midazolam has been researched along with Absence Seizure in 250 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare efficacy and safety of Intranasal and Intramuscular routes of midazolam administration in terminating seizures." | 9.51 | The IN-MIDAZ study - Intranasal midazolam in aborting seizures - An epilepsy monitoring unit based randomized controlled trial for efficacy. ( Appukuttan, R; Mehta, S; Ramanujan, B; Shaikh, RG; Singh, RK; Tripathi, M; Vibha, D, 2022) |
| "We compared the efficacy and safety of intramuscular with buccal midazolam as first-line treatment for active seizures in children brought to the emergency department." | 9.34 | Intramuscular Versus Buccal Midazolam for Pediatric Seizures: A Randomized Double-Blinded Trial. ( Al Jawala, SA; Alansari, K; Barkat, M; Mohamed, AH; Othman, SA, 2020) |
| "Midazolam nasal spray (MDZ-NS) is indicated for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern, in patients 12 years of age and older with epilepsy." | 9.34 | Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial. ( Choi, EJ; Cleveland, JM; King, A; Meng, TC; Pullman, WE; Sequeira, DJ; Sinha, SR; Spencer, DC; Van Ess, PJ; Wheless, JW, 2020) |
| "Among autonomic seizures apnea still represent a challenge for physicians, and it might constitute the only isolated sign of neurological disorder." | 9.22 | Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review. ( Consentino, MC; Falsaperla, R; Marino, S; Ruggieri, M; Vitaliti, G, 2022) |
| "The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam." | 9.20 | Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. ( Azizi Malamiri, R; Fayezi, A; Jafari, M; Maraghi, E; Momen, AA; Nikkhah, A; Riahi, K, 2015) |
| "The objective of this study is to compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of acute childhood seizures." | 9.17 | A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures. ( Shanbag, P; Thakker, A, 2013) |
| "To compare the efficacy and tolerability of buccal midazolam with rectal diazepam as emergency treatment in residential adults with convulsive or non-convulsive serial seizures or status epilepticus (SE), and ascertain the preference between the two treatment options among the patients and the nursing staff." | 9.15 | Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. ( Lossius, MI; Nakken, KO, 2011) |
| "We reviewed the efficacy and a pharmacokinetics of intranasal midazolam (MDL) for status epilepticus in childhood epilepsies." | 9.14 | [Study of an efficacy and a pharmacokinetics of intranasal midazolam for status epilepticus on childhood epilepsy]. ( Inoue, T; Ishikawa, J; Kawawaki, H; Kimura, S; Kuki, I; Nukui, M; Okazaki, S; Shiomi, M; Togawa, M; Tomiwa, K, 2010) |
| "This study compares the effectiveness of midazolam and dexmedetomidine for the sedation of eclampsia patients admitted to our intensive care unit (ICU)." | 9.14 | Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit. ( Akin, A; Boyaci, A; Esmaoglu, A; Ulgey, A, 2009) |
| " Our aim was to evaluate the efficacy and usability of buccal midazolam in controlling seizures in children with acute prolonged seizures, by comparing it with rectal diazepam." | 9.14 | Efficacy and usability of buccal midazolam in controlling acute prolonged convulsive seizures in children. ( Ashrafi, MR; Bavarian, B; Karimi, P; Khosroshahi, N; Kompani, F; Malamiri, RA; Mirzaei, M; Zarch, AV, 2010) |
| "To compare the efficacy of midazolam and diazepam for treatment of acute seizures in children." | 9.14 | [A control study on the treatment of acute seizures with midazolam and diazepam in children]. ( Tang, RH; Zhou, JB, 2010) |
| "Our goal was to compare the efficacy and safety of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children." | 9.13 | Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. ( Byarugaba, J; Mpimbaza, A; Ndeezi, G; Rosenthal, PJ; Staedke, S, 2008) |
| "To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures." | 9.12 | Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures. ( Manohar, R; Mittal, P; Rawat, AK, 2006) |
| "To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam." | 9.11 | Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005) |
| "Eighty-two episodes of status epilepticus or clusters of seizures in 45 children were treated with intravenous midazolam." | 9.10 | [Eight-year study on the treatment with intravenous midazolam for status epilepticus and clusters of seizures in children]. ( Minagawa, K; Watanabe, T, 2003) |
| " We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures." | 9.09 | Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999) |
| "To compare treatment of ongoing seizures using intramuscular (IM) midazolam versus intravenous (IV) diazepam." | 9.08 | A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. ( Altieri, MA; Chamberlain, JM; Futterman, C; Ochsenschlager, DW; Waisman, Y; Young, GM, 1997) |
| "Oromucosal midazolam (Buccolam™) is a benzodiazepine approved for the treatment of pediatric patients with acute, prolonged, convulsive seizures." | 8.88 | Oromucosal midazolam: a review of its use in pediatric patients with prolonged acute convulsive seizures. ( Garnock-Jones, KP, 2012) |
| "To discuss mainly the use of propofol and barbiturates in the anesthesia of refractory status epilepticus (RSE)." | 8.84 | Propofol and barbiturates for the anesthesia of refractory convulsive status epilepticus: pros and cons. ( Kälviäinen, R; Parviainen, I; Ruokonen, E, 2007) |
| "A short cut review was carried out to establish whether buccal midazolam is better than rectal diazepam for treating prolonged seizures in childhood and adolescence." | 8.82 | Best evidence topic report. Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence. ( Body, R; Ijaz, M, 2005) |
| "This cohort study assesses the effectiveness of midazolam treatment in terminating pediatric seizures in the prehospital setting." | 8.31 | Assessment of First-line Therapy With Midazolam for Prehospital Seizures in Children. ( Nov, S; Shavit, D; Shavit, I; Siman-Tov, M; Strugo, R, 2023) |
| " Severity of seizures were quantified for an hour and treated with midazolam (3 mg/kg, i." | 8.31 | Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy. ( Almanza, A; Bryant, E; Carlo, AM; Corson, BE; Gage, M; Kharate, M; Mafuta, C; Massey, N; Meyer, C; Ostrander, M; Rao, NS; Samidurai, M; Showman, L; Thippeswamy, T; Trevino, L; Vasanthi, SS; Wachter, L; Wang, C; Wohlgemuth, M, 2023) |
| "Acute intoxication with tetramethylenedisulfotetramine (TETS) can trigger status epilepticus (SE) in humans." | 8.02 | Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus. ( Boosalis, CA; Bruun, DA; Calsbeek, JJ; Chaudhari, AJ; Garbow, JR; González, EA; Harvey, DJ; Lein, PJ; Rogawski, MA; Rowland, DJ; Saito, NH; Zolkowska, D, 2021) |
| "Midazolam delivered by continuous rate infusion (CRI) might be effective in dogs with cluster seizures (CS) or status epilepticus (SE)." | 8.02 | Continuous rate infusion of midazolam as emergent treatment for seizures in dogs. ( Bray, KY; Early, PJ; Mariani, CL; Muñana, KR; Olby, NJ, 2021) |
| "Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult." | 8.02 | Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021) |
| "Provide standards for basic epilepsy education and rescue medication (Midazolam) administration." | 8.02 | UK framework for basic epilepsy training and oromucosal midazolam administration. ( Bagary, M; Chisanga, E; Jory, C; Shankar, R; Tittensor, P; Tittensor, S, 2021) |
| " We have previously demonstrated a major inflammatory response with subsequent brain damage which was correlated with the duration of the sarin-induced seizures (Chapman et al." | 7.91 | Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: Suggested role of prostaglandins. ( Chapman, S; Egoz, I; Gez, R; Grauer, E; Lazar, S, 2019) |
| "The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram." | 7.91 | Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019) |
| "A previous European cost-utility study reported that use of buccal midazolam in the community setting for the treatment of prolonged seizures (ie, seizures lasting ≥5 minutes) in children was associated with an overall €12 507 399 reduction in annual costs charged to the Italian national health service compared with rectal diazepam." | 7.88 | Midazolam vs diazepam in prolonged seizures in children: A pharmacoeconomic approach. ( Beghi, E; Capovilla, G; Franzoni, E; Minicucci, F; Perucca, E; Romeo, A; Verrotti, A; Vigevano, F, 2018) |
| "Midazolam is commonly used to treat refractory seizures in newborns and as a first-line anti-epileptic drug in children." | 7.88 | Midazolam as a first-line treatment for neonatal seizures: Retrospective study. ( Dao, K; Diezi, M; Giannoni, E; Lebon, S; Roulet-Perez, E, 2018) |
| "BACKGROUND Recurrent seizure in patients with magnesium sulfate-treated eclampsia is very rare and requires meticulous management due to poor prognosis." | 7.88 | Recurrent Seizures in 2 Patients with Magnesium Sulfate-Treated Eclampsia at a Secondary Hospital. ( Achmadi, A; Aldika Akbar, MI; Harsono, AAH; Joewono, HT, 2018) |
| "Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits." | 7.88 | Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam. ( de Araujo Furtado, M; Du, F; Kundrick, E; Lumley, LA; Marrero-Rosado, B; O'Brien, S; Schultz, CR; Stone, M; Walker, K, 2018) |
| " We hypothesized that publication of a pivotal pre-hospital clinical trial (RAMPART), demonstrating superiority of intramuscular midazolam over intravenous lorazepam, altered the national utilization rates of midazolam for pre-hospital benzodiazepine-treated seizures, while upholding its safety and efficacy outside the trial setting." | 7.85 | Pre-hospital midazolam for benzodiazepine-treated seizures before and after the Rapid Anticonvulsant Medication Prior to Arrival Trial: A national observational cohort study. ( Meurer, WJ; Shtull-Leber, E; Silbergleit, R, 2017) |
| "To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures." | 7.83 | Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016) |
| "Currently, evidence supports the use of intranasal midazolam as an effective, and in many cases, preferable treatment option for prolonged seizures in children." | 7.83 | Implementation of Intranasal Midazolam for Prolonged Seizures in a Child Neurology Practice. ( Crawford, D, 2016) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 7.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| "This study aims to explore carer perceptions of training in out-of-hospital use of buccal midazolam for emergency management of seizures." | 7.81 | Exploring carer perceptions of training in out-of-hospital use of buccal midazolam for emergency management of seizures (2008-2012). ( Beavis, E; Bye, AM; Connolly, AM; Lawson, JA; Mugica-Cox, B, 2015) |
| "We identified 2 risk factors for apnea in children transported for seizure: seizure on arrival to the pediatric ED and out-of-hospital administration of midazolam." | 7.80 | Risk factors for apnea in pediatric patients transported by paramedics for out-of-hospital seizure. ( Bosson, N; Fang, A; Fernando, T; Gausche-Hill, M; Huang, M; Kaji, AH; Lee, J; Santillanes, G, 2014) |
| " To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 7.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
| "Oromucosal midazolam (Buccolam™), a benzodiazepine, is approved in the EU for the treatment of paediatric patients (aged 3 months to <18 years) with acute, prolonged, convulsive seizures." | 7.78 | Oromucosal midazolam: a guide to its use in paediatric patients with prolonged acute convulsive seizures. ( Garnock-Jones, KP; Lyseng-Williamson, KA; Scott, LJ, 2012) |
| "This study evaluated the anticonvulsant effectiveness of midazolam to stop seizures elicited by the nerve agent soman when midazolam was administered by different routes (intramuscular, intranasal or sublingual) at one of two different times after the onset of seizure activity." | 7.75 | Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures. ( LaMont, JC; McDonough, JH; McMonagle, JD; Shih, TM; Van Shura, KE, 2009) |
| "Two guinea pig models were used to study the anticonvulsant potency of diazepam, midazolam, and scopolamine against seizures induced by the nerve agents tabun, sarin, soman, cyclosarin, O-ethyl S-(2-(diisopropylamino)ethyl)methylphosphonothioate (VX), and O-isobutyl S-(2-diethylamino)ethyl)-methyl phosphonothioate (VR)." | 7.74 | Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine. ( McDonough, JH; Rowland, TC; Shih, TM, 2007) |
