Page last updated: 2024-10-31

midazolam and Acathisia, Drug-Induced

midazolam has been researched along with Acathisia, Drug-Induced in 35 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"03 mg/kg of midazolam just before the end of surgery reduces emergence agitation without delaying the emergence time in children having strabismus surgery with sevoflurane anesthesia."9.19Comparison of the effects of 0.03 and 0.05 mg/kg midazolam with placebo on prevention of emergence agitation in children having strabismus surgery. ( Cho, EJ; Cho, JE; Lee, HW; Yoon, SZ, 2014)
" This, however, does not result in a reduced incidence of emergence delirium after sevoflurane anesthesia."9.12Midazolam does not reduce emergence delirium after sevoflurane anesthesia in children. ( Breschan, C; Jost, R; Likar, R; Platzer, M; Stettner, H, 2007)
"A comprehensive literature search was conducted to identify clinical trials that observed the effect of midazolam and clonidine on preventing EA in children after their emergence from sevoflurane anesthesia."8.89Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis. ( Li, J; Wang, Y; Zhang, C; Zhao, D, 2013)
"03 mg/kg of midazolam just before the end of surgery reduces emergence agitation without delaying the emergence time in children having strabismus surgery with sevoflurane anesthesia."5.19Comparison of the effects of 0.03 and 0.05 mg/kg midazolam with placebo on prevention of emergence agitation in children having strabismus surgery. ( Cho, EJ; Cho, JE; Lee, HW; Yoon, SZ, 2014)
" This, however, does not result in a reduced incidence of emergence delirium after sevoflurane anesthesia."5.12Midazolam does not reduce emergence delirium after sevoflurane anesthesia in children. ( Breschan, C; Jost, R; Likar, R; Platzer, M; Stettner, H, 2007)
"A comprehensive literature search was conducted to identify clinical trials that observed the effect of midazolam and clonidine on preventing EA in children after their emergence from sevoflurane anesthesia."4.89Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis. ( Li, J; Wang, Y; Zhang, C; Zhao, D, 2013)
" Midazolam, a benzodiazepine commonly administered to children for anxiolysis, may precipitate paradoxical agitation and delirium, a rare but alarming effect that warrants prompt identification and treatment."3.81Successful flumazenil reversal of paradoxical reaction to midazolam in a child. ( Beck, LA; Jackson, BF; Losek, JD, 2015)
"An increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observed in an elderly, ASA classification group II, cardiovascularly medicated male, 12 min after performance of axillary block with mepivacaine 850 mg containing adrenaline 0."3.70An unusual toxic reaction to axillary block by mepivacaine with adrenaline. ( Koscielniak-Nielsen, ZJ, 1998)
"Metoclopramide was administered as a 2-minute bolus infusion."2.77A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. ( Aydin, B; Erdur, B; Ergin, A; Kabay, B; Ozen, M; Parlak, I; Tura, P, 2012)
"Postoperative pain was evaluated with the 10-point Children's and Infants' Postoperative Pain Scale."2.76Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial. ( Köner, O; Menda, F; Mercan, A; Sözübir, S; Türe, H, 2011)
"Midazolam and propofol have been examined with the aim of reducing emergence agitation after sevoflurane anaesthesia."2.76Prophylactic use of midazolam or propofol at the end of surgery may reduce the incidence of emergence agitation after sevoflurane anaesthesia. ( Kim, YH; Lim, HJ; Yoon, SM; Yoon, SZ, 2011)
"Flumazenil is a competitive benzodiazepine antagonist that acts to reverse their sedative and hypnotic effects."2.68Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy. ( al-Kawas, FH; Benjamin, SB; Fleischer, DE; Gallagher, J; Ginsberg, G; Kankaria, A; Lewis, JH; Nguyen, CC, 1996)
"Propofol was effective when used throughout anaesthesia (RR 0."2.50Effects of sevoflurane versus other general anaesthesia on emergence agitation in children. ( Ahmed, S; Burgoyne, LL; Chooi, C; Costi, D; Cyna, AM; Ellwood, J; Larsson, JN; Middleton, P; Stephens, K; Strickland, P, 2014)
