midazolam has been researched along with Aging in 60 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the pressor and tachycardiac responses to ephedrine in elderly and young patients given either clonidine or midazolam during propofol anesthesia." | 9.10 | The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003) |
| "The effect of aging on the pharmacodynamics of midazolam was investigated in a double-blinded study involving 39 consenting patients ranging in age from 39 to 77 yr." | 7.69 | Aging increases pharmacodynamic sensitivity to the hypnotic effects of midazolam. ( Bai, SA; Jacobs, JR; Marty, J; Reves, JG; Smith, LR; White, WD, 1995) |
| " The purpose of the present investigations was to determine the influence of increasing age on the pharmacokinetics and pharmacodynamics of midazolam in male BN/BiRij rats as an animal model of aging." | 7.68 | Pharmacokinetic-EEG effect relationship of midazolam in aging BN/BiRij rats. ( Danhof, M; Hovinga, S; Langemeijer, MW; Mandema, JW; Stijnen, AM; van Bezooijen, CF, 1992) |
| " The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group." | 5.48 | Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 5.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| " Using the two-compartment model we estimated distribution half-life (t1/2a), elimination half-life (t1/2el), clearance (Cl), and volumes of distribution (Vz = volume in elimination phase)." | 5.27 | [The pharmacokinetics of midazolam in various kinds of anesthesia]. ( Asskali, F; Behne, M; Förster, H; Kessler, P; Seiz, W; Zobel, R, 1987) |
| "In 139 patients anxiety, sedation and adverse effects were measured at 6 consecutive perioperative time points after administration of midazolam, clonidine or a placebo." | 5.14 | [Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage]. ( Ivleva-Sauerborn, A; Seifert, B; Spahn, DR; Zalunardo, MP, 2010) |
| "We studied the pressor and tachycardiac responses to ephedrine in elderly and young patients given either clonidine or midazolam during propofol anesthesia." | 5.10 | The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003) |
| "5 mg/kg oral midazolam at 20-40 min before induction of anesthesia." | 3.74 | Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children. ( Anderson, GM; Kain, ZN; MacLaren, J; Mayes, LC; McClain, BC; Saadat, H; Wang, SM, 2007) |
| "Because information on the optimal dose of midazolam for sedation of nonventilated infants after major surgery is scant, a population pharmacokinetic and pharmacodynamic model is developed for this specific group." | 2.72 | Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery. ( Danhof, M; Dejongh, J; Knibbe, CA; Mathôt, RA; Peeters, MY; Prins, SA; Tibboel, D; van Schaik, RH; Warris, C, 2006) |
| "Age-related comorbidities and consequently polypharmacy are highly prevalent in the elderly, resulting in an increased risk for drug-drug interactions (DDIs)." | 2.72 | Clinical Data Combined With Modeling and Simulation Indicate Unchanged Drug-Drug Interaction Magnitudes in the Elderly. ( Battegay, M; Courlet, P; Decosterd, LA; Kinvig, H; Marzolini, C; Penny, MA; Siccardi, M; Stader, F, 2021) |
| "05 mg/kg over a 30-minute period) and oral doses of midazolam (3-8 mg of a stable isotope, (15)N(3)-midazolam) before and after 7 days of rifampin dosing (600 mg once daily in the evening)." | 2.71 | The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity. ( Ambrosius, WT; Bruce, MA; Gorski, JC; Haehner-Daniels, B; Hall, SD; Hamman, MA; Vannaprasaht, S, 2003) |
