midazolam has been researched along with Anxiety, Separation in 20 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Anxiety, Separation: Anxiety experienced by an individual upon separation from a person or object of particular significance to the individual.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin was not only as effective as midazolam in alleviating preoperative anxiety in children, but it was also associated with a tendency towards faster recovery, lower incidence of excitement postoperatively and a lower incidence of sleep disturbance at week 2 postoperatively." | 5.11 | Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. ( Albassam, A; Aldammas, F; Alotibi, W; Naguib, M; Riad, W; Samarkandi, A; Thalaj, A, 2005) |
| "Both midazolam and parental presence during induction of anesthesia are routinely used to treat preoperative anxiety in children." | 5.08 | Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective? ( Caramico, LA; Hofstadter, MB; Kain, ZN; Mayes, LC; Wang, SM, 1998) |
| " At the initial surgery, children were assigned (no parental intervention) to receive oral midazolam (n = 13), or parental presence during the induction of anesthesia (PPIA, n = 27), or PPIA + midazolam (n = 10) or no intervention (n = 33)." | 3.72 | Parental intervention choices for children undergoing repeated surgeries. ( Caldwell-Andrews, AA; Kain, ZN; Krivutza, DM; Mayes, LC; Wang, SM; Weinberg, ME, 2003) |
| " However, various dosing regimens when used alone or in combination have variable efficacy and side effect profile." | 2.71 | Comparative evaluation of midazolam and ketamine with midazolam alone as oral premedication. ( Chari, P; Ghai, B; Grandhe, RP; Kumar, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Ghaffar, HS | 1 |
| Kamal, SM | 1 |
| El Sherif, FA | 1 |
| Mohamed, SA | 1 |
| Sathyamoorthy, M | 1 |
| Hamilton, TB | 1 |
| Wilson, G | 1 |
| Talluri, R | 1 |
| Fawad, L | 1 |
| Adamiak, B | 1 |
| Wallace, C | 1 |
| Borissova, I | 1 |
| Heard, C | 1 |
| Eskandarian, T | 1 |
| Arabzade Moghadam, S | 1 |
| Reza Ghaemi, S | 1 |
| Bayani, M | 1 |
| Damle, SG | 1 |
| Gandhi, M | 1 |
| Laheri, V | 1 |
| Kazak, Z | 1 |
| Sezer, GB | 1 |
| Yilmaz, AA | 1 |
| Ates, Y | 1 |
| Wang, X | 1 |
| Zhou, ZJ | 1 |
| Zhang, XF | 1 |
| Zheng, S | 1 |
| Kain, ZN | 2 |
| Caldwell-Andrews, AA | 1 |
| Wang, SM | 2 |
| Krivutza, DM | 1 |
| Weinberg, ME | 1 |
| Mayes, LC | 2 |
| Samarkandi, A | 1 |
| Naguib, M | 1 |
| Riad, W | 1 |
| Thalaj, A | 1 |
| Alotibi, W | 1 |
| Aldammas, F | 1 |
| Albassam, A | 1 |
| Ghai, B | 1 |
| Grandhe, RP | 1 |
| Kumar, A | 1 |
| Chari, P | 1 |
| Horiuchi, T | 1 |
| Kawaguchi, M | 1 |
| Kurehara, K | 1 |
| Kawaraguchi, Y | 1 |
| Sasaoka, N | 1 |
| Furuya, H | 1 |
| Mishra, LD | 1 |
| Sinha, GK | 1 |
| Bhaskar Rao, P | 1 |
| Sharma, V | 1 |
| Satya, K | 1 |
| Gairola, R | 1 |
| Yuen, VM | 1 |
| Hui, TW | 1 |
| Irwin, MG | 1 |
| Yuen, MK | 1 |
| Davis, PJ | 1 |
| Tome, JA | 1 |
| McGowan, FX | 1 |
| Cohen, IT | 1 |
| Latta, K | 1 |
| Felder, H | 1 |
| Levine, MF | 2 |
| Hartley, EJ | 1 |
| Macpherson, BA | 1 |
| Burrows, FA | 1 |
| Lerman, J | 3 |
| Spahr-Schopfer, IA | 2 |
| Hartley, E | 2 |
| MacPherson, B | 1 |
| Durry, M | 1 |
| Caramico, LA | 1 |
| Hofstadter, MB | 1 |
| Beebe, DS | 1 |
| Belani, KG | 1 |
| Chang, PN | 1 |
| Hesse, PS | 1 |
| Schuh, JS | 1 |
| Liao, JC | 1 |
| Palahniuk, RJ | 1 |
| Payne, KA | 1 |
| Coetzee, AR | 1 |
| Mattheyse, FJ | 1 |
| Heydenrych, JJ | 1 |
| McMillan, CO | 1 |