" Extrapyramidal side effects like tardive dyskinesia are known to develop with chronic use of metoclopramide, while acute akathisia is a lesser known side effect following IV administration."1.37Case of acute akathisia from intravenous metoclopramide. ( Lim, BL; Qiu, LM, 2011)
" Eight patients developed adverse reactions, 3 of which required further evaluation in the emergency department."1.37Safety of deep sedation in an urban oral and maxillofacial surgery training program. ( Braidy, HF; Singh, P; Ziccardi, VB, 2011)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.71)18.7374
1990's13 (37.14)18.2507
2000's5 (14.29)29.6817
2010's15 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhong, L1
Shen, K1
Zhai, S1
Chen, T1
Tao, Q1
Chen, L1
Tao, Y1
Qiu, L1
Tan, D1
Xia, H1
Sun, S1
Wang, F1
Zhang, C1
Li, J1
Zhao, D1
Wang, Y1
Cho, EJ1
Yoon, SZ2
Cho, JE1
Lee, HW1
Zhou, Y1
Jin, X1
Kang, Y1
Liang, G1
Liu, T1
Deng, N1
Costi, D1
Cyna, AM1
Ahmed, S1
Stephens, K1
Strickland, P1
Ellwood, J1
Larsson, JN1
Chooi, C1
Burgoyne, LL1
Middleton, P1
Jackson, BF1
Beck, LA1
Losek, JD1
Yap, CYL1
Taylor, DM1
Knott, JC1
Taylor, SE1
Phillips, GA1
Karro, J1
Chan, EW1
Kong, DCM1
Castle, DJ1
Ayerza Casas, A1
Ayerza Casas, V1
Crespo Escudero, P1
Tsai, PS1
Hsu, YW1
Lin, CS1
Ko, YP1
Huang, CJ1
Erdur, B2
Tura, P1
Aydin, B1
Ozen, M1
Ergin, A2
Parlak, I2
Kabay, B1
Qiu, LM1
Lim, BL1
Braidy, HF1
Singh, P1
Ziccardi, VB1
Köner, O1
Türe, H1
Mercan, A1
Menda, F1
Sözübir, S1
Kim, YH1
Lim, HJ1
Yoon, SM1
Maeda, S1
Tomoyasu, Y1
Higuchi, H1
Mori, T1
Egusa, M1
Miyawaki, T1
Breschan, C1
Platzer, M1
Jost, R1
Stettner, H1
Likar, R1
Parlak, M1
Ayrik, C1
Tomruk, O1
Turkcuer, I1
Ergin, N1
Voepel-Lewis, T1
Mitchell, A1
Malviya, S1
Krajnik, M1
Zylicz, Z1
Hollman, GA1
Bartlett, SE1
Cramond, T1
Smith, MT1
Lawrence, K1
Thurston, TA1
Williams, CG1
Foshee, SL1
Kankaria, A1
Lewis, JH1
Ginsberg, G1
Gallagher, J1
al-Kawas, FH1
Nguyen, CC1
Fleischer, DE1
Benjamin, SB1
Khan, LC1
Lustik, SJ1
Massanari, M1
Novitsky, J1
Reinstein, LJ1
Koscielniak-Nielsen, ZJ1
Beskow, A1
Westrin, P1
Lapin, SL1
Auden, SM1
Goldsmith, LJ1
Reynolds, AM1
Fulton, SA1
Mullen, KD1
Mets, B1
Horsell, A1
Linton, DM1
Roelofse, JA1
Joubert, JJ1
Sury, MR1
Billingham, I1
Russell, GN1
Hopkins, CS1
Thornington, R1
Vivori, E1
Short, TG1
Forrest, P1
Galletly, DC1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Midazolam Effect on Agitation Postnasal Surgery: A Double Blinded Randomized Controlled Trial[NCT05165914]100 participants (Actual)Interventional2021-05-27Completed
Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Unit[NCT03194360]141 participants (Actual)Observational2015-12-01Completed
Emergence Delirium in Children: a Randomized Clinical Trial of Different Doses of Sevoflurane During Induction of Anesthesia[NCT02707016]80 participants (Anticipated)Interventional2015-12-31Recruiting
Investigation of the DNA Methylation Profile in Children Who Presented Emergence Delirium[NCT03787849]175 participants (Actual)Interventional2018-09-24Completed
Effect of Single-dose Dexmedetomidine on Emergence Agitation and Postoperative Behavior Changes After Sevoflurane Anesthesia in Children[NCT03596775]Early Phase 196 participants (Anticipated)Interventional2018-09-01Not yet recruiting
Oro-dispersible Olanzapine (Wafer) Versus Conventional Oral Haloperidol or Diazepam Tablets for the Management of Acute Agitation in the Accident and Emergency Department - a Multicentre Randomised Clinical Trial[NCT03246620]Phase 412 participants (Actual)Interventional2017-09-01Terminated (stopped due to The study was terminated prematurely due to difficulties in patient recruitment and associated potential for selection bias.)
Hydroxyzine Dihydrochloride Premedication is a Necessity for Pediatric Patients Undergoing Strabismus Surgery; An Observational Clinical Trial Controlled With Midazolam[NCT03806270]45 participants (Actual)Observational [Patient Registry]2018-10-01Completed
Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric[NCT02463929]Phase 450 participants (Actual)Interventional2014-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Heart Rate-1