| "Midazolam pretreatment was associated with a significant reduction in propofol dose requirement in both younger and older patients." | 2.70 | Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults. ( Bhaskaran, NC; Claydon, P; Cressey, DM; Reilly, CS, 2001) |
| " Eligible study patients were enrolled into one of three study arms: Arm I (midazolam/metabolite pharmacokinetic evaluation after oral administration of a syrup formulation), Arm II (the absolute bioavailability of midazolam syrup), and Arm III (midazolam and metabolite pharmacokinetics after IV administration)." | 2.70 | The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration. ( Akbari, B; Blumer, JL; Kearns, GL; Khoo, KC; Pou, S; Reed, MD; Rodarte, A, 2001) |
| "To determine whether age-dependent pharmacokinetic and pharmacodynamic alterations account for a more pronounced response to benzodiazepines among elderly patients." | 2.69 | Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction. ( Dilger, K; Klotz, U; Mikus, G; Platten, HP; Schweizer, E, 1998) |
| " Given a compound out of the group of benzodiazepines as an example this paper represents todays methods of integrated pharmacokinetic-pharmacodynamic modelling as well as the special computer aided strategies of drug dosing as powerful tools in the anaesthetic drug development process." | 2.69 | [Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. A comparative study with young and old volunteers with benzdiazepine as an example]. ( Albrecht, S; Hering, W; Ihmsen, H; Schüttler, J; Schwilden, H, 1999) |
| "The propofol requirements were significantly less in the midazolam-fentanyl groups, regardless of age, and among the premedicated patients older than 60 yr compared with the other age groups." | 2.69 | The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion. ( Ballester, JA; Elizalde, JL; Escobar, A; Olmos, M; Vidarte, MA, 2000) |
| "The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability of several drugs." | 2.44 | Intestinal metabolism and transport of drugs in children: the effects of age and disease. ( Johnson, TN; Thomson, M, 2008) |
| " Concomitant intake of rifampicin (600 mg/die) induced especially the presystemic (prehepatic) metabolism of verapamil so that oral bioavailability approached zero and PD effects almost diminished." | 2.40 | Effect of age on pharmacokinetics and pharmacodynamics in man. ( Klotz, U, 1998) |
| "Midazolam also has a relatively rapid onset of action and high metabolic clearance when compared with other benzodiazepines." | 2.37 | Midazolam: pharmacology and uses. ( Fragen, RJ; Greenblatt, DJ; Reves, JG; Vinik, HR, 1985) |
| " These data are important for informing adult and pediatric dosing recommendations for NA-induced seizures." | 1.51 | Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats. ( Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K, 2019) |
| " The mean hepatic clearances determined by in silico fitting for individual pharmacokinetic models of warfarin and midazolam in the aged group were, respectively, 23% and 56% smaller than those for the young group." | 1.48 | Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. ( Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H, 2018) |
| "For propofol, there was a significantly lower dosing for older patients: 17% for patients aged 65-79 and 29% for those aged >80, which was still in less than the recommendations." | 1.43 | Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Liu, J; Schonberger, RB, 2016) |
