Page last updated: 2024-10-31

midazolam and Apnea

midazolam has been researched along with Apnea in 38 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Apnea: A transient absence of spontaneous respiration.

Research Excerpts

ExcerptRelevanceReference
"Among autonomic seizures apnea still represent a challenge for physicians, and it might constitute the only isolated sign of neurological disorder."9.22Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review. ( Consentino, MC; Falsaperla, R; Marino, S; Ruggieri, M; Vitaliti, G, 2022)
"Capnography provides noninvasive monitoring of ventilation and can enable early recognition of altered respiration patterns and apnea."9.17Capnography improves detection of apnea during procedural sedation for percutaneous transhepatic cholangiodrainage. ( Kochs, EF; Schlag, C; Schmid, RM; von Delius, S; Wagenpfeil, S; Wörner, A, 2013)
"Succinylcholine was associated with a significantly more rapid desaturation and longer recovery of oxygen saturation than rocuronium during rapid sequence induction in overweight patients."9.15Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients. ( Huang, S; Li, S; Ma, H; Tang, L; Wang, Z, 2011)
"Apnea developing as a result of oversedation is a potential clinical problem in patients undergoing flexible bronchoscopy (FB) under sedation."7.85End-tidal capnographic monitoring to detect apnea episodes during flexible bronchoscopy under sedation. ( Abe, M; Fujie, M; Hirota, K; Ishiwata, T; Kawata, N; Suzuki, K; Tatsumi, K; Terada, J; Tsushima, K, 2017)
"Apnea is a known complication of pediatric seizures, but patient factors that predispose children are unclear."7.80Risk factors for apnea in pediatric patients transported by paramedics for out-of-hospital seizure. ( Bosson, N; Fang, A; Fernando, T; Gausche-Hill, M; Huang, M; Kaji, AH; Lee, J; Santillanes, G, 2014)
" Congenital myasthenic syndrome with episodic apnea is a rare cause of recurrent apnea in infancy."7.75Congenital myasthenic syndrome with episodic apnea. ( Agus, MS; Burgess, SL; Burpee, TM; Darras, BT; Estrella, E; Kang, PB; Kunkel, LM; Mallory, LA; Nurko, S; Shaw, JG, 2009)
" The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated."7.68Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990)
"Ten patients developed apnea or cardiopulmonary arrest during or following endoscopy in more than 10,000 consecutive endoscopies."7.68Apnea and cardiopulmonary arrest during and after endoscopy. ( Iber, FL; Kruss, DM; Livak, A, 1992)
" Evidence of apnea, hypotension, hypertension and hypoxemia were recorded during surgery."5.51Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery. ( Gao, Y; Yan, F, 2022)
"We conclude that upper airway obstruction contributes considerably to decreases in SpO2 during midazolam sedation for spinal anaesthesia."5.29Upper airway obstruction during midazolam sedation: modification by nasal CPAP. ( Isono, S; Nishino, T; Nozaki-Taguchi, N; Numai, T; Taguchi, N, 1995)
" However, IPI registration was more effective in reducing the incidence of apnea episodes."5.24Clinical value of the Integrated Pulmonary Index ( Beitz, A; Geist, C; Heringlake, S; Kronshage, T; Meining, A; Müller, M; Pox, CP; Riphaus, A; Schmiegel, W; von Delius, S; Wehrmann, T, 2017)
"Among autonomic seizures apnea still represent a challenge for physicians, and it might constitute the only isolated sign of neurological disorder."5.22Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review. ( Consentino, MC; Falsaperla, R; Marino, S; Ruggieri, M; Vitaliti, G, 2022)
