Page last updated: 2024-10-31

midazolam and Aura

midazolam has been researched along with Aura in 89 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"Midazolam nasal spray (MDZ-NS) is indicated for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern, in patients 12 years of age and older with epilepsy."9.34Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial. ( Choi, EJ; Cleveland, JM; King, A; Meng, TC; Pullman, WE; Sequeira, DJ; Sinha, SR; Spencer, DC; Van Ess, PJ; Wheless, JW, 2020)
"To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy."9.14Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy. ( Adelgais, K; Dudley, N; Filloux, F; Firth, S; Greenberg, R; Healy, A; Holsti, M; Olsen, C; Schunk, J, 2010)
"The aim of this study was to determine whether intranasal midazolam is a safe and effective rescue medication in adolescent and adult patients with severe epilepsy."9.09Is intranasal midazolam an effective rescue medication in adolescents and adults with severe epilepsy? ( Clarke, M; Comish, S; Ibitoye, M; Scheepers, B; Scheepers, M, 2000)
" Severity of seizures were quantified for an hour and treated with midazolam (3 mg/kg, i."8.31Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy. ( Almanza, A; Bryant, E; Carlo, AM; Corson, BE; Gage, M; Kharate, M; Mafuta, C; Massey, N; Meyer, C; Ostrander, M; Rao, NS; Samidurai, M; Showman, L; Thippeswamy, T; Trevino, L; Vasanthi, SS; Wachter, L; Wang, C; Wohlgemuth, M, 2023)
"Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult."8.02Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021)
"Provide standards for basic epilepsy education and rescue medication (Midazolam) administration."8.02UK framework for basic epilepsy training and oromucosal midazolam administration. ( Bagary, M; Chisanga, E; Jory, C; Shankar, R; Tittensor, P; Tittensor, S, 2021)
"Oro-mucosal midazolam maleate (OMM) with suitable training to family and carers is being increasingly recognized as the treatment of choice to mitigate the development of status epilepticus in non-hospital community settings."8.02Oro-mucosal midazolam maleate: Use and effectiveness in adults with epilepsy in the UK. ( Boyle, A; Goodwin, M; Grant, A; Higgins, R; Hudson, S; Pearson, J; Reuber, M; Shankar, R; Storer, A; Toland, J, 2021)
"The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram."7.91Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."7.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"Buccal midazolam is effective and safe in the treatment of prolonged seizures and has the advantage of being a convenient and socially acceptable administration form."7.73[Prolonged convulsions treated with buccal midazolam in a setting of mentally retarded patients with refractory epilepsy]. ( Batista, D; Bausà, T; Elias, C; Font, D; Hijano, A; Melendez, R; Rocha, A, 2006)
"This paper demonstrates how oral midazolam can be employed as an alternative method of behaviour management to general anaesthesia for the dental treatment of people with learning disabilities."7.70Oral midazolam for adults with learning disabilities. ( Boyle, CA; Fleming, GJ; Manley, MC, 2000)
"The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy."7.70Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999)
"Sixteen of 19 seizures (84."6.71Buccal midazolam for treatment of prolonged seizures in children. ( Dogrul, M; Kutlu, NO; Soylu, H; Yakinci, C, 2003)
"Midazolam is a short-acting benzodiazepine that has clearly demonstrated to be an effective option for the acute management of epileptic seizures."6.50The safety and tolerability of intranasal midazolam in epilepsy. ( Mula, M, 2014)
" In-MDZ was well tolerated without major adverse events."5.56Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring. ( Balaban, Ü; Fuest, S; Herrmann, E; Kay, L; Knake, S; Reif, PS; Rosenow, F; Schubert-Bast, S; Strzelczyk, A; von Blomberg, A; Zöllner, JP, 2020)
"The baseline demographic and seizure characteristics including the severity of epilepsy were comparable between the INM group (n = 50) and controls (n = 50)."5.51Impact of prescribing intranasal midazolam as rescue medication for domiciliary management of acute seizure among children with epilepsy. ( Behgal, J; Bhardwaj, H; Kaushik, JS; Lather, T, 2019)
"Hypotension is said to be a rare side effect, but with no reported cases in people administered buccal midazolam."5.36Significant hypotension following buccal midazolam administration. ( Kensche, M; Sander, JW; Sisodiya, SM, 2010)
"Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug."5.36Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010)
"Midazolam nasal spray (MDZ-NS) is indicated for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern, in patients 12 years of age and older with epilepsy."5.34Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial. ( Choi, EJ; Cleveland, JM; King, A; Meng, TC; Pullman, WE; Sequeira, DJ; Sinha, SR; Spencer, DC; Van Ess, PJ; Wheless, JW, 2020)
"5-30 Hz) of the EEG as derived by Fast Fourier Transformation analysis was used as pharmacodynamic endpoint."5.30Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy. ( Cleton, A; Danhof, M; Voskuyl, RA, 1998)
"Midazolam was able to reduce spike-and-wave activity in all three models, but there were quantitative differences: the lower dose was effective only against rhythmic metrazol activity, but its action against two other models was negligible, whereas the higher dose of midazolam resulted in significant effects in all three models."5.30Midazolam suppresses spike-and-wave rhythm accompanying three different models of epileptic seizures. ( Kubová, H; Mares, P; Mocková, M, 1999)