| "Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®." | 1.39 | Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013) |
| "Previously published pharmacokinetic parameters can be used to develop maturation models that address gaps in current knowledge regarding the influence of age on a drug's disposition." | 1.37 | A maturation model for midazolam clearance. ( Anderson, BJ; Larsson, P, 2011) |
| "Allopregnanolone (AlloP) is a neurosteroid that plays an important role during neural development." | 1.36 | Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood. ( Darbra, S; Pallarès, M, 2010) |
| "1." | 1.35 | Administration of midazolam in infancy does not affect learning and memory of adult mice. ( Deng, XM; Liu, Y; Liu, ZQ; Xiong, YC; Xu, B; Xu, H; Zhang, WS, 2009) |
| "Correct dosing of drugs in neonates, infants and children is hampered by a general lack of knowledge about drug disposition in this population." | 1.33 | Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants and children : how accurate are available scaling methods? ( Björkman, S, 2006) |
| " Prediction of the disposition of theophylline and midazolam, two model drugs with dissimilar physicochemical and pharmacokinetic characteristics, yielded results that generally tallied with literature data." | 1.33 | Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs. ( Björkman, S, 2005) |
| " Pharmacokinetic parameters were similar in both groups (clearance, 399+/-91 and 388+/-97 mL/min; steady-state volume of distribution, 85+/-22 and 104 +/-11 L in young and elderly subjects, respectively)." | 1.30 | The effect of age on the pharmacokinetics and pharmacodynamics of midazolam. ( Albrecht, S; Dingemanse, J; Geisslinger, G; Hering, W; Ihmsen, H; Schüttler, J; Schwilden, H, 1999) |
| "0 micrograms kg-1, the dosage was adjusted to the patients needs (0." | 1.30 | No reduction in the sufentanil requirement of elderly patients undergoing ventilatory support in the medical intensive care unit. ( Frass, M; Freye, E; Hammerschmidt, V; Hofbauer, R; Kofler, J; Kordova, H; Staudinger, T; Tesinsky, P; Vrastiolova, M, 1999) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 1.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| " Amnesic effect correlated more with the dose than the dosage determined by body weight." | 1.28 | [The effect of age and gender on the effect of midazolam as intramuscular premedicant]. ( Tabuchi, Y, 1992) |
| " Bioavailability appeared incomplete (F = 0." | 1.27 | Pharmacokinetics of midazolam in the aged. ( Brophy, TO; Eadie, MJ; Heazlewood, V; Smith, MT; Tyrer, JH, 1984) |
| " Comparison of young men vs elderly men, young women vs elderly women, young men vs young women, elderly men vs elderly women, and young women OCS-users vs young women non-OCS users indicated no substantial differences in the pharmacokinetic profile of midazolam between groups except for the comparison between the young and elderly men groups." | 1.27 | Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics. ( Holazo, AA; Patel, IH; Winkler, MB, 1988) |
| " Using the two-compartment model we estimated distribution half-life (t1/2a), elimination half-life (t1/2el), clearance (Cl), and volumes of distribution (Vz = volume in elimination phase)." | 1.27 | [The pharmacokinetics of midazolam in various kinds of anesthesia]. ( Asskali, F; Behne, M; Förster, H; Kessler, P; Seiz, W; Zobel, R, 1987) |