| "The IN-MAD midazolam controlled seizures better than PR diazepam in the prehospital setting and resulted in fewer respiratory complications and fewer admissions." | 7.74 | Prehospital intranasal midazolam for the treatment of pediatric seizures. ( Filloux, FM; Firth, SD; Furnival, RA; Holsti, M; Joyce, SM; Sill, BL, 2007) |
| " Intra-arterial verapamil was started; during this treatment, the patient developed right-sided focal motor seizures." | 7.74 | Intra-arterial verapamil-induced seizures: case report and review of the literature. ( Nwagwu, CI; Westhout, FD, 2007) |
| "Until a few years ago, rectal diazepam (RD) was the only option available to parents and carers managing prolonged seizures." | 7.73 | Community use of intranasal midazolam for managing prolonged seizures. ( Coulthard, K; Harbord, M; Kay, D; Kyrkou, M; Kyrkou, N, 2006) |
| "Buccal midazolam is effective and safe in the treatment of prolonged seizures and has the advantage of being a convenient and socially acceptable administration form." | 7.73 | [Prolonged convulsions treated with buccal midazolam in a setting of mentally retarded patients with refractory epilepsy]. ( Batista, D; Bausà, T; Elias, C; Font, D; Hijano, A; Melendez, R; Rocha, A, 2006) |
| "To determine which is the most effective and safe treatment for controlling seizures in children out-of-hospital: diazepam or midazolam." | 7.71 | Controlling seizures in the prehospital setting: diazepam or midazolam? ( Browne, GJ; Lam, LT; Rainbow, J, 2002) |
| ") administration of a non-selective full benzodiazepine receptor agonist, midazolam, and a neuroactive steroid, allopregnanolone, on picrotoxin-induced seizures and striatal dopamine metabolism, were studied in mice." | 7.71 | Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures. ( Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J, 2001) |
| "This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure." | 7.71 | Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002) |
| "In order to determine the efficiency of intranasal midazolam in prolonged convulsive episodes, we conducted a prospective study in children with various types of seizures." | 7.70 | Intranasal midazolam for prolonged convulsive seizures. ( Dogrul, M; Durmaz, Y; Kutlu, NO; Yakinci, C, 2000) |
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 7.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 7.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome." | 6.73 | Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007) |
| "Midazolam is a relatively new anticonvulsive agent in the benzodiazepine group." | 6.71 | Buccal midazolam for treatment of prolonged seizures in children. ( Dogrul, M; Kutlu, NO; Soylu, H; Yakinci, C, 2003) |
| "Midazolam was then administered by continuous intravenous infusion (0." | 6.68 | Midazolam in the treatment of refractory neonatal seizures. ( Bodensteiner, JB; Buckley, DJ; Gingold, M; Gutierrez, AR; Penney, S; Sheth, RD, 1996) |
| "Midazolam is a recently developed water-soluble benzodiazepine that shares anxiolytic, muscle relaxant, hypnotic and anticonvulsant actions with other members of this class." | 6.68 | Midazolam in treatment of various types of seizures in children. ( Durmaz, Y; Karabiber, H; Müngen, B; Sahin, S; Yakinci, C, 1997) |
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 5.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "To compare efficacy and safety of Intranasal and Intramuscular routes of midazolam administration in terminating seizures." | 5.51 | The IN-MIDAZ study - Intranasal midazolam in aborting seizures - An epilepsy monitoring unit based randomized controlled trial for efficacy. ( Appukuttan, R; Mehta, S; Ramanujan, B; Shaikh, RG; Singh, RK; Tripathi, M; Vibha, D, 2022) |
| "Seizures were aborted in 36 (72%) users in the INM group; of the rest of 14 children, 4 (8%) used it for the second time." | 5.51 | Impact of prescribing intranasal midazolam as rescue medication for domiciliary management of acute seizure among children with epilepsy. ( Behgal, J; Bhardwaj, H; Kaushik, JS; Lather, T, 2019) |
| "Cessation of seizure was achieved in 85% of the adults and in 97% of the children, if all options of the MTAS-EMS were used." | 5.51 | Treatment of Seizures in Children and Adults in the Emergency Medical System of the City of Zurich, Switzerland - Midazolam vs. Diazepam - A Retrospective Analysis. ( Baulig, W; Dette-Oltmann, K; Mariotti, S; Schenk, P; Theusinger, OM, 2019) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 5.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "The control index seizure was the preceding, alternatively the next successive seizure without application of in-MDZ." | 5.42 | Intranasal midazolam during presurgical epilepsy monitoring is well tolerated, delays seizure recurrence, and protects from generalized tonic-clonic seizures. ( Bauer, S; Belke, M; Fründ, D; Kay, L; Knake, S; Reif, PS; Rosenow, F; Strzelczyk, A, 2015) |
| " For each drug treatment in each brain area, anticonvulsant ED₅₀ values were calculated using an up-down dosing procedure over successive animals." | 5.38 | Neuropharmacological specificity of brain structures involved in soman-induced seizures. ( McDonough, JH; Shih, TM; Skovira, JW, 2012) |
| " Since midazolam is frequently used in neonates for sedation during various examinations, future investigations on the selection of appropriate drugs and dosage for sedation in neonates, including the usage of midazolam, are necessary." | 5.37 | [Paroxysmal automatic movements mimicking neonatal seizures induced by midazolam]. ( Arakaki, Y; Ishizaki, Y; Mimaki, N; Ohtsuka, Y; Watabe, S, 2011) |
| " Anticonvulsant effective doses (ED(50)) were determined using an up-down dosing procedure over successive animals." | 5.36 | Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. ( McDonough, JH; Shih, TM; Skovira, JW, 2010) |
| "shortening seizure latency and inducing a more profound increase of NO production than PTZ in all brain structures." | 5.36 | Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures. ( Bjelaković, G; Jelenković, A; Jevtović-Stoimenov, T; Pavlović, D; Stevanović, I; Stojanović, I, 2010) |
| "We compared the efficacy and safety of intramuscular with buccal midazolam as first-line treatment for active seizures in children brought to the emergency department." | 5.34 | Intramuscular Versus Buccal Midazolam for Pediatric Seizures: A Randomized Double-Blinded Trial. ( Al Jawala, SA; Alansari, K; Barkat, M; Mohamed, AH; Othman, SA, 2020) |
| "Midazolam nasal spray (MDZ-NS) is indicated for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern, in patients 12 years of age and older with epilepsy." | 5.34 | Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial. ( Choi, EJ; Cleveland, JM; King, A; Meng, TC; Pullman, WE; Sequeira, DJ; Sinha, SR; Spencer, DC; Van Ess, PJ; Wheless, JW, 2020) |
| "Effective and quick management of these seizures is critical." | 5.33 | Efficacy of the ketamine-atropine combination in the delayed treatment of soman-induced status epilepticus. ( Baubichon, D; Bernabé, D; Burckhart, MF; Carpentier, P; Dorandeu, F; Four, E; Lallement, G, 2005) |
| "Centrally mediated seizures and convulsions are common consequences of exposure to organophosphates (OPs)." | 5.33 | Anticonvulsant treatment of sarin-induced seizures with nasal midazolam: an electrographic, behavioral, and histological study in freely moving rats. ( Brandeis, R; Cohen, G; Gilat, E; Kadar, T; Kapon, Y; Levy, A; Rabinovitz, I; Sahar, R, 2005) |
| "Midazolam was administered to 22 patients by intravenous bolus injection (0." | 5.33 | [Etiology and management of neonatal seizures--successful treatment by midazolam]. ( Imataka, G; Kawaguchi, N; Suzumura, H; Yamanouchi, H, 2006) |
| "While occasional myoclonic jerks are prevalent in cancer patients receiving opioids, severe myoclonic jerks and seizures due to opioids are uncommon." | 5.30 | Strychnine-like multifocal myoclonus and seizures in extremely high-dose opioid administration: treatment strategies. ( Hagen, N; Swanson, R, 1997) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 5.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| "Midazolam was able to reduce spike-and-wave activity in all three models, but there were quantitative differences: the lower dose was effective only against rhythmic metrazol activity, but its action against two other models was negligible, whereas the higher dose of midazolam resulted in significant effects in all three models." | 5.30 | Midazolam suppresses spike-and-wave rhythm accompanying three different models of epileptic seizures. ( Kubová, H; Mares, P; Mocková, M, 1999) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 5.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "CSH (200 mg/kg, i." | 5.27 | Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures. ( Cottrell, GA; Robertson, HA, 1987) |
| " Head-to-head trials comparing buccal versus intranasal midazolam versus rectal diazepam would provide useful information to inform the management of the first stage of convulsive status epilepticus in adults, especially when intravenous or intramuscular access is not feasible." | 5.22 | Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence. ( Aucott, L; Booth, C; Brazzelli, M; Counsell, C; Cruickshank, M; Imamura, M; Manson, P; Scotland, G, 2022) |
| "Among autonomic seizures apnea still represent a challenge for physicians, and it might constitute the only isolated sign of neurological disorder." | 5.22 | Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review. ( Consentino, MC; Falsaperla, R; Marino, S; Ruggieri, M; Vitaliti, G, 2022) |
| "The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam." | 5.20 | Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. ( Azizi Malamiri, R; Fayezi, A; Jafari, M; Maraghi, E; Momen, AA; Nikkhah, A; Riahi, K, 2015) |
| "The objective of this study is to compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of acute childhood seizures." | 5.17 | A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures. ( Shanbag, P; Thakker, A, 2013) |
| "To compare the efficacy and tolerability of buccal midazolam with rectal diazepam as emergency treatment in residential adults with convulsive or non-convulsive serial seizures or status epilepticus (SE), and ascertain the preference between the two treatment options among the patients and the nursing staff." | 5.15 | Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. ( Lossius, MI; Nakken, KO, 2011) |
| "We reviewed the efficacy and a pharmacokinetics of intranasal midazolam (MDL) for status epilepticus in childhood epilepsies." | 5.14 | [Study of an efficacy and a pharmacokinetics of intranasal midazolam for status epilepticus on childhood epilepsy]. ( Inoue, T; Ishikawa, J; Kawawaki, H; Kimura, S; Kuki, I; Nukui, M; Okazaki, S; Shiomi, M; Togawa, M; Tomiwa, K, 2010) |
| "This study compares the effectiveness of midazolam and dexmedetomidine for the sedation of eclampsia patients admitted to our intensive care unit (ICU)." | 5.14 | Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit. ( Akin, A; Boyaci, A; Esmaoglu, A; Ulgey, A, 2009) |
| " Our aim was to evaluate the efficacy and usability of buccal midazolam in controlling seizures in children with acute prolonged seizures, by comparing it with rectal diazepam." | 5.14 | Efficacy and usability of buccal midazolam in controlling acute prolonged convulsive seizures in children. ( Ashrafi, MR; Bavarian, B; Karimi, P; Khosroshahi, N; Kompani, F; Malamiri, RA; Mirzaei, M; Zarch, AV, 2010) |
| "To compare the efficacy of midazolam and diazepam for treatment of acute seizures in children." | 5.14 | [A control study on the treatment of acute seizures with midazolam and diazepam in children]. ( Tang, RH; Zhou, JB, 2010) |
| "Our goal was to compare the efficacy and safety of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children." | 5.13 | Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. ( Byarugaba, J; Mpimbaza, A; Ndeezi, G; Rosenthal, PJ; Staedke, S, 2008) |
| " Randomized controlled/prospective randomized trials comparing IN midazolam against IV/rectal BDZ in the treatment of acute seizures in pediatric patients were included in the meta-analysis." | 5.12 | Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis. ( Chhabra, R; Gupta, LK; Gupta, R, 2021) |
| "The benzodiazepine midazolam (MDZ) is commonly used as first-line treatment in patients with acute seizures." | 5.12 | Clinical pharmacokinetic and pharmacodynamic profile of midazolam nasal spray. ( Bouw, MR; Chung, SS; Gidal, B; King, A; Tomasovic, J; Van Ess, PJ; Wheless, JW, 2021) |