"To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy."5.14Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy. ( Adelgais, K; Dudley, N; Filloux, F; Firth, S; Greenberg, R; Healy, A; Holsti, M; Olsen, C; Schunk, J, 2010)
"The aim of this study was to determine whether intranasal midazolam is a safe and effective rescue medication in adolescent and adult patients with severe epilepsy."5.09Is intranasal midazolam an effective rescue medication in adolescents and adults with severe epilepsy? ( Clarke, M; Comish, S; Ibitoye, M; Scheepers, B; Scheepers, M, 2000)
" Severity of seizures were quantified for an hour and treated with midazolam (3 mg/kg, i."4.31Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy. ( Almanza, A; Bryant, E; Carlo, AM; Corson, BE; Gage, M; Kharate, M; Mafuta, C; Massey, N; Meyer, C; Ostrander, M; Rao, NS; Samidurai, M; Showman, L; Thippeswamy, T; Trevino, L; Vasanthi, SS; Wachter, L; Wang, C; Wohlgemuth, M, 2023)
"The aim of this study was to review out-of-hospital use of intranasal diazepam and midazolam for treatment of acute repetitive seizures (ARS) at a typical adult epilepsy center."4.12Use of new intranasal benzodiazepines at a typical adult epilepsy center. ( Benbadis, SR; Li, C, 2022)
"Provide standards for basic epilepsy education and rescue medication (Midazolam) administration."4.02UK framework for basic epilepsy training and oromucosal midazolam administration. ( Bagary, M; Chisanga, E; Jory, C; Shankar, R; Tittensor, P; Tittensor, S, 2021)
"Oro-mucosal midazolam maleate (OMM) with suitable training to family and carers is being increasingly recognized as the treatment of choice to mitigate the development of status epilepticus in non-hospital community settings."4.02Oro-mucosal midazolam maleate: Use and effectiveness in adults with epilepsy in the UK. ( Boyle, A; Goodwin, M; Grant, A; Higgins, R; Hudson, S; Pearson, J; Reuber, M; Shankar, R; Storer, A; Toland, J, 2021)
"Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult."4.02Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021)
"The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram."3.91Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019)
" To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings."3.78Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012)
"Fosphenytoin was developed to eliminate the poor aqueous solubility and irritant properties of intravenous phenytoin."3.77New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol. ( Bebin, M; Bleck, TP, 1994)
"Forty consecutive patients with neurological disorders (encephalopathy, autism, and epilepsy) were referred to dental treatment, and 45 sedations were performed; all were sedated with Midazolam (intramuscular 0."3.76Special care dentistry: Midazolam conscious sedation for patients with neurological diseases. ( Capp, PL; Cillo, MT; de Faria, ME; de Siqueira, JT; Prado, EG; Siqueira, SR, 2010)
"Rectal diazepam is established as a standard rescue or emergency treatment for seizure or status epilepticus; however, the rectal route of administration has not been universally accepted."3.76A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations. ( Bertram, E; de Haan, GJ; Doelman, G; Edelbroek, P; van der Geest, P, 2010)
"Buccal Midazolam in its propriety form is the rescue medication most commonly prescribed by EPIC epilepsy paediatricians."3.75The community use of rescue medication for prolonged epileptic seizures in children. ( Klimach, VJ, 2009)
"During her first pregnancy, a 37-year-old woman with idiopathic generalised epilepsy that was adequately controlled with lamotrigine experienced a series of epileptic seizures following an elective caesarean section."3.73[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy]. ( Bloem, BR; Renier, WO; Voermans, NC; Zwarts, MJ, 2005)
"Buccal midazolam is effective and safe in the treatment of prolonged seizures and has the advantage of being a convenient and socially acceptable administration form."3.73[Prolonged convulsions treated with buccal midazolam in a setting of mentally retarded patients with refractory epilepsy]. ( Batista, D; Bausà, T; Elias, C; Font, D; Hijano, A; Melendez, R; Rocha, A, 2006)
"This paper demonstrates how oral midazolam can be employed as an alternative method of behaviour management to general anaesthesia for the dental treatment of people with learning disabilities."3.70Oral midazolam for adults with learning disabilities. ( Boyle, CA; Fleming, GJ; Manley, MC, 2000)
"The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy."3.70Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999)
" We studied the pharmacokinetic and pharmacodynamic aspects of an oral 15-mg dose of midazolam in 6 patients with epilepsy who are also taking carbamazepine (CBZ) or phenytoin (PHT)."3.69Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin. ( Backman, JT; Laaksovirta, H; Neuvonen, PJ; Ojala, M; Olkkola, KT, 1996)
"Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy."2.82Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022)
"Sixteen of 19 seizures (84."2.71Buccal midazolam for treatment of prolonged seizures in children. ( Dogrul, M; Kutlu, NO; Soylu, H; Yakinci, C, 2003)
"Sevoflurane is a methyl ether anaesthetic commonly used for induction and maintenance of general anaesthesia in children."2.70Sevoflurane anaesthesia in children after induction of anaesthesia with midazolam and thiopental does not cause epileptiform EEG. ( Hyvärinen, A; Kokki, H; Nieminen, K; Partanen, J; Westerèn-Punnonen, S; Yppärilä, H, 2002)
