midazolam has been researched along with Alcohol Drinking in 13 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Interruption of sedation due to a poor response to modified neuroleptanalgesia (m-NLA) with midazolam often occurs during endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma (ESCC) because most patients have a history of heavy alcohol intake." | 9.27 | Comparison of propofol with midazolam in endoscopic submucosal dissection for esophageal squamous cell carcinoma: a randomized controlled trial. ( Arakawa, T; Fujiwara, Y; Fukunaga, S; Kamata, N; Kato, K; Machida, H; Maruyama, H; Minamino, H; Nagami, Y; Ominami, M; Sakai, T; Shiba, M; Sugimori, S; Tanaka, F; Tanigawa, T; Tominaga, K; Watanabe, T; Yamagami, H, 2018) |
| "We found that ketamine leads to significantly greater mystical-type effects (by Hood Mysticism Scale) and dissociation (by Clinician Administered Dissociative States Scale) compared to the active control." | 5.41 | Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial. ( Azhari, N; Dakwar, E; Haug, NA; Rothberg, RL, 2021) |
| "Deramciclane appears to be a safe and well-tolerated drug and we suggest that it might be useful in the treatment of anxiety in alcoholics." | 5.32 | Comparison of deramciclane to benzodiazepine agonists in behavioural activity of mice and in alcohol drinking of alcohol-preferring rats. ( Honkanen, A; Ingman, K; Korpi, ER; Sallinen, J, 2004) |
| "Interruption of sedation due to a poor response to modified neuroleptanalgesia (m-NLA) with midazolam often occurs during endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma (ESCC) because most patients have a history of heavy alcohol intake." | 5.27 | Comparison of propofol with midazolam in endoscopic submucosal dissection for esophageal squamous cell carcinoma: a randomized controlled trial. ( Arakawa, T; Fujiwara, Y; Fukunaga, S; Kamata, N; Kato, K; Machida, H; Maruyama, H; Minamino, H; Nagami, Y; Ominami, M; Sakai, T; Shiba, M; Sugimori, S; Tanaka, F; Tanigawa, T; Tominaga, K; Watanabe, T; Yamagami, H, 2018) |
| " In conclusion, in individuals with moderate alcohol consumption, there was no alteration in the hepatic CYP3A activity, but the reduced midazolam oral bioavailability suggests that moderate alcohol consumption may cause intestinal CYP3A induction." | 2.71 | Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. ( Chalasani, N; Gorski, JC; Hall, SD; Kolwankar, D; Liangpunsakul, S; Pinto, A, 2005) |
| "Deramciclane appears to be a safe and well-tolerated drug and we suggest that it might be useful in the treatment of anxiety in alcoholics." | 1.32 | Comparison of deramciclane to benzodiazepine agonists in behavioural activity of mice and in alcohol drinking of alcohol-preferring rats. ( Honkanen, A; Ingman, K; Korpi, ER; Sallinen, J, 2004) |
| "Harman treatment (27 nmol/hr) disturbed the regular rhythms at lower ethanol concentrations but mimicked the ultradian rhythm which was observed at high ethanol concentrations in CSF-treated animals." | 1.27 | Harman induces preference for ethanol in rats: is the effect specific for ethanol? ( Büchau, C; Rommelspacher, H; Weiss, J, 1987) |
| "Midazolam was administered intravenously (0." | 1.27 | No evidence of a genetic polymorphism in the oxidative metabolism of midazolam. ( Eichelbaum, M; Kassai, A; Klotz, U; Toth, G, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Savarese, AM | 1 |
| Metten, P | 1 |
| Phillips, TJ | 1 |
| Jensen, BE | 1 |
| Crabbe, JC | 1 |
| Ozburn, AR | 1 |
| Rothberg, RL | 1 |
| Azhari, N | 1 |
| Haug, NA | 1 |
| Dakwar, E | 1 |
| Townsend, EA | 1 |
| Platt, DM | 1 |
| Rowlett, JK | 1 |
| Roma, PG | 1 |
| Freeman, KB | 1 |
| Ominami, M | 1 |
| Nagami, Y | 1 |
| Shiba, M | 1 |
| Tominaga, K | 1 |
| Sakai, T | 1 |
| Maruyama, H | 1 |
| Kato, K | 1 |
| Minamino, H | 1 |
| Fukunaga, S | 1 |
| Tanaka, F | 1 |
| Sugimori, S | 1 |
| Kamata, N | 1 |
| Machida, H | 1 |
| Yamagami, H | 1 |
| Tanigawa, T | 1 |
| Watanabe, T | 1 |
| Fujiwara, Y | 1 |
| Arakawa, T | 1 |
| Rose, L | 1 |
| Burry, L | 1 |
| Mallick, R | 1 |
| Luk, E | 1 |
| Cook, D | 1 |
| Fergusson, D | 1 |
| Dodek, P | 1 |
| Burns, K | 1 |
