midazolam has been researched along with Anxiety Disorders in 21 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Anxiety Disorders: Persistent and disabling ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that ketamine has anxiolytic effects in patients with treatment-resistant generalized anxiety and social anxiety disorders." | 9.34 | Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study. ( Broughton, L; Glue, P; Le Nedelec, M; McNaughton, N; Medlicott, NJ; Neehoff, S; Sabadel, A; Shadli, S, 2020) |
| "Patients receiving ketamine for refractory depression and anxiety report dissociative symptoms in the first 60 min post-dose." | 9.24 | Effect of ketamine dose on self-rated dissociation in patients with treatment refractory anxiety disorders. ( Castle, C; Glue, P; Gray, A; Neehoff, S, 2017) |
| "We previously reported that ketamine has anxiolytic effects in patients with treatment-resistant generalized anxiety and social anxiety disorders." | 5.34 | Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study. ( Broughton, L; Glue, P; Le Nedelec, M; McNaughton, N; Medlicott, NJ; Neehoff, S; Sabadel, A; Shadli, S, 2020) |
| "To examine the effect of high baseline anxiety on response to ketamine versus midazolam (active placebo) in treatment-resistant depression (TRD)." | 5.30 | Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression. ( Cusin, C; Debattista, C; Fava, M; Flynn, M; Freeman, MP; Hock, RS; Hoeppner, B; Ionescu, DF; Iosifescu, DV; Mathew, SJ; Papakostas, GI; Salloum, NC; Sanacora, G; Trivedi, MH, 2019) |
| "Patients receiving ketamine for refractory depression and anxiety report dissociative symptoms in the first 60 min post-dose." | 5.24 | Effect of ketamine dose on self-rated dissociation in patients with treatment refractory anxiety disorders. ( Castle, C; Glue, P; Gray, A; Neehoff, S, 2017) |
| "The use of midazolam for dental care in patients with intellectual disability is poorly documented." | 5.17 | Conscious sedation procedures using intravenous midazolam for dental care in patients with different cognitive profiles: a prospective study of effectiveness and safety. ( Collado, V; Faulks, D; Hennequin, M; Nicolas, E, 2013) |
| "Oral midazolam is commonly administered to reduce anxiety in children presenting for medical procedures or surgery." | 4.31 | Residual unabsorbed midazolam: a case report. ( Baboolal, HA; Gulati, A, 2023) |
| " Dosage adjustments must be considered in the elderly, individuals with medical disorders, and patients taking multiple medications." | 2.38 | Antianxiety/sedative drugs. The benzodiazepines. ( Giacalone, VF, 1992) |
| "Catatonia is a well-described neuropsychiatric syndrome that has been the subject of several texts." | 1.37 | Cases of catatonia on an academic electroconvulsive therapy service: lessons to learn. ( Aloysi, AS; Kellner, CH; Popeo, DM, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, YJ | 1 |
| Park, EJ | 1 |
| Lee, YM | 1 |
| Kim, SC | 1 |
| Kang, B | 1 |
| Lee, KJ | 1 |
| Jang, HJ | 1 |
| Lee, EH | 1 |
| Kim, JY | 1 |
| Choi, SY | 1 |
| Jin Kim, H | 1 |
| Kang, Y | 1 |
| Choe, BH | 1 |
| Lee, J | 1 |
| Yi, DY | 1 |
| Baboolal, HA | 1 |
| Gulati, A | 1 |
| Glue, P | 2 |
| Neehoff, S | 2 |
| Sabadel, A | 1 |
| Broughton, L | 1 |
| Le Nedelec, M | 1 |
| Shadli, S | 1 |
| McNaughton, N | 1 |
| Medlicott, NJ | 1 |
| Castle, C | 1 |
| Gray, A | 1 |
| Salloum, NC | 1 |
| Fava, M | 1 |
| Freeman, MP | 1 |
| Flynn, M | 1 |
| Hoeppner, B | 1 |
| Hock, RS | 1 |
| Cusin, C | 1 |
| Iosifescu, DV | 1 |
| Trivedi, MH | 1 |
| Sanacora, G | 1 |
| Mathew, SJ | 1 |
| Debattista, C | 1 |
| Ionescu, DF | 1 |
| Papakostas, GI | 1 |
| Collado, V | 1 |
| Faulks, D | 1 |
| Nicolas, E | 1 |
| Hennequin, M | 1 |
| Clark, K | 1 |
| Currow, D | 1 |
| Skórzewska, A | 2 |
| Lehner, M | 2 |
| Wisłowska-Stanek, A | 2 |
| Turzyńska, D | 2 |
| Sobolewska, A | 2 |
| Krząścik, P | 1 |
| Płaźnik, A | 2 |
| McMurray, KM | 1 |
| Du, X | 1 |
| Brownlee, M | 1 |
| Palmer, AA | 1 |
| Dionigi, A | 1 |
| Gremigni, P | 1 |
| dos Reis, LM | 1 |
| Canto-de-Souza, A | 1 |
| de Paula Soares, V | 1 |
| Zangrossi, H | 2 |
| Taracha, E | 1 |
| Maciejak, P | 1 |
| Szyndler, J | 1 |
| Hamed, A | 1 |
| Bidziński, A | 1 |
| Aloysi, AS | 1 |
| Popeo, DM | 1 |
| Kellner, CH | 1 |
| Kim, SS | 1 |
| Wang, H | 1 |
| Li, XY | 1 |
| Chen, T | 1 |
| Mercaldo, V | 1 |
| Descalzi, G | 1 |
| Wu, LJ | 1 |
| Zhuo, M | 1 |
| Egydio, F | 1 |
| Pires, GN | 1 |
| Tufik, S | 1 |
| Andersen, ML | 1 |
| Bueno, CH | 1 |
| Nogueira, RL | 1 |
| Soares, VP | 1 |
| Viana, MB | 1 |
| Albrechet-Souza, L | 1 |
| Borelli, KG | 1 |
| Brandão, ML | 1 |
| Jakobsson, M | 1 |
| Strang, P | 1 |
| Hoffman, WE | 1 |
| Balyasnikova, IV | 1 |
| Mahay, H | 1 |
| Danilov, SM | 1 |
| Baughman, VL | 1 |
| Giacalone, VF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Music as a Potential Intervention to Improve Hemodynamic Tolerability of Repetitive Sub-Anesthetic IV Ketamine Infusions in Bipolar and Unipolar Depression: A Pilot Study[NCT04701866] | 32 participants (Actual) | Interventional | 2021-01-11 | Completed | |||
| Conscious Sedation With Midazolam in Dentally Anxious Patients: Effect of the Administration Route (Oral Versus Intravenous Administration)[NCT01874717] | Phase 3 | 131 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for midazolam and Anxiety Disorders
| Article | Year |
|---|---|
Wound-healing and benzodiazepines: does sleep play a role in this relationship?