"Capnography enables the measurement of end-tidal CO2 and thereby the early detection of apnea, prompting immediate intervention to restore ventilation."5.19Capnographic monitoring of propofol-based sedation during colonoscopy. ( Albert, J; Bojunga, J; Filmann, N; Friedrich-Rust, M; Herrmann, E; Kannengiesser, M; Meckbach, Y; Schroeter, H; Trojan, J; Welte, C; Welte, M; Zeuzem, S, 2014)
"Capnography provides noninvasive monitoring of ventilation and can enable early recognition of altered respiration patterns and apnea."5.17Capnography improves detection of apnea during procedural sedation for percutaneous transhepatic cholangiodrainage. ( Kochs, EF; Schlag, C; Schmid, RM; von Delius, S; Wagenpfeil, S; Wörner, A, 2013)
"Succinylcholine was associated with a significantly more rapid desaturation and longer recovery of oxygen saturation than rocuronium during rapid sequence induction in overweight patients."5.15Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients. ( Huang, S; Li, S; Ma, H; Tang, L; Wang, Z, 2011)
" During CV, time to reach Ramsay Sedation Scale level 5 (RSS-5; induction time); time to reach RSS-2 (recovery time); and side effects including desaturation, apnea, and changes in hemodynamic parameters were recorded by a person blinded to the patient treatment allocation."5.12Age effect on efficacy and side effects of two sedation and analgesia protocols on patients going through cardioversion: a randomized clinical trial. ( Erdur, B; Ergin, A; Parlak, I; Parlak, M; Sagiroglu, E, 2006)
" Postextubation apnea characteristics were similar between the groups."5.08Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. ( Asokumar, B; Carroll, J; Cheng, DC; David, T; Karski, J; Mickle, D; Nierenberg, H; Peniston, C; Raveendran, G; Roger, S; Sandler, A; Tong, J; Zelovitsky, J, 1996)
"min-1), (2) the incidence of apnea and desaturation of oxygen (< 80%), (3) the degree of sedation, and (4) the serum levels of bilirubin and unbound bilirubin after surgery."5.08[Midazolam for anesthetic induction in neonates]. ( Iwasawa, K; Kadosaki, M; Kawakami, K; Mitono, H; Ohata, J; Saito, I, 1998)
" While these results are consistent with those for apnea, contingency analyses of the oxygen saturation and EtCO2 results were not statistically significant."5.07The safety and efficacy of outpatient midazolam intravenous sedation for oral surgery with and without fentanyl. ( Beirne, OR; Fiset, L; Martin, M; Milgrom, P; Tay, KM; Weinstein, P, 1993)
" Low-dose intravenous ketamine as the primary anesthetic following premedication with fentanyl and midazolam, and in conjunction with nitrous oxide, appeared to produce less hypoxia, hypercarbia, and apnea than when methohexital was used."5.07A double-blind comparison of low-dose intravenous ketamine and methohexital in adults. ( Anderson, JA; Blankstein, KC, 1991)
" The following 4 cardiopulmonary complications were assessed: hypoxia, hypotension, arrhythmias, and apnea."4.82Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. ( Khandwala, F; Lopez, R; Qadeer, MA; Vargo, JJ; Zuccaro, G, 2005)
" This study examined associations between capnography waveform abnormalities and the onset of apnea."3.96Pre-apneic capnography waveform abnormalities during procedural sedation and analgesia. ( Chang, K; Collins, P; Conway, A; Fingleton, J; Mafeld, S; Parotto, M; Sutherland, J, 2020)
