midazolam has been researched along with Alcoholic Cirrhosis in 3 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Elimination half-life was 135 +/- 40 min in controls and 168 +/- 30 min in cirrhosis (P less than 0." | 1.27 | Pharmacokinetics of midazolam in anaesthetized cirrhotic patients. ( Chauvin, M; Duvaldestin, P; Farinotti, R; Haberer, JP; Servin, F; Trouvin, JH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, GR | 1 |
| Miller, E | 1 |
| MacGilchrist, AJ | 1 |
| Birnie, GG | 1 |
| Cook, A | 1 |
| Scobie, G | 1 |
| Murray, T | 1 |
| Watkinson, G | 1 |
| Brodie, MJ | 1 |
| Trouvin, JH | 1 |
| Farinotti, R | 1 |
| Haberer, JP | 1 |
| Servin, F | 1 |
| Chauvin, M | 1 |
| Duvaldestin, P | 1 |
3 other studies available for midazolam and Alcoholic Cirrhosis
| Article | Year |
|---|---|
What changes drug metabolism in critically ill patients--III? Effect of pre-existing disease on the metabolism of midazolam.
Topics: Adult; Biotransformation; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Graft Rejection; | 1996 |
Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis.
Topics: Adult; Antipyrine; Benzodiazepines; Endoscopy; Flicker Fusion; Half-Life; Humans; Hypnotics and Seda | 1986 |
Pharmacokinetics of midazolam in anaesthetized cirrhotic patients.
Topics: Adult; Aged; Anesthesia, General; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Midazolam; Middl | 1988 |