| "To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures." | 5.12 | Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures. ( Manohar, R; Mittal, P; Rawat, AK, 2006) |
| "In 11/15 patients, seizures were abolished with the addition of midazolam." | 5.11 | Midazolam and amplitude-integrated EEG in asphyxiated full-term neonates. ( Bos, SA; de Vries, LS; Groenendaal, F; Rademaker, CM; Schobben, AF; Toet, MC; van Leuven, K, 2004) |
| "To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam." | 5.11 | Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005) |
| "Eighty-two episodes of status epilepticus or clusters of seizures in 45 children were treated with intravenous midazolam." | 5.10 | [Eight-year study on the treatment with intravenous midazolam for status epilepticus and clusters of seizures in children]. ( Minagawa, K; Watanabe, T, 2003) |
| " We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures." | 5.09 | Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999) |
| "To compare treatment of ongoing seizures using intramuscular (IM) midazolam versus intravenous (IV) diazepam." | 5.08 | A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. ( Altieri, MA; Chamberlain, JM; Futterman, C; Ochsenschlager, DW; Waisman, Y; Young, GM, 1997) |
| "Oromucosal midazolam (Buccolam™) is a benzodiazepine approved for the treatment of pediatric patients with acute, prolonged, convulsive seizures." | 4.88 | Oromucosal midazolam: a review of its use in pediatric patients with prolonged acute convulsive seizures. ( Garnock-Jones, KP, 2012) |
| "To discuss mainly the use of propofol and barbiturates in the anesthesia of refractory status epilepticus (RSE)." | 4.84 | Propofol and barbiturates for the anesthesia of refractory convulsive status epilepticus: pros and cons. ( Kälviäinen, R; Parviainen, I; Ruokonen, E, 2007) |
| "A short cut review was carried out to establish whether buccal midazolam is better than rectal diazepam for treating prolonged seizures in childhood and adolescence." | 4.82 | Best evidence topic report. Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence. ( Body, R; Ijaz, M, 2005) |
| "This cohort study assesses the effectiveness of midazolam treatment in terminating pediatric seizures in the prehospital setting." | 4.31 | Assessment of First-line Therapy With Midazolam for Prehospital Seizures in Children. ( Nov, S; Shavit, D; Shavit, I; Siman-Tov, M; Strugo, R, 2023) |
| " Severity of seizures were quantified for an hour and treated with midazolam (3 mg/kg, i." | 4.31 | Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy. ( Almanza, A; Bryant, E; Carlo, AM; Corson, BE; Gage, M; Kharate, M; Mafuta, C; Massey, N; Meyer, C; Ostrander, M; Rao, NS; Samidurai, M; Showman, L; Thippeswamy, T; Trevino, L; Vasanthi, SS; Wachter, L; Wang, C; Wohlgemuth, M, 2023) |
| " Driving advice was documented in 9 patients and Buccal midazolam (Buccalam) for rescue therapy for prolonged seizures was prescribed once." | 4.12 | Seizure management in a Model Three hospital: what does specialist neurology add? ( Bradley, M; Chalissery, A; Nursing, M; Tacheva, A, 2022) |
| "PS was characterized by 1) convulsive seizures shorter than 15 min, 2) seizures treatable with small doses of midazolam, and 3) autonomic symptoms." | 4.12 | Differentiating early clinical features of Panayiotopoulos syndrome from acute encephalopathy. ( Ishiguro, A; Kawakami, S; Kubota, M; Nagata, C; Terashima, H, 2022) |
| "The aim of this study was to review out-of-hospital use of intranasal diazepam and midazolam for treatment of acute repetitive seizures (ARS) at a typical adult epilepsy center." | 4.12 | Use of new intranasal benzodiazepines at a typical adult epilepsy center. ( Benbadis, SR; Li, C, 2022) |
| "Acute intoxication with tetramethylenedisulfotetramine (TETS) can trigger status epilepticus (SE) in humans." | 4.02 | Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus. ( Boosalis, CA; Bruun, DA; Calsbeek, JJ; Chaudhari, AJ; Garbow, JR; González, EA; Harvey, DJ; Lein, PJ; Rogawski, MA; Rowland, DJ; Saito, NH; Zolkowska, D, 2021) |
| "Midazolam delivered by continuous rate infusion (CRI) might be effective in dogs with cluster seizures (CS) or status epilepticus (SE)." | 4.02 | Continuous rate infusion of midazolam as emergent treatment for seizures in dogs. ( Bray, KY; Early, PJ; Mariani, CL; Muñana, KR; Olby, NJ, 2021) |
| "Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult." | 4.02 | Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021) |
| "To describe the epidemiology and outcomes of convulsive status epilepticus (CSE) since the introduction of buccal midazolam and the change in International League Against Epilepsy definition of CSE to include seizures of at least 5 minutes." | 4.02 | Epidemiology and outcome of status epilepticus in children: a Scottish population cohort study. ( Brand, C; Chatterton Dickson, L; Leonard, P; Mclellan, A; Mesalles-Naranjo, O; Mitchell, C; Ramsay, A; Shetty, J, 2021) |
| "Provide standards for basic epilepsy education and rescue medication (Midazolam) administration." | 4.02 | UK framework for basic epilepsy training and oromucosal midazolam administration. ( Bagary, M; Chisanga, E; Jory, C; Shankar, R; Tittensor, P; Tittensor, S, 2021) |
| "None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures." | 3.96 | Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats. ( Kubová, H; Kudová, E; Mareš, P; Valeš, K, 2020) |
| "The aims of this study were to evaluate the management of pediatric seizures carried out by parents or caregivers in an outpatient setting and to evaluate the differences in terms of immediate management and subsequent outcome when comparing the use of rectal diazepam versus buccal midazolam." | 3.91 | Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. ( Julliand, S; Moretti, R; Rinaldi, VE; Titomanlio, L, 2019) |
| " We have previously demonstrated a major inflammatory response with subsequent brain damage which was correlated with the duration of the sarin-induced seizures (Chapman et al." | 3.91 | Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: Suggested role of prostaglandins. ( Chapman, S; Egoz, I; Gez, R; Grauer, E; Lazar, S, 2019) |
| "The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram." | 3.91 | Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019) |
| "A previous European cost-utility study reported that use of buccal midazolam in the community setting for the treatment of prolonged seizures (ie, seizures lasting ≥5 minutes) in children was associated with an overall €12 507 399 reduction in annual costs charged to the Italian national health service compared with rectal diazepam." | 3.88 | Midazolam vs diazepam in prolonged seizures in children: A pharmacoeconomic approach. ( Beghi, E; Capovilla, G; Franzoni, E; Minicucci, F; Perucca, E; Romeo, A; Verrotti, A; Vigevano, F, 2018) |
| " This study aimed to analyze the effects of midazolam-induced BS on the occurrence outcomes in refractory status epilepticus patients." | 3.88 | Does burst-suppression achieve seizure control in refractory status epilepticus? ( Chisurajinda, S; Geater, A; Phabphal, K; Somboon, T; Unwongse, K, 2018) |
| "Midazolam is commonly used to treat refractory seizures in newborns and as a first-line anti-epileptic drug in children." | 3.88 | Midazolam as a first-line treatment for neonatal seizures: Retrospective study. ( Dao, K; Diezi, M; Giannoni, E; Lebon, S; Roulet-Perez, E, 2018) |
| "BACKGROUND Recurrent seizure in patients with magnesium sulfate-treated eclampsia is very rare and requires meticulous management due to poor prognosis." | 3.88 | Recurrent Seizures in 2 Patients with Magnesium Sulfate-Treated Eclampsia at a Secondary Hospital. ( Achmadi, A; Aldika Akbar, MI; Harsono, AAH; Joewono, HT, 2018) |
| "Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits." | 3.88 | Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam. ( de Araujo Furtado, M; Du, F; Kundrick, E; Lumley, LA; Marrero-Rosado, B; O'Brien, S; Schultz, CR; Stone, M; Walker, K, 2018) |
| " We hypothesized that publication of a pivotal pre-hospital clinical trial (RAMPART), demonstrating superiority of intramuscular midazolam over intravenous lorazepam, altered the national utilization rates of midazolam for pre-hospital benzodiazepine-treated seizures, while upholding its safety and efficacy outside the trial setting." | 3.85 | Pre-hospital midazolam for benzodiazepine-treated seizures before and after the Rapid Anticonvulsant Medication Prior to Arrival Trial: A national observational cohort study. ( Meurer, WJ; Shtull-Leber, E; Silbergleit, R, 2017) |
| " Acute seizures were treated with intranasal midazolam." | 3.83 | Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study. ( Heimans, JJ; Koekkoek, JA; Postma, TJ; Reijneveld, JC; Taphoorn, MJ, 2016) |
| "To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second- or third-line antiepileptic drug (AED) for neonatal seizures." | 3.83 | Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. ( Boylan, GB; de Vries, LS; Groenendaal, F; Hellström-Westas, L; Pressler, RM; Toet, MC; van den Broek, MP; van Rooij, LG; Weeke, LC, 2016) |
| " She went on to have several episodes of non-convulsive status epilepticus also with similar periodicity, which would abate only with midazolam infusion, without the need for ventilatory support." | 3.83 | A case of recurrent status epilepticus and successful management with progesterone. ( Arora, A; Dash, D; Malhotra, V; Mehta, S; Ramanujam, B; Tripathi, M, 2016) |
| "Intravenous diazepam has been a first-line therapy to stop seizures in children for many years." | 3.83 | Intranasal midazolam for seizure cessation in the community setting. ( Goldman, RD; Zelcer, M, 2016) |
| "Currently, evidence supports the use of intranasal midazolam as an effective, and in many cases, preferable treatment option for prolonged seizures in children." | 3.83 | Implementation of Intranasal Midazolam for Prolonged Seizures in a Child Neurology Practice. ( Crawford, D, 2016) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 3.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| "This study aims to explore carer perceptions of training in out-of-hospital use of buccal midazolam for emergency management of seizures." | 3.81 | Exploring carer perceptions of training in out-of-hospital use of buccal midazolam for emergency management of seizures (2008-2012). ( Beavis, E; Bye, AM; Connolly, AM; Lawson, JA; Mugica-Cox, B, 2015) |
| "Status epilepticus in children was characterized by heterogeneous etiology, prolonged duration and commonly good response to midazolam only given in high doses." | 3.81 | Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus. ( Djuric, M; Jankovic, B; Kravljanac, R; Pekmezovic, T, 2015) |
| "Inflammation was induced by injecting poly(I:C) (pIC 10 mg/kg, postnatal day 12-14), seizure was induced by injecting pilocarpine hydrochloride (PILO 200 mg/kg, postnatal day 15) into C57BL/6J mice, and the pIC+PILO mice were used as the iSE model (miSE)." | 3.81 | Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. ( Hirai, S; Morio, T; Nakajima, K; Okado, H, 2015) |
| "We identified 2 risk factors for apnea in children transported for seizure: seizure on arrival to the pediatric ED and out-of-hospital administration of midazolam." | 3.80 | Risk factors for apnea in pediatric patients transported by paramedics for out-of-hospital seizure. ( Bosson, N; Fang, A; Fernando, T; Gausche-Hill, M; Huang, M; Kaji, AH; Lee, J; Santillanes, G, 2014) |
| " In experiment 2, both emulsified isoflurane and midazolam significantly suppressed lidocaine-induced tonic-clonic seizures." | 3.80 | Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats. ( Chen, X; Huang, H; Liu, J; Wang, X; Zhang, W; Zhou, C, 2014) |
| "This baby developed persistent electroencephalographic seizures due to massive doses of phenobarbital and midazolam." | 3.80 | Exacerbation of benign familial neonatal epilepsy induced by massive doses of phenobarbital and midazolam. ( Hirose, S; Ihara, Y; Ishii, A; Izumi, T; Maeda, T; Sekiguchi, K; Shimizu, M, 2014) |
| " Magnesium sulfate (MGS) is used to suppress eclamptic seizures in pregnant women with hypertension and was shown to block kainate-induced convulsions." | 3.79 | Magnesium sulfate treatment against sarin poisoning: dissociation between overt convulsions and recorded cortical seizure activity. ( Bloch-Shilderman, E; Brandeis, R; Egoz, I; Grauer, E; Katalan, S; Lazar, S; Rabinovitz, I; Raveh, L, 2013) |