"Apnea developing as a result of oversedation is a potential clinical problem in patients undergoing flexible bronchoscopy (FB) under sedation."3.85End-tidal capnographic monitoring to detect apnea episodes during flexible bronchoscopy under sedation. ( Abe, M; Fujie, M; Hirota, K; Ishiwata, T; Kawata, N; Suzuki, K; Tatsumi, K; Terada, J; Tsushima, K, 2017)
"Apnea is a known complication of pediatric seizures, but patient factors that predispose children are unclear."3.80Risk factors for apnea in pediatric patients transported by paramedics for out-of-hospital seizure. ( Bosson, N; Fang, A; Fernando, T; Gausche-Hill, M; Huang, M; Kaji, AH; Lee, J; Santillanes, G, 2014)
" Congenital myasthenic syndrome with episodic apnea is a rare cause of recurrent apnea in infancy."3.75Congenital myasthenic syndrome with episodic apnea. ( Agus, MS; Burgess, SL; Burpee, TM; Darras, BT; Estrella, E; Kang, PB; Kunkel, LM; Mallory, LA; Nurko, S; Shaw, JG, 2009)
" The adverse event (AE) rate was 18% and included apnea (10%), inadequate sedation (3%), bradycardia (2%), desaturation (1%), hypotension (1%) and bag-valve-mask use (1%)."3.73Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS). ( Mensour, M; Michaud, J; Pineau, R; Sahai, V, 2006)
"The purpose of this study was to examine the anaesthetic requirement of intrathecal midazolam in a dose-response fashion in isoflurane-anaesthetized, tracheostomized rats, and to evaluate the apnoeic threshold after each intrathecal midazolam dose."3.69Intrathecal midazolam reduces isoflurane MAC and increases the apnoeic threshold in rats. ( Forster, A; Jorge-Costa, M; Morel, DR; Pizzolato, GP; Schwieger, IM, 1994)
"Ten patients developed apnea or cardiopulmonary arrest during or following endoscopy in more than 10,000 consecutive endoscopies."3.68Apnea and cardiopulmonary arrest during and after endoscopy. ( Iber, FL; Kruss, DM; Livak, A, 1992)
" The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated."3.68Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990)
"Sevoflurane is an alternative to propofol for induction of anaesthesia and has a lower incidence of apnoea."2.71Comparison of propofol and sevoflurane for laryngeal mask airway insertion. ( Coskuner, I; Demirel, CB; Huseyinoglu, UA; Kati, I; Silay, E; Yagmur, C, 2003)
"Midazolam pretreatment was associated with a significant reduction in propofol dose requirement in both younger and older patients."2.70Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults. ( Bhaskaran, NC; Claydon, P; Cressey, DM; Reilly, CS, 2001)
"Propofol and midazolam were compared in 40 adult patients in A."1.31A comparative study of induction and recovery characteristics of propofol and midazolam. ( Dangnan, F; Edomwonyi, NP; Okonofua, BA; Weerasinghe, AS, 2001)
"We conclude that upper airway obstruction contributes considerably to decreases in SpO2 during midazolam sedation for spinal anaesthesia."1.29Upper airway obstruction during midazolam sedation: modification by nasal CPAP. ( Isono, S; Nishino, T; Nozaki-Taguchi, N; Numai, T; Taguchi, N, 1995)
"Midazolam is a new alternative agent for induction in combination anaesthesia."1.26Midazolam compared with thiopentone as an induction agent. ( Kanto, J; Pakkanen, A, 1982)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.26)18.7374
1990's14 (36.84)18.2507
2000's11 (28.95)29.6817
2010's8 (21.05)24.3611
2020's3 (7.89)2.80