"The lowest heart rate observed from EKG monitorization at the time-out after the anesthesia induction, and just before the surgery starts. Heart rate-1 is a data, not an assessing change, which is recoded during the time-out. The time-out is when the patient's name, the procedure, the surgent name is repeated before the operation starts." (NCT03806270)
Timeframe: "1 minute, at the time out, through study completion an average of 6 months"

Interventionbeats per minute (Mean)
Midazolam114.4
Midazolam&Hydroxyzine dihydrochloride1/2125.8
Midazolam&Hydroxyzine Dihydrochloride122.3

Heart Rate-2

The heart rate observed from EKG monitorization at the time operator warns the investigator just before the traction of the orbital muscle. Heart rate-2 is a data, not an assessing change, which is recorded during the operation at the time operator warns. The heart rate observed from EKG monitorization, before every orbital muscle traction at the time the operator's warning before traction. (NCT03806270)
Timeframe: 1 minute, at the strabismus surgery operation, through study completion an average of 6 months

Interventionbeats per minute (Mean)
Midazolam110.4
Midazolam&Hydroxyzine dihydrochloride1/2125.3
Midazolam&Hydroxyzine Dihydrochloride124.8

Heart Rate-3

The lowest heart rate observed from EKG monitorization, after every orbital muscle traction within 120 seconds. Heart rate-3 is a data, not an assessing change, which is recorded within 120 seconds after traction applied. (NCT03806270)
Timeframe: within 120 seconds after the orbital muscle traction, at the strabismus surgery operation, through study completion an average of 6 months

Interventionbeats per minute (Mean)
Midazolam90.8
Midazolam&Hydroxyzine dihydrochloride1/2113.4
Midazolam&Hydroxyzine Dihydrochloride117.9

Number of Observed Oculocardiac Reflex(OCR)

The OCR is a heartbeat anomaly(bradycardia, any arrhythmia, or cardiac arrest) associated with traction applied to the extraocular muscles during strabismus surgery. The specific criteria were as follows: the lowest heart rate observed within 120 seconds from EKG monitorization, after every orbital muscle traction, was less than 20% of the heart rate observed directly preceding traction of the orbital muscle. Additionally, any kind of arrhythmia or cardiac arrest occurrence within 120 seconds after orbital muscle traction was also defined as an OCR. (NCT03806270)
Timeframe: 2 minutes, at the strabismus surgery operation after recording Heart Rate-3, through study completion an average of 6 months

Interventionorbital muscles (Count of Units)
Midazolam15
Midazolam&Hydroxyzine dihydrochloride1/26
Midazolam&Hydroxyzine Dihydrochloride1

Number of Orbital Muscles of the Participants With Different Considerations Taken With Respect to the Treatment of OCR

The investigator records every OCR treatment like; pausing surgery, atropin 20mcg/kg intravenous treatment or cardiac resuscitation. (NCT03806270)
Timeframe: within 5 minutes after defining the OCR occurrence, at the strabismus surgery operation, through study completion an average of 6 months

,,
Interventionnumber of orbital muscle/s, OCR occured (Number)
pausing surgeryatropin administrationcardiac resuscitation
Midazolam1320
Midazolam&Hydroxyzine Dihydrochloride100
Midazolam&Hydroxyzine dihydrochloride1/2600

Reviews

5 reviews available for midazolam and Acathisia, Drug-Induced

ArticleYear
Effect of ancillary drugs on sevoflurane related emergence agitation in children undergoing ophthalmic surgery: a Bayesian network meta-analysis.
    BMC anesthesiology, 2019, 08-01, Volume: 19, Issue:1