"In the diazepam group, the seizures of 13 (60%) patients terminated in 10 minutes; however, 9 (40%) patients did not respond."2.70Effects of intranasal midazolam and rectal diazepam on acute convulsions in children: prospective randomized study. ( Akgün, D; Fişgin, T; Gurer, Y; Okuyaz, C; Senbil, N; Teziç, T; Zorlu, P, 2002)
"Midazolam is a benzodiazepine hypnotic with a rapid onset and short duration of action."2.52Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal. ( Reddy, DS; Reddy, SD, 2015)
"Midazolam is a short-acting benzodiazepine that has clearly demonstrated to be an effective option for the acute management of epileptic seizures."2.50The safety and tolerability of intranasal midazolam in epilepsy. ( Mula, M, 2014)
"When (sub)clinical seizures are treated, there is no consensus about the most appropriate treatment for neonatal seizures and how to assess the efficacy of treatment."2.49Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013)
"Acute treatment of breakthrough seizures and clusters of seizures at home with rectal BZDs (usually DZP, 0."2.39Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996)
" In-MDZ was well tolerated without major adverse events."1.56Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring. ( Balaban, Ü; Fuest, S; Herrmann, E; Kay, L; Knake, S; Reif, PS; Rosenow, F; Schubert-Bast, S; Strzelczyk, A; von Blomberg, A; Zöllner, JP, 2020)
"The baseline demographic and seizure characteristics including the severity of epilepsy were comparable between the INM group (n = 50) and controls (n = 50)."1.51Impact of prescribing intranasal midazolam as rescue medication for domiciliary management of acute seizure among children with epilepsy. ( Behgal, J; Bhardwaj, H; Kaushik, JS; Lather, T, 2019)
"Epilepsy is a spectrum of neurological disorders with many causal factors."1.46Inhibitory synapse deficits caused by familial α1 GABA ( Chen, X; Durisic, N; Keramidas, A; Lynch, JW, 2017)
"To determine the prognostic factors for encephalopathy with bright tree appearance (BTA) in the acute phase through retrospective case evaluation."1.42Prognostic factors for acute encephalopathy with bright tree appearance. ( Azuma, J; Iwatani, Y; Kagitani-Shimono, K; Kitai, Y; Nabatame, S; Nagai, T; Nakano, S; Okinaga, T; Ozono, K; Tominaga, K; Yamamoto, T, 2015)
"She was seizure-free after the surgery."1.40Peri-ictal headache due to epileptiform activity in a disconnected hemisphere. ( Delalande, O; Dvorak, J; Jahodova, A; Komarek, V; Kršek, P; Kyncl, M; Tichy, M; Vydrova, R, 2014)
"In patients with high-grade glioma seizures occur relatively frequently during the end-of-life phase."1.40[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase]. ( Boddaert, MS; Koekkoek, JA; Taphoorn, M, 2014)
"Hypotension is said to be a rare side effect, but with no reported cases in people administered buccal midazolam."1.36Significant hypotension following buccal midazolam administration. ( Kensche, M; Sander, JW; Sisodiya, SM, 2010)
"Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug."1.36Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010)
"Whilst observing the seizure pattern and excluding the differential diagnoses, evidence emerged that psychological factors had played a large part in her clinical picture."1.32Postoperative pseudoepileptic seizures in a known epileptic: complications in recovery. ( Chambers, N; Ng, L, 2003)
"The objective of this study was to characterize quantitatively the pharmacodynamic interaction between midazolam (MDL), an allosteric modulator of the gamma-aminobutyric acid subtype A (GABAA) receptor, and tiagabine (TGB), an inhibitor of synaptic GABA uptake."1.32Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction. ( Danhof, M; Edelbroek, PM; Jonker, DM; Piotrovsky, VK; Vermeij, DA; Voskuyl, RA, 2003)
"Midazolam was able to reduce spike-and-wave activity in all three models, but there were quantitative differences: the lower dose was effective only against rhythmic metrazol activity, but its action against two other models was negligible, whereas the higher dose of midazolam resulted in significant effects in all three models."1.30Midazolam suppresses spike-and-wave rhythm accompanying three different models of epileptic seizures. ( Kubová, H; Mares, P; Mocková, M, 1999)
"5-30 Hz) of the EEG as derived by Fast Fourier Transformation analysis was used as pharmacodynamic endpoint."1.30Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy. ( Cleton, A; Danhof, M; Voskuyl, RA, 1998)
"Midazolam (4 mg) was given 3 min after the last dose of narcotic."1.29Epileptiform activity during opioid anesthesia. ( Husain, MV; Kearse, LA; Koski, G; McPeck, K; Philbin, DM, 1993)
"The midazolam was dripped slowly into the anterior nares."1.29Nasal rather than rectal benzodiazepines in the management of acute childhood seizures? ( Brown, JK; Clarke, M; O'Regan, ME, 1996)
"Midazolam is a water-soluble benzodiazepine imide that has been used in recent years to manage status epilepticus (SE)."1.29[Treatment of status epilepticus with midazolam: report of four cases]. ( Aguilera Olivares, L; Galdames Poblete, D; Silva-Rosas, C, 1994)
"Carbamazepine was the most effective to block SEA at concentrations of 1-15 microM."1.27Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. ( Franceschetti, S; Hamon, B; Heinemann, U; Konnerth, A; Yaari, Y, 1985)
"Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration."1.27A pharmacodynamic evaluation of midazolam as an antiepileptic compound. ( Jawad, S; Oxley, J; Richens, A; Wilson, J, 1986)