Authors

AuthorsStudies
Gao, Y1
Yan, F1
Falsaperla, R1
Consentino, MC1
Vitaliti, G1
Marino, S1
Ruggieri, M1
Conway, A1
Collins, P1
Chang, K1
Mafeld, S1
Sutherland, J1
Fingleton, J1
Parotto, M1
Schlag, C1
Wörner, A1
Wagenpfeil, S1
Kochs, EF1
Schmid, RM1
von Delius, S2
Bosson, N1
Santillanes, G1
Kaji, AH1
Fang, A1
Fernando, T1
Huang, M1
Lee, J1
Gausche-Hill, M1
Friedrich-Rust, M1
Welte, M1
Welte, C1
Albert, J1
Meckbach, Y1
Herrmann, E1
Kannengiesser, M1
Trojan, J1
Filmann, N1
Schroeter, H1
Zeuzem, S1
Bojunga, J1
Lewis, SR1
Nicholson, A1
Reed, SS1
Kenth, JJ1
Alderson, P1
Smith, AF1
Riphaus, A1
Wehrmann, T1
Kronshage, T1
Geist, C1
Pox, CP1
Heringlake, S1
Schmiegel, W1
Beitz, A1
Meining, A1
Müller, M1
Ishiwata, T1
Tsushima, K1
Fujie, M1
Suzuki, K1
Hirota, K1
Abe, M1
Kawata, N1
Terada, J1
Tatsumi, K1
Mallory, LA1
Shaw, JG1
Burgess, SL1
Estrella, E1
Nurko, S1
Burpee, TM1
Agus, MS1
Darras, BT1
Kunkel, LM1
Kang, PB1
Tang, L1
Li, S1
Huang, S1
Ma, H1
Wang, Z1
Levitzky, BE1
Lopez, R2
Dumot, JA1
Vargo, JJ2
Kati, I1
Demirel, CB1
Huseyinoglu, UA1
Silay, E1
Yagmur, C1
Coskuner, I1
von Goedecke, A1
Keller, C1
Wagner-Berger, HG1
Voelckel, WG1
Hörmann, C1
Zecha-Stallinger, A1
Wenzel, V1
Arai, YC1
Fukunaga, K1
Hirota, S1
Qadeer, MA1
Khandwala, F1
Zuccaro, G1
Knott, JC1
Taylor, DM1
Castle, DJ1
Parlak, M1
Parlak, I1
Erdur, B1
Ergin, A1
Sagiroglu, E1
Mensour, M1
Pineau, R1
Sahai, V1
Michaud, J1
Kachko, L1
Simhi, E1
Tzeitlin, E1
Efrat, R1
Tarabikin, E1
Peled, E1
Metzner, I1
Katz, J1
Pakkanen, A1
Kanto, J1
Melvin, MA1
Johnson, BH1
Quasha, AL1
Eger, EI1
Nozaki-Taguchi, N1
Isono, S1
Nishino, T1
Numai, T1
Taguchi, N1
Milgrom, P1
Beirne, OR1
Fiset, L1
Weinstein, P1
Tay, KM1
Martin, M1
Donnelly, MB1
Scott, WA1
Daly, DS1
Schwieger, IM1
Jorge-Costa, M1
Pizzolato, GP1
Forster, A1
Morel, DR1
Cheng, DC1
Karski, J1
Peniston, C1
Asokumar, B1
Raveendran, G1
Carroll, J1
Nierenberg, H1
Roger, S1
Mickle, D1
Tong, J1
Zelovitsky, J1
David, T1
Sandler, A1
Zacharias, M1
Hunter, KM1
Parkinson, R1
Bellman, MH1
Rufino-Ruiz, J1
Gálvez-Mateos, R1
Cruz-Mañas, J1
Kawakami, K1
Ohata, J1
Kadosaki, M1
Saito, I1
Iwasawa, K1
Mitono, H1
Oshima, T1
Masaki, Y1
Toyooka, H1
Cressey, DM1
Claydon, P1
Bhaskaran, NC1
Reilly, CS1
Edomwonyi, NP1
Okonofua, BA1
Weerasinghe, AS1
Dangnan, F1
Iber, FL1
Livak, A1
Kruss, DM1
Weisman, SJ1
Schechter, NL1
Blankstein, KC1
Anderson, JA1
Bailey, PL1
Pace, NL1
Ashburn, MA1
Moll, JW1
East, KA1
Stanley, TH1

