midazolam has been researched along with Airway Obstruction in 38 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Airway Obstruction: Any hindrance to the passage of air into and out of the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We demonstrate that the arousal-independent compensatory neuromuscular responses to upper airway obstruction during midazolam anesthesia were partially maintained in women, and that gender may be a major determinant of the strength of compensatory responses during anesthesia." | 9.14 | The effect of gender on compensatory neuromuscular response to upper airway obstruction in normal subjects under midazolam general anesthesia. ( Ayuse, T; Hoshino, Y; Kirkness, JP; Kurata, S; Oi, K; Patil, SP; Schneider, H; Schwartz, AR, 2009) |
| "We conclude that upper airway obstruction contributes considerably to decreases in SpO2 during midazolam sedation for spinal anaesthesia." | 5.29 | Upper airway obstruction during midazolam sedation: modification by nasal CPAP. ( Isono, S; Nishino, T; Nozaki-Taguchi, N; Numai, T; Taguchi, N, 1995) |
| "This report describes weekly repeated anesthesia in a 7-yr-old, 1,030 kg, female Eastern black rhinoceros ( Diceros bicornis michaeli), that was immobilized six times using a combination of 2 mg etorphine (0." | 3.88 | REPEATED ANESTHESIA IN A BLACK RHINOCEROS ( DICEROS BICORNIS) TO MANAGE UPPER RESPIRATORY OBSTRUCTION. ( Adkesson, MJ; Aitken-Palmer, C; Bailey, RS; Chinnadurai, CK; Langan, JN; Mora, IM; Tang, KN, 2018) |
| "This conference reports a case of acute functional airway obstruction occurring in the postoperative anesthesia care unit, which was diagnosed by fiberoptic laryngoscopy and successfully treated with intravenous midazolam after other more common causes of stridor were ruled out." | 3.72 | Paradoxical vocal cord motion: an often misdiagnosed cause of postoperative stridor. ( Caruso, LJ; Larsen, B; Villariet, DB, 2004) |
| "Upper airway obstruction (UAO) during sedation can often cause clinically significant adverse events." | 2.72 | Differences between midazolam and propofol sedation on upper airway collapsibility using dynamic negative airway pressure. ( Bailey, P; Karan, S; Norton, JR; Palmer, L; Rackovsky, O; Varlese, A; Voter, WA; Ward, DS, 2006) |
| "Flumazenil was completely effective in reversing the potential for midazolam to cause UAO." | 2.70 | Use of dynamic negative airway pressure (DNAP) to assess sedative-induced upper airway obstruction. ( Bailey, PL; Basco, MG; Hayes, JL; Litman, RS; Schwartz, AR; Ward, DS, 2002) |
| "The etiology of the acutely developed atelectasis was unclear." | 1.34 | Pulmonary atelectasis manifested after induction of anesthesia: a contribution of sinobronchial syndrome? ( Amagasa, S; Igarashi, A; Oda, S; Yokoo, N, 2007) |
| "One hundred twenty-seven patients with obstructive sleep apnea and SUS underwent sleep endoscopy." | 1.33 | Sleep endoscopy versus modified Mallampati score in sleep apnea and snoring. ( de Vries, N; den Herder, C; van Tinteren, H, 2005) |
| "Although the incidence of respiratory depression was higher in patients receiving deep sedation with propofol than in patients who were lightly sedated (17." | 1.32 | Use of deep intravenous sedation with propofol and the laryngeal mask airway during transesophageal echocardiography. ( Arens, J; Ferson, D; Sapire, K; Sinha, A; Swafford, J; Thakar, D, 2003) |
| "In no case was laryngospasm or total airway obstruction observed." | 1.31 | Additional clinical observations utilizing bispectral analysis. ( Sandler, NA, 2000) |