Research

Studies (89)

TimeframeStudies, this research(%)All Research%
pre-19903 (3.37)18.7374
1990's22 (24.72)18.2507
2000's20 (22.47)29.6817
2010's25 (28.09)24.3611
2020's19 (21.35)2.80

Authors

AuthorsStudies
Li, C1
Benbadis, SR1
Welzel, B2
Schmidt, R1
Johne, M2
Löscher, W2
Kuanyshbek, A1
Wang, M1
Andersson, Å1
Tuifua, M1
Palmer, EE1
Sachdev, RK1
Mu, TW1
Vetter, I1
Keramidas, A2
Golub, V2
Ramakrishnan, S2
Reddy, DS3
Sortino, V1
Praticò, A1
Marino, S1
Criscione, R1
Ruggieri, M1
Pisani, F1
Falsaperla, R1
Meyer, S1
Langer, J1
Poryo, M1
Bay, JG1
Wagenpfeil, S1
Heinrich, B1
Nunold, H1
Strzelczyk, A2
Ebrahimi-Fakhari, D1
Moeller, AA1
Stefanescu, AR1
Stefanescu, BM1
Golomb, MR1
Boyle, FA1
Buss, WF1
Rose, RS1
Wing, SE1
Vasanthi, SS1
Rao, NS1
Samidurai, M1
Massey, N1
Meyer, C1
Gage, M1
Kharate, M1
Almanza, A1
Wachter, L1
Mafuta, C1
Trevino, L1
Carlo, AM1
Bryant, E1
Corson, BE1
Wohlgemuth, M1
Ostrander, M1
Showman, L1
Wang, C1
Thippeswamy, T1
von Blomberg, A1
Kay, L1
Knake, S1
Fuest, S1
Zöllner, JP1
Reif, PS1
Herrmann, E1
Balaban, Ü1
Schubert-Bast, S1
Rosenow, F1
Sutter, R1
Kaplan, PW1
Spencer, DC1
Sinha, SR1
Choi, EJ1
Cleveland, JM1
King, A1
Meng, TC1
Pullman, WE1
Sequeira, DJ1
Van Ess, PJ1
Wheless, JW2
Fedak Romanowski, EM1
McNamara, NA1
Neil, EE1
Gottlieb-Smith, R1
Dang, LT1
Zombori, L1
Bacon, M1
Wood, H1
Chatterjee, F1
Venkateswaran, R1
Lampariello, S1
Yoong, M1
Ben-Ari, Y1
Delpire, E1
Tittensor, P1
Tittensor, S1
Chisanga, E1
Bagary, M1
Jory, C1
Shankar, R2
Goodwin, M1
Toland, J1
Boyle, A1
Grant, A1
Pearson, J1
Storer, A1
Higgins, R1
Hudson, S1
Reuber, M1
Chen, X1
Durisic, N1
Lynch, JW1
Nunley, S1
Glynn, P1
Rust, S1
Vidaurre, J1
Albert, DVF1
Patel, AD1
Vigevano, F1
Kirkham, FJ1
Wilken, B1
Raspall-Chaure, M1
Grebla, R1
Lee, D2
Werner-Kiechle, T1
Lagae, L1
Lather, T1
Behgal, J1
Bhardwaj, H1
Kaushik, JS1
Owusu, KA1
Dhakar, MB1
Bautista, C1
McKimmy, D1
Cotugno, S1
Sukumar, N1
Deng, Y1
Farooque, P1
Hirsch, LJ1
Maciel, CB1
van Rooij, LG1
Hellström-Westas, L1
de Vries, LS1
Gladwell, D1
Batty, AJ1
Brereton, N1
Tate, E1
Rawcliffe, L1
Winslade, J1
Conroy, SE1
Koekkoek, JA1
Boddaert, MS1
Taphoorn, M1
Vydrova, R1
Kršek, P1
Kyncl, M1
Jahodova, A1
Dvorak, J1
Komarek, V1
Delalande, O1
Tichy, M1
Azuma, J1
Nabatame, S1
Nakano, S1
Iwatani, Y1
Kitai, Y1
Tominaga, K1
Kagitani-Shimono, K1
Okinaga, T1
Yamamoto, T1
Nagai, T1
Ozono, K1
Shrot, S1
Ramaty, E1
Biala, Y1
Bar-Klein, G1
Daninos, M1
Kamintsky, L1
Makarovsky, I1
Statlender, L1
Rosman, Y1
Krivoy, A1
Lavon, O1
Kassirer, M1
Friedman, A1
Yaari, Y2
Mula, M1
Reddy, SD1
Hayashi, T1
Higuchi, H1
Tomoyasu, Y1
Ishii-Maruhama, M1
Maeda, S1
Miyawaki, T1
Klimach, VJ1
Joshi, CN1
Greenberg, CR1
Mhanni, AA1
Salman, MS1
Tilz, C1
Resch, R1
Hofer, T1
Eggers, C1
de Haan, GJ1
van der Geest, P1
Doelman, G1
Bertram, E1
Edelbroek, P1
Nakken, KO1
Rytter, EM1
Brockmeier, F1
Holsti, M1
Dudley, N1
Schunk, J1
Adelgais, K1
Greenberg, R1
Olsen, C1
Healy, A1
Firth, S1
Filloux, F1
Capp, PL1
de Faria, ME1
Siqueira, SR1
Cillo, MT1
Prado, EG1
de Siqueira, JT1
Eker, HE1
Yalcin Cok, O1
Aribogan, A1
Arslan, G1
van der Heide, MJ1
Roze, E1
van der Veere, CN1
Ter Horst, HJ1
Brouwer, OF1
Bos, AF1
Jennekens, W1
Dankers, F1
Janssen, F1
Toet, M1
van der Aa, N1
Niemarkt, H1
van Pul, C1
de Vries, L1
Andriessen, P1
Bakan, M1
Idin, K1
Karaaslan, K1
Ozturk, E1
Kensche, M1
Sander, JW1
Sisodiya, SM1
Nieminen, K1
Westerèn-Punnonen, S1
Kokki, H1
Yppärilä, H1
Hyvärinen, A1
Partanen, J1
Jonker, DM1
Vermeij, DA1
Edelbroek, PM1
Voskuyl, RA2
Piotrovsky, VK1
Danhof, M3
Kutlu, NO1
Dogrul, M1
Yakinci, C1
Soylu, H1
Ng, L1
Chambers, N1
Szmuk, P1
Kee, S1
Pivalizza, EG1
Warters, RD1
Abramson, DC1
Ezri, T1
Boylan, GB1
Rennie, JM1
Chorley, G1
Pressler, RM1
Fox, GF1
Farrer, K1
Morton, M1
Binnie, CD1
Voermans, NC1
Zwarts, MJ1
Renier, WO1
Bloem, BR1
Almeida, AN1
Tavares, C1
Tibano, A1
Sasaki, S1
Murata, KN1
Marino, R1
Bhattacharyya, M1
Kalra, V1
Gulati, S1
Jugovac, I1
Imas, O1
Hudetz, AG1
Melendez, R1
Batista, D1
Font, D1
Bausà, T1
Hijano, A1
Rocha, A1
Elias, C1
Kearse, LA1
Koski, G1
Husain, MV1
Philbin, DM1
McPeck, K1
Bebin, M1
Bleck, TP1
González-Darder, JM2
García-Teno, M1
Gandolfo, G1
Scherschlicht, R1
Gottesmann, C1
Kubová, H2
Mares, P2
Vorlícek, J1
Galdames Poblete, D1
Silva-Rosas, C1
Aguilera Olivares, L1
Backman, JT1
Olkkola, KT1
Ojala, M1
Laaksovirta, H1
Neuvonen, PJ1
Mitchell, WG1
O'Regan, ME1
Brown, JK1
Clarke, M2
Dixon, M1
Barker, I1
Scott, RC1
Neville, BG1
Besag, FM1
Boyd, SG1
Momota, Y1
Artru, AA1
Powers, KM1
Mautz, DS1
Ueda, Y1
Cleton, A2
Scheepers, M3
Scheepers, B3
Clough, P2
Ellis, SJ1
Baddely, L1
Comish, S2
Cordes, L1
Chattopadhyay, A1
Morris, B1
Blackburn, L1
Wassmer, E1
Whitehouse, W1
Van der Graaf, PH1
Ghijsen, W1
Voskuyl, R1
Jeannet, PY1
Roulet, E1
Maeder-Ingvar, M1
Gehri, M1
Jutzi, A1
Deonna, T1
Mocková, M1
Ibitoye, M1
Boyle, CA1
Manley, MC1
Fleming, GJ1
Montenegro, MA1
Guerreiro, MM1
Caldas, JP1
Moura-Ribeiro, MV1
Guerreiro, CA1
Watts, JC1
Brierly, A1
Tiffin, PA1
Perini, AF1
Fişgin, T1
Gurer, Y1
Teziç, T1
Senbil, N1
Zorlu, P1
Okuyaz, C1
Akgün, D1
van den Anker, JN1
Sauer, PJ1
Gómez-Cárdenas, E1
Guerrero, M1
Segura-Pastor, D1
Gil-Salú, JL1
Heinemann, U1
Franceschetti, S1
Hamon, B1
Konnerth, A1
Ghilain, S1
van Rijckevorsel-Harmant, K1
Harmant, J1
de Barsy, TH1
Jawad, S1
Oxley, J1
Wilson, J1
Richens, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Placebo Controlled Trial Examining the Safety and Efficacy of Midazolam Intranasal Spray (USL261) for the Treatment of Intermittent Bouts of Increased Seizure Activity in the Epilepsy Monitoring Unit (EMU)[NCT01999777]Phase 362 participants (Actual)Interventional2013-11-30Completed
Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612]Phase 2358 participants (Actual)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants That Were Seizure-free