Clinical Trials (12)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Importance of Integrated Pulmonary Index in Pediatric Patients Undergoing Bronchoscopy Procedures Under Sedation[NCT05137587]60 participants (Actual)Interventional2022-09-01Completed
The Value of Integrated Pulmonary Index Monitoring[NCT05356819]154 participants (Actual)Interventional2018-10-01Completed
Importance of Integrated Pulmonary Index in Pediatric Patients Undergoing Endoscopy Procedures Under Sedation[NCT05137574]60 participants (Actual)Interventional2021-05-10Completed
Preoxygenation With Optiflow™, a High Flow Nasal Cannula (HFNC), is Superior to Preoxygenation With Facemask in Morbidly Obese Patients Undergoing General Anesthesia[NCT03009877]0 participants (Actual)Interventional2018-07-31Withdrawn (stopped due to withdrawn prior to IRB approval)
"A Less-rapid Sequence Anesthetic Induction/Intubation Sequence? Does Apneic Oxygenation by Means of an Oxygenating Laryngoscope Blade Prolong the Duration of Apnea Without Desaturation in Paralyzed Non-obese and Morbidly Obese Patients?"[NCT02943629]0 participants (Actual)Interventional2016-11-30Withdrawn (stopped due to Lack of feasibility)
[NCT02039453]160 participants (Anticipated)Interventional2013-09-30Recruiting
A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol.[NCT02314559]Phase 4164 participants (Actual)Interventional2015-02-28Completed
Oro-dispersible Olanzapine (Wafer) Versus Conventional Oral Haloperidol or Diazepam Tablets for the Management of Acute Agitation in the Accident and Emergency Department - a Multicentre Randomised Clinical Trial[NCT03246620]Phase 412 participants (Actual)Interventional2017-09-01Terminated (stopped due to The study was terminated prematurely due to difficulties in patient recruitment and associated potential for selection bias.)
Intramuscular Olanzapine Versus Haloperidol or Midazolam for the Management of Acute Agitation in the Emergency Department - a Multicentre Randomised Clinical Trial[NCT02380118]Phase 4167 participants (Actual)Interventional2014-12-31Terminated (stopped due to Primary endpoint reached based on data projection from interim analysis.)
The Effect of Preoperative Anxiolysis With Intravenous Midazolam on Intraoperative Sevoflurane Gas Consumption: A Prospective Randomized Controlled Study[NCT05371600]Phase 480 participants (Anticipated)Interventional2022-12-02Recruiting
Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848]11 participants (Actual)Interventional2008-01-31Terminated (stopped due to Difficulty with enrollment)
Dex vs Dazzle: Dexmedetomidine vs Midazolam for Intraoperative Sedation[NCT02878837]Phase 4120 participants (Actual)Interventional2016-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Apnea-Hypopnea Index (AHI)

Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

Interventionevents per hour (Mean)
AUTOCPAP2.1
CPAP1.2

Cardiopulmonary Complications

Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Autoadjusting CPAP (VPAP Auto)0
CPAP Arm (Usual Care)0

Sleep Related Hypoxemia

(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

InterventionPercentage of time < 90% saturation (Mean)
AUTOCPAP10.5
CPAP7.1

Reviews

3 reviews available for midazolam and Apnea

ArticleYear
Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review.
    Autonomic neuroscience : basic & clinical, 2022, Volume: 243

    Topics: Apnea; Electroencephalography; Humans; Infant, Newborn; Levetiracetam; Midazolam; Seizures

2022
Anaesthetic and sedative agents used for electrical cardioversion.
    The Cochrane database of systematic reviews, 2015, Mar-22, Issue:3

    Topics: Anesthetics; Apnea; Diazepam; Electric Countershock; Etomidate; Fentanyl; Humans; Hypnotics and Seda

2015
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005

Trials

17 trials available for midazolam and Apnea

ArticleYear
Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery.
    Current drug metabolism, 2022, Volume: 23, Issue:1

    Topics: Anesthesia; Apnea; Dexmedetomidine; Humans; Hypertension; Hypnotics and Sedatives; Hypotension; Hypo

2022
Capnography improves detection of apnea during procedural sedation for percutaneous transhepatic cholangiodrainage.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2013, Volume: 27, Issue:10

    Topics: Aged; Apnea; Capnography; Conscious Sedation; Digestive System Surgical Procedures; Female; Germany;

2013
Capnographic monitoring of propofol-based sedation during colonoscopy.
    Endoscopy, 2014, Volume: 46, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Apnea; Body Mass Index; Capnography; Colono

2014
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Clinical value of the Integrated Pulmonary Index
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Capnography; Deep Sedation; Endoscopy, Gastrointestinal; Fema