| "To evaluate the effects of pretreatment, midazolam (M), propofol (P), ziprasidone (Z), and two combinations of [(midazolam plus propofol (MP); midazolam plus ziprasidone (MZ)] in mice models in the prevention of seizures, and death due to acute cocaine toxicity." | 3.79 | Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model. ( Erdur, B; Ergin, A; Kortunay, S; Yuksel, A, 2013) |
| " To quantify effects of a loading dose of midazolam and lidocaine on the EEG frequency spectrum of full-term neonates with perinatal arterial ischemic stroke (PAIS), 11 full-term infants underwent multi-channel amplitude-integrated EEG (aEEG) and EEG recordings." | 3.78 | Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke. ( Andriessen, P; Dankers, F; de Vries, L; Janssen, F; Jennekens, W; Niemarkt, H; Toet, M; van der Aa, N; van Pul, C, 2012) |
| "Oromucosal midazolam (Buccolam™), a benzodiazepine, is approved in the EU for the treatment of paediatric patients (aged 3 months to <18 years) with acute, prolonged, convulsive seizures." | 3.78 | Oromucosal midazolam: a guide to its use in paediatric patients with prolonged acute convulsive seizures. ( Garnock-Jones, KP; Lyseng-Williamson, KA; Scott, LJ, 2012) |
| "The number of animals with seizures was lower in the etomidate (60%), phenytoin (40%), and phenytoin/midazolam (40%) groups (P<0." | 3.78 | Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity. ( Degirmenci, E; Erdur, B; Ergin, A; Kortunay, S; Seyit, M; Yuksel, A, 2012) |
| "A 13-month-old male who ingested 20 diphenhydramine (25 mg) tablets presented with seizures and ultimately progressed to status epilepticus and wide-complex tachycardia." | 3.77 | Survival after diphenhydramine ingestion with hemodialysis in a toddler. ( Hendrickson, RG; Horowitz, BZ; McKeown, NJ; West, PL, 2011) |
| " Initial electrocardiograms revealed sinus tachycardia at a rate of 180 beats per minute, a prolonged QRS of 130 milliseconds (from a baseline of 65 milliseconds), and a positive terminal R wave in aVR, which later resolved after sodium bicarbonate treatment." | 3.77 | Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate. ( Cole, JB; Gross, EA; Smith, SW; Stellpflug, SJ, 2011) |
| "This study compared the potencies of epidurally delivered muscimol, lidocaine, midazolam, pentobarbital and gamma-aminobutyric acid (GABA) to prevent focal neocortical seizures induced by locally applied acetylcholine (Ach), in rats (n=5)." | 3.76 | Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats. ( Baptiste, SL; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2010) |
| "Cocaine toxicity results in cardiovascular complications, seizures, and death and accounts for approximately 20% of drug-related emergency department visits every year." | 3.75 | A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. ( Baladi, MG; Cooper, ZD; Jutkiewicz, EM; Narasimhan, D; Sunahara, RK; Woods, JH, 2009) |
| "This study evaluated the anticonvulsant effectiveness of midazolam to stop seizures elicited by the nerve agent soman when midazolam was administered by different routes (intramuscular, intranasal or sublingual) at one of two different times after the onset of seizure activity." | 3.75 | Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures. ( LaMont, JC; McDonough, JH; McMonagle, JD; Shih, TM; Van Shura, KE, 2009) |
| "In a previous study, the efficacy and safety of buccal midazolam was compared to that of rectal diazepam in the treatment of prolonged seizures in children aged three months to 12 years in Kampala, Uganda." | 3.75 | Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. ( Byarugaba, J; Mpimbaza, A; Ndeezi, G; Rosenthal, PJ; Staedke, SG, 2009) |
| "Two guinea pig models were used to study the anticonvulsant potency of diazepam, midazolam, and scopolamine against seizures induced by the nerve agents tabun, sarin, soman, cyclosarin, O-ethyl S-(2-(diisopropylamino)ethyl)methylphosphonothioate (VX), and O-isobutyl S-(2-diethylamino)ethyl)-methyl phosphonothioate (VR)." | 3.74 | Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine. ( McDonough, JH; Rowland, TC; Shih, TM, 2007) |
| "The IN-MAD midazolam controlled seizures better than PR diazepam in the prehospital setting and resulted in fewer respiratory complications and fewer admissions." | 3.74 | Prehospital intranasal midazolam for the treatment of pediatric seizures. ( Filloux, FM; Firth, SD; Furnival, RA; Holsti, M; Joyce, SM; Sill, BL, 2007) |
| " Intra-arterial verapamil was started; during this treatment, the patient developed right-sided focal motor seizures." | 3.74 | Intra-arterial verapamil-induced seizures: case report and review of the literature. ( Nwagwu, CI; Westhout, FD, 2007) |
| "Sevoflurane-induced seizures are most often described during mask induction of anesthesia when high concentrations of the volatile agent are administered concomitant with alveolar hyperventilation." | 3.74 | Repetitive generalized seizure-like activity during emergence from sevoflurane anesthesia. ( Iqbal, Z; Kumar, V; Markan, S; Mohanram, A; Pagel, PS, 2007) |
| "We report a case of citalopram poisoning in a 10-month-old infant with refractory seizures, and an absence of cardiovascular events with subsequent excellent outcome." | 3.73 | Clinical course and toxicokinetic data following isolated citalopram overdose in an infant. ( Baker, SD; Bose, S; Levsky, M; Masullo, LN; Miller, MA, 2006) |
| "Until a few years ago, rectal diazepam (RD) was the only option available to parents and carers managing prolonged seizures." | 3.73 | Community use of intranasal midazolam for managing prolonged seizures. ( Coulthard, K; Harbord, M; Kay, D; Kyrkou, M; Kyrkou, N, 2006) |
| "Buccal midazolam is effective and safe in the treatment of prolonged seizures and has the advantage of being a convenient and socially acceptable administration form." | 3.73 | [Prolonged convulsions treated with buccal midazolam in a setting of mentally retarded patients with refractory epilepsy]. ( Batista, D; Bausà, T; Elias, C; Font, D; Hijano, A; Melendez, R; Rocha, A, 2006) |
| "A telephone survey was carried out to evaluate the effectiveness and convenience of nasal/buccal midazolam in terminating prolonged seizures in the community." | 3.72 | Nasal/buccal midazolam use in the community. ( Macleod, S; O'Regan, ME; Wilson, MT, 2004) |
| " This report presents three infants treated with midazolam for status epilepticus and repetitive seizures who proved resistant to other anticonvulsants (phenobarbitone, lidocaine)." | 3.72 | Burst suppression on amplitude-integrated electroencephalogram may be induced by midazolam: a report on three cases. ( Bos, AF; Brouwer, OF; ter Horst, HJ, 2004) |
| "To determine which is the most effective and safe treatment for controlling seizures in children out-of-hospital: diazepam or midazolam." | 3.71 | Controlling seizures in the prehospital setting: diazepam or midazolam? ( Browne, GJ; Lam, LT; Rainbow, J, 2002) |
| ") administration of a non-selective full benzodiazepine receptor agonist, midazolam, and a neuroactive steroid, allopregnanolone, on picrotoxin-induced seizures and striatal dopamine metabolism, were studied in mice." | 3.71 | Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures. ( Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J, 2001) |
| "The effects of allopregnanolone and midazolam, given intracerebroventricularly, on the behavioral and biochemical effects of picrotoxin, were examined in a model of neurotoxin-induced seizures, in mice." | 3.71 | Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam. ( Bidziński, A; Członkowska, AI; Kostowski, W; Krzaścik, P; Maciejak, P; Plaznik, A; Szyndler, J; Walkowiak, J, 2002) |
| "This case report describes an uncommon complication (blindness) occurring after an inadvertent overdosage of a frequently used local anesthetic (lidocaine) during a regional anesthetic procedure." | 3.71 | Temporary bilateral blindness after acute lidocaine toxicity. ( Sawyer, RJ; von Schroeder, H, 2002) |
| "Kainic acid (KA) causes seizures and extensive brain damage in rats." | 3.70 | Kainic acid causes redox changes in cerebral cortex extracellular fluid: NMDA receptor activity increases ascorbic acid whereas seizure activity increases uric acid. ( Layton, ME; Pazdernik, TL; Samson, FE, 1998) |
| "In order to determine the efficiency of intranasal midazolam in prolonged convulsive episodes, we conducted a prospective study in children with various types of seizures." | 3.70 | Intranasal midazolam for prolonged convulsive seizures. ( Dogrul, M; Durmaz, Y; Kutlu, NO; Yakinci, C, 2000) |
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 3.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 3.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "The anticonvulsant effects and duration of protective action of midazolam against Metrazol induced seizures were studied in 528 rats aged 7,12,18,25 and 90 days." | 3.68 | The effect of ontogenetic development on the anticonvulsant activity of midazolam. ( Kubová, H; Mares, P, 1992) |
| "The cholinergic agonist pilocarpine triggers sustained limbic seizures in rodents." | 3.68 | Substantia nigra regulates action of antiepileptic drugs. ( Andrews, JS; Bortolotto, ZA; Bressler, K; Calderazzo-Filho, LS; Cavalheiro, EA; Löschmann, PA; Turski, L, 1990) |
| "Midazolam meleate, a water soluble 1,4 benzodiazepine, was used intravenously in 20 patients suffering seizures, of whom 12 were in status epilepticus." | 3.67 | Midazolam: an effective intravenous agent for seizure control. ( Galvin, GM; Jelinek, GA, 1987) |
| "A second dose could be given if seizures did not terminate within 10 min or recurred from 10 min to 6 h." | 3.30 | Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial. ( Brunnert, M; Campos, R; Chen, L; Fakhoury, T; Meng, TC; Pullman, WE; Szaflarski, JP; Van Ess, P, 2023) |
| "Despite new antiseizure medications, the development of cholinergic-induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops." | 3.01 | Treatment of cholinergic-induced status epilepticus with polytherapy targeting GABA and glutamate receptors. ( de Araujo Furtado, M; Lumley, L; Nguyen, D; Niquet, J, 2023) |
| "5%) discontinued because of a treatment-emergent adverse event (TEAE) during the TDP and none during the CP." | 2.90 | Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters-a randomized, double-blind, placebo-controlled trial. ( Detyniecki, K; Meng, TC; Pullman, WE; Sequeira, DJ; Van Ess, PJ; Wheless, JW, 2019) |
| " Patients were monitored for treatment-emergent adverse events (TEAEs) throughout, and the main seizure-related outcome was treatment success, defined as seizure termination within 10 minutes and no recurrence 10 minutes-6 hours after drug administration." | 2.90 | Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters: An open-label extension trial. ( Detyniecki, K; Meng, TC; Pullman, WE; Sequeira, DJ; Van Ess, PJ; Wheless, JW, 2019) |
| "Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings." | 2.82 | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability. ( Beuchat, I; Gelhard, S; Kay, L; Kienitz, R; Lucaciu, A; Mann, C; Rosenow, F; Schäfer, JH; Schubert-Bast, S; Siebenbrodt, K; Strzelczyk, A; von Brauchitsch, S; Willems, LM; Zöllner, JP, 2022) |
| "The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus." | 2.82 | Rescue therapies for seizure clusters: Pharmacology and target of treatments. ( Detyniecki, K; Gidal, B, 2022) |
| "Diazepam rectal gel is an effective rescue therapy for seizure clusters, though adults and adolescents may have social reservations regarding its administration." | 2.82 | Rescue Treatments for Seizure Clusters. ( Gidal, BE; Kotloski, RJ, 2022) |
| "We aimed to inquire whether any seizure rescue medications are included in the in-flight medical emergency kits of the main airlines in the world." | 2.82 | Seizure rescue medications are missing from in-flight medical emergency kits. ( Asadi-Pooya, AA; Hosseini, SA, 2022) |
| "For diazepam group it was 84." | 2.77 | Intravenous diazepam, midazolam and lorazepam in acute seizure control. ( Gathwala, G; Goel, M; Mittal, K; Singh, J, 2012) |
| "Partial seizures, generalized tonic, clonic and tonic-clonic convulsions were included irrespective of duration or cause." | 2.74 | Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial. ( Chakrabarty, B; Talukdar, B, 2009) |
| "Propofol was administered until the patients did not respond to a verbal command." | 2.74 | Premedication with dexmedetomidine and midazolam attenuates agitation after electroconvulsive therapy. ( Bulut, M; Ganidagli, S; Koruk, S; Mizrak, A; Oner, U, 2009) |
| " Plasma concentration-time data were fitted using pharmacokinetic models." | 2.73 | Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions. ( Edwards, G; Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Ward, SA, 2008) |