"A participant was considered seizure-free if he or she completed the 6-hour Treatment Phase without seizures recorded, premature discontinuation of study drug, rescue intervention for acute central respiratory depression adverse event (AE), and alterations to background anti-epileptic drug (AED) therapy. Otherwise, the participant was included in the analysis for seizure-free events with the outcome of seizure." (NCT01999777)
Timeframe: 6 hours

InterventionParticipants (Count of Participants)
USL26117
Placebo12

Time to First Seizure Following Treatment (TFSFT)

Time to first seizure following treatment was defined as time from treatment with study drug to the onset of the next seizure, rescue intervention (for acute central respiratory depression AE) to maintain subject safety, alterations to background AED therapy, early termination, or 6 hours, whichever came first. (NCT01999777)
Timeframe: 6 hours

Interventionhours (Median)
USL261NA
Placebo3.9

Length of Seizure After Study Medication Administration

Length of seizure. (NCT00326612)
Timeframe: 24 hours

InterventionMinutes (Median)
Intranasal Midazolam3.0
Rectal Diazepam4.3

Number of Patients Needed to be Seen or Treated in the Emergency Department for Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam21
Rectal Diazepam17

Number of Patients That Were Admitted to the Hospital After Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam4
Rectal Diazepam3

Number of Patients Who Had a Repeat Seizure Within 12 Hours After Their Seizure Who Used Study Medication

(NCT00326612)
Timeframe: 12 hours

Interventionparticipants (Number)
Intranasal Midazolam1
Rectal Diazepam1

Number of Patients Who Needed Additional Medication to Treat the Seizure in the Emergency Department Within 24 Hours

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam5
Rectal Diazepam5

Respiratory Depression Requiring Intubation

Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam1
Rectal Diazepam0

Respiratory Depression Requiring Oxygen at Discharge From the Emergency Department.

Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam3
Rectal Diazepam1

Reviews

7 reviews available for midazolam and Aura

ArticleYear
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review.
    Acta bio-medica : Atenei Parmensis, 2022, 12-16, Volume: 93, Issue:6

    Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac

2022
Seizure Rescue Medications for Out-Of-Hospital Use in Children.
    The Journal of pediatrics, 2021, Volume: 229

    Topics: Administration, Intranasal; Administration, Rectal; Anticonvulsants; Benzodiazepines; Child; Diazepa

2021
Treatment of neonatal seizures.
    Seminars in fetal & neonatal medicine, 2013, Volume: 18, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo

2013
The safety and tolerability of intranasal midazolam in epilepsy.
    Expert review of neurotherapeutics, 2014, Volume: 14, Issue:7

    Topics: Administration, Intranasal; Anticonvulsants; Epilepsy; Humans; Midazolam

2014
Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal.
    Epilepsia, 2015, Volume: 56, Issue:6

    Topics: Animals; Anticonvulsants; Epilepsy; Humans; Midazolam; Organophosphate Poisoning

2015
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes

1994
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
    Epilepsia, 1996, Volume: 37 Suppl 1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea

1996

Trials

10 trials available for midazolam and Aura

ArticleYear
Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial.
    Epilepsia, 2020, Volume: 61, Issue:11

    Topics: Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Child; Double-Blind Method; Epilepsy