| "Midazolam kinetics were determined in 11 younger (22 to 30 yr) and 11 older (50 to 60 yr) women to determine age-related differences in the kinetics of this water-soluble benzodiazepine." | 1.27 | Midazolam kinetics in women of two age groups. ( Avram, MJ; Caldwell, NJ; Fragen, RJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (15.00) | 18.7374 |
| 1990's | 16 (26.67) | 18.2507 |
| 2000's | 18 (30.00) | 29.6817 |
| 2010's | 16 (26.67) | 24.3611 |
| 2020's | 1 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Stader, F | 1 |
| Courlet, P | 1 |
| Kinvig, H | 1 |
| Penny, MA | 1 |
| Decosterd, LA | 1 |
| Battegay, M | 1 |
| Siccardi, M | 1 |
| Marzolini, C | 1 |
| Toda, A | 1 |
| Uehara, S | 1 |
| Inoue, T | 1 |
| Utoh, M | 1 |
| Kusama, T | 1 |
| Shimizu, M | 1 |
| Uno, Y | 1 |
| Mogi, M | 1 |
| Sasaki, E | 1 |
| Yamazaki, H | 1 |
| Xu, J | 1 |
| Mathena, RP | 1 |
| Singh, S | 1 |
| Kim, J | 1 |
| Long, JJ | 1 |
| Li, Q | 1 |
| Junn, S | 1 |
| Blaize, E | 1 |
| Mintz, CD | 1 |
| Matson, L | 1 |
| Dunn, E | 1 |
| Haines, K | 1 |
| Miller-Smith, S | 1 |
| Lee-Stubbs, R | 1 |
| Whitten, K | 1 |
| Ardinger, C | 1 |
| McCarren, H | 1 |
| McDonough, J | 1 |
| Lacoh, CM | 1 |
| Bodogan, T | 1 |
| Kaila, K | 1 |
| Fiumelli, H | 1 |
| Vutskits, L | 2 |
| Koyama, Y | 1 |
| Andoh, T | 1 |
| Kamiya, Y | 1 |
| Morita, S | 1 |
| Miyazaki, T | 1 |
| Uchimoto, K | 1 |
| Mihara, T | 1 |
| Goto, T | 1 |
| Czwornog, J | 1 |
| Austin, GL | 1 |
| Takeuchi, Y | 1 |
| Osterop, SF | 1 |
| Virtanen, MA | 1 |
| Loepke, JR | 1 |
| Joseph, B | 1 |
| Loepke, AW | 1 |
| Salem, F | 1 |
| Abduljalil, K | 1 |
| Kamiyama, Y | 1 |
| Rostami-Hodjegan, A | 1 |
| Akhtar, S | 1 |
| Liu, J | 1 |
| Heng, J | 1 |
| Dai, F | 1 |
| Schonberger, RB | 1 |
| Burg, MM | 1 |
| Johnson, TN | 1 |
| Thomson, M | 1 |
| van Alfen-van der Velden, AA | 1 |
| Claessen, VP | 1 |
| Hopman, JC | 1 |
| Klaessens, JH | 1 |
| Sengers, RC | 1 |
| Liem, KD | 1 |
| Xu, H | 1 |
| Liu, ZQ | 1 |
| Liu, Y | 1 |
| Zhang, WS | 1 |
| Xu, B | 1 |
| Xiong, YC | 1 |
| Deng, XM | 1 |
| Darbra, S | 1 |
| Pallarès, M | 1 |
| de Wildt, SN | 1 |
| Kearns, GL | 2 |
| Murry, DJ | 1 |
| Koren, G | 1 |
| van den Anker, JN | 1 |
| Zalunardo, MP | 1 |
| Ivleva-Sauerborn, A | 1 |
| Seifert, B | 1 |
| Spahn, DR | 1 |
| Anderson, BJ | 1 |
| Larsson, P | 1 |
| Fudickar, A | 1 |
| Voss, D | 1 |
| Serocki, G | 1 |
| Jeckström, W | 1 |
| Ambrosch, P | 1 |
| Steinfath, M | 1 |
| Bein, B | 1 |
| Polasek, TM | 1 |
| Patel, F | 1 |
| Jensen, BP | 1 |
| Sorich, MJ | 1 |
| Wiese, MD | 1 |
| Doogue, MP | 1 |
| Ishiyama, T | 1 |
| Kashimoto, S | 1 |
| Oguchi, T | 1 |
| Matsukawa, T | 1 |
| Kumazawa, T | 1 |
| Gorski, JC | 1 |
| Vannaprasaht, S | 1 |
| Hamman, MA | 1 |
| Ambrosius, WT | 1 |
| Bruce, MA | 1 |
| Haehner-Daniels, B | 1 |
| Hall, SD | 1 |
| Wauthier, V | 2 |
| Verbeeck, RK | 2 |
| Buc Calderon, P | 1 |
| Fernandez, M | 1 |
| Lejus, C | 1 |
| Rivault, O | 1 |
| Bazin, V | 1 |
| Le Roux, C | 1 |
| Bizouarn, P | 1 |
| Pinaud, M | 1 |
| Bessa, JM | 1 |
| Oliveira, M | 1 |
| Cerqueira, JJ | 1 |
| Almeida, OF | 1 |
| Sousa, N | 1 |
| Björkman, S | 2 |
| Calderon, PB | 1 |
| Peeters, MY | 1 |
| Prins, SA | 1 |
| Knibbe, CA | 1 |
| Dejongh, J | 1 |
| Mathôt, RA | 1 |
| Warris, C | 1 |
| van Schaik, RH | 1 |
| Tibboel, D | 1 |
| Danhof, M | 2 |
| Kain, ZN | 1 |
| MacLaren, J | 1 |
| McClain, BC | 1 |
| Saadat, H | 1 |
| Wang, SM | 1 |
| Mayes, LC | 1 |
