Page last updated: 2024-10-31

midazolam and Acidosis

midazolam has been researched along with Acidosis in 6 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.

Research Excerpts

ExcerptRelevanceReference
"Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia."7.88Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018)
"Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia."3.88Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018)
"Midazolam kinetics was simultaneously determined in plasma and brain using striatal microdialysis."1.33Cerebral and plasma kinetics of a high dose of midazolam and correlations with its respiratory effects in rats. ( Baud, FJ; Borron, SW; Boschi, G; Declèves, X; Galliot-Guilley, M; Lesguillons, N; Megarbane, B; Monier, C; Risède, P; Trout, H, 2005)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kaess, BM1
Feurich, F1
Bürkle, G1
Ehrlich, JR1
Awab, A1
Alilou, M1
El Moussaoui, R1
El Hijri, A1
Azzouzi, A1
Megarbane, B1
Lesguillons, N1
Galliot-Guilley, M1
Borron, SW1
Trout, H1
Declèves, X1
Risède, P1
Monier, C1
Boschi, G1
Baud, FJ1
Matsuda, M1
Matsumoto, S1
Noguchi, M1
Isshiki, A1
Watanabe, Y1
Pepperman, ML1
Macrae, D1
Noble, WH1
Baker, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651]Phase 120 participants (Actual)Interventional2013-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for midazolam and Acidosis

ArticleYear
Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis.
    International journal of cardiology, 2018, 05-15, Volume: 259

    Topics: Acidosis; Aged; Anesthetics, Intravenous; Drug Therapy, Combination; Female; Fentanyl; Follow-Up Stu

2018
[Rhabdomyolysis in severe acute asthma].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2

    Topics: Acidosis; Acute Disease; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Biomarkers; Combined Modal

2009
Cerebral and plasma kinetics of a high dose of midazolam and correlations with its respiratory effects in rats.
    Toxicology letters, 2005, Oct-15, Volume: 159, Issue:1

    Topics: Acidosis; Animals; Bicarbonates; Blood Gas Analysis; Brain; Chromatography, High Pressure Liquid; Ha

2005
[Effects of intravenous anesthetics on acidosis induced apoptosis in primary brain cell culture].
    Masui. The Japanese journal of anesthesiology, 2007, Volume: 56, Issue:8

    Topics: Acidosis; Anesthetics, Intravenous; Animals; Apoptosis; Brain; Calcium; Cells, Cultured; Female; Hum

2007
A comparison of propofol and other sedative use in paediatric intensive care in the United Kingdom.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:2

    Topics: Acidosis; Adolescent; Child; Child, Preschool; Female; Humans; Hypnotics and Sedatives; Infant; Infu

1997
MAO inhibitors and coronary artery surgery: a patient death.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:10

    Topics: Acidosis; Anesthesia, Intravenous; Angina, Unstable; Cause of Death; Coronary Artery Bypass; Fentany

1992