2020
Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy.
    Archives of pediatrics & adolescent medicine, 2010, Volume: 164, Issue:8

    Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Anticonvulsants; Child; Child, Pr

2010
Children on phenobarbital monotherapy requires more sedatives during MRI.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:10

    Topics: Anesthetics, Dissociative; Anticonvulsants; Child; Child, Preschool; Conscious Sedation; Double-Blin

2011
Sevoflurane anaesthesia in children after induction of anaesthesia with midazolam and thiopental does not cause epileptiform EEG.
    British journal of anaesthesia, 2002, Volume: 89, Issue:6

    Topics: Anesthesia, General; Anesthetics, Inhalation; Child; Child, Preschool; Electroencephalography; Epile

2002
Buccal midazolam for treatment of prolonged seizures in children.
    Brain & development, 2003, Volume: 25, Issue:4

    Topics: Administration, Buccal; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Sc

2003
Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study.
    Neurology, 2004, Feb-10, Volume: 62, Issue:3

    Topics: Anticonvulsants; Clonazepam; Drug Resistance; Electroencephalography; Epilepsy; Female; Humans; Infa

2004
Intranasal midazolam vs rectal diazepam in acute childhood seizures.
    Pediatric neurology, 2006, Volume: 34, Issue:5

    Topics: Acute Disease; Administration, Intranasal; Anticonvulsants; Child; Child, Preschool; Diazepam; Epile

2006
New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Dioxolanes

1994
Is intranasal midazolam an effective rescue medication in adolescents and adults with severe epilepsy?
    Seizure, 2000, Volume: 9, Issue:6

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Child; Epilepsy; Feasibility Studies; Female; G

2000
Effects of intranasal midazolam and rectal diazepam on acute convulsions in children: prospective randomized study.
    Journal of child neurology, 2002, Volume: 17, Issue:2

    Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Presc

2002

Other Studies

73 other studies available for midazolam and Aura

ArticleYear
Use of new intranasal benzodiazepines at a typical adult epilepsy center.
    Epilepsy & behavior : E&B, 2022, Volume: 134

    Topics: Administration, Intranasal; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Epilepsy, G

2022
Midazolam Prevents the Adverse Outcome of Neonatal Asphyxia.
    Annals of neurology, 2023, Volume: 93, Issue:2

    Topics: Animals; Asphyxia; Asphyxia Neonatorum; Benzodiazepines; Epilepsy; Humans; Infant, Newborn; Midazola

2023
Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABA
    Neuropharmacology, 2022, Dec-15, Volume: 221

    Topics: Epilepsy; gamma-Aminobutyric Acid; Humans; Midazolam; Receptors, GABA-A; Valproic Acid

2022
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
    Experimental neurology, 2023, Volume: 360

    Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa

2023
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
    Experimental neurology, 2023, Volume: 360

    Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa

2023
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
    Experimental neurology, 2023, Volume: 360

    Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa

2023
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
    Experimental neurology, 2023, Volume: 360

    Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa

2023
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two-year prospective surveillance study.
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Critical Care; Diazepam; Epilepsy; Female; Humans; Male; Midazol

2023
A Standardized, 3-Tiered, Seizure Burden-Based Protocol for the Treatment of Neonatal Seizures.
    Journal of child neurology, 2023, Volume: 38, Issue:3-4

    Topics: Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Midazo

2023
Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia.
    Epilepsy & behavior : E&B, 2023, Volume: 142

    Topics: Animals; Anticonvulsants; Asphyxia; Asphyxia Neonatorum; Bumetanide; Epilepsy; Humans; Infant, Newbo

2023
Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy.
    Journal of neuroinflammation, 2023, Jul-12, Volume: 20, Issue:1

    Topics: Animals; Atropine; Cytokines; Enzyme Inhibitors; Epilepsy; Gliosis; Male; Midazolam; Neuroglia; Nitr

2023
Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring.
    CNS drugs, 2020, Volume: 34, Issue:5

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Child; Child, Preschool; Electroencephalography

2020
Transnasal Revolution? The Promise of Midazolam Spray to Prevent Seizure Clusters.
    CNS drugs, 2020, Volume: 34, Issue:5

    Topics: Administration, Intranasal; Electroencephalography; Epilepsy; Humans; Midazolam; Seizures

2020
Intranasal diazepam (Valtoco) and midazolam (Nayzilam) for seizure clusters.
    The Medical letter on drugs and therapeutics, 2020, Apr-20, Volume: 62, Issue:1596

    Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Humans; Midazolam; Seizures

2020
Severe cortical damage associated with COVID-19 case report.
    Seizure, 2021, Volume: 84

    Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo

2021
Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details.
    Epilepsia, 2021, Volume: 62, Issue:4

    Topics: Animals; Anticonvulsants; Bumetanide; Epilepsy; Humans; Midazolam; Phenobarbital; Prohibitins; Seizu

2021
A critical evaluation of midazolam nasal spray for the treatment of patients with seizure clusters.
    Expert review of neurotherapeutics, 2021, Volume: 21, Issue:11

    Topics: Administration, Intranasal; Anticonvulsants; Epilepsy; Humans; Midazolam; Nasal Sprays; Quality of L

2021
UK framework for basic epilepsy training and oromucosal midazolam administration.
    Epilepsy & behavior : E&B, 2021, Volume: 122

    Topics: Caregivers; Epilepsy; Humans; Midazolam; Seizures; United Kingdom

2021
Oro-mucosal midazolam maleate: Use and effectiveness in adults with epilepsy in the UK.
    Epilepsy & behavior : E&B, 2021, Volume: 123

    Topics: Adult; Anticonvulsants; Epilepsy; Humans; Midazolam; Status Epilepticus; United Kingdom

2021
Inhibitory synapse deficits caused by familial α1 GABA
    Neurobiology of disease, 2017, Volume: 108

    Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Coculture Techniques; Epilepsy; HEK293 Cel