    Topics: Akathisia, Drug-Induced; Analgesics; Anesthesia Recovery Period; Anesthetics, Inhalation; Bayes Theo

2019
Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis.
    Clinical therapeutics, 2013, Volume: 35, Issue:10

    Topics: Akathisia, Drug-Induced; Analgesics; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous;

2013
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Effects of sevoflurane versus other general anaesthesia on emergence agitation in children.
    The Cochrane database of systematic reviews, 2014, Sep-12, Issue:9

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, General; Ane

2014
Delayed postoperative agitation in a child after preoperative midazolam.
    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2007, Volume: 22, Issue:5

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Algorithms; Ambulatory Surgical Procedures; Antidote

2007
Completion of upper endoscopic procedures despite paradoxical reaction to midazolam: a role for flumazenil?
    The American journal of gastroenterology, 2000, Volume: 95, Issue:3

    Topics: Adult; Akathisia, Drug-Induced; Antidotes; Conscious Sedation; Endoscopy, Digestive System; Female;

2000

Trials

12 trials available for midazolam and Acathisia, Drug-Induced

ArticleYear
Comparison of the effects of 0.03 and 0.05 mg/kg midazolam with placebo on prevention of emergence agitation in children having strabismus surgery.
    Anesthesiology, 2014, Volume: 120, Issue:6

    Topics: Adolescent; Akathisia, Drug-Induced; Anesthesia Recovery Period; Child; Child, Preschool; Double-Bli

2014
Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients: a prospective, randomized study.
    Critical care (London, England), 2014, Jun-16, Volume: 18, Issue:3

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthetics, Intravenous; Critical Illness; Dru

2014
Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial.
    Addiction (Abingdon, England), 2017, Volume: 112, Issue:7

    Topics: Acute Disease; Adolescent; Adult; Aged; Akathisia, Drug-Induced; Australia; Benzodiazepines; Dopamin

2017
Ketamine but not propofol provides additional effects on attenuating sevoflurane-induced emergence agitation in midazolam premedicated pediatric patients.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:11

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Inhalat

2008
A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:1

    Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Double-Blind Method; Female; Humans; H

2012
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
Prophylactic use of midazolam or propofol at the end of surgery may reduce the incidence of emergence agitation after sevoflurane anaesthesia.
    Anaesthesia and intensive care, 2011, Volume: 39, Issue:5

    Topics: Adolescent; Akathisia, Drug-Induced; Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation

2011
Midazolam does not reduce emergence delirium after sevoflurane anesthesia in children.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:4

    Topics: Administration, Rectal; Age Factors; Akathisia, Drug-Induced; Anesthesia, General; Anesthetics, Inha

2007
Midazolam vs. diphenhydramine for the treatment of metoclopramide-induced akathisia: a randomized controlled trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2007, Volume: 14, Issue:8

    Topics: Adult; Akathisia, Drug-Induced; Analysis of Variance; Diphenhydramine; Dose-Response Relationship, D

2007
Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy.
    Gastrointestinal endoscopy, 1996, Volume: 44, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Anesthetics, Intravenous; Antidotes; Chi-Sq

1996
Sevoflurane causes more postoperative agitation in children than does halothane.
    Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:5

    Topics: Adolescent; Age Factors; Akathisia, Drug-Induced; Anesthetics, Inhalation; Anesthetics, Intravenous;

1999
Effects of sevoflurane anaesthesia on recovery in children: a comparison with halothane.
    Paediatric anaesthesia, 1999, Volume: 9, Issue:4

    Topics: Administration, Oral; Akathisia, Drug-Induced; Analysis of Variance; Anesthesia Recovery Period; Ane

1999

Other Studies

18 other studies available for midazolam and Acathisia, Drug-Induced

ArticleYear
Application of sedation-agitation scale in conscious sedation before bronchoscopy in children.
    Medicine, 2019, Volume: 98, Issue:1

    Topics: Akathisia, Drug-Induced; Anesthesia, Local; Anti-Anxiety Agents; Anxiety; Bronchoscopy; Child; Child

2019
Successful flumazenil reversal of paradoxical reaction to midazolam in a child.
    The Journal of emergency medicine, 2015, Volume: 48, Issue:3

