midazolam has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrahao, A | 1 |
| Meng, Y | 1 |
| Llinas, M | 1 |
| Huang, Y | 1 |
| Hamani, C | 1 |
| Mainprize, T | 1 |
| Aubert, I | 1 |
| Heyn, C | 1 |
| Black, SE | 1 |
| Hynynen, K | 1 |
| Lipsman, N | 1 |
| Zinman, L | 1 |
| Oliver, DJ | 1 |
| Campbell, C | 1 |
| O'brien, T | 1 |
| Sloan, R | 1 |
| Sykes, N | 1 |
| Tallon, C | 1 |
| Taylor-Horan, J | 1 |
| Udoma, M | 1 |
| Kawa, C | 1 |
| Stewart, J | 1 |
| Hilden, K | 1 |
| Adler, DG | 1 |
| Tietze, C | 1 |
| Bromberg, MB | 1 |
| Fang, JC | 1 |
1 trial available for midazolam and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound.
Topics: Aged; Amyotrophic Lateral Sclerosis; Anesthetics, Intravenous; Blood-Brain Barrier; Brain; Drug Deli | 2019 |
2 other studies available for midazolam and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Medication in the last days of life for motor neuron disease/amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Analgesics, Opioid; Anti-Anxiety Agen | 2010 |
A retrospective study of nurse-assisted propofol sedation in patients with amyotrophic lateral sclerosis undergoing percutaneous endoscopic gastrostomy.
Topics: Aged; Amyotrophic Lateral Sclerosis; Anesthesia; Conscious Sedation; Endoscopy; Female; Fentanyl; Ga | 2012 |