midazolam has been researched along with Aggression in 25 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression." | 8.93 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Gandhi, P; Huf, G, 2016) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 8.85 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Huf, G; Raveendran, NS, 2009) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 8.82 | Haloperidol plus promethazine for psychosis induced aggression. ( Alexander, J; Allen, MH; Huf, G, 2005) |
| "Midazolam requires BZD-sensitive α1- and α2-containing GABAA receptors in order to escalate aggression and α2- and α3-containing receptors to reduce social anxiety-like behavior." | 7.81 | α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice. ( Chen, Y; Chu, A; DeBold, JF; Hwa, LS; Miczek, KA; Newman, EL; Rudolph, U; Smith, KS; Takahashi, A, 2015) |
| "The aims of this study were to (1) describe behavioral and corticosterone elevations that occur in aggressive mice conditioned to respond for the opportunity to fight another mouse, (2) determine if corticosterone elevations are necessary for operant responding and escalated aggression, and (3) determine if corticosterone elevations alter the aggression-heightening effects of gamma-aminobutyric acid (GABA)(A) receptor positive modulators." | 7.73 | Escalated aggression as a reward: corticosterone and GABA(A) receptor positive modulators in mice. ( DeBold, JF; Fish, EW; Miczek, KA, 2005) |
| "When droperidol was compared with placebo, for the outcome of tranquillisation or asleep by 30 minutes we found evidence of a clear difference (1 RCT, N = 227, RR 1." | 6.53 | Droperidol for psychosis-induced aggression or agitation. ( Khokhar, MA; Rathbone, J, 2016) |
| "All medications produced a calming effect within one hour of administration, but only olanzapine and haloperidol reduced agitation by less than 10 points, and only olanzapine reduced aggression by less than four points in the first hour." | 5.15 | Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone. ( Baldaçara, L; Cordeiro, DC; Jackoswski, AP; Sanches, M, 2011) |
| " Midazolam was more rapidly sedating than haloperidol-promethazine, reducing the time people are exposed to aggression." | 5.10 | Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. ( , 2003) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression." | 4.93 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Gandhi, P; Huf, G, 2016) |
| "Haloperidol in combination with promethazine, and olanzapine, are effective in psychotic agitation, although haloperidol plus promethazine has a more rapid onset of effect faster; lorazepam is effective in non-psychotic agitation, aggression or excitement as well as in acute agitation of unknown origin." | 4.87 | [Rapid tranquillisation; review of the literature and recommendations]. ( Bak, M; Marcelis, M; van Os, J, 2011) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 4.85 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Huf, G; Raveendran, NS, 2009) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 4.82 | Haloperidol plus promethazine for psychosis induced aggression. ( Alexander, J; Allen, MH; Huf, G, 2005) |
| "Midazolam requires BZD-sensitive α1- and α2-containing GABAA receptors in order to escalate aggression and α2- and α3-containing receptors to reduce social anxiety-like behavior." | 3.81 | α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice. ( Chen, Y; Chu, A; DeBold, JF; Hwa, LS; Miczek, KA; Newman, EL; Rudolph, U; Smith, KS; Takahashi, A, 2015) |
| "The aims of this study were to (1) describe behavioral and corticosterone elevations that occur in aggressive mice conditioned to respond for the opportunity to fight another mouse, (2) determine if corticosterone elevations are necessary for operant responding and escalated aggression, and (3) determine if corticosterone elevations alter the aggression-heightening effects of gamma-aminobutyric acid (GABA)(A) receptor positive modulators." | 3.73 | Escalated aggression as a reward: corticosterone and GABA(A) receptor positive modulators in mice. ( DeBold, JF; Fish, EW; Miczek, KA, 2005) |