2017
Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:2

    Topics: Adult; Androstanols; Anesthesia, General; Apnea; Blood Gas Analysis; Body Mass Index; Endpoint Deter

2011
Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:2

    Topics: Adult; Androstanols; Anesthesia, General; Apnea; Blood Gas Analysis; Body Mass Index; Endpoint Deter

2011
Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:2

    Topics: Adult; Androstanols; Anesthesia, General; Apnea; Blood Gas Analysis; Body Mass Index; Endpoint Deter

2011
Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:2

    Topics: Adult; Androstanols; Anesthesia, General; Apnea; Blood Gas Analysis; Body Mass Index; Endpoint Deter

2011
Moderate sedation for elective upper endoscopy with balanced propofol versus fentanyl and midazolam alone: a randomized clinical trial.
    Endoscopy, 2012, Volume: 44, Issue:1

    Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Deep Sedation; Endoscopy, Digesti

2012
Comparison of propofol and sevoflurane for laryngeal mask airway insertion.
    The Tohoku journal of experimental medicine, 2003, Volume: 200, Issue:3

    Topics: Adult; Analysis of Variance; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Blood Pressur

2003
Developing a strategy to improve ventilation in an unprotected airway with a modified mouth-to-bag resuscitator in apneic patients.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:5

    Topics: Adult; Air Pressure; Apnea; Cardiopulmonary Resuscitation; Endpoint Determination; Female; Heart Arr

2004
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
    Annals of emergency medicine, 2006, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R

2006
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
    Annals of emergency medicine, 2006, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R

2006
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
    Annals of emergency medicine, 2006, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R

2006
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
    Annals of emergency medicine, 2006, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R

2006
Age effect on efficacy and side effects of two sedation and analgesia protocols on patients going through cardioversion: a randomized clinical trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2006, Volume: 13, Issue:5

    Topics: Age Factors; Aged; Analgesia; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Blood Pre

2006
The safety and efficacy of outpatient midazolam intravenous sedation for oral surgery with and without fentanyl.
    Anesthesia progress, 1993, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Anesthesia, Dental; Apnea; Chi-Square Distribution; Conscious Sedation; Dental An

1993
Sedation for upper gastrointestinal endoscopy: a comparison of alfentanil-midazolam and meperidine-diazepam.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:12

    Topics: Age Factors; Alfentanil; Anesthesia Recovery Period; Apnea; Conscious Sedation; Diazepam; Dizziness;

1994
Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial.
    The Journal of thoracic and cardiovascular surgery, 1996, Volume: 112, Issue:3

    Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Catecholamines;

1996
[Midazolam for anesthetic induction in neonates].
    Masui. The Japanese journal of anesthesiology, 1998, Volume: 47, Issue:5

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Apnea; Bilirubin; Blood Press

1998
Flumazenil antagonizes midazolam-induced airway narrowing during nasal breathing in humans.
    British journal of anaesthesia, 1999, Volume: 82, Issue:5

    Topics: Adult; Airway Obstruction; Airway Resistance; Anti-Anxiety Agents; Apnea; Female; Flumazenil; GABA M

1999
Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults.
    Anaesthesia, 2001, Volume: 56, Issue:2

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Intravenou

2001
A double-blind comparison of low-dose intravenous ketamine and methohexital in adults.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1991, Volume: 49, Issue:5

    Topics: Adolescent; Adult; Amnesia; Anesthesia, Dental; Apnea; Carbon Dioxide; Double-Blind Method; Female;

1991

Other Studies

18 other studies available for midazolam and Apnea

ArticleYear
Pre-apneic capnography waveform abnormalities during procedural sedation and analgesia.
    Journal of clinical monitoring and computing, 2020, Volume: 34, Issue:5

    Topics: Analgesia; Apnea; Capnography; Conscious Sedation; Humans; Midazolam

2020
Risk factors for apnea in pediatric patients transported by paramedics for out-of-hospital seizure.
    Annals of emergency medicine, 2014, Volume: 63, Issue:3