| "Some reports suggest that seizures themselves may have a deleterious effect on long-term neurological outcome." | 2.73 | Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures. ( Benzaqen, O; Shany, E; Watemberg, N, 2007) |
| "Midazolam is a relatively new anticonvulsive agent in the benzodiazepine group." | 2.71 | Buccal midazolam for treatment of prolonged seizures in children. ( Dogrul, M; Kutlu, NO; Soylu, H; Yakinci, C, 2003) |
| "In the diazepam group, the seizures of 13 (60%) patients terminated in 10 minutes; however, 9 (40%) patients did not respond." | 2.70 | Effects of intranasal midazolam and rectal diazepam on acute convulsions in children: prospective randomized study. ( Akgün, D; Fişgin, T; Gurer, Y; Okuyaz, C; Senbil, N; Teziç, T; Zorlu, P, 2002) |
| "Midazolam was then administered by continuous intravenous infusion (0." | 2.68 | Midazolam in the treatment of refractory neonatal seizures. ( Bodensteiner, JB; Buckley, DJ; Gingold, M; Gutierrez, AR; Penney, S; Sheth, RD, 1996) |
| "Midazolam is a recently developed water-soluble benzodiazepine that shares anxiolytic, muscle relaxant, hypnotic and anticonvulsant actions with other members of this class." | 2.68 | Midazolam in treatment of various types of seizures in children. ( Durmaz, Y; Karabiber, H; Müngen, B; Sahin, S; Yakinci, C, 1997) |
| "Controlling seizures in children approaching death can be difficult, and there is a limited evidence base to guide best practice." | 2.66 | Seizure management in children requiring palliative care: a review of current practice. ( Baba, M; Beringer, A; Harris, N; Mellor, C; Rogers, R; Sharples, P; Taylor, K, 2020) |
| "Neonatal seizures constitute the most frequent presenting neurologic sign encountered in the neonatal intensive care unit." | 2.55 | The use of phenobarbital and other anti-seizure drugs in newborns. ( El-Dib, M; Soul, JS, 2017) |
| "Most seizure emergencies occur outside of the hospital, and there is a need for treatment interventions that can be administered quickly and safely by nonclinical caregivers." | 2.52 | Intranasal therapies for acute seizures. ( Kälviäinen, R, 2015) |
| "Thirty minutes of seizure activity is usually the time period used in longstanding definitions of CSE but it is not acceptable to wait for 30 minutes before treatment." | 2.50 | What are the best ways to deliver benzodiazepines in children/patients with prolonged convulsive seizures? ( Chin, RF, 2014) |
| "Current therapeutic options to treat neonatal seizures (i." | 2.49 | Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013) |
| "Once SE is controlled, prevention of seizure recurrence should be individualized to each patient." | 2.40 | Management approaches to prolonged seizures and status epilepticus. ( Bleck, TP, 1999) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| "We included 361 177 encounters for seizure." | 1.91 | Prehospital Seizure Management in Children: An Evaluation of a Nationally Representative Sample. ( Martin-Gill, C; Ramgopal, S, 2023) |
| "Midazolam-treated rats had significant neuronal degeneration in limbic structures, mainly at one month postexposure, followed by neuronal loss in the basolateral amygdala and the CA1 hippocampal area." | 1.91 | Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Rossetti, K, 2023) |
| "Of 147,821 pediatric calls for seizures, 88% received ALS responses." | 1.91 | National Variation in EMS Response and Antiepileptic Medication Administration for Children with Seizures in the Prehospital Setting. ( Dayan, PS; Firnberg, MT; Lerner, EB; Ma, CX; Mann, NC; Nan, N; Shah, MI, 2023) |
| "Midazolam was the first medication administered in 87/100 (87%) instances, mean dose of 0." | 1.72 | Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus. ( Babl, FE; Borland, ML; Dalziel, SR; Emeto, TI; Furyk, JS; George, S; Hearps, SJ; O'Brien, S; Phillips, N; Riney, K; Watt, K; Wilson, C, 2022) |
| "All deceased patients experienced generalized convulsive status epilepticus and failure of anesthetic tapering-off, significantly higher than survivors." | 1.72 | Factors associated with mortality in patients with super-refractory status epilepticus. ( Chien, ME; Fang, YT; Hsu, KS; Huang, CW; Lee, TL; Lin, SH; Tu, YH; Wu, YJ, 2022) |
| " There was a wide variability with respect to dosing ranges for medications." | 1.62 | Variation in Prehospital Protocols for Pediatric Seizure Within the United States. ( Martin-Gill, C; McCans, K; Owusu-Ansah, S; Ramgopal, S, 2021) |
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 1.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| " The team created an automated monthly report to monitor prescribed seizure rescue medication dosing compliance." | 1.56 | Using quality improvement to implement the CNS/AAN quality measure on rescue medication for seizures. ( Cohen, DM; Debs, A; Gibson, A; Herbst, J; Karn, M; Parker, W; Patel, AD; Terry, D; Yarosz, S, 2020) |
| "At discharge, all survivors were seizure free." | 1.51 | Treatment options in pediatric super-refractory status epilepticus. ( Arayakarnkul, P; Chomtho, K, 2019) |
| "Seizures were aborted in 36 (72%) users in the INM group; of the rest of 14 children, 4 (8%) used it for the second time." | 1.51 | Impact of prescribing intranasal midazolam as rescue medication for domiciliary management of acute seizure among children with epilepsy. ( Behgal, J; Bhardwaj, H; Kaushik, JS; Lather, T, 2019) |
| "Rapid control of seizure activity is important to minimize neuronal injury and the resulting neurological and behavioral disorders; however, early treatment will not be possible after mass release of OPs or NAs." | 1.51 | Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure. ( Bealer, SL; Dudek, FE; Pouliot, W; Roach, B; Spampanato, J, 2019) |
| "Cessation of seizure was achieved in 85% of the adults and in 97% of the children, if all options of the MTAS-EMS were used." | 1.51 | Treatment of Seizures in Children and Adults in the Emergency Medical System of the City of Zurich, Switzerland - Midazolam vs. Diazepam - A Retrospective Analysis. ( Baulig, W; Dette-Oltmann, K; Mariotti, S; Schenk, P; Theusinger, OM, 2019) |
| " These data are important for informing adult and pediatric dosing recommendations for NA-induced seizures." | 1.51 | Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats. ( Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K, 2019) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 1.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults." | 1.46 | Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report. ( Arı, ME; Ekici, F, 2017) |
| "• For seizures with duration of more than 5 min, the administration of anticonvulsive rescue medication is recommended." | 1.43 | Administration of anticonvulsive rescue medication in children-discrepancies between parents' self-reports and limited practical performance. ( Bernhard, MK; Bertsche, A; Bertsche, T; Frontini, R; Hoppe, SC; Kaune, A; Kiess, W; Merkenschlager, A; Neininger, MP; Schumacher, PM; Syrbe, S, 2016) |
| "The objective was to evaluate the anticonvulsant effectiveness and hemodynamic safety of midazolam in hypothermic newborns and to provide dosing guidance." | 1.42 | Anticonvulsant effectiveness and hemodynamic safety of midazolam in full-term infants treated with hypothermia. ( de Vries, LS; Egberts, T; Groenendaal, F; Huitema, AD; Rademaker, K; Toet, MC; van den Broek, MP; van Straaten, HL, 2015) |
| "Midazolam is a benzodiazepine anticonvulsant with rapid onset and short duration of action." | 1.42 | Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors. ( Clossen, BL; Reddy, DS; Reddy, SD; Younus, I, 2015) |
| "The seizures were unresponsive to bolus midazolam, phenytoin infusion and levetiracetam infusion." | 1.42 | A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature. ( Çelik, T; Çelik, Ü; Gezgin, AE; Kaya, MS; Kömür, M; Tolunay, O, 2015) |
| "The control index seizure was the preceding, alternatively the next successive seizure without application of in-MDZ." | 1.42 | Intranasal midazolam during presurgical epilepsy monitoring is well tolerated, delays seizure recurrence, and protects from generalized tonic-clonic seizures. ( Bauer, S; Belke, M; Fründ, D; Kay, L; Knake, S; Reif, PS; Rosenow, F; Strzelczyk, A, 2015) |
| "In patients with high-grade glioma seizures occur relatively frequently during the end-of-life phase." | 1.40 | [Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase]. ( Boddaert, MS; Koekkoek, JA; Taphoorn, M, 2014) |
| "In midazolam (10 mg/kg) treated rats, clonic seizures were observed 25 min after drug administration and the number of rats exhibiting clonic seizures was highest within 40 min." | 1.40 | Comparison between the effect of propofol and midazolam on picrotoxin-induced convulsions in rat. ( Abdel Razzak, RL; Alzoubi, KH; Hasan, ZA, 2014) |
| "She was seizure-free after the surgery." | 1.40 | Peri-ictal headache due to epileptiform activity in a disconnected hemisphere. ( Delalande, O; Dvorak, J; Jahodova, A; Komarek, V; Kršek, P; Kyncl, M; Tichy, M; Vydrova, R, 2014) |
| "Midazolam proved to be a safe drug." | 1.39 | Higher mortality rate is associated with advanced age and periodic lateralized epileptiform discharges in patients with refractory status epilepticus. ( Garzon, E; Liberalesso, PB; Sakamoto, AC; Yacubian, EM, 2013) |
| "Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together." | 1.39 | Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. ( Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM, 2013) |
| "In children, convulsive seizures lasting-more than 5 minutes constitute a life-threatening condition." | 1.39 | Midazolam oral transmucosal route. An alternative to rectal diazepam for some children. ( , 2013) |
| "In animal convulsion models, some anticonvulsants have been found to suppress oxidative reactions associated with convulsions." | 1.38 | Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. ( Arai, Y; Higuchi, H; Maeda, S; Miyawaki, T; Shimada, M; Tomoyasu, Y, 2012) |
| "Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
| " For each drug treatment in each brain area, anticonvulsant ED₅₀ values were calculated using an up-down dosing procedure over successive animals." | 1.38 | Neuropharmacological specificity of brain structures involved in soman-induced seizures. ( McDonough, JH; Shih, TM; Skovira, JW, 2012) |
| "To assess the effects of lipid on ropivacaine-induced convulsion and LD50 in rats and compare with those of the traditional anticonvulsants midazolam and propofol." | 1.38 | [Effects of pretreatment of lipid, midazolam and propofol on ropivacaine-induced convulsion and LD50 in rats]. ( Lü, XL; Wan, FH; Zuo, YX, 2012) |
| "The severity of DFP-induced ECoG seizures was assessed by continuous radio telemetry recordings in unrestrained and freely moving rats." | 1.37 | Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology. ( Auta, J; Costa, E; Davis, JM; Guidotti, A; Kadriu, B, 2011) |
| " Since midazolam is frequently used in neonates for sedation during various examinations, future investigations on the selection of appropriate drugs and dosage for sedation in neonates, including the usage of midazolam, are necessary." | 1.37 | [Paroxysmal automatic movements mimicking neonatal seizures induced by midazolam]. ( Arakaki, Y; Ishizaki, Y; Mimaki, N; Ohtsuka, Y; Watabe, S, 2011) |
| " Anticonvulsant effective doses (ED(50)) were determined using an up-down dosing procedure over successive animals." | 1.36 | Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. ( McDonough, JH; Shih, TM; Skovira, JW, 2010) |
| "shortening seizure latency and inducing a more profound increase of NO production than PTZ in all brain structures." | 1.36 | Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures. ( Bjelaković, G; Jelenković, A; Jevtović-Stoimenov, T; Pavlović, D; Stevanović, I; Stojanović, I, 2010) |
| "We hypothesized that seizures, during limited substrate availability, aggravate hypoglycemia-induced brain damage." | 1.34 | Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction. ( Abdelmalik, PA; Adamchik, Y; Burnham, WM; Carlen, PL; Liang, P; Samoilova, M; Shannon, P; Weisspapir, M; Yiu, A, 2007) |
| "Effective and quick management of these seizures is critical." | 1.33 | Efficacy of the ketamine-atropine combination in the delayed treatment of soman-induced status epilepticus. ( Baubichon, D; Bernabé, D; Burckhart, MF; Carpentier, P; Dorandeu, F; Four, E; Lallement, G, 2005) |