| " Deep sedation was induced in 260 patients using midazolam, phenergan, and meperidine, then maintained with intermittent dosing of meperidine at the following mean doses: midazolam 0." | 1.30 | Evaluation of the safety and efficacy of deep sedation for electrophysiology procedures administered in the absence of an anesthetist. ( Brandon, MJ; Geiger, MJ; Kearney, MM; Kent, V; Natale, A; Newby, KH; Wase, A, 1997) |
| "We conclude that upper airway obstruction contributes considerably to decreases in SpO2 during midazolam sedation for spinal anaesthesia." | 1.29 | Upper airway obstruction during midazolam sedation: modification by nasal CPAP. ( Isono, S; Nishino, T; Nozaki-Taguchi, N; Numai, T; Taguchi, N, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 12 (31.58) | 18.2507 |
| 2000's | 14 (36.84) | 29.6817 |
| 2010's | 10 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gargiulo, M | 1 |
| Cortese, A | 1 |
| Pantaleo, G | 1 |
| Parascandalo, S | 1 |
| Amato, M | 1 |
| Mora, IM | 1 |
| Langan, JN | 1 |
| Bailey, RS | 1 |
| Aitken-Palmer, C | 1 |
| Adkesson, MJ | 1 |
| Tang, KN | 1 |
| Chinnadurai, CK | 1 |
| Vanderveken, OM | 3 |
| Maurer, JT | 1 |
| Hohenhorst, W | 2 |
| Hamans, E | 3 |
| Lin, HS | 1 |
| Vroegop, AV | 2 |
| Anders, C | 1 |
| de Vries, N | 3 |
| Van de Heyning, PH | 2 |
| Boudewyns, AN | 1 |
| Scholman, J | 1 |
| Saldien, V | 1 |
| Wouters, K | 1 |
| Braem, MJ | 1 |
| De Vito, A | 1 |
| Carrasco Llatas, M | 1 |
| Vanni, A | 1 |
| Bosi, M | 1 |
| Braghiroli, A | 1 |
| Campanini, A | 1 |
| Kotecha, BT | 1 |
| Maurer, J | 1 |
| Montevecchi, F | 1 |
| Piccin, O | 1 |
| Sorrenti, G | 1 |
| Vicini, C | 1 |
| Moustafa, MA | 1 |
| Emara, DM | 1 |
| Nouh, MR | 1 |
| Ayuse, T | 5 |
| Hoshino, Y | 1 |
| Kurata, S | 3 |
| Schneider, H | 3 |
| Kirkness, JP | 1 |
| Patil, SP | 1 |
| Schwartz, AR | 4 |
| Oi, K | 4 |
| Gerónimo Pardo, M | 1 |
| Mateo Cerdán, CM | 1 |
| Moreno Salcedo, JM | 1 |
| Sharma, R | 1 |
| AuBuchon, J | 1 |
| Krucylak, C | 1 |
| Murray, DJ | 1 |
| Shiota, M | 1 |
| Oda, Y | 1 |
| Taniguchi, M | 1 |
| Hamabata, T | 1 |
| Mizumoto, H | 1 |
| Hata, D | 1 |
| Ferson, D | 1 |
| Thakar, D | 1 |
| Swafford, J | 1 |
| Sinha, A | 1 |
| Sapire, K | 1 |
| Arens, J | 1 |
| Larsen, B | 1 |
| Caruso, LJ | 1 |
| Villariet, DB | 1 |
| Bowdle, TA | 1 |
| Inazawa, T | 2 |
| Okayasu, I | 2 |
| Sakamoto, E | 2 |
| den Herder, C | 1 |
| van Tinteren, H | 1 |
| Ikeda, H | 1 |
| Norton, JR | 1 |
| Ward, DS | 3 |
| Karan, S | 1 |
| Voter, WA | 1 |
| Palmer, L | 1 |
| Varlese, A | 1 |
| Rackovsky, O | 1 |
| Bailey, P | 1 |
| Kotsev, S | 1 |
| Igarashi, A | 1 |
| Amagasa, S | 1 |
| Oda, S | 1 |
| Yokoo, N | 1 |
| Forster, A | 1 |
| Gardaz, JP | 1 |
| Suter, PM | 1 |
| Gemperle, M | 1 |
| Rothschild, MA | 1 |
| Cotcamp, D | 1 |
| Cotton, RT | 1 |
| Nozaki-Taguchi, N | 1 |
| Isono, S | 1 |
| Nishino, T | 1 |
| Numai, T | 1 |
| Taguchi, N | 1 |
| Cay, DL | 1 |
| Gentil, B | 1 |
| Tehindrazanarivelo, A | 1 |
| Lienhart, A | 1 |
| Meyer, B | 1 |
| Fleury, B | 1 |
| Negus, BH | 1 |
| Street, NE | 1 |
| Drummond, GB | 1 |
| Zacharias, M | 1 |
| Hunter, KM | 1 |
| Parkinson, R | 1 |
| Litman, RS | 3 |
| Sanderson, PM | 1 |
| Geiger, MJ | 1 |
| Wase, A | 1 |
| Kearney, MM | 1 |
| Brandon, MJ | 1 |
| Kent, V | 1 |
| Newby, KH | 1 |
| Natale, A | 1 |
| Kottra, JA | 1 |
| Berkowitz, RJ | 1 |
| Oshima, T | 1 |
| Masaki, Y | 1 |
| Toyooka, H | 1 |
| Sandler, NA | 1 |
| Hayes, JL | 1 |
| Basco, MG | 1 |
| Bailey, PL | 1 |
| Mamaya, B | 1 |
| Bezel, R | 1 |
| Russi, E | 1 |
| Kronauer, H | 1 |
| Mothersill, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Drug-Induced Sleep Endoscopy for the Optimisation of Treatment of Patients With Obstruction Sleep Apnoea[NCT02855515] | 120 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
| Propofolsleep - A Observational Study on Cardiopulmonary and Pharyngeal Reactions While Drug Induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea Syndrome Under PSI Monitoring[NCT03224936] | 20 participants (Anticipated) | Observational | 2017-08-22 | Active, not recruiting | |||