2017
Healthcare Utilization Characteristics for Intranasal Midazolam Versus Rectal Diazepam.
    Journal of child neurology, 2018, Volume: 33, Issue:2

    Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Adult; Ambulatory Care; Anticonvulsa

2018
Effect of rescue medication on seizure duration in non-institutionalized children with epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2018, Volume: 22, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Mida

2018
Impact of prescribing intranasal midazolam as rescue medication for domiciliary management of acute seizure among children with epilepsy.
    Epilepsy & behavior : E&B, 2019, Volume: 96

    Topics: Administration, Intranasal; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Disease Ma

2019
Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit.
    Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A

    Topics: Administration, Intranasal; Administration, Intravenous; Adult; Anticonvulsants; Epilepsy; Female; H

2019
The cost effectiveness of licensed oromucosal midazolam (Buccolam(®)) for the treatment of children experiencing acute epileptic seizures: an approach when trial evidence is limited.
    Paediatric drugs, 2013, Volume: 15, Issue:2

    Topics: Acute Disease; Administration, Buccal; Administration, Rectal; Child; Cost-Benefit Analysis; Decisio

2013
Buccolam: the first centralized paediatric use marketing authorization.
    International journal of pharmaceutics, 2013, Nov-30, Volume: 457, Issue:1

    Topics: Administration, Buccal; Anticonvulsants; Child; Epilepsy; Europe; Humans; Licensure; Marketing; Mida

2013
[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase].
    Nederlands tijdschrift voor geneeskunde, 2014, Volume: 158, Issue:1

    Topics: Anticonvulsants; Clonazepam; Epilepsy; Glioma; Humans; Midazolam; Seizures; Terminal Care

2014
Peri-ictal headache due to epileptiform activity in a disconnected hemisphere.
    Epileptic disorders : international epilepsy journal with videotape, 2014, Volume: 16, Issue:2

    Topics: Anticonvulsants; Brain; Carbamazepine; Child, Preschool; Electroencephalography; Epilepsy; Female; F

2014
Prognostic factors for acute encephalopathy with bright tree appearance.
    Brain & development, 2015, Volume: 37, Issue:2

    Topics: Acute Disease; Anti-Anxiety Agents; Brain; Brain Diseases; Child; Child, Preschool; Creatinine; Diaz

2015
Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
    Toxicology, 2014, Sep-02, Volume: 323

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chronic Diseas

2014
Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study.
    Journal of anesthesia, 2016, Volume: 30, Issue:1

    Topics: Administration, Intravenous; Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Therapy, Co

2016
The community use of rescue medication for prolonged epileptic seizures in children.
    Seizure, 2009, Volume: 18, Issue:5

    Topics: Administration, Buccal; Anticonvulsants; Child; Epilepsy; Female; Humans; Male; Midazolam; Rescue Wo

2009
Ketogenic diet in Alpers-Huttenlocher syndrome.
    Pediatric neurology, 2009, Volume: 40, Issue:4

    Topics: Anticonvulsants; Brain; Child, Preschool; Cognition; Diet, Ketogenic; Diffuse Cerebral Sclerosis of

2009
Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide.
    Epilepsia, 2010, Volume: 51, Issue:2

    Topics: Acetamides; Adult; Anticonvulsants; Diazepam; Drug Resistance; Drug Therapy, Combination; Epilepsy;

2010
Guidelines for diagnosis and management of childhood epilepsy.
    Indian pediatrics, 2009, Volume: 46, Issue:8

    Topics: Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Hu

2009
A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Benzodiazepines; Diazepam; Drug A

2010
[Benzodiazepines in the treatment of epilepsy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2010, Apr-22, Volume: 130, Issue:8

    Topics: Administration, Buccal; Anticonvulsants; Benzodiazepines; Epilepsy; Humans; Midazolam; Status Epilep

2010
Special care dentistry: Midazolam conscious sedation for patients with neurological diseases.
    European journal of paediatric dentistry, 2010, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Local; Autistic Disorder; Brain Damage, Chronic;

2010
Long-term neurological outcome of term-born children treated with two or more anti-epileptic drugs during the neonatal period.
    Early human development, 2012, Volume: 88, Issue:1

    Topics: Anticonvulsants; Apgar Score; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Fol

2012
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:6

    Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy;

2012
Anaesthesia and orphan disease: anaesthetic management of a child with Pena-Shokeir syndrome.
    European journal of anaesthesiology, 2012, Volume: 29, Issue:12

    Topics: Alopecia; Anesthesia; Anesthetics; Child; Cleft Palate; Craniofacial Abnormalities; Epilepsy; Female

2012
Significant hypotension following buccal midazolam administration.
    BMJ case reports, 2010, Dec-15, Volume: 2010

    Topics: Administration, Buccal; Epilepsy; GABA Modulators; Humans; Hypotension; Male; Midazolam; Severity of

2010
Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction.
    Epilepsia, 2003, Volume: 44, Issue:3

    Topics: Allosteric Regulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; E

2003
Postoperative pseudoepileptic seizures in a known epileptic: complications in recovery.
    British journal of anaesthesia, 2003, Volume: 91, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, General; Epilepsy; Female; Humans; Hypnotics and Sedatives;

2003
Anaesthesia for magnetoencephalography in children with intractable seizures.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:9

    Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child, Preschool; Chloral Hy

2003
[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy].
    Nederlands tijdschrift voor geneeskunde, 2005, Jun-18, Volume: 149, Issue:25

    Topics: Adult; Anticonvulsants; Cesarean Section; Clonazepam; Diazepam; Epilepsy; Epilepsy, Generalized; Epi

2005
Dexmedetomidine for awake craniotomy without laryngeal mask.
    Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:3B

    Topics: Adult; Anesthetics, Combined; Conscious Sedation; Craniotomy; Dexmedetomidine; Epilepsy; Female; Fen