| "Diazepam was administered as the first-line drug on 157 of 177 occasions (88." | 1.33 | [Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children]. ( Eto, Y; Hamano, S; Hayakawa, M; Kikuchi, K; Minamitani, M; Sugiyama, N; Tanaka, M; Yamashita, S; Yoshinari, S, 2005) |
| "Centrally mediated seizures and convulsions are common consequences of exposure to organophosphates (OPs)." | 1.33 | Anticonvulsant treatment of sarin-induced seizures with nasal midazolam: an electrographic, behavioral, and histological study in freely moving rats. ( Brandeis, R; Cohen, G; Gilat, E; Kadar, T; Kapon, Y; Levy, A; Rabinovitz, I; Sahar, R, 2005) |
| "Centrally mediated seizures are a common consequence of exposure to organophosphates (OP) despite conventional treatment with atropine and an oxime." | 1.33 | Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain. ( Chapman, S; Gilat, E; Kadar, T, 2006) |
| "Midazolam was administered to 22 patients by intravenous bolus injection (0." | 1.33 | [Etiology and management of neonatal seizures--successful treatment by midazolam]. ( Imataka, G; Kawaguchi, N; Suzumura, H; Yamanouchi, H, 2006) |
| "Hypertension was present in all groups during anaesthesia with mean (+/- SD) systolic pressure of 30." | 1.33 | Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus). ( Jago, M; Stegmann, GF, 2006) |
| "Treatment with midazolam (1 mg/kg i." | 1.32 | Nasal midazolam as a novel anticonvulsive treatment against organophosphate-induced seizure activity in the guinea pig. ( Alkalai, D; Amitai, G; Brandeis, R; Cohen, G; Eshel, G; Gilat, E; Goldman, M; Lahat, E; Levy, A; Rabinovitz, I, 2003) |
| "The seizures were initially treated with midazolam i." | 1.32 | Postoperative pseudoepileptic seizures in a known epileptic: complications in recovery. ( Chambers, N; Ng, L, 2003) |
| " The mean time-plasma concentration data were fit to standard pharmacokinetic models." | 1.32 | Pharmacokinetic studies of intramuscular midazolam in guinea pigs challenged with soman. ( Byers, CE; Capacio, BR; McDonough, JH; Merk, KA; Smith, JR, 2004) |
| "There was no previous history of seizures." | 1.31 | Bilateral frontal haemorrhages associated with continuous spinal analgesia. ( Buist, M; Burnes, J; Crofts, TR; Monagle, J, 2001) |
| "While occasional myoclonic jerks are prevalent in cancer patients receiving opioids, severe myoclonic jerks and seizures due to opioids are uncommon." | 1.30 | Strychnine-like multifocal myoclonus and seizures in extremely high-dose opioid administration: treatment strategies. ( Hagen, N; Swanson, R, 1997) |
| "Generalized tonic-clonic seizures were suppressed in all age groups, the three youngest groups being more sensitive than older animals." | 1.30 | The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats. ( Haugvicová, R; Kubová, H; Mares, P; Mikulecká, A, 1999) |
| "Midazolam was able to reduce spike-and-wave activity in all three models, but there were quantitative differences: the lower dose was effective only against rhythmic metrazol activity, but its action against two other models was negligible, whereas the higher dose of midazolam resulted in significant effects in all three models." | 1.30 | Midazolam suppresses spike-and-wave rhythm accompanying three different models of epileptic seizures. ( Kubová, H; Mares, P; Mocková, M, 1999) |
| "Rats treated with diazepam for 3 weeks were tolerant to diazepam, clonazepam, clobazam, and midazolam." | 1.29 | Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam. ( Ramsey-Williams, VA; Rosenberg, HC; Wu, Y, 1994) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 1.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "The behavioral pattern of convulsion produced by pentylenetetrazol was similar to that produced by systemic administration of BW373U86." | 1.29 | Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice. ( Chang, KJ; Comer, SD; De Costa, BR; Hoenicke, EM; McNutt, RW; Mosberg, HI; Sable, AI; Woods, JH, 1993) |
| "Zolpidem is a new, short-acting hypnotic of imidazopyridine structure which binds selectively to a subpopulation of receptors involved in the action of benzodiazepines [omega 1 (BZ1) sites of the gamma-aminobutyric acidA receptors]." | 1.28 | Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1992) |
| "Midazolam was replaced by saline in the other 12." | 1.28 | Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog. ( Askenasi, R; Leduc, D; Lheureux, P; Vranckx, M, 1992) |
| "Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
| "While epinephrine enhanced lidocaine seizure activity and lethality by approximately 50%, midazolam almost completely prevented lidocaine-induced convulsions but had no significant effect on mortality." | 1.28 | Effect of midazolam pretreatment on the intravenous toxicity of lidocaine with and without epinephrine in rats. ( Mito, RS; Torbiner, ML; Yagiela, JA, 1989) |
| "Pretreatment with atropine alone did not prevent paraoxon-induced seizures but did reduce mortality." | 1.27 | Comparative effects of diazepam and midazolam on paraoxon toxicity in rats. ( Domino, EF; Krutak-Krol, H, 1985) |
| "CSH (200 mg/kg, i." | 1.27 | Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures. ( Cottrell, GA; Robertson, HA, 1987) |
| "Etidocaine and bupivacaine convulsions were more difficult to suppress than those induced by lidocaine." | 1.26 | Benzodiazepines protect mice from local anesthetic convulsions and deaths. ( Bonin, JD; de Jong, RH, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (4.00) | 18.7374 |
| 1990's | 35 (14.00) | 18.2507 |
| 2000's | 60 (24.00) | 29.6817 |
| 2010's | 94 (37.60) | 24.3611 |
| 2020's | 51 (20.40) | 2.80 |
| Authors | Studies |
|---|---|
| Calsbeek, JJ | 1 |
| González, EA | 2 |
| Boosalis, CA | 1 |
| Zolkowska, D | 2 |
| Bruun, DA | 2 |
| Rowland, DJ | 2 |
| Saito, NH | 1 |
| Harvey, DJ | 2 |
| Chaudhari, AJ | 1 |
| Rogawski, MA | 3 |
| Garbow, JR | 1 |
| Lein, PJ | 3 |
| Chhabra, R | 2 |
| Gupta, R | 2 |
| Gupta, LK | 2 |
| Bradley, M | 1 |
| Nursing, M | 1 |
| Tacheva, A | 1 |
| Chalissery, A | 1 |
| Cruickshank, M | 1 |
| Imamura, M | 1 |
| Counsell, C | 1 |
| Aucott, L | 1 |
| Manson, P | 1 |
| Booth, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label Safety Study of USL261 in the Outpatient Treatment of Subjects With Seizure Clusters[NCT01529034] | Phase 3 | 175 participants (Actual) | Interventional | 2012-07-31 | Terminated | ||
| A Randomized, Double-Blind, Placebo Controlled Trial Examining the Safety and Efficacy of Midazolam Intranasal Spray (USL261) for the Treatment of Intermittent Bouts of Increased Seizure Activity in the Epilepsy Monitoring Unit (EMU)[NCT01999777] | Phase 3 | 62 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| A Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of Intranasal Midazolam (USL261) in the Outpatient Treatment of Subjects With Seizure Clusters. ARTEMIS-1: Acute Rescue Therapy in Epilepsy With Midazolam Intranasal Spray-1[NCT01390220] | Phase 3 | 292 participants (Actual) | Interventional | 2011-06-30 | Terminated | ||
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Duration of participant study participation for collection of long term safety data (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | months (Median) |
|---|---|
| USL261 | 16.80 |
Participants requiring emergency room (ER)/emergency medical service (EMS) visit within 24 hours after any USL261 treated seizure cluster (including for continued seizures) (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | Participants (Count of Participants) |
|---|---|
| USL261 | 20 |
Number of Treated Seizure Clusters Meeting Criteria for Treatment Success: Termination of seizure(s) within 10 minutes and no recurrence within 6 hours after administration of first dose of USL261 (intranasal midazolam 5 mg) (NCT01529034)
Timeframe: 6 hours after first dose of USL261 for each treated seizure cluster
| Intervention | Seizure cluster episodes (Count of Units) |
|---|---|
| USL261 | 1108 |
Change in participant Brief Smell Identification Test (B-SIT) score from baseline to last visit with assessment. The B-SIT is a self-administered 12-item test; the score indicates odors correctly identified (0 to 12). The B-SIT was added while the study was already ongoing (Protocol Amendment 4, 20 May 2015) in response to a regulatory request. The test was only implemented at sites in the United States and included only participants considered by the investigator to have adequate cognitive ability to perform the test. Baseline was defined as the latest non-missing value prior to administration of USL261 in the Test Dose Phase of Study P261-401. (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | score on a scale (Mean) |
|---|---|
| USL261 | -0.6 |
Participants with abnormal findings, at any time post baseline, on nasal examination considered clinically significant by the investigator (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | Participants (Count of Participants) |
|---|---|
| USL261 | 1 |
Participants meeting predefined safety criteria for vital signs (systolic blood pressure [SBP] <85 mm Hg, SBP change from baseline >/= 40 mm Hg, diastolic BP [DBP] <50 mm Hg, DBP change from baseline >/=30 mm Hg, pulse rate <50 beats per minute (bpm), pulse rate >120 bpm, pulse rate change >/= 40 bpm at any visit post baseline or for caregiver recorded participant respiration rate [RR] <8 breaths per minute (brpm) or >24 brpm) after any USL261 treated seizure cluster episode. Abnormal vital signs were assessed separately by investigator and recorded as adverse events if applicable. (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | Participants (Count of Participants) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SBP <85 mm Hg | SBP change from baseline ≥ 40 mm Hg | DBP <50 mm Hg | DBP change from baseline ≥ 30 mm Hg | Pulse rate <50 bpm | Pulse rate >120 bpm | Pulse rate change from baseline >/= 40 bpm | Caregiver recorded RR <8 brpm | Caregiver recorded RR >24 brpm | |
| USL261 | 0 | 1 | 2 | 3 | 2 | 1 | 4 | 1 | 29 |
Participants with abnormal findings, at any time post baseline, on neurologic examination considered clinically significant by the investigator (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | Participants (Count of Participants) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mental status | Cranial nerves II-XII | Motor strength of limbs | Deep tendon reflexes | Sensory exam | Station and gait | Hopping | Romberg test | Finger-to-nose test | Heel-to-shin test | Rapid alternating movements | Nystagmus | Tremor/Other abnormal movements | |
| USL261 | 10 | 1 | 2 | 2 | 1 | 5 | 0 | 0 | 1 | 1 | 2 | 0 | 0 |
Participants with abnormal findings, at any time post baseline, on physical examination considered clinically significant by the investigator. (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | Participants (Count of Participants) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Skin | Head/Eyes/Ears/Nose/Throat | Neck | Thyroid | Lungs | Heart | Abdomen | Lymph nodes | Extremities | |
| USL261 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Participants with abnormal laboratory finding, at any time post baseline, meeting predefined criteria. Abnormal laboratory findings were assessed separately by investigator and recorded as adverse events if applicable. Alanine aminotransferase (ALT); Alkaline phosphatase (ALP); Aspartate aminotransferase (AST); Gamma glutamyl transferase (GGT); upper limit of normal (ULN) (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | Participants (Count of Participants) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ALT >ULN & ≤3xULN | Albumin <30 g/L | ALP >2.5xULN | AST >ULN & ≤3xULN | AST >5x ULN & <20xULN | Bicarbonate <15.9 mmol/L | Cholesterol >7.75 mmol/L | Creatinine >1.5xULN | Creatinine >2x baseline | GGT >2.5xULN | Glucose <3 mmol/L | Glucose <8.9 mmol/L | Phosphate <0.8 mmol/L | Potassium >5.5 mmol/L | Sodium <130 mmol/L | Sodium >150 mmol/L | Hemoglobin <100 g/L | Hemoglobin decrease 20 g/L | Leukocytes <3x10^9/L | Lymphocytes <0.8x10^9/L | Neutrophils <1.5x10^9/L | |
| USL261 | 26 | 2 | 1 | 17 | 1 | 6 | 5 | 1 | 2 | 14 | 3 | 5 | 13 | 5 | 11 | 1 | 5 | 10 | 4 | 4 | 8 |
Participants with suicidal ideation reported on Columbia-Suicide Severity Rating Scale (C-SSRS) questionnaire at any post-baseline visit. Responses including: Wish to be Dead; Non-Specific Active Suicidal Thoughts; Active Suicidal Ideation with Some Intent to Act, without Specific Plan; Active Suicidal Ideation with Specific Plan and Intent; and Any Suicidal Ideation Regardless of Type. (NCT01529034)
Timeframe: From Baseline/(Screening) to End of Safety-Follow-up (up to 56 months) as per assessment table of the study.