| Supraglottic Airway Use for Transesophageal Echocardiography: a Safe Alternative to Deep Sedation for Patients With High-risk Cardiopulmonary Disease. (SGA-TEE)[NCT04939220] | 110 participants (Anticipated) | Interventional | 2024-02-29 | Not yet recruiting | |||
| UPright Incline Positioning in COVID-19 Patients for Oxygen SATuration Improvement With Hypoxemic Respiratory Failure (UPSAT)[NCT04344561] | 7 participants (Actual) | Interventional | 2020-05-25 | Terminated (stopped due to Inability to recruit) | |||
| Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation[NCT04310579] | Phase 1 | 55 participants (Actual) | Interventional | 2020-06-15 | Completed | ||
| Effect of Increasing Depth of Dexmedetomidine and Propofol Anesthesia on Upper Airway Morphology in Children With History of Obstructive Sleep Apnea[NCT01344759] | Phase 4 | 60 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
This is the count of the number of patients who needed an artificial airway. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | Number of artifical airway events (Number) |
|---|---|
| Mild OSA and Dexmedetomidine | 0 |
| Mild OSA and Propofol | 1 |
| Moderate OSA and Dexmedetomidine | 1 |
| Moderate OSA and Propofol | 1 |
| Severe OSA and Dexmedetomidine | 2 |
| Severe OSA and Propofol | 5 |
The Obstructive Index is a count of the obstructive apnea events per hour of sleep (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | Apnea events/hour of sleep (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 4.2 |
| Mild OSA and Propofol | 3.0 |
| Moderate OSA and Dexmedetomidine | 8.0 |
| Moderate OSA and Propofol | 8.0 |
| Severe OSA and Dexmedetomidine | 16.7 |
| Severe OSA and Propofol | 17.1 |
The respiratory disturbance index is a count of respiratory disturbance events per hour of sleep. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | respir.disturbance events/hr of sleep (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 5.1 |
| Mild OSA and Propofol | 3.2 |
| Moderate OSA and Dexmedetomidine | 8.8 |
| Moderate OSA and Propofol | 7.1 |
| Severe OSA and Dexmedetomidine | 16.6 |
| Severe OSA and Propofol | 25.2 |
The patient's oxygen saturation on room air. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | percentage of SpO2 (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 87.2 |
| Mild OSA and Propofol | 88.0 |
| Moderate OSA and Dexmedetomidine | 86.3 |
| Moderate OSA and Propofol | 89.0 |
| Severe OSA and Dexmedetomidine | 84.0 |
| Severe OSA and Propofol | 88.0 |
The primary outcome measures will be the cross sectional area of the pharyngeal airway of the patients measured at two levels soft palate (nasopharyngeal) and base of the tongue (retroglossal). Magnetic resonance images of the airway were obtained during low (1 mcg/kg/hr) and high (3 mcg/kg/hr) doses of DEX or low (100 mcg/kg/m) and high (200 mcg/kg/m) doses of Propofol. All were administered through an intravenous (IV) catheter. (NCT01344759)
Timeframe: during MRI within first 10 minutes of scanning
| Intervention | mm^2 (Median) | |||
|---|---|---|---|---|
| Low Dose Sedative, Nasopharyngeal measurement | High Dose Sedative, Nasopharyngeal measurement | Low Dose Sedative, Retroglossal measurement | High dose sedative, Retroglossal measurement | |
| Dexmedetomidine | 178.5 | 235.4 | 120.9 | 120.5 |
| Propofol | 239.9 | 201.6 | 115.1 | 108.1 |
6 trials available for midazolam and Airway Obstruction
| Article | Year |
|---|---|
The effect of gender on compensatory neuromuscular response to upper airway obstruction in normal subjects under midazolam general anesthesia.