| Anderson, GM | 1 |
| Avram, MJ | 1 |
| Fragen, RJ | 2 |
| Caldwell, NJ | 1 |
| Smith, MT | 1 |
| Heazlewood, V | 1 |
| Eadie, MJ | 1 |
| Brophy, TO | 1 |
| Tyrer, JH | 1 |
| Brophy, T | 1 |
| Dundee, JW | 1 |
| Heazelwood, V | 1 |
| Kawar, P | 1 |
| Varghese, A | 1 |
| Ward, M | 1 |
| Jacobs, JR | 1 |
| Reves, JG | 3 |
| Marty, J | 1 |
| White, WD | 2 |
| Bai, SA | 1 |
| Smith, LR | 1 |
| Griffith, WH | 1 |
| Murchison, DA | 1 |
| Rovira, C | 1 |
| Ben-Ari, Y | 1 |
| Kubová, H | 2 |
| Mares, P | 2 |
| Vorlícek, J | 1 |
| Hughes, J | 1 |
| Gill, AM | 1 |
| Mulhearn, H | 1 |
| Powell, E | 1 |
| Choonara, I | 1 |
| Hering, W | 3 |
| Ihmsen, H | 3 |
| Albrecht, S | 3 |
| Schwilden, H | 3 |
| Schüttler, J | 3 |
| Platten, HP | 1 |
| Schweizer, E | 1 |
| Dilger, K | 1 |
| Mikus, G | 1 |
| Klotz, U | 2 |
| Vivarelli, R | 1 |
| Zanotti, F | 1 |
| Battaglia, D | 1 |
| Caggese, G | 1 |
| Stella, G | 1 |
| Gilli, G | 1 |
| Guberti, A | 1 |
| Geisslinger, G | 1 |
| Dingemanse, J | 1 |
| Hofbauer, R | 1 |
| Tesinsky, P | 1 |
| Hammerschmidt, V | 1 |
| Kofler, J | 1 |
| Staudinger, T | 1 |
| Kordova, H | 1 |
| Vrastiolova, M | 1 |
| Frass, M | 1 |
| Freye, E | 1 |
| Mikulecká, A | 1 |
| Haugvicová, R | 1 |
| Olmos, M | 1 |
| Ballester, JA | 1 |
| Vidarte, MA | 1 |
| Elizalde, JL | 1 |
| Escobar, A | 1 |
| Bickford, PC | 1 |
| Breiderick, L | 1 |
| Cressey, DM | 1 |
| Claydon, P | 1 |
| Bhaskaran, NC | 1 |
| Reilly, CS | 1 |
| Mathew, JP | 1 |
| Weatherwax, KJ | 1 |
| East, CJ | 1 |
| Reed, MD | 1 |
| Rodarte, A | 1 |
| Blumer, JL | 1 |
| Khoo, KC | 1 |
| Akbari, B | 1 |
| Pou, S | 1 |
| Otis, TS | 1 |
| Mody, I | 1 |
| Hovinga, S | 1 |
| Stijnen, AM | 1 |
| Langemeijer, MW | 1 |
| Mandema, JW | 1 |
| van Bezooijen, CF | 1 |
| Tabuchi, Y | 1 |
| Reynolds, JN | 1 |
| Carlen, PL | 1 |
| Loew, F | 1 |
| Pawlak, C | 1 |
| Benaroyo, L | 1 |
| Junod, JP | 1 |
| Vinik, HR | 1 |
| Greenblatt, DJ | 1 |
| Holazo, AA | 1 |
| Winkler, MB | 1 |
| Patel, IH | 1 |
| Behne, M | 1 |
| Zobel, R | 1 |
| Asskali, F | 1 |
| Förster, H | 1 |
| Kessler, P | 1 |
| Seiz, W | 1 |
| Baughman, VL | 1 |
| Hoffman, WE | 1 |
| Albrecht, RF | 1 |
| Miletich, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302] | Phase 4 | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| The Effect of Two Distraction Strategies in Reducing Preoperative Anxiety in Children：A Randomized Controlled Trial[NCT05285995] | 181 participants (Actual) | Interventional | 2019-04-07 | Completed | |||
| Comparing Pediatric Oral Sedation Outcomes Using Midazolam and Hydroxyzine With and Without Meperidine[NCT04068948] | Phase 4 | 37 participants (Actual) | Interventional | 2019-06-25 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Children's behavior during sedation is rated on the Houpt Behavior Rating Scale. A successful sedation is rated as Excellent, Very Good, or Good. A failed sedation is rated as Fair, Poor, or Aborted. (NCT04068948)
Timeframe: At completion of procedure
| Intervention | Participants (Count of Participants) |
|---|---|
| Midazolam, Hydroxyzine, Meperidine | 11 |
| Midazolam, Hydroxyzine | 9 |
5 reviews available for midazolam and Aging
| Article | Year |
|---|---|
Clinical Data Combined With Modeling and Simulation Indicate Unchanged Drug-Drug Interaction Magnitudes in the Elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Clarithromycin; Cohort Studies; Comorbidity; Computer Simulat | 2021 |
Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio.