    Topics: Airway Management; Anticonvulsants; Apnea; Child; Child, Preschool; Emergency Medical Services; Fema

2014
End-tidal capnographic monitoring to detect apnea episodes during flexible bronchoscopy under sedation.
    BMC pulmonary medicine, 2017, 01-07, Volume: 17, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apnea; Bronchoscopy; Capnography; Female; Humans; Hypnotics and Seda

2017
Congenital myasthenic syndrome with episodic apnea.
    Pediatric neurology, 2009, Volume: 41, Issue:1

    Topics: Amino Acid Sequence; Apnea; Blepharoptosis; Choline O-Acetyltransferase; Cholinesterase Inhibitors;

2009
Comparison of a combination of midazolam and diazepam and midazolam alone as oral premedication on preanesthetic and emergence condition in children.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:5

    Topics: Adenoidectomy; Anesthesia; Anesthesia Recovery Period; Anesthesia, Inhalation; Apnea; Behavior; Chil

2005
Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS).
    CJEM, 2006, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Apnea; Blood Gas Monitoring, Transcutaneous; Bradycardia; Cana

2006
Spinal anesthesia in neonates and infants - a single-center experience of 505 cases.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:7

    Topics: Anesthesia, Spinal; Anesthetics, Local; Apnea; Body Weight; Bradycardia; Bupivacaine; Female; Gestat

2007
Midazolam compared with thiopentone as an induction agent.
    Acta anaesthesiologica Scandinavica, 1982, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aged; Apnea; Benzodiazepines; Female; Humans; Male; Midazolam; Middle Aged; Prean

1982
Induction of anesthesia with midazolam decreases halothane MAC in humans.
    Anesthesiology, 1982, Volume: 57, Issue:3

    Topics: Adult; Anesthetics; Apnea; Benzodiazepines; Blood Pressure; Dose-Response Relationship, Drug; Drug I

1982
Upper airway obstruction during midazolam sedation: modification by nasal CPAP.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:8

    Topics: Abdomen; Adult; Age Factors; Airway Obstruction; Anesthesia, Spinal; Apnea; Female; Humans; Hypnotic

1995
Intrathecal midazolam reduces isoflurane MAC and increases the apnoeic threshold in rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:2

    Topics: Anesthesia, Spinal; Animals; Apnea; Blood Pressure; Carbon Dioxide; Dose-Response Relationship, Drug

1994
Respiratory effects of intravenous midazolam.
    The New Zealand dental journal, 1996, Volume: 92, Issue:409

    Topics: Adolescent; Adult; Airway Obstruction; Anesthesia, Dental; Anesthesia, Intravenous; Anesthetics, Int

1996
Midazolam co-induction and laryngeal mask insertion.
    Anaesthesia, 1997, Volume: 52, Issue:1

    Topics: Apnea; Humans; Hypnotics and Sedatives; Laryngeal Masks; Midazolam

1997
[Apnea and retarded awakening following oral premedication with midazolam].
    Revista espanola de anestesiologia y reanimacion, 1997, Volume: 44, Issue:3

    Topics: Anesthesia Recovery Period; Apnea; Child, Preschool; Humans; Hypnotics and Sedatives; Male; Midazola

1997
A comparative study of induction and recovery characteristics of propofol and midazolam.
    The Nigerian postgraduate medical journal, 2001, Volume: 8, Issue:2

    Topics: Adolescent; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Blood Pressure; Femal

2001
Apnea and cardiopulmonary arrest during and after endoscopy.
    Journal of clinical gastroenterology, 1992, Volume: 14, Issue:2

    Topics: Aged; Apnea; Butorphanol; Databases, Factual; Diazepam; Endoscopy, Gastrointestinal; Heart Arrest; H

1992
Therapeutic orphans.
    Pediatrics, 1992, Volume: 89, Issue:4 Pt 1

    Topics: Anesthesia, Intravenous; Apnea; Bone Marrow Examination; Child; Fentanyl; Humans; Midazolam

1992
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990