Page last updated: 2024-10-31

midazolam and Asthma

midazolam has been researched along with Asthma in 7 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Sixty patients aged 18-75 yr taking bronchodilators chronically for asthma were anesthetized with midazolam, fentanyl, nitrous oxide, and isoflurane; the trachea was intubated without paralysis."9.08Atracurium versus vecuronium in asthmatic patients. A blinded, randomized comparison of adverse events. ( Caldwell, JE; Fisher, DM; Lau, M, 1995)
"We present the case of a young female with a history of allergies to medicines, specifically to benzodiazepines, who presented bronchospasm and oxygen saturation drop after receiving a dose of midazolam into her eye while she was working."8.12[Ketamine as a treatment of bronchospasm due to an anaphylaxis. A case report]. ( Ávila-García, JE; Calleja-Alarcón, S; Guerrero-Escobar, JC; Romero-Gutiérrez, L; Sánchez-Hurtado, LA, 2022)
"Sixty patients aged 18-75 yr taking bronchodilators chronically for asthma were anesthetized with midazolam, fentanyl, nitrous oxide, and isoflurane; the trachea was intubated without paralysis."5.08Atracurium versus vecuronium in asthmatic patients. A blinded, randomized comparison of adverse events. ( Caldwell, JE; Fisher, DM; Lau, M, 1995)
"Propofol, a new intravenous sedative agent, was investigated in 41 asthmatic patients undergoing day-case (outpatient) fiberoptic bronchoscopy."5.07A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy. ( Burke, CM; Clarkson, K; O'Connell, F; Pathmakanthan, S; Power, CK, 1993)
"We present the case of a young female with a history of allergies to medicines, specifically to benzodiazepines, who presented bronchospasm and oxygen saturation drop after receiving a dose of midazolam into her eye while she was working."4.12[Ketamine as a treatment of bronchospasm due to an anaphylaxis. A case report]. ( Ávila-García, JE; Calleja-Alarcón, S; Guerrero-Escobar, JC; Romero-Gutiérrez, L; Sánchez-Hurtado, LA, 2022)
"Conditions precipitating acute respiratory failure (ARF) were classified into two groups: type 1 (38 episodes) and type 2 (78 episodes)."1.35Predictive factors of non invasive ventilation failure in critically ill children: a prospective epidemiological study. ( Concha, A; Díaz, JJ; Los Arcos, M; Mayordomo-Colunga, J; Medina, A; Menéndez, S; Rey, C, 2009)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's2 (28.57)29.6817
2010's0 (0.00)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Calleja-Alarcón, S1
Sánchez-Hurtado, LA1
Romero-Gutiérrez, L1
Guerrero-Escobar, JC1
Ávila-García, JE1
Mayordomo-Colunga, J1
Medina, A1
Rey, C1
Díaz, JJ1
Concha, A1
Los Arcos, M1
Menéndez, S1
Awab, A1
Alilou, M1
El Moussaoui, R1
El Hijri, A1
Azzouzi, A1
Caldwell, JE1
Lau, M1
Fisher, DM1
Clarkson, K1
Power, CK1
O'Connell, F1
Pathmakanthan, S1
Burke, CM1
Achar, MN1
Achar, KN1
Yakel, DL1
Whittaker, SE1
Elstad, MR1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Efficacy and Safety of Gastric Feeding in Critically Ill Pediatric Patients Receiving Non-invasive Positive Pressure Ventilation: A Pilot Study[NCT01301352]30 participants (Actual)Interventional2011-02-28Completed
[NCT00440960]Phase 40 participants InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for midazolam and Asthma

ArticleYear
Atracurium versus vecuronium in asthmatic patients. A blinded, randomized comparison of adverse events.
    Anesthesiology, 1995, Volume: 83, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Asthma; Atracurium; Female; Fentanyl; Hemodynamics; Humans; Male;

1995
A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy.
    Chest, 1993, Volume: 104, Issue:4

    Topics: Ambulatory Care; Asthma; Bronchoscopy; Dose-Response Relationship, Drug; Fiber Optic Technology; Hum

1993

Other Studies

5 other studies available for midazolam and Asthma

ArticleYear
[Ketamine as a treatment of bronchospasm due to an anaphylaxis. A case report].
    Revista medica del Instituto Mexicano del Seguro Social, 2022, May-02, Volume: 60, Issue:3

    Topics: Anaphylaxis; Asthma; Bronchial Spasm; Female; Humans; Ketamine; Midazolam

2022
Predictive factors of non invasive ventilation failure in critically ill children: a prospective epidemiological study.
    Intensive care medicine, 2009, Volume: 35, Issue:3

    Topics: Adolescent; Anti-Anxiety Agents; Anxiety; Asthma; Bronchiolitis; Child; Child, Preschool; Critical I

2009
[Rhabdomyolysis in severe acute asthma].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2

    Topics: Acidosis; Acute Disease; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Biomarkers; Combined Modal

2009
Efficacy of ketamine infusion in refractory asthma complicated by acute myocardial infarction.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:1

    Topics: Asthma; Bronchial Spasm; Conscious Sedation; Female; Humans; Infusions, Intravenous; Ketamine; Midaz

1993
Midazolam-induced angioedema and bronchoconstriction.
    Critical care medicine, 1992, Volume: 20, Issue:2

    Topics: Adult; Angioedema; Asthma; Bronchoconstriction; Drug Hypersensitivity; Female; Humans; Midazolam

1992