Page last updated: 2024-10-31

midazolam and Alzheimer Disease

midazolam has been researched along with Alzheimer Disease in 4 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"Midazolam is a hypnotic-sedative drug with pleiotropic properties."1.91Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease. ( Chen, Y; Luan, H; Wang, P; Wu, Y, 2023)
"Midazolam treatment decreased GM1 expression in the detergent-resistant membrane microdomains of neurons, and these effects were regulated by the gamma-aminobutyric acid-A receptor."1.42Midazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor. ( Arima, H; Hirate, H; Kusama, N; Sobue, K; Sugiura, T; Suzuki, K; Yamamoto, N, 2015)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Wang, P6
Luan, H3
Wu, Y3
Chen, Y3
Yamamoto, N1
Arima, H1
Sugiura, T1
Hirate, H1
Kusama, N1
Suzuki, K1
Sobue, K1
Passmore, MJ1
Sheldon, L1
Lax, S1
Wilkins-Ho, M1
Illing, M1
Kálmán, J1
Palotás, M1
Pákáski, M1
Hugyecz, M1
Janka, Z1
Palotás, A1

Other Studies

4 other studies available for midazolam and Alzheimer Disease

ArticleYear
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
    Brain and behavior, 2023, Volume: 13, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H

2023
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
    Brain and behavior, 2023, Volume: 13, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H

2023
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
    Brain and behavior, 2023, Volume: 13, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H

2023
Midazolam alleviates cellular senescence in SH-SY5Y neuronal cells in Alzheimer's disease.
    Brain and behavior, 2023, Volume: 13, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cellular Senescence; Cyclooxygenase 2; H

2023
Midazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor.
    Biochemical and biophysical research communications, 2015, Feb-20, Volume: 457, Issue:4

    Topics: Alzheimer Disease; Amyloid; Anesthetics, Intravenous; Animals; Cells, Cultured; G(M1) Ganglioside; M

2015
Oral midazolam for dementia-related response agitation.
    Journal of the American Geriatrics Society, 2009, Volume: 57, Issue:3

    Topics: Administration, Oral; Aged, 80 and over; Aggression; Alzheimer Disease; Female; Humans; Hypnotics an

2009
Unchanged rat brain amyloid precursor protein levels after exposure to benzodiazepines in vivo.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:9

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthesia, General; Animals; Antibodies, Monoclonal; Benz

2006