Topics: Adolescent; Adult; Age Factors; Aging; Child; Child, Preschool; Computer Simulation; Hepatobiliary E | 2016 |
Intestinal metabolism and transport of drugs in children: the effects of age and disease.
Topics: Aging; Biological Availability; Child; Cyclosporine; Cytochrome P-450 Enzyme System; Dose-Response R | 2008 |
Effect of age on pharmacokinetics and pharmacodynamics in man.
Topics: Adolescent; Adult; Aged; Aging; Anti-Anxiety Agents; Area Under Curve; Calcium Channel Blockers; Hum | 1998 |
Midazolam: pharmacology and uses.
Topics: Adult; Aged; Aging; Ambulatory Surgical Procedures; Anesthetics; Animals; Benzodiazepines; Benzodiaz | 1985 |
15 trials available for midazolam and Aging
| Article | Year |
|---|---|
[Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo : Randomized double-blind study with age-adjusted dosage].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia; Anxiety; Blood Gas Analysis; | 2010 |
The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia, Intravenous; Anest | 2003 |
The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity.
Topics: Administration, Oral; Adult; Aged; Aging; Algorithms; Antibiotics, Antitubercular; Area Under Curve; | 2003 |
Single-breath vital capacity rapid inhalation induction with sevoflurane: feasibility in children.
Topics: Adjuvants, Anesthesia; Adolescent; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Ch | 2005 |
Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery.
Topics: Aging; Biotransformation; Electroencephalography; Face; Female; Humans; Hypnotics and Sedatives; Inf | 2006 |
Steady-state plasma concentrations of midazolam in critically ill infants and children.
Topics: Adolescent; Aging; Child; Child, Preschool; Critical Illness; Humans; Infant; Infusions, Intravenous | 1996 |
[RO 48-6791--a short acting benzodiazepine. Pharmacokinetics and pharmacodynamics in young and old subjects in comparison to midazolam].
Topics: Adjuvants, Anesthesia; Adult; Aged; Aging; Anti-Anxiety Agents; Benzodiazepines; Cross-Over Studies; | 1996 |
Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction.
Topics: Adolescent; Adult; Aged; Aging; Amnesia; Analgesics, Opioid; Area Under Curve; Codeine; Female; Half | 1998 |
[Premedication with intranasal midazolam in children of various ages].
Topics: Adjuvants, Anesthesia; Administration, Intranasal; Aging; Child; Child, Preschool; Humans; Infant; M | 1998 |
[Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. A comparative study with young and old volunteers with benzdiazepine as an example].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anti-Anxiety Agents; Benzodiazepines; | 1999 |
The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion.
Topics: Adjuvants, Anesthesia; Adult; Aged; Aging; Analgesics, Opioid; Anesthetics, Intravenous; Blood Press | 2000 |
Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Intravenou | 2001 |
Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state.
Topics: Adjuvants, Anesthesia; Aged; Aging; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation | 2001 |
The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration.
Topics: Administration, Oral; Adolescent; Aging; Anti-Anxiety Agents; Area Under Curve; Biotransformation; C | 2001 |
Comparison of midazolam and oxazepam as hypnotics in elderly hospitalized patients. A double-blind clinical trial.
