midazolam has been researched along with Anoxia, Brain in 8 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pre-treatment with midazolam diminishes increased expression of cerebral endothelial intercellular adhesion molecule-1 and P-selectin expression following hypoxia-reoxygenation." | 5.35 | The effect of midazolam on cerebral endothelial (P-selectin and ICAM-1) adhesion molecule expression during hypoxia-reperfusion injury in vitro. ( Ghori, K; Harmon, D; Lan, W; Seigne, P; Shorten, GD; Walsh, F, 2008) |
| " Late awakening was more frequent with midazolam (58% vs 45%) and was associated with higher rates of delirium (62% vs 39%) and unfavorable 3-months outcome (27% vs 12%; all p = 0." | 3.91 | Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. ( Eckert, P; Miroz, JP; Oddo, M; Rey, A; Rossetti, AO, 2019) |
| "Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines." | 2.37 | Midazolam: pharmacology and uses. ( Fragen, RJ; Greenblatt, DJ; Reves, JG; Vinik, HR, 1985) |
| "Pretreatment with midazolam reversed H/R-induced apoptosis and downregulation of EAAT2 mRNA and protein expression in the hippocampus." | 1.56 | Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2. ( Dong, Y; Liu, H; Ma, C; Shan, Y; Sun, S; Tang, Z; Yang, F; Zhang, Y, 2020) |
| "Pre-treatment with midazolam diminishes increased expression of cerebral endothelial intercellular adhesion molecule-1 and P-selectin expression following hypoxia-reoxygenation." | 1.35 | The effect of midazolam on cerebral endothelial (P-selectin and ICAM-1) adhesion molecule expression during hypoxia-reperfusion injury in vitro. ( Ghori, K; Harmon, D; Lan, W; Seigne, P; Shorten, GD; Walsh, F, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, Z | 1 |
| Yang, F | 1 |
| Dong, Y | 1 |
| Ma, C | 1 |
| Sun, S | 1 |
| Shan, Y | 1 |
| Zhang, Y | 1 |
| Liu, H | 1 |
| Rey, A | 1 |
| Rossetti, AO | 1 |
| Miroz, JP | 1 |
| Eckert, P | 1 |
| Oddo, M | 1 |
| van Alfen-van der Velden, AA | 2 |
| Claessen, VP | 1 |
| Hopman, JC | 2 |
| Klaessens, JH | 2 |
| Sengers, RC | 2 |
| Liem, KD | 2 |
| Weaver, JM | 1 |
| Feuth, T | 1 |
| Ghori, K | 1 |
| Harmon, D | 1 |
| Lan, W | 1 |
| Seigne, P | 1 |
| Walsh, F | 1 |
| Shorten, GD | 1 |
| Nugent, M | 1 |
| Artru, AA | 1 |
| Michenfelder, JD | 1 |
| Reves, JG | 1 |
| Fragen, RJ | 1 |
| Vinik, HR | 1 |
| Greenblatt, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302] | Phase 4 | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Anoxia, Brain
| Article | Year |
|---|---|
Midazolam: pharmacology and uses.
Topics: Adult; Aged; Aging; Ambulatory Surgical Procedures; Anesthetics; Animals; Benzodiazepines; Benzodiaz | 1985 |
7 other studies available for midazolam and Anoxia, Brain
| Article | Year |
|---|---|
Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2.
Topics: Animals; Animals, Newborn; Brain Injuries; Dose-Response Relationship, Drug; Excitatory Amino Acid T | 2020 |
Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery.
Topics: Aged; Cohort Studies; Coma; Delirium; Electroencephalography; Evoked Potentials, Motor; Female; Hear | 2019 |
Changes in cerebral oxygenation and hemodynamics during cranial ultrasound in preterm infants.
Topics: Aging; Analgesics, Opioid; Biomarkers; Brain; Cerebrovascular Circulation; Cranial Fontanelles; Echo | 2009 |
The fallacy of a lifesaving sublingual injection of flumazenil.
Topics: Anesthesia Recovery Period; Antidotes; Benzodiazepines; Conscious Sedation; Drug Overdose; Flumazeni | 2011 |
Effects of midazolam and morphine on cerebral oxygenation and hemodynamics in ventilated premature infants.
Topics: Blood Flow Velocity; Blood Pressure; Blood Volume; Brain; Gestational Age; Heart Rate; Hemoglobins; | 2006 |
The effect of midazolam on cerebral endothelial (P-selectin and ICAM-1) adhesion molecule expression during hypoxia-reperfusion injury in vitro.
Topics: Animals; Brain; Cell Adhesion Molecules; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, | 2008 |
Cerebral metabolic, vascular and protective effects of midazolam maleate: comparison to diazepam.
Topics: Anesthetics; Animals; Benzodiazepines; Diazepam; Dogs; Hypoxia, Brain; Midazolam; Oxygen Consumption | 1982 |