study of Sublingual Midazolam in Association With Morphine by Oral Route in Arm Fracture in Children at the Emergency Children Care[NCT00416039] | Phase 3 | 60 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions[NCT00596050] | Phase 4 | 50 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Systemic Absorption of Lidocaine After Ultrasound Guided Hematoma Block for Reduction of Different Types of Pediatric Distal Radius Fractures[NCT04359017] | Phase 4 | 0 participants (Actual) | Interventional | 2020-11-01 | Withdrawn (stopped due to Sponsoring staff have left institution) | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for midazolam and Bone Fractures
| Article | Year |
|---|---|
[Sedation and analgesia in emergency structure. Paediatry: Which sedation and analgesia for the child under spontaneous ventilation?].
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, D | 2012 |
Sedation and analgesia for pediatric fracture reduction in the emergency department: a systematic review.
Topics: Analgesics; Child; Drug Combinations; Emergency Service, Hospital; Fentanyl; Fractures, Bone; Humans | 2006 |
9 trials available for midazolam and Bone Fractures
| Article | Year |
|---|---|
Axillary nerve block in comparison with intravenous midazolam/fentanyl for painless reduction of upper extremity fractures.
Topics: Analgesics, Opioid; Arm Injuries; Axilla; Drug Therapy, Combination; Fentanyl; Fractures, Bone; Huma | 2014 |
Evaluating the hematoma block as an adjunct to procedural sedation for closed reduction of distal forearm fractures.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Conscious Sedation; Double-Blind Method; Fe | 2014 |
Comparison of morphine-midazolam versus morphine injection for pain relief in patients with limb fractures - a clinical trial.
Topics: Adolescent; Adult; Analgesics, Opioid; Double-Blind Method; Drug Therapy, Combination; Female; Fract | 2015 |
Oral midazolam for removal of Kirschner wires in the children's orthopaedic outpatient department: a randomized controlled trial.
Topics: Adjuvants, Anesthesia; Administration, Oral; Anti-Anxiety Agents; Anxiety; Bone Wires; Child; Child, | 2010 |
Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study.
Topics: Administration, Oral; Administration, Sublingual; Adolescent; Analgesics, Opioid; Child; Child, Pres | 2011 |
Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Anesthetics, Intravenous; Attitude of Health Personnel; Do | 2011 |
Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation and analgesia in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Conscious Sedation; Emergency | 2011 |
Comparison of ketamine-low-dose midozolam with midazolam-fentanyl for orthopedic emergencies: a double-blind randomized trial.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthetics, Intravenous; Chi-Square Distribution; Child; Child | 2013 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
7 other studies available for midazolam and Bone Fractures
| Article | Year |
|---|---|
Emergency department procedural sedation: the London experience.
Topics: Academic Medical Centers; Adult; Aged; Analgesia; Cohort Studies; Confidence Intervals; Conscious Se | 2015 |
Procedural sedation for fracture reduction in children with hyperactivity.
Topics: Adjuvants, Anesthesia; Adolescent; Attention Deficit Disorder with Hyperactivity; Case-Control Studi | 2008 |
[Intravenous midazolam-ketamine anaesthesia for closed reduction of forearm fractures in children: impact of additional axillary plexus anaesthesia].
Topics: Adolescent; Anesthesia, Intravenous; Anesthetics, Dissociative; Brachial Plexus; Child; Child, Presc | 2006 |
Brachial plexus block for the child with Kartagener's syndrome.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Brachial Plexus; Child; Dextrocar | 2008 |
Conscious sedation for pediatric orthopaedic emergencies.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Conscious Sedation; Emergencies; Female; Fentany | 1996 |
The safety of ketamine sedation in the treatment of traumatic fractures in children.
Topics: Anesthetics, Dissociative; Child; Conscious Sedation; Fractures, Bone; Humans; Hypnotics and Sedativ | 2001 |
Temporary bilateral blindness after acute lidocaine toxicity.
Topics: Acute Disease; Adult; Anesthetics, Local; Blindness; Female; Fractures, Bone; GABA Modulators; Hand | 2002 |