| "Midazolam is a relatively short-acting water-soluble benzodiazepine that provides anxiolysis and anterograde amnesia and can be given orally with few adverse effects." | 2.68 | Premedication with oral midazolam for voiding cystourethrography in children: safety and efficacy. ( Elder, JS; Longenecker, R, 1995) |
| "When droperidol was compared with placebo, for the outcome of tranquillisation or asleep by 30 minutes we found evidence of a clear difference (1 RCT, N = 227, RR 1." | 2.53 | Droperidol for psychosis-induced aggression or agitation. ( Khokhar, MA; Rathbone, J, 2016) |
| "Sedation and restlessness in all patients were controlled by midazolam administered intravenously by the attending anaesthesiologist; these parameters were later objectively confirmed by recorded actigrams." | 2.41 | The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature. ( Flaishon, R; Ogorek, D; Szold, O; Weinbroum, AA, 2001) |
| " Eight patients developed adverse reactions, 3 of which required further evaluation in the emergency department." | 1.37 | Safety of deep sedation in an urban oral and maxillofacial surgery training program. ( Braidy, HF; Singh, P; Ziccardi, VB, 2011) |
| "Midazolam was administered to three mentally retarded patients with acute and refractory aggressivity and violence." | 1.28 | Midazolam for aggressivity and violence in three mentally retarded patients. ( Bond, WS; Kurtz, MB; Mandos, LA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bak, M | 2 |
| Weltens, I | 1 |
| Bervoets, C | 1 |
| De Fruyt, J | 1 |
| Samochowiec, J | 1 |
| Fiorillo, A | 1 |
| Sampogna, G | 1 |
| Bienkowski, P | 1 |
| Preuss, WU | 1 |
| Misiak, B | 1 |
| Frydecka, D | 1 |
| Samochowiec, A | 1 |
| Bak, E | 1 |
| Drukker, M | 1 |
| Dom, G | 1 |
| Newman, EL | 1 |
| Smith, KS | 1 |
| Takahashi, A | 1 |
| Chu, A | 1 |
| Hwa, LS | 1 |
| Chen, Y | 1 |
| DeBold, JF | 3 |
| Rudolph, U | 1 |
| Miczek, KA | 3 |
| Huf, G | 3 |
| Alexander, J | 3 |
| Gandhi, P | 1 |
| Allen, MH | 3 |
| Khokhar, MA | 1 |
| Rathbone, J | 1 |
| Passmore, MJ | 1 |
| Sheldon, L | 1 |
| Lax, S | 1 |
| Wilkins-Ho, M | 1 |
| Illing, M | 1 |
| Raveendran, NS | 1 |
| Isbister, GK | 1 |
| Calver, LA | 1 |
| Page, CB | 1 |
| Stokes, B | 1 |
| Bryant, JL | 1 |
| Downes, MA | 1 |
| Baldaçara, L | 1 |
| Sanches, M | 1 |
| Cordeiro, DC | 1 |
| Jackoswski, AP | 1 |
| Braidy, HF | 1 |
| Singh, P | 1 |
| Ziccardi, VB | 1 |
| van Os, J | 1 |
| Marcelis, M | 1 |
| Chan, WP | 1 |
| Chilvers, CR | 1 |
| Gourley, SL | 1 |
| Yin, W | 1 |
| Cook, J | 1 |
| Fish, EW | 1 |
| Shibata, K | 1 |
| Kataoka, Y | 1 |
| Gomita, Y | 1 |
| Ueki, S | 1 |
| Rehm, WF | 1 |
| Beglinger, R | 1 |
| Becker, M | 1 |
| Hamza, B | 1 |
| Heizmann, P | 1 |
| Schulze, J | 1 |
| Elder, JS | 1 |
| Longenecker, R | 1 |
| Massanari, M | 1 |
| Novitsky, J | 1 |
| Reinstein, LJ | 1 |
| Weinbroum, AA | 1 |
| Szold, O | 1 |
| Ogorek, D | 1 |
| Flaishon, R | 1 |
| Wroblewski, BA | 1 |
| Joseph, AB | 1 |
| Vellucci, SV | 1 |
| Herbert, J | 1 |
| Keverne, EB | 1 |
| Bond, WS | 1 |
| Mandos, LA | 1 |
| Kurtz, MB | 1 |
| Rodgers, RJ | 1 |
| Waters, AJ | 1 |
| Graham, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for midazolam and Aggression
| Article | Year |
|---|---|
The pharmacological management of agitated and aggressive behaviour: A systematic review and meta-analysis.
Topics: Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; H | 2019 |
Haloperidol plus promethazine for psychosis-induced aggression.
Topics: Aggression; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; P | 2016 |
Droperidol for psychosis-induced aggression or agitation.
