midazolam has been researched along with Asphyxia Neonatorum in 11 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Asphyxia Neonatorum: Respiratory failure in the newborn. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 5.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "In 11/15 patients, seizures were abolished with the addition of midazolam." | 5.11 | Midazolam and amplitude-integrated EEG in asphyxiated full-term neonates. ( Bos, SA; de Vries, LS; Groenendaal, F; Rademaker, CM; Schobben, AF; Toet, MC; van Leuven, K, 2004) |
| " This report presents three infants treated with midazolam for status epilepticus and repetitive seizures who proved resistant to other anticonvulsants (phenobarbitone, lidocaine)." | 3.72 | Burst suppression on amplitude-integrated electroencephalogram may be induced by midazolam: a report on three cases. ( Bos, AF; Brouwer, OF; ter Horst, HJ, 2004) |
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 1.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrate." | 1.51 | Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia. ( Cools, F; de Haan, TR; Dijk, PH; Dijkman, KP; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van Bel, F; van den Broek, MPH; van der Lee, JH; van Heijst, A; van Straaten, HLM; Zecic, A; Zonnenberg, IA, 2019) |
| "The objective was to evaluate the anticonvulsant effectiveness and hemodynamic safety of midazolam in hypothermic newborns and to provide dosing guidance." | 1.42 | Anticonvulsant effectiveness and hemodynamic safety of midazolam in full-term infants treated with hypothermia. ( de Vries, LS; Egberts, T; Groenendaal, F; Huitema, AD; Rademaker, K; Toet, MC; van den Broek, MP; van Straaten, HL, 2015) |
| "Midazolam is a frequently used sedative for this indication, although it has never been investigated how therapeutic hypothermia and asphyxia influence midazolam metabolism in neonates." | 1.39 | Disposition of midazolam in asphyxiated neonates receiving therapeutic hypothermia--a pilot study. ( Junghaenel, S; Mueller, C; Roth, B; Weiss, V; Welzing, L; Wiesen, MH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Welzel, B | 2 |
| Schmidt, R | 1 |
| Johne, M | 3 |
| Löscher, W | 3 |
| Römermann, K | 1 |
| Hampel, P | 1 |
| Gailus, B | 1 |
| Theilmann, W | 1 |
| Ala-Kurikka, T | 1 |
| Kaila, K | 1 |
| Allegaert, K | 1 |
| Smits, A | 1 |
| van den Anker, JN | 1 |
| Favié, LMA | 1 |
| Groenendaal, F | 3 |
| van den Broek, MPH | 1 |
| Rademaker, CMA | 1 |
| de Haan, TR | 1 |
| van Straaten, HLM | 1 |
| Dijk, PH | 1 |
| van Heijst, A | 1 |
| Simons, SHP | 1 |
| Dijkman, KP | 1 |
| Rijken, M | 1 |
| Zonnenberg, IA | 1 |
| Cools, F | 1 |
| Zecic, A | 1 |
| van der Lee, JH | 1 |
| Nuytemans, DHGM | 1 |
| van Bel, F | 1 |
| Egberts, TCG | 1 |
| Huitema, ADR | 1 |
| Welzing, L | 1 |
| Junghaenel, S | 1 |
| Weiss, V | 1 |
| Roth, B | 1 |
| Mueller, C | 1 |
| Wiesen, MH | 1 |
| van den Broek, MP | 1 |
| van Straaten, HL | 1 |
| Huitema, AD | 1 |
| Egberts, T | 1 |
| Toet, MC | 2 |
| de Vries, LS | 2 |
| Rademaker, K | 1 |
| ter Horst, HJ | 1 |
| Brouwer, OF | 1 |
| Bos, AF | 1 |
| Hellström-Westas, L | 1 |
| van Leuven, K | 1 |
| Schobben, AF | 1 |
| Bos, SA | 1 |
| Rademaker, CM | 1 |
| Kulkarni, A | 1 |
1 trial available for midazolam and Asphyxia Neonatorum
| Article | Year |
|---|---|
Midazolam and amplitude-integrated EEG in asphyxiated full-term neonates.
Topics: Anticonvulsants; Asphyxia Neonatorum; Brain; Electroencephalography; Gestational Age; Humans; Infant | 2004 |
10 other studies available for midazolam and Asphyxia Neonatorum
| Article | Year |
|---|---|
Midazolam Prevents the Adverse Outcome of Neonatal Asphyxia.
Topics: Animals; Asphyxia; Asphyxia Neonatorum; Benzodiazepines; Epilepsy; Humans; Infant, Newborn; Midazola | 2023 |
Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia.
Topics: Animals; Anticonvulsants; Asphyxia; Asphyxia Neonatorum; Bumetanide; Epilepsy; Humans; Infant, Newbo | 2023 |
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Bumetanide; Disease Models, Animal; | 2021 |
Phenobarbital Increases Midazolam Clearance in Neonates Treated with Hypothermia: Do We Really Need to Know?
Topics: Anticonvulsants; Asphyxia Neonatorum; Drug Therapy, Combination; Humans; Hypothermia, Induced; Infan | 2019 |
Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Drug Interactions; Drug Therapy, Combination; Female; Humans; | 2019 |
Disposition of midazolam in asphyxiated neonates receiving therapeutic hypothermia--a pilot study.
Topics: Asphyxia Neonatorum; Biological Availability; Germany; Humans; Hypothermia, Induced; Infant, Newborn | 2013 |
Anticonvulsant effectiveness and hemodynamic safety of midazolam in full-term infants treated with hypothermia.
Topics: Anticonvulsants; Arterial Pressure; Asphyxia Neonatorum; Electroencephalography; Female; Hemodynamic | 2015 |
Burst suppression on amplitude-integrated electroencephalogram may be induced by midazolam: a report on three cases.
Topics: Anesthetics, Intravenous; Asphyxia Neonatorum; Electroencephalography; Gestational Age; Humans; Infa | 2004 |
Midazolam and amplitude-integrated EEG.
Topics: Anticonvulsants; Asphyxia Neonatorum; Electroencephalography; Humans; Infant, Newborn; Midazolam; Se | 2004 |
Midazolam sedation in mechanically ventilated newborns.
Topics: Analgesia; Asphyxia Neonatorum; Humans; Hypnotics and Sedatives; Infant, Newborn; Midazolam; Respira | 2002 |