| Granton, J | 1 |
| Ferguson, N | 1 |
| Devlin, JW | 1 |
| Steinberg, M | 1 |
| Keenan, S | 1 |
| Reynolds, S | 1 |
| Tanios, M | 1 |
| Fowler, RA | 1 |
| Jacka, M | 1 |
| Olafson, K | 1 |
| Skrobik, Y | 1 |
| Mehta, S | 1 |
| Fairbairn, N | 1 |
| Hayashi, K | 1 |
| Kaplan, K | 1 |
| Suwannawong, P | 1 |
| Qi, J | 1 |
| Wood, E | 1 |
| Kerr, T | 1 |
| Ingman, K | 1 |
| Sallinen, J | 1 |
| Honkanen, A | 1 |
| Korpi, ER | 1 |
| Liangpunsakul, S | 1 |
| Kolwankar, D | 1 |
| Pinto, A | 1 |
| Gorski, JC | 1 |
| Hall, SD | 1 |
| Chalasani, N | 1 |
| Augsburger, M | 1 |
| Giroud, C | 1 |
| Rivier, L | 1 |
| Tracqui, A | 1 |
| Mangin, P | 1 |
| Söderpalm, AH | 1 |
| Hansen, S | 1 |
| Lichtor, JL | 1 |
| Zacny, J | 1 |
| Apfelbaum, JL | 1 |
| Lane, BS | 1 |
| Rupani, G | 1 |
| Thisted, RA | 1 |
| Dohrn, C | 1 |
| Korttila, K | 1 |
| Rommelspacher, H | 1 |
| Büchau, C | 1 |
| Weiss, J | 1 |
| Kassai, A | 1 |
| Toth, G | 1 |
| Eichelbaum, M | 1 |
| Klotz, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial of Daily Sedative Interruption in Critically Ill, Mechanically Ventilated Patients Being Managed With a Sedation Protocol[NCT00675363] | 410 participants (Anticipated) | Interventional | 2008-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for midazolam and Alcohol Drinking
| Article | Year |
|---|---|
Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial.
Topics: Alcohol Drinking; Behavior, Addictive; Dissociative Disorders; Double-Blind Method; Female; Hallucin | 2021 |
Comparison of propofol with midazolam in endoscopic submucosal dissection for esophageal squamous cell carcinoma: a randomized controlled trial.
Topics: Aged; Alcohol Drinking; Anesthetics, Intravenous; Endoscopic Mucosal Resection; Esophageal Neoplasms | 2018 |
Prevalence, risk factors, and outcomes associated with physical restraint use in mechanically ventilated adults.
Topics: Adult; Aged; Alcohol Drinking; Analgesics, Opioid; Antipsychotic Agents; Benzodiazepines; Clinical P | 2016 |
Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics.
Topics: Adult; Alcohol Drinking; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chlorzoxazo | 2005 |
Alcohol after sedation with i.v. midazolam-fentanyl: effects on psychomotor functioning.
Topics: Adult; Alcohol Drinking; Double-Blind Method; Drug Interactions; Ethanol; Fentanyl; Humans; Male; Mi | 1991 |
8 other studies available for midazolam and Alcohol Drinking
| Article | Year |
|---|---|
Midazolam, methamphetamine, morphine and nicotine intake in high-drinking-in-the-dark mice.
Topics: Alcohol Drinking; Animals; Ethanol; Female; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Midazol | 2022 |
Reinforcing effectiveness of midazolam, ethanol, and sucrose: behavioral economic comparison of a mixture relative to its component solutions.
Topics: Alcohol Drinking; Animals; Benzodiazepines; Ethanol; Male; Midazolam; Rats; Reinforcement Schedule; | 2017 |
Factors associated with methadone treatment among injection drug users in Bangkok, Thailand.
Topics: Adult; Age Factors; Alcohol Drinking; Cross-Sectional Studies; Female; Humans; Male; Methadone; Meth | 2012 |
Comparison of deramciclane to benzodiazepine agonists in behavioural activity of mice and in alcohol drinking of alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Benzodiazepines; Camphanes; Diazepam; Dose-Response Relationship, Drug; G | 2004 |
Car crash after massive ingestion of digoxin and midazolam.
Topics: Accidents, Traffic; Adult; Alcohol Drinking; Autopsy; Cardiotonic Agents; Digoxin; Humans; Hypnotics | 1998 |
Benzodiazepines enhance the consumption and palatability of alcohol in the rat.
Topics: Alcohol Drinking; Animals; Anti-Anxiety Agents; Brain; Chlordiazepoxide; Diazepam; Dose-Response Rel | 1998 |
Harman induces preference for ethanol in rats: is the effect specific for ethanol?
Topics: Activity Cycles; Alcohol Drinking; Alkaloids; Animals; Benzimidazoles; Carbolines; Chlormethiazole; | 1987 |
No evidence of a genetic polymorphism in the oxidative metabolism of midazolam.
Topics: Age Factors; Alcohol Drinking; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Midazolam; | 1988 |