Topics: Acute Disease; Aggression; Antipsychotic Agents; Benzodiazepines; Droperidol; Haloperidol; Humans; M | 2016 |
Haloperidol plus promethazine for psychosis-induced aggression.
Topics: Aggression; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; O | 2009 |
[Rapid tranquillisation; review of the literature and recommendations].
Topics: Aggression; Benzodiazepines; Conscious Sedation; Drug Therapy, Combination; Haloperidol; Humans; Hyp | 2011 |
Haloperidol plus promethazine for psychosis induced aggression.
Topics: Aggression; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; Promethazine; Psyc | 2005 |
The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature.
Topics: Aged; Aggression; Anesthesia, Epidural; Anesthesia, Spinal; Anti-Anxiety Agents; Female; Flumazenil; | 2001 |
Benzodiazepines and their antagonists: a pharmacoethological analysis with particular reference to effects on "aggression".
Topics: Aggression; Agonistic Behavior; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Ben | 1985 |
5 trials available for midazolam and Aggression
| Article | Year |
|---|---|
Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study.
Topics: Acute Disease; Adult; Aggression; Double-Blind Method; Droperidol; Drug Therapy, Combination; Emerge | 2010 |
Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Double-Blind Method; Dru | 2011 |
Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine.
Topics: Adult; Aggression; Drug Therapy, Combination; Emergency Service, Hospital; Emergency Services, Psych | 2003 |
Premedication with oral midazolam for voiding cystourethrography in children: safety and efficacy.
Topics: Administration, Oral; Affect; Aggression; Anger; Child; Child, Preschool; Female; Humans; Infant; Ma | 1995 |
Misuse of midazolam.
Topics: Acute Disease; Aggression; Clinical Trials as Topic; Humans; Midazolam; Psychomotor Agitation; Psych | 1988 |
12 other studies available for midazolam and Aggression
| Article | Year |
|---|---|
α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Fear; Female; Male; Mice; Mice, | 2015 |
Oral midazolam for dementia-related response agitation.
Topics: Administration, Oral; Aged, 80 and over; Aggression; Alzheimer Disease; Female; Humans; Hypnotics an | 2009 |
Safety of deep sedation in an urban oral and maxillofacial surgery training program.
Topics: Adjuvants, Anesthesia; Adult; Age Factors; Aggression; Akathisia, Drug-Induced; Ambulatory Surgical | 2011 |
Induction of anaesthesia in the home.
Topics: Adult; Aggression; Anesthesia; Anesthetics, Dissociative; Home Care Services, Hospital-Based; Humans | 2002 |
Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists.
Topics: Aggression; Agonistic Behavior; Animals; Arousal; Dose-Response Relationship, Drug; GABA Modulators; | 2005 |
Escalated aggression as a reward: corticosterone and GABA(A) receptor positive modulators in mice.
Topics: Aggression; Agonistic Behavior; Animals; Arousal; Conditioning, Operant; Corticosterone; Dose-Respon | 2005 |
Localization of the site of the anticonflict action of benzodiazepines in the amygdaloid nucleus of rats.
Topics: Aggression; Amygdala; Animals; Anti-Anxiety Agents; Benzodiazepines; Chlordiazepoxide; Diazepam; Hum | 1982 |
[Use of benzodiazepines in swine].
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Chemical Phenomena; Chemistry; Clonazepam | 1982 |
Paradoxical reactions in children associated with midazolam use during endoscopy.
Topics: Adjuvants, Anesthesia; Adolescent; Adolescent Behavior; Aggression; Akathisia, Drug-Induced; Anti-An | 1997 |
Intramuscular midazolam for treatment of acute seizures or behavioral episodes in patients with brain injuries.
Topics: Adult; Aggression; Brain Injuries; Epilepsy, Post-Traumatic; Humans; Injections, Intramuscular; Male | 1992 |
The effect of midazolam and beta-carboline carboxylic acid ethyl ester on behaviour, steroid hormones and central monoamine metabolites in social groups of talapoin monkeys.
Topics: Aggression; Animals; Carbolines; Cercopithecidae; Homovanillic Acid; Hormones; Hydrocortisone; Hydro | 1986 |
Midazolam for aggressivity and violence in three mentally retarded patients.
Topics: Adolescent; Adult; Aggression; Female; Humans; Intellectual Disability; Male; Midazolam; Violence | 1989 |