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| Wish to be dead | Non-specific active | Active without specific plan | Active with specific plan/intent | Any suicidal ideation | |
| USL261 | 3 | 3 | 3 | 1 | 4 |
"A participant was considered seizure-free if he or she completed the 6-hour Treatment Phase without seizures recorded, premature discontinuation of study drug, rescue intervention for acute central respiratory depression adverse event (AE), and alterations to background anti-epileptic drug (AED) therapy. Otherwise, the participant was included in the analysis for seizure-free events with the outcome of seizure." (NCT01999777)
Timeframe: 6 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| USL261 | 17 |
| Placebo | 12 |
Time to first seizure following treatment was defined as time from treatment with study drug to the onset of the next seizure, rescue intervention (for acute central respiratory depression AE) to maintain subject safety, alterations to background AED therapy, early termination, or 6 hours, whichever came first. (NCT01999777)
Timeframe: 6 hours
| Intervention | hours (Median) |
|---|---|
| USL261 | NA |
| Placebo | 3.9 |
Occurrence of next seizure with a start time >10 minutes and up to 24 hours after administration of the double-blind dose in the CP. Participants who did not have another seizure before the end of the 24-hour observation period were censored at the end of the observation period. Participants administered the open-label second dose who did not have a seizure were censored at the time of the administration. (NCT01390220)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| USL261 CP | 50 |
| Placebo CP | 31 |
Treatment Success is defined as achieving both of the following: 1) termination of seizure(s) within 10 minutes after double-blind study drug administration, and 2) no recurrence of seizure(s) beginning 10 minutes after study drug administration to 6 hours after study drug administration. Participants who received the open-label second dose within 6 hours of administration of the double-blind dose were analyzed as having had a seizure. (NCT01390220)
Timeframe: 6 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| USL261 CP | 72 |
| Placebo CP | 23 |
Participants with recurrence of seizure(s) >10 minutes and up to 4 hours after administration of the double-blind dose in the CP. Participants who received the open-label second dose within 4 hours of administration of the double-blind dose were analyzed as having had a seizure. (NCT01390220)
Timeframe: 4 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| USL261 CP | 51 |
| Placebo CP | 40 |
Time to next seizure with a start time >10 minutes and up to 24 hours after administration of the double-blind dose in the CP. Participants who did not have another seizure before the end of the 24-hour observation period were censored at the end of the observation period. Participants administered the open-label second dose who did not have a seizure were censored at the time of the administration. (NCT01390220)
Timeframe: 24 hours
| Intervention | Hours (Median) |
|---|---|
| USL261 CP | NA |
| Placebo CP | 12.1 |
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
28 reviews available for midazolam and Absence Seizure
| Article | Year |
|---|---|
Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis.
Topics: Administration, Intranasal; Anticonvulsants; Benzodiazepines; Child; Diazepam; Humans; Midazolam; Pr | 2021 |
Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Seizures; Status Epilepticus | 2022 |
Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis.
Topics: Anticonvulsants; Benzodiazepines; Child; Diazepam; Humans; Lorazepam; Midazolam; Network Meta-Analys | 2022 |
Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Humans; Lorazepam; | 2022 |
Rescue therapies for seizure clusters: Pharmacology and target of treatments.
Topics: Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy, | 2022 |
Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review.
Topics: Apnea; Electroencephalography; Humans; Infant, Newborn; Levetiracetam; Midazolam; Seizures | 2022 |
Rescue Treatments for Seizure Clusters.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Humans; Lorazepam; Midazolam; Nasal S | 2022 |
Seizure rescue medications are missing from in-flight medical emergency kits.
Topics: Aerospace Medicine; Diazepam; First Aid; Humans; Midazolam; Seizures | 2022 |
Treatment of cholinergic-induced status epilepticus with polytherapy targeting GABA and glutamate receptors.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Benzodiazepines; Cholinergic Agents; gamma-Aminobuty | 2023 |
Early polytherapy for benzodiazepine-refractory status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Administration Schedule; Drug Resistant Epilepsy; Dr | 2019 |
Seizure Rescue Medications for Out-Of-Hospital Use in Children.
Topics: Administration, Intranasal; Administration, Rectal; Anticonvulsants; Benzodiazepines; Child; Diazepa | 2021 |
Clinical pharmacokinetic and pharmacodynamic profile of midazolam nasal spray.
Topics: Child; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Midazolam; Nasal Sprays; P | 2021 |
Seizure management in children requiring palliative care: a review of current practice.
Topics: Anticonvulsants; Child; Child, Preschool; England; Female; Humans; Infant; Infusions, Intravenous; M | 2020 |
The use of phenobarbital and other anti-seizure drugs in newborns.
Topics: Anticonvulsants; Fructose; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Midazolam; Phen | 2017 |
Treatment of neonatal seizures.
Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo | 2013 |
What are the best ways to deliver benzodiazepines in children/patients with prolonged convulsive seizures?
Topics: Anticonvulsants; Benzodiazepines; Child; Emergency Service, Hospital; Humans; Midazolam; Seizures; S | 2014 |
Overview of clinical efficacy and risk data of benzodiazepines for prolonged seizures.
Topics: Anticonvulsants; Benzodiazepines; Humans; Midazolam; Seizures; Status Epilepticus | 2014 |
Intranasal therapies for acute seizures.
Topics: Acute Disease; Administration, Intranasal; Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; | 2015 |
Recent advances in status epilepticus.
Topics: Amides; Anticonvulsants; Diazepam; Humans; Midazolam; Seizures; Status Epilepticus | 2016 |
Clinical practice: the treatment of acute convulsive seizures in children.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Diazepam; GABA Modulators; Humans; Lorazepam | 2011 |
Oromucosal midazolam: a review of its use in pediatric patients with prolonged acute convulsive seizures.
Topics: Administration, Buccal; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Hum | 2012 |
Buccolam(®) (buccal midazolam): a review of its use for the treatment of prolonged acute convulsive seizures in the dental practice.
Topics: Administration, Buccal; Anticonvulsants; Dentistry; Humans; Midazolam; Seizures | 2012 |
The use of intrathecal midazolam in humans: a case study of process.
Topics: Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Injections, Spinal; Midazol | 2004 |
Best evidence topic report. Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Child; Diazepam; Emergency Medical Servi | 2005 |
Best evidence topic report. Intranasal midazolam in patients with fits.
Topics: Administration, Intranasal; Humans; Hypnotics and Sedatives; Midazolam; Seizures; Treatment Outcome | 2005 |
Propofol and barbiturates for the anesthesia of refractory convulsive status epilepticus: pros and cons.
Topics: Anesthetics, Intravenous; Anticonvulsants; Barbiturates; Dose-Response Relationship, Drug; Humans; M | 2007 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Management approaches to prolonged seizures and status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; | 1999 |
33 trials available for midazolam and Absence Seizure
| Article | Year |
|---|---|
The IN-MIDAZ study - Intranasal midazolam in aborting seizures - An epilepsy monitoring unit based randomized controlled trial for efficacy.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Child; Drug Resistant Epilepsy; Humans; Midazola | 2022 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: Results of a phase 3, open-label extension trial.
Topics: Epilepsy, Generalized; Humans; Midazolam; Nasal Sprays; Quality of Life; Seizures; Treatment Outcome | 2023 |
Intramuscular Versus Buccal Midazolam for Pediatric Seizures: A Randomized Double-Blinded Trial.
Topics: Administration, Buccal; Adolescent; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; E | 2020 |
Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial.
Topics: Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Child; Double-Blind Method; Epilepsy | 2020 |
Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters-a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anticonvulsants; Child; Double-Blind Method; Fe | 2019 |
Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters: An open-label extension trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Female; Humans; Male; Midazolam; Middle Aged; Nasal | 2019 |
[Study of an efficacy and a pharmacokinetics of intranasal midazolam for status epilepticus on childhood epilepsy].
Topics: Administration, Intranasal; Child; Child, Preschool; Female; Humans; Infant; Male; Midazolam; Seizur | 2010 |
Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Huma | 2015 |
Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions.
Topics: Administration, Buccal; Adolescent; Africa; Anticonvulsants; Child; Child, Preschool; Drug Administr | 2008 |
Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial.
Topics: Administration, Buccal; Child; Child, Preschool; Diazepam; Female; Follow-Up Studies; Humans; Infant | 2009 |
Premedication with dexmedetomidine and midazolam attenuates agitation after electroconvulsive therapy.
Topics: Adult; Anesthesia; Bipolar Disorder; Blood Pressure; Depressive Disorder, Major; Dexmedetomidine; El | 2009 |
Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit.
Topics: Adult; Blood Pressure; Dexmedetomidine; Eclampsia; Female; Heart Rate; Humans; Hypnotics and Sedativ | 2009 |
Efficacy and usability of buccal midazolam in controlling acute prolonged convulsive seizures in children.
Topics: Acute Disease; Administration, Buccal; Administration, Rectal; Anticonvulsants; Child; Child, Presch | 2010 |
[A control study on the treatment of acute seizures with midazolam and diazepam in children].
Topics: Acute Disease; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Male; Midazolam; | 2010 |
Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus.
Topics: Administration, Buccal; Administration, Rectal; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; | 2011 |
Is intranasal midazolam better than rectal diazepam for home management of acute seizures?
Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Child; Diazepam; Disease Manageme | 2011 |
Intravenous diazepam, midazolam and lorazepam in acute seizure control.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Injections, In | 2012 |
A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures.
Topics: Administration, Intranasal; Administration, Intravenous; Child; Child, Preschool; Diazepam; Emergenc | 2013 |
Buccal midazolam for treatment of prolonged seizures in children.
Topics: Administration, Buccal; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Sc | 2003 |
[Eight-year study on the treatment with intravenous midazolam for status epilepticus and clusters of seizures in children].