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Burns; Humans; Mice; Midazolam; Rats; Sleep Depriva | 2012 |
[Midazolam (Dormicum) in terminal anxiety and agitation. The last choice alternative in palliative care].
Topics: Anti-Anxiety Agents; Anxiety Disorders; Humans; Midazolam; Palliative Care; Psychomotor Agitation; T | 1999 |
Antianxiety/sedative drugs. The benzodiazepines.
Topics: Age Factors; Anxiety Disorders; Benzodiazepines; Conscious Sedation; Drug Interactions; Drug Overdos | 1992 |
5 trials available for midazolam and Anxiety Disorders
| Article | Year |
|---|---|
Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Blood Pressure; Brain-Derived Neuro | 2020 |
Effect of ketamine dose on self-rated dissociation in patients with treatment refractory anxiety disorders.
Topics: Adolescent; Anxiety; Anxiety Disorders; Dissociative Disorders; Double-Blind Method; Humans; Ketamin | 2017 |
Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression.
Topics: Adult; Anxiety; Anxiety Disorders; Depressive Disorder, Major; Depressive Disorder, Treatment-Resist | 2019 |
Conscious sedation procedures using intravenous midazolam for dental care in patients with different cognitive profiles: a prospective study of effectiveness and safety.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthetics, Intravenous; Anxiety Disorders; Child; Cog | 2013 |
GABA alpha6 receptors mediate midazolam-induced anxiolysis.
Topics: Adult; Aged; Analysis of Variance; Anesthesia; Anesthetics, Intravenous; Anxiety Disorders; Double-B | 2002 |
13 other studies available for midazolam and Anxiety Disorders
| Article | Year |
|---|---|
Effects of anxiety on sedation among pediatric patients undergoing esophagogastroduodenoscopy.
Topics: Adolescent; Anxiety; Anxiety Disorders; Child; Endoscopy, Digestive System; Humans; Hypnotics and Se | 2022 |
Residual unabsorbed midazolam: a case report.
Topics: Administration, Oral; Anxiety; Anxiety Disorders; Child; Child, Preschool; Humans; Hypnotics and Sed | 2023 |
Midazolam in palliative care: at what cost?
Topics: Anxiety Disorders; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Midazolam; New South Wal | 2015 |
GABAergic control of the activity of the central nucleus of the amygdala in low- and high-anxiety rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Basolateral Nuclear Complex; Central Amygdaloid Nuc | 2015 |
Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Basolateral Nuclear Complex; Disease Models, Animal | 2016 |
A combined intervention of art therapy and clown visits to reduce preoperative anxiety in children.
Topics: Anesthesia, General; Anxiety Disorders; Art Therapy; Child; Child, Preschool; Female; Humans; Laught | 2017 |
Intra-periaqueductal gray matter injections of midazolam fail to alter anxiety in plus-maze experienced mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Avoidance Learning; Disease Models, Animal | 2008 |
Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety Disorders; Avoidance Learning; Escape Re | 2009 |
The effects of midazolam and D-cycloserine on the release of glutamate and GABA in the basolateral amygdala of low and high anxiety rats during extinction trial of a conditioned fear test.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Anxiety Disorders; Conditioning, Classical; Cyclos | 2010 |
Cases of catatonia on an academic electroconvulsive therapy service: lessons to learn.
Topics: Aged; Aged, 80 and over; Anxiety Disorders; Catatonia; Depressive Disorder; Depressive Disorder, Maj | 2011 |
Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.
Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Cells, Cultured; Depressive Disorder; GABA Mo | 2011 |
Panicolytic-like effect induced by the stimulation of GABAA and GABAB receptors in the dorsal periaqueductal grey of rats.
Topics: Analysis of Variance; Animals; Anxiety Disorders; Avoidance Learning; Baclofen; Behavior, Animal; Ca | 2005 |
Activity of the medial prefrontal cortex and amygdala underlies one-trial tolerance of rats in the elevated plus-maze.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Brain Mapping; Cognitio | 2008 |