Topics: Adaptation, Physiological; Adult; Airway Obstruction; Anesthetics, Intravenous; Electroencephalograp | 2009 |
Nocturnal arterial oxygen desaturation and episodic airway obstruction after ambulatory surgery.
Topics: Adult; Aged; Airway Obstruction; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia; Ane | 2004 |
Differences between midazolam and propofol sedation on upper airway collapsibility using dynamic negative airway pressure.
Topics: Adult; Air Pressure; Airway Obstruction; Electroencephalography; Female; Humans; Hypnotics and Sedat | 2006 |
Comparison of sedation with midazolam and ketamine: effects on airway muscle activity.
Topics: Adult; Aged; Airway Obstruction; Anesthesia, General; Electromyography; Humans; Hypnotics and Sedati | 1996 |
Flumazenil antagonizes midazolam-induced airway narrowing during nasal breathing in humans.
Topics: Adult; Airway Obstruction; Airway Resistance; Anti-Anxiety Agents; Apnea; Female; Flumazenil; GABA M | 1999 |
Use of dynamic negative airway pressure (DNAP) to assess sedative-induced upper airway obstruction.
Topics: Adult; Air Pressure; Airway Obstruction; Arousal; Carbon Dioxide; Female; Flumazenil; GABA Modulator | 2002 |
32 other studies available for midazolam and Airway Obstruction
| Article | Year |
|---|---|
A relapsed lower-lip squamous cell carcinoma treated with curative electrochemotherapy in an elderly patient.
Topics: Airway Obstruction; Analgesics, Opioid; Antibiotics, Antineoplastic; Bleomycin; Carcinoma, Squamous | 2018 |
REPEATED ANESTHESIA IN A BLACK RHINOCEROS ( DICEROS BICORNIS) TO MANAGE UPPER RESPIRATORY OBSTRUCTION.
Topics: Actinomyces; Actinomycosis; Airway Obstruction; Anesthesia; Anesthetics; Animals; Animals, Zoo; Etor | 2018 |
Evaluation of drug-induced sleep endoscopy as a patient selection tool for implanted upper airway stimulation for obstructive sleep apnea.
Topics: Airway Obstruction; Electric Stimulation; Endoscopy; Female; Fiber Optic Technology; Humans; Hypnoti | 2013 |
Drug-induced sleep endoscopy in sleep-disordered breathing: report on 1,249 cases.
Topics: Adult; Age Factors; Airway Obstruction; Anthropometry; Body Mass Index; Clinical Competence; Cohort | 2014 |
European position paper on drug-induced sedation endoscopy (DISE).
Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based | 2014 |
European position paper on drug-induced sedation endoscopy (DISE).
Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based | 2014 |
European position paper on drug-induced sedation endoscopy (DISE).
Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based | 2014 |
European position paper on drug-induced sedation endoscopy (DISE).
Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based | 2014 |
Effect of a neck collar on upper airway size in children sedated with propofol-midazolam combination during magnetic resonance imaging.
Topics: Airway Management; Airway Obstruction; Anatomy, Cross-Sectional; Body Weight; Child, Preschool; Cons | 2015 |
[Transient decerebrate rigidity from hypoxemia during administration of propofol, midazolam-flumazenil, and remifentanil-naloxone].
Topics: Airway Obstruction; Anesthetics, Intravenous; Bradycardia; Cardiotonic Agents; Cholangiopancreatogra | 2010 |
Airway compromise from a common European adder bite to the tongue; some fundamental concerns!
Topics: Airway Obstruction; Alcoholic Intoxication; Edema; Emergency Medical Services; Glasgow Coma Scale; H | 2010 |
Subglottic airway foreign body: a near miss.
Topics: Airway Obstruction; Analgesics; Anesthetics, Inhalation; Bronchodilator Agents; Bronchoscopy; Child, | 2011 |
Dexmedetomidine infusion for sedation in the intensive care setting in an infant with airway compromise due to congenital mediastinal neuroblastoma.
Topics: Airway Management; Airway Obstruction; Analgesics, Opioid; Antineoplastic Agents; Carboplatin; Criti | 2012 |
Use of deep intravenous sedation with propofol and the laryngeal mask airway during transesophageal echocardiography.
Topics: Adult; Aged; Airway Obstruction; Anesthesiology; Anesthetics, Intravenous; Cardiology; Drug Therapy, | 2003 |
Paradoxical vocal cord motion: an often misdiagnosed cause of postoperative stridor.