2005
Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam.
    Anesthesiology, 2006, Volume: 105, Issue:4

    Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain; Consciousness; Data Interpretation, Stat

2006
[Prolonged convulsions treated with buccal midazolam in a setting of mentally retarded patients with refractory epilepsy].
    Neurologia (Barcelona, Spain), 2006, Volume: 21, Issue:8

    Topics: Administration, Oral; Adult; Epilepsy; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Mid

2006
Epileptiform activity during opioid anesthesia.
    Electroencephalography and clinical neurophysiology, 1993, Volume: 87, Issue:6

    Topics: Anesthesia, General; Brain; Brain Mapping; Dose-Response Relationship, Drug; Electroencephalography;

1993
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
    Neurological research, 1995, Volume: 17, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul

1995
Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Heart Rate;

1994
Stable anticonvulsant action of benzodiazepines during development in rats.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:9

    Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Electric Stimulation; Electroencephal

1993
[Treatment of status epilepticus with midazolam: report of four cases].
    Neurologia (Barcelona, Spain), 1994, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Male; Midazolam; Treatment Outcome

1994
Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin.
    Epilepsia, 1996, Volume: 37, Issue:3

    Topics: Administration, Oral; Adult; Carbamazepine; Drug Interactions; Enzyme Induction; Epilepsy; Female; F

1996
Nasal rather than rectal benzodiazepines in the management of acute childhood seizures?
    Developmental medicine and child neurology, 1996, Volume: 38, Issue:11

    Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Adolescent; Anti-Anxiety Agents;

1996
A case report or a cautionary tale?
    British dental journal, 1997, Jan-25, Volume: 182, Issue:2

    Topics: Anesthesia, Dental; Dental Care for Chronically Ill; Epilepsy; Female; Humans; Midazolam; Seizures

1997
Nasal rather than rectal benzodiazepines in the management of acute childhood seizures?
    Developmental medicine and child neurology, 1997, Volume: 39, Issue:2

    Topics: Administration, Inhalation; Administration, Rectal; Adolescent; Benzodiazepines; Epilepsy; Humans; M

1997
Posttreatment with propofol terminates lidocaine-induced epileptiform electroencephalogram activity in rabbits: effects on cerebrospinal fluid dynamics.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:4

    Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Cerebrospinal Fluid; Electroencephalography;

1998
Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy.
    British journal of pharmacology, 1998, Volume: 125, Issue:4

    Topics: Amygdala; Animals; Benzodiazepines; Electric Stimulation; Electroencephalography; Epilepsy; Injectio

1998
Midazolam via the intranasal route: an effective rescue medication for severe epilepsy in adults with learning disability.
    Seizure, 1998, Volume: 7, Issue:6

    Topics: Administration, Intranasal; Adult; Epilepsy; Female; GABA Modulators; Humans; Learning Disabilities;

1998
Buccal midazolam and rectal diazepam for epilepsy.
    Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166

    Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anti-Anxiety Agents; Anticonvulsants; Ch

1999
Buccal midazolam and rectal diazepam for epilepsy.
    Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166

    Topics: Administration, Buccal; Administration, Intranasal; Administration, Rectal; Anti-Anxiety Agents; Ant

1999
Buccal midazolam and rectal diazepam for epilepsy.
    Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166

    Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anti-Anxiety Agents; Anticonvulsants; Ch

1999
Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.
    Pharmaceutical research, 1999, Volume: 16, Issue:11

    Topics: Adaptation, Physiological; Animals; Anticonvulsants; Brain; Chlorine; Disease Models, Animal; Dose-R

1999
Home and hospital treatment of acute seizures in children with nasal midazolam.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 1999, Volume: 3, Issue:2

    Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepa

1999
Midazolam suppresses spike-and-wave rhythm accompanying three different models of epileptic seizures.
    Physiological research, 1999, Volume: 48, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalogra

1999
Oral midazolam for adults with learning disabilities.
    Dental update, 2000, Volume: 27, Issue:4

    Topics: Administration, Oral; Adult; Anesthesia, Dental; Behavior Therapy; Conscious Sedation; Dental Calcul

2000
Epileptic manifestations induced by midazolam in the neonatal period.
    Arquivos de neuro-psiquiatria, 2001, Volume: 59, Issue:2-A

    Topics: Epilepsy; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Infant, Premature; Male; Midazol

2001
Midazolam for treatment of postoperative nausea.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Antiemetics; Epilepsy; Female; GABA Modulators; Humans; Midazolam; Middle Aged; Postoperative Nausea

2001
The use of antiepileptic drugs in learning disabled people with epilepsy: an audit of adult in-patients in a treatment and continuing care service.
    Seizure, 2001, Volume: 10, Issue:7

    Topics: Adult; Anticonvulsants; Brain; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Learning

2001
The use of midazolam in the preterm neonate.
    European journal of pediatrics, 1992, Volume: 151, Issue:2

    Topics: Epilepsy; Gestational Age; Hemodynamics; Humans; Infant, Newborn; Infant, Premature, Diseases; Inten

1992
Intrathecal antiepileptic drugs in experimental epilepsy.
    Stereotactic and functional neurosurgery, 1991, Volume: 57, Issue:3

    Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship,

1991
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices.
    Brain research, 1985, Jan-28, Volume: 325, Issue:1-2

    Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cell Membrane Permeability; Epilepsy; Hipp

1985
Midazolam in the treatment of epileptic seizures.
    Journal of neurology, neurosurgery, and psychiatry, 1988, Volume: 51, Issue:5

    Topics: Adult; Aged; Electroencephalography; Epilepsy; Evoked Potentials; Female; Humans; Male; Midazolam; M

1988
A pharmacodynamic evaluation of midazolam as an antiepileptic compound.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:9

    Topics: Adult; Anticonvulsants; Diazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Injections, I

1986