Topics: Aged; Aged, 80 and over; Aging; Body Weight; Clinical Trials as Topic; Double-Blind Method; Dreams; | 1988 |
40 other studies available for midazolam and Aging
| Article | Year |
|---|---|
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.
Topics: Administration, Intravenous; Aging; Animals; Caffeine; Callithrix; Cytochrome P-450 CYP2C19; Genotyp | 2018 |
Early Developmental Exposure to Repetitive Long Duration of Midazolam Sedation Causes Behavioral and Synaptic Alterations in a Rodent Model of Neurodevelopment.
Topics: Aging; Animals; Behavior, Animal; Cells, Cultured; Conscious Sedation; Dentate Gyrus; Developmental | 2019 |
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Elect | 2019 |
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt.
Topics: Aging; Anesthetics, Intravenous; Animals; Animals, Newborn; Female; Gene Expression Regulation, Deve | 2013 |
Bumetanide, an inhibitor of cation-chloride cotransporter isoform 1, inhibits γ-aminobutyric acidergic excitatory actions and enhances sedative actions of midazolam in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Bumetanide; CA3 Region, Hippocampal; Calcium; Calcium Signaling; C | 2013 |
Body mass index, age, and gender affect prep quality, sedation use, and procedure time during screening colonoscopy.
Topics: Aging; Anesthetics, Intravenous; Body Mass Index; Colonoscopy; Female; Fentanyl; Humans; Male; Midaz | 2013 |
Screening colonoscopy: still the best choice, but for how long?
Topics: Aging; Body Mass Index; Colonoscopy; Female; Fentanyl; Humans; Male; Midazolam | 2013 |
Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt.
Topics: Aging; Animals; Apoptosis; Calbindin 2; Calbindins; Dose-Response Relationship, Drug; GABAergic Neur | 2015 |
Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice.
Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous | 2016 |
Changes in cerebral oxygenation and hemodynamics during cranial ultrasound in preterm infants.
Topics: Aging; Analgesics, Opioid; Biomarkers; Brain; Cerebrovascular Circulation; Cranial Fontanelles; Echo | 2009 |
Administration of midazolam in infancy does not affect learning and memory of adult mice.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Avoidance Learning; Hypnotics and Sedatives; Learning | 2009 |
Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood.
Topics: 5-alpha Reductase Inhibitors; Aging; Animals; Animals, Newborn; Anti-Anxiety Agents; Brain; Enzyme I | 2010 |
Ontogeny of midazolam glucuronidation in preterm infants.
Topics: Administration, Oral; Aging; Biotransformation; Female; Glucuronides; Humans; Infant, Newborn; Infan | 2010 |
A maturation model for midazolam clearance.
Topics: Adolescent; Aging; Algorithms; Body Weight; Child; Child, Preschool; Female; Half-Life; Humans; Hypn | 2011 |
Clinically relevant asymmetry of bispectral index during recovery from anaesthesia for ear-nose-throat surgery in adults and children.
Topics: Adult; Aging; Anesthesia; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; | 2011 |
Predicted metabolic drug clearance with increasing adult age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; M | 2013 |
Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress?
Topics: Age Factors; Aging; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Cytoch | 2004 |
Age-related qualitative shift in emotional behaviour: paradoxical findings after re-exposure of rats in the elevated-plus maze.
Topics: Aging; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, An | 2005 |
Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs.
Topics: Adolescent; Aging; Body Composition; Bronchodilator Agents; Cardiac Output; Child; Child, Preschool; | 2005 |
Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants and children : how accurate are available scaling methods?
Topics: Aging; Alfentanil; Child; Child, Preschool; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; | 2006 |
Decreased CYP3A2 expression and activity in senescent male Wistar rats: is there a role for HNF4alpha?
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; COUP Transcription Factor II; Cytochrome P-450 CYP3A; | 2006 |
Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children.
Topics: Aging; Analysis of Variance; Anesthesia; Anxiety; Child; Child, Preschool; Emotions; Ethnicity; Fema | 2007 |
Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children.