    Topics: Akathisia, Drug-Induced; Anti-Anxiety Agents; Antidotes; Child, Preschool; Delirium; Female; Flumaze

2015
Paradoxical reaction after intranasal midazolam administration.
    Medicina clinica, 2017, 04-07, Volume: 148, Issue:7

    Topics: Administration, Intranasal; Akathisia, Drug-Induced; Child, Preschool; Female; Humans; Hypnotics and

2017
Case of acute akathisia from intravenous metoclopramide.
    Singapore medical journal, 2011, Volume: 52, Issue:1

    Topics: Abdominal Pain; Adult; Akathisia, Drug-Induced; Diphenhydramine; Emergency Service, Hospital; Female

2011
Safety of deep sedation in an urban oral and maxillofacial surgery training program.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2011, Volume: 69, Issue:8

    Topics: Adjuvants, Anesthesia; Adult; Age Factors; Aggression; Akathisia, Drug-Induced; Ambulatory Surgical

2011
Midazolam is associated with delay in recovery and agitation after ambulatory general anesthesia for dental treatment in patients with disabilities: a retrospective cohort study.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012, Volume: 70, Issue:6

    Topics: Administration, Oral; Adult; Akathisia, Drug-Induced; Ambulatory Care; Analysis of Variance; Anesthe

2012
Terminal restlessness and nicotine withdrawal.
    Lancet (London, England), 1995, Oct-14, Volume: 346, Issue:8981

    Topics: Aged; Akathisia, Drug-Induced; Humans; Hypnotics and Sedatives; Male; Midazolam; Nicotine; Substance

1995
Oral midazolam and emergence delirium.
    Annals of emergency medicine, 1995, Volume: 25, Issue:6

    Topics: Akathisia, Drug-Induced; Delirium; Humans; Infant; Midazolam

1995
The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex.
    Life sciences, 1994, Volume: 54, Issue:10

    Topics: Akathisia, Drug-Induced; Animals; Behavior, Animal; Binding Sites; Dose-Response Relationship, Drug;

1994
Reversal of midazolam sedation.
    Critical care medicine, 1993, Volume: 21, Issue:9

    Topics: Akathisia, Drug-Induced; Conscious Sedation; Critical Care; Flumazenil; Humans; Midazolam; Substance

1993
Reversal of a paradoxical reaction to midazolam with flumazenil.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:1

    Topics: Adult; Akathisia, Drug-Induced; Anesthetics, Intravenous; Antidotes; Flumazenil; GABA Modulators; Hu

1996
Treatment of a paradoxical reaction to midazolam with haloperidol.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:1

    Topics: Akathisia, Drug-Induced; Anti-Anxiety Agents; Antipsychotic Agents; Haloperidol; Humans; Hypnotics a

1997
Paradoxical reactions in children associated with midazolam use during endoscopy.
    Clinical pediatrics, 1997, Volume: 36, Issue:12

    Topics: Adjuvants, Anesthesia; Adolescent; Adolescent Behavior; Aggression; Akathisia, Drug-Induced; Anti-An

1997
An unusual toxic reaction to axillary block by mepivacaine with adrenaline.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:7

    Topics: Absorption; Aged; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Arrhythmia Agents; Antihypertens

1998
Midazolam-induced benzodiazepine withdrawal syndrome.
    Anaesthesia, 1991, Volume: 46, Issue:1

    Topics: Akathisia, Drug-Induced; Humans; Intermittent Positive-Pressure Ventilation; Male; Midazolam; Middle

1991
Unpleasant sequelae of benzodiazepine sedation.
    Anaesthesia, 1990, Volume: 45, Issue:10

    Topics: Akathisia, Drug-Induced; Child; Humans; Midazolam; Preanesthetic Medication

1990
Acute benzodiazepine withdrawal syndrome after midazolam infusions in children.
    Critical care medicine, 1989, Volume: 17, Issue:3

    Topics: Acute Disease; Akathisia, Drug-Induced; Child; Child, Preschool; Cognition Disorders; Confusion; Fem

1989
Paradoxical reactions to benzodiazepines--a genetically determined phenomenon?
    Anaesthesia and intensive care, 1987, Volume: 15, Issue:3

    Topics: Adult; Akathisia, Drug-Induced; Humans; Male; Midazolam; Twins; Twins, Monozygotic

1987