| Sikich, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Premedication With Different Nebulized Ketamine,Dexmedetomidine Versus Midazolam in Oncologic Preschool Children[NCT02935959] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After Failed Pediatric Procedural Sedation: a Randomized Controlled Trial[NCT04822064] | 70 participants (Anticipated) | Interventional | 2022-09-22 | Recruiting | |||
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children: a Randomized Controlled Trial[NCT04820205] | 136 participants (Anticipated) | Interventional | 2021-09-03 | Recruiting | |||
| Comparing Intranasal Dexmedetomidine With Oral Midazolam as Premedication for Older Children Undergoing General Anesthesia for Dental Rehabilitation[NCT02250703] | Phase 3 | 75 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Use of Handheld Audiovisual Devices to Treat Pediatric Preoperative Anxiety: A Randomized Control Trial.[NCT02286674] | 200 participants (Actual) | Interventional | 2014-11-30 | Completed | |||
| Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309] | Phase 3 | 25 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT[NCT04034771] | Phase 3 | 38 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| Intranasal Dexmedetomidine Decreases Emergence Delirium in Pediatric Patients After Sevoflurane Based General Anesthesia[NCT00778063] | 40 participants (Actual) | Interventional | 2008-09-30 | Terminated (stopped due to Difficulty enrolling patients) | |||
| Does Anxiety in Children on the Day of Surgery Impact Compliance in the Ophthalmology Clinic?[NCT02704442] | 82 participants (Anticipated) | Observational | 2016-02-29 | Recruiting | |||
| Perioperative EEG-Monitoring and Emergence Delirium in Children: a Prospective Observational Study[NCT04091724] | 400 participants (Anticipated) | Observational | 2019-12-02 | Recruiting | |||
| Adaptive Care in the Perioperative Setting: An Observational Study[NCT03353129] | 60 participants (Actual) | Observational | 2017-08-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Level of sedation at separation from parents and at the time of mask induction will be measured on a scale of 0 to 4 (University of Michigan Sedation Scale)~University of Michigan Sedation Scale:~0 -Awake/Alert~1 -Minimally Sedated: Tired/sleepy, appropriate response to verbal conversation and/or sounds.~2- Moderately Sedated: Somnolent/sleeping, easily aroused with light tactile stimulation.~3 - Deeply Sedated: Deep sleep, arousable only with significant physical stimulation.~4 - Unarousable~Moderately and Deeply sedated: Satisfactory Awake, minimally sedate, unarousable: Unsatisfactory" (NCT02250703)
Timeframe: Day 0:Just before the patient will be brought to the operating room
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Satisfactory sedation on separation from parents | Unsatisfactory sedation on separation from parents | Satisfactory sedation on transfer to OR table | Unsatisfactory sedation on transfer to OR table | |
| Dexmedetomidine | 25 | 11 | 22 | 14 |
| Midazolam | 15 | 22 | 12 | 25 |
17 trials available for midazolam and Anxiety, Separation
| Article | Year |
|---|---|
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anxiety, Separation; Bone Marrow Examination | 2018 |
The effect of nasal midazolam premedication on parents-child separation and recovery time in dental procedures under general anaesthesia.
Topics: Administration, Intranasal; Anesthesia Recovery Period; Anesthesia, Dental; Anesthesia, General; Anx | 2015 |
Comparison of oral ketamine and oral midazolam as sedative agents in pediatric dentistry.