Topics: Aging; Analysis of Variance; Anesthesia; Anxiety; Child; Child, Preschool; Emotions; Ethnicity; Fema | 2007 |
Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children.
Topics: Aging; Analysis of Variance; Anesthesia; Anxiety; Child; Child, Preschool; Emotions; Ethnicity; Fema | 2007 |
Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children.
Topics: Aging; Analysis of Variance; Anesthesia; Anxiety; Child; Child, Preschool; Emotions; Ethnicity; Fema | 2007 |
Midazolam kinetics in women of two age groups.
Topics: Adult; Aging; Benzodiazepines; Female; Humans; Kinetics; Midazolam; Middle Aged | 1983 |
Pharmacokinetics of midazolam in the aged.
Topics: Administration, Oral; Aged; Aging; Benzodiazepines; Endoscopy; Erythrocytes; Female; Humans; Injecti | 1984 |
Midazolam, a water-soluble benzodiazepine, for gastroscopy.
Topics: Adult; Aged; Aging; Atropine; Benzodiazepines; Gastroscopy; Humans; Hypnotics and Sedatives; Injecti | 1982 |
Aging increases pharmacodynamic sensitivity to the hypnotic effects of midazolam.
Topics: Adult; Aged; Aging; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Midazolam; Mi | 1995 |
Enhancement of GABA-activated membrane currents in aged Fischer 344 rat basal forebrain neurons.
Topics: Action Potentials; Aging; Animals; Bicuculline; Drug Synergism; gamma-Aminobutyric Acid; Ion Channel | 1995 |
Developmental study of benzodiazepine effects on monosynaptic GABAA-mediated IPSPs of rat hippocampal neurons.
Topics: Aging; Animals; Anti-Anxiety Agents; Carbolines; Convulsants; Culture Techniques; Dose-Response Rela | 1993 |
Stable anticonvulsant action of benzodiazepines during development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Electric Stimulation; Electroencephal | 1993 |
The effect of age on the pharmacokinetics and pharmacodynamics of midazolam.
Topics: Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Dose-Response Relationship, Drug; Electroence | 1999 |
No reduction in the sufentanil requirement of elderly patients undergoing ventilatory support in the medical intensive care unit.
Topics: Aged; Aging; Analgesics, Opioid; Conscious Sedation; Critical Care; Female; Humans; Hypnotics and Se | 1999 |
The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Anta | 1999 |
Benzodiazepine modulation of GABAergic responses is intact in the cerebellum of aged F344 rats.
Topics: Action Potentials; Aging; Animals; Anti-Anxiety Agents; Cerebellum; Dose-Response Relationship, Drug | 2000 |
Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Anesthetics, Local; Animal | 1992 |
Pharmacokinetic-EEG effect relationship of midazolam in aging BN/BiRij rats.
Topics: Aging; Animals; Electroencephalography; Injections, Intravenous; Male; Midazolam; Rats | 1992 |
[The effect of age and gender on the effect of midazolam as intramuscular premedicant].
Topics: Adolescent; Adult; Aged; Aging; Female; Humans; Injections, Intramuscular; Male; Midazolam; Middle A | 1992 |
The effects of midazolam on hippocampal dentate gyrus granule neurons from young and old Fischer 344 rats.
Topics: Aging; Animals; Evoked Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Midazolam; | 1989 |
Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics.
Topics: Adult; Aged; Aged, 80 and over; Aging; Contraceptives, Oral, Hormonal; Female; Humans; Injections, I | 1988 |
[The pharmacokinetics of midazolam in various kinds of anesthesia].
Topics: Adolescent; Adult; Aging; Anesthesia; Body Weight; Female; Half-Life; Humans; Male; Midazolam; Middl | 1987 |
Cerebral vascular and metabolic effects of fentanyl and midazolam in young and aged rats.
Topics: Aging; Animals; Cerebral Cortex; Cerebrovascular Circulation; Depression, Chemical; Electroencephalo | 1987 |