Topics: Airway Obstruction; Anesthetics, Intravenous; Diagnosis, Differential; Female; Fiber Optic Technolog | 2004 |
Mouth-opening increases upper-airway collapsibility without changing resistance during midazolam sedation.
Topics: Adult; Airway Obstruction; Airway Resistance; Conscious Sedation; Humans; Hypnotics and Sedatives; I | 2004 |
Sleep endoscopy versus modified Mallampati score in sleep apnea and snoring.
Topics: Airway Obstruction; Endoscopy; Female; Humans; Hypnotics and Sedatives; Larynx; Male; Midazolam; Mid | 2005 |
Effect of mandibular position on upper airway collapsibility and resistance.
Topics: Adult; Airway Obstruction; Airway Resistance; Dental Occlusion, Centric; Humans; Hypnotics and Sedat | 2005 |
The effects of head and body positioning on upper airway collapsibility in normal subjects who received midazolam sedation.
Topics: Adult; Airway Obstruction; Humans; Hypnotics and Sedatives; Male; Midazolam; Posture; Respiratory Sy | 2006 |
An unusual case of airway obstruction.
Topics: Airway Obstruction; Alfentanil; Anesthetics, Inhalation; Humans; Intubation, Intratracheal; Male; Me | 2006 |
Pulmonary atelectasis manifested after induction of anesthesia: a contribution of sinobronchial syndrome?
Topics: Adult; Airway Obstruction; Analgesics, Opioid; Anesthesia, General; Anesthetics, Intravenous; Blood | 2007 |
Respiratory depression by midazolam and diazepam.
Topics: Adult; Airway Obstruction; Benzodiazepines; Diazepam; Female; Humans; Male; Midazolam; Phlebitis; Re | 1980 |
Postoperative medical management in single-stage laryngotracheoplasty.
Topics: Accidents; Adolescent; Airway Obstruction; Anti-Anxiety Agents; Cartilage; Child; Child, Preschool; | 1995 |
Upper airway obstruction during midazolam sedation: modification by nasal CPAP.
Topics: Abdomen; Adult; Age Factors; Airway Obstruction; Anesthesia, Spinal; Apnea; Female; Humans; Hypnotic | 1995 |
Midazolam-opioid combination and postoperative upper airway obstruction in children.
Topics: Airway Obstruction; Analgesics, Opioid; Anti-Anxiety Agents; Child; Humans; Laryngismus; Midazolam; | 1994 |
[Respiratory effects of midazolam in patients with obstructive sleep apnea syndromes].
Topics: Adult; Airway Obstruction; Female; Humans; Male; Midazolam; Middle Aged; Oxygen; Polysomnography; Re | 1994 |
Midazolam-opioid combination and postoperative upper airway obstruction in children.
Topics: Adenoidectomy; Airway Obstruction; Anesthesia, Intravenous; Child; Flumazenil; Humans; Male; Midazol | 1994 |
Respiratory effects of intravenous midazolam.
Topics: Adolescent; Adult; Airway Obstruction; Anesthesia, Dental; Anesthesia, Intravenous; Anesthetics, Int | 1996 |
Airway obstruction after oral midazolam.
Topics: Airway Obstruction; Child, Preschool; Humans; Laryngoscopy; Midazolam; Tracheostomy | 1996 |
A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium.
Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Anesthesiology; Bronchial Spasm; Ch | 1997 |
Evaluation of the safety and efficacy of deep sedation for electrophysiology procedures administered in the absence of an anesthetist.
Topics: Adjuvants, Anesthesia; Airway Obstruction; Anesthesia, Intravenous; Anesthesiology; Anesthetics, Int | 1997 |
Breathing patterns and levels of consciousness in children during administration of nitrous oxide after oral midazolam premedication.
Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Analgesia; Anesthesia, Inhalation; | 1997 |
Additional clinical observations utilizing bispectral analysis.
Topics: Airway Obstruction; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthe | 2000 |
Airway management in spontaneously breathing anaesthetized children: comparison of the Laryngeal Mask Airway with the cuffed oropharyngeal airway.
Topics: Adjuvants, Anesthesia; Adolescent; Airway Obstruction; Anesthesia; Anesthetics; Anesthetics, Inhalat | 2002 |
[Life-threatening apnea after midazolam administration in a patient with obstructive sleep apnea syndrome].
Topics: Adult; Airway Obstruction; Airway Resistance; Humans; Lung Volume Measurements; Male; Midazolam; Pos | 1987 |