Topics: Administration, Oral; Anesthesia Recovery Period; Anesthesia, Dental; Anesthesia, General; Anxiety, | 2008 |
Premedication with oral midazolam with or without parental presence.
Topics: Administration, Oral; Anesthetics, Intravenous; Anxiety, Separation; Child; Child, Preschool; Dental | 2010 |
A comparison of two different doses of rectal ketamine added to 0.5 mg x kg(-1) midazolam and 0.02 mg x kg(-1) atropine in infants and young children.
Topics: Administration, Rectal; Anesthetics, Dissociative; Anxiety, Separation; Atropine; Catheterization, C | 2010 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Anxiety, Separatio | 2005 |
Comparative evaluation of midazolam and ketamine with midazolam alone as oral premedication.
Topics: Adjuvants, Anesthesia; Administration, Oral; Anesthesia Recovery Period; Anesthetics, Dissociative; | 2005 |
Evaluation of relatively low dose of oral transmucosal ketamine premedication in children: a comparison with oral midazolam.
Topics: Administration, Buccal; Anesthesia, Inhalation; Anesthetics, Dissociative; Anxiety, Separation; Chil | 2005 |
Injectable midazolam as oral premedicant in pediatric neurosurgery.
Topics: Age Factors; Anesthesia Recovery Period; Anesthesia, General; Anxiety, Separation; Child, Preschool; | 2005 |
A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial.
Topics: Administration, Intranasal; Administration, Oral; Adrenergic alpha-Agonists; Anxiety, Separation; Ch | 2008 |
A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial.
Topics: Administration, Intranasal; Administration, Oral; Adrenergic alpha-Agonists; Anxiety, Separation; Ch | 2008 |
A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial.
Topics: Administration, Intranasal; Administration, Oral; Adrenergic alpha-Agonists; Anxiety, Separation; Ch | 2008 |
A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial.
Topics: Administration, Intranasal; Administration, Oral; Adrenergic alpha-Agonists; Anxiety, Separation; Ch | 2008 |
Preanesthetic medication with intranasal midazolam for brief pediatric surgical procedures. Effect on recovery and hospital discharge times.
Topics: Administration, Intranasal; Anesthesia Recovery Period; Anxiety, Separation; Child, Preschool; Doubl | 1995 |
Oral midazolam premedication for children with congenital cyanotic heart disease undergoing cardiac surgery: a comparative study.
Topics: Administration, Oral; Administration, Rectal; Anxiety, Separation; Atropine; Awareness; Child; Child | 1993 |
Oral midazolam premedication in children: the minimum time interval for separation from parents.
Topics: Administration, Oral; Ambulatory Surgical Procedures; Anesthesia, Inhalation; Anxiety, Separation; C | 1993 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective?
Topics: Adaptation, Psychological; Adjuvants, Anesthesia; Adult; Anesthesia; Anxiety; Anxiety, Separation; B | 1998 |
Effectiveness of preoperative sedation with rectal midazolam, ketamine, or their combination in young children.
Topics: Administration, Rectal; Anxiety, Separation; Atropine; Catheterization, Central Venous; Child; Child | 1992 |
Behavioural changes in children following minor surgery--is premedication beneficial?
Topics: Anxiety, Separation; Child; Child Behavior; Child, Preschool; Enuresis; Feeding Behavior; Hernia, In | 1992 |
Premedication of children with oral midazolam.
Topics: Acoustic Stimulation; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anxiety, Separatio | 1992 |
3 other studies available for midazolam and Anxiety, Separation
| Article | Year |
|---|---|
Pre-medication before dental procedures: A randomized controlled study comparing intranasal dexmedetomidine with oral midazolam.
Topics: Administration, Intranasal; Administration, Oral; Anxiety, Separation; Child; Child Behavior; Child, | 2019 |
Parental intervention choices for children undergoing repeated surgeries.
Topics: Anesthesia; Anxiety; Anxiety, Separation; Child; Child, Preschool; Chronic Disease; Female; Humans; | 2003 |
Oral midazolam in children: the effect at time and adjunct therapy.
Topics: Administration, Oral; Anxiety, Separation; Child; Clinical Trials as Topic; Cohort Studies; Double-B | 1993 |