midazolam has been researched along with Affective Psychosis, Bipolar in 8 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this double-blind randomized controlled trial, 25 adults with BD I/II and current treatment-refractory depression received either: (1) nitrous oxide (20 min at 25% concentration) plus intravenous saline (n = 12), or (2) medical air plus intravenous midazolam (2 mg total; n = 13)." | 5.69 | Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement. ( Belo, S; Choi, M; Choi, S; Detzler, G; Dimick, MK; Goldstein, BI; Herrmann, N; Iazzetta, J; Kim, WSH; Levitt, A; MacIntosh, BJ; McIntyre, RS; Mitchell, RHB; Omrin, D; Orser, BA; Riegert, D; Schaffer, A, 2023) |
| "To evaluate feasibility and effects of a sub-anesthetic infusion dose of ketamine versus midazolam on suicidal ideation in bipolar depression." | 5.24 | Ketamine versus midazolam in bipolar depression with suicidal thoughts: A pilot midazolam-controlled randomized clinical trial. ( Burke, AK; Cooper, TB; Ellis, SP; Grunebaum, MF; Keilp, JG; Mann, JJ; Marver, JE; Milak, MS; Moitra, VK; Oquendo, MA; Sublette, ME, 2017) |
| "All medications produced a calming effect within one hour of administration, but only olanzapine and haloperidol reduced agitation by less than 10 points, and only olanzapine reduced aggression by less than four points in the first hour." | 5.15 | Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone. ( Baldaçara, L; Cordeiro, DC; Jackoswski, AP; Sanches, M, 2011) |
| "Propofol was administered until the patients did not respond to a verbal command." | 2.74 | Premedication with dexmedetomidine and midazolam attenuates agitation after electroconvulsive therapy. ( Bulut, M; Ganidagli, S; Koruk, S; Mizrak, A; Oner, U, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, WSH | 1 |
| Dimick, MK | 1 |
| Omrin, D | 1 |
| Mitchell, RHB | 1 |
| Riegert, D | 1 |
| Levitt, A | 1 |
| Schaffer, A | 1 |
| Belo, S | 1 |
| Iazzetta, J | 1 |
| Detzler, G | 1 |
| Choi, M | 1 |
| Choi, S | 1 |
| Herrmann, N | 1 |
| McIntyre, RS | 1 |
| MacIntosh, BJ | 1 |
| Orser, BA | 1 |
| Goldstein, BI | 1 |
| Grunebaum, MF | 2 |
| Ellis, SP | 1 |
| Keilp, JG | 1 |
| Moitra, VK | 1 |
| Cooper, TB | 1 |
| Marver, JE | 1 |
| Burke, AK | 1 |
| Milak, MS | 1 |
| Sublette, ME | 1 |
| Oquendo, MA | 1 |
| Mann, JJ | 1 |
| Wojdacz, R | 1 |
| Święcicki, Ł | 1 |
| Antosik-Wójcińska, A | 1 |
| Wilkinson, ST | 1 |
| Farmer, C | 1 |
| Ballard, ED | 1 |
| Mathew, SJ | 1 |
| Murrough, JW | 1 |
| Sos, P | 1 |
| Wang, G | 1 |
| Gueorguieva, R | 1 |
| Zarate, CA | 1 |
| Mizrak, A | 1 |
| Koruk, S | 1 |
| Ganidagli, S | 1 |
| Bulut, M | 1 |
| Oner, U | 1 |
| Baldaçara, L | 1 |
| Sanches, M | 1 |
| Cordeiro, DC | 1 |
| Jackoswski, AP | 1 |
| Kuo, YL | 1 |
| Tsai, HF | 1 |
| Lai, MC | 1 |
| Lin, CH | 1 |
| Yang, YK | 1 |
| Augoustides, JG | 1 |
| Greenblatt, E | 1 |
| Abbas, MA | 1 |
| O'Reardon, JP | 1 |
| Datto, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder[NCT02351869] | Phase 2 | 25 participants (Actual) | Interventional | 2015-08-31 | Terminated (stopped due to This study was terminated due to COVID-19 pandemic-related halting of recruitment in the context of an upcoming replacement of the study MRI scanner.) | ||
| A Single Ketamine Infusion Combined With Music for Suicidal Ideation During a Depressive Episode: A Randomized Open Label Clinical Trial[NCT04658420] | Phase 2 | 200 participants (Anticipated) | Interventional | 2021-07-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Affective Psychosis, Bipolar
| Article | Year |
|---|---|
Comparison of the effect of intravenous anesthetics used for anesthesia during electroconvulsive therapy on the hemodynamic safety and the course of ECT.
Topics: Anesthetics; Anesthetics, Intravenous; Autonomic Nervous System; Bipolar Disorder; Depressive Disord | 2017 |
4 trials available for midazolam and Affective Psychosis, Bipolar
| Article | Year |
|---|---|
Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Treatment-Resistant; Double-Bli | 2023 |
Ketamine versus midazolam in bipolar depression with suicidal thoughts: A pilot midazolam-controlled randomized clinical trial.
Topics: Adult; Anesthetics, Dissociative; Biomarkers; Bipolar Disorder; Brain-Derived Neurotrophic Factor; D | 2017 |
Premedication with dexmedetomidine and midazolam attenuates agitation after electroconvulsive therapy.
Topics: Adult; Anesthesia; Bipolar Disorder; Blood Pressure; Depressive Disorder, Major; Dexmedetomidine; El | 2009 |
Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam and haloperidol alone.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Double-Blind Method; Dru | 2011 |
3 other studies available for midazolam and Affective Psychosis, Bipolar
| Article | Year |
|---|---|
Impact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder, Major | 2019 |
Anti-NMDA receptor encephalitis with the initial presentation of psychotic mania.
Topics: Adolescent; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antimanic Agents; Bipolar Disorder; Ele | 2012 |
Clinical approach to agitation after electroconvulsive therapy: a case report and literature review.
Topics: Anesthesia Recovery Period; Bipolar Disorder; Drug Therapy, Combination; Electroconvulsive Therapy; | 2002 |