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; Injections, Intr | 2003 |
Midazolam and amplitude-integrated EEG in asphyxiated full-term neonates.
Topics: Anticonvulsants; Asphyxia Neonatorum; Brain; Electroencephalography; Gestational Age; Humans; Infant | 2004 |
Midazolam in neonatal seizures with no response to phenobarbital.
Topics: Age Factors; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Resistance; Electroencep | 2005 |
Intramuscular midazolam vs intravenous diazepam for acute seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Humans; Infant; Injections, Intramuscular; Injec | 2005 |
Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures.
Topics: Administration, Intranasal; Child; Child, Preschool; Conscious Sedation; Diazepam; Female; Humans; H | 2006 |
Comparison of continuous drip of midazolam or lidocaine in the treatment of intractable neonatal seizures.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Dose-Response Relationship, D | 2007 |
Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial.
Topics: Administration, Buccal; Administration, Rectal; Anticonvulsants; Child; Child, Preschool; Developing | 2008 |
Midazolam in the treatment of refractory neonatal seizures.
Topics: Anticonvulsants; Drug Resistance; Electroencephalography; Humans; Infant, Newborn; Infusions, Intrav | 1996 |
A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children.
Topics: Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Inf | 1997 |
A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Humans; Infant; Injections, Intramuscul | 1997 |
Midazolam in treatment of various types of seizures in children.
Topics: Acute Disease; Anticonvulsants; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Injection | 1997 |
Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsa | 1999 |
Nasal midazolam effects on childhood acute seizures.
Topics: Administration, Intranasal; Adolescent; Child; Child, Preschool; Female; GABA Modulators; Half-Life; | 2000 |
Effects of intranasal midazolam and rectal diazepam on acute convulsions in children: prospective randomized study.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Presc | 2002 |
189 other studies available for midazolam and Absence Seizure
| Article | Year |
|---|---|
Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus.
Topics: Animals; Brain; Bridged-Ring Compounds; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; | 2021 |
Seizure management in a Model Three hospital: what does specialist neurology add?
Topics: Emergency Service, Hospital; Hospitals; Humans; Midazolam; Neurology; Retrospective Studies; Seizure | 2022 |
Reply to comment on "Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis".
Topics: Administration, Intranasal; Benzodiazepines; Child; Humans; Midazolam; Seizures; Status Epilepticus | 2022 |
Differentiating early clinical features of Panayiotopoulos syndrome from acute encephalopathy.
Topics: Electroencephalography; Epilepsies, Partial; Humans; Midazolam; Retrospective Studies; Seizures; Sta | 2022 |
Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Cohort Studies; Female; Humans; Levetirac | 2022 |
Factors associated with mortality in patients with super-refractory status epilepticus.
Topics: Anticonvulsants; Heart Diseases; Humans; Midazolam; Middle Aged; Retrospective Studies; Seizures; St | 2022 |
Use of new intranasal benzodiazepines at a typical adult epilepsy center.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Epilepsy, G | 2022 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Prehospital Seizure Management in Children: An Evaluation of a Nationally Representative Sample.
Topics: Benzodiazepines; Child; Emergency Medical Services; Humans; Midazolam; Retrospective Studies; Seizur | 2023 |
Assessment of First-line Therapy With Midazolam for Prehospital Seizures in Children.
Topics: Anticonvulsants; Child; Emergency Medical Services; Humans; Midazolam; Seizures | 2023 |
A Standardized, 3-Tiered, Seizure Burden-Based Protocol for the Treatment of Neonatal Seizures.
Topics: Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Midazo | 2023 |
Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia.
Topics: Animals; Anticonvulsants; Asphyxia; Asphyxia Neonatorum; Bumetanide; Epilepsy; Humans; Infant, Newbo | 2023 |
Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Female; Male; Midazolam; Nerve Agents; Rats; Seizur | 2023 |
Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy.
Topics: Animals; Atropine; Cytokines; Enzyme Inhibitors; Epilepsy; Gliosis; Male; Midazolam; Neuroglia; Nitr | 2023 |
National Variation in EMS Response and Antiepileptic Medication Administration for Children with Seizures in the Prehospital Setting.
Topics: Anticonvulsants; Child; Emergency Medical Services; Emergency Medical Technicians; Female; Humans; M | 2023 |
A Comparative Analysis of Prehospital Emergency Treatments: Midazolam Intramuscularly, Diazepam Enema, and Chloral Hydrate Enema for Pediatric Convulsions.
Topics: Child; Chloral Hydrate; Diazepam; Emergency Medical Services; Enema; Humans; Midazolam; Seizures | 2023 |
Stimulus-induced rhythmic, periodic ictal discharges during funduscopic examination in a patient with status epilepticus.
Topics: Electroencephalography; Humans; Male; Midazolam; Phenytoin; Seizures; Status Epilepticus; Young Adul | 2019 |
Adenovirus as a rare cause of acute necrotising encephalitis.
Topics: Adenoviridae Infections; Anticonvulsants; Female; Humans; Hypnotics and Sedatives; Infant; Leukoence | 2019 |
Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam.
Topics: Animals; Anticonvulsants; beta-Cyclodextrins; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Variation in Prehospital Protocols for Pediatric Seizure Within the United States.
Topics: Anticonvulsants; Benzodiazepines; Child; Emergency Medical Services; Humans; Midazolam; Seizures; Un | 2021 |
Transnasal Revolution? The Promise of Midazolam Spray to Prevent Seizure Clusters.
Topics: Administration, Intranasal; Electroencephalography; Epilepsy; Humans; Midazolam; Seizures | 2020 |
Intranasal diazepam (Valtoco) and midazolam (Nayzilam) for seizure clusters.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Humans; Midazolam; Seizures | 2020 |
Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Male; Midazolam; Muscimol; | 2020 |
Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice.
Topics: Animals; Anticonvulsants; Brain; Carboxylesterase; Drug Therapy, Combination; Electroencephalography | 2020 |
Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate.
Topics: Animals; Brain Diseases; Cholinesterase Inhibitors; Diazepam; GABA Modulators; Gliosis; Isoflurophat | 2020 |
Using quality improvement to implement the CNS/AAN quality measure on rescue medication for seizures.
Topics: Adult; Anticonvulsants; Humans; Medication Errors; Midazolam; Quality Improvement; Quality Indicator | 2020 |
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Bumetanide; Disease Models, Animal; | 2021 |
Severe cortical damage associated with COVID-19 case report.
Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo | 2021 |
Cannabidiol reduces soman-induced lethality and seizure severity in female plasma carboxylesterase knockout mice treated with midazolam.
Topics: Animals; Anticonvulsants; Cannabidiol; Carboxylesterase; Electroencephalography; Female; Mice; Mice, | 2021 |
Continuous rate infusion of midazolam as emergent treatment for seizures in dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Hospitals, Animal; Hospitals, Teaching; Midazolam; Ret | 2021 |
Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details.
Topics: Animals; Anticonvulsants; Bumetanide; Epilepsy; Humans; Midazolam; Phenobarbital; Prohibitins; Seizu | 2021 |
A critical evaluation of midazolam nasal spray for the treatment of patients with seizure clusters.
Topics: Administration, Intranasal; Anticonvulsants; Epilepsy; Humans; Midazolam; Nasal Sprays; Quality of L | 2021 |
Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice.
Topics: Acetylcholinesterase; Anesthetics; Animals; Brain; Carboxylesterase; Chemical Warfare Agents; Diseas | 2021 |
Epidemiology and outcome of status epilepticus in children: a Scottish population cohort study.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Emergency Service, Hospital; F | 2021 |
Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study.
Topics: Anticonvulsants; Child; Child, Preschool; Cohort Studies; Humans; Male; Midazolam; Retrospective Stu | 2021 |
UK framework for basic epilepsy training and oromucosal midazolam administration.
Topics: Caregivers; Epilepsy; Humans; Midazolam; Seizures; United Kingdom | 2021 |
The efficacy of γ-aminobutyric acid type A receptor (GABA
Topics: Animals; Behavior, Animal; Bridged-Ring Compounds; Convulsants; GABA Modulators; Hypnotics and Sedat | 2021 |
Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting.
Topics: Administration, Buccal; Administration, Rectal; Ambulatory Care; Anticonvulsants; Child; Child, Pres | 2019 |
Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report.
Topics: Adolescent; Adolescent Behavior; Anticonvulsants; Brugada Syndrome; Chicago; Electrocardiography; El | 2017 |
Awake caudal anaesthesia in neonates/young infants for improved patient safety.
Topics: Adenosine; Adjuvants, Anesthesia; Anesthesia, Caudal; Anti-Arrhythmia Agents; Bupivacaine; Fat Emuls | 2017 |
Midazolam vs diazepam in prolonged seizures in children: A pharmacoeconomic approach.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anticonvulsants; Child; Decision Trees; | 2018 |
Effect of rescue medication on seizure duration in non-institutionalized children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Mida | 2018 |
Does burst-suppression achieve seizure control in refractory status epilepticus?
Topics: Adult; Anticonvulsants; Drug Resistant Epilepsy; Electroencephalography; Female; Humans; Male; Midaz | 2018 |
Midazolam as a first-line treatment for neonatal seizures: Retrospective study.
Topics: Anticonvulsants; Electroencephalography; Female; Humans; Infant, Newborn; Male; Midazolam; Retrospec | 2018 |
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Injuries; Cholinesterase Inhibitors; Drug Re | 2018 |
Recurrent Seizures in 2 Patients with Magnesium Sulfate-Treated Eclampsia at a Secondary Hospital.
Topics: Anticonvulsants; Cesarean Section; Drug Therapy, Combination; Eclampsia; Female; Humans; Magnesium S | 2018 |
Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.
Topics: Animals; Anticonvulsants; Carboxylesterase; Cell Count; Chemical Warfare Agents; Cholinesterase Reac | 2018 |
Treatment options in pediatric super-refractory status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diet, Ketogenic; Drug Resistant Epilepsy; Ence | 2019 |
Seizure as the Presenting Symptom for Atypical Hemolytic Uremic Syndrome.
Topics: Atypical Hemolytic Uremic Syndrome; Buffers; Calcium Gluconate; Electroencephalography; Female; Huma | 2019 |
Impact of prescribing intranasal midazolam as rescue medication for domiciliary management of acute seizure among children with epilepsy.
Topics: Administration, Intranasal; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Disease Ma | 2019 |
Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: Suggested role of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Atropine; Brain Diseases; Chemical Warfare Agent | 2019 |
Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Isoflurophate; Male; Midazolam; Neuroprotective Ag | 2019 |
Treatment of Seizures in Children and Adults in the Emergency Medical System of the City of Zurich, Switzerland - Midazolam vs. Diazepam - A Retrospective Analysis.
Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Hum | 2019 |
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Elect | 2019 |
Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Anticonvulsants; Epilepsy; Female; H | 2019 |
Higher mortality rate is associated with advanced age and periodic lateralized epileptiform discharges in patients with refractory status epilepticus.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Electroenceph | 2013 |
Camphor poisoning: personal experience.
Topics: Camphor; Ceremonial Behavior; Child, Preschool; Humans; Infant; Midazolam; Seizures | 2013 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; | 2013 |
Pediatric emergency medicine: legal briefs.
Topics: Accidents, Traffic; Amputation, Surgical; Baseball; Brain Damage, Chronic; Child; Colon; Commitment | 2013 |
Seizure protection by intrapulmonary delivery of midazolam in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Routes; Kainic Acid; | 2013 |
Midazolam oral transmucosal route. An alternative to rectal diazepam for some children.
Topics: Administration, Buccal; Administration, Rectal; Anticonvulsants; Child; Diazepam; Drug Interactions; | 2013 |
Seizure activity occurring in two dogs after S-ketamine-induction.
Topics: Acepromazine; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Animals; Anticonvu | 2013 |
Risk factors for apnea in pediatric patients transported by paramedics for out-of-hospital seizure.
Topics: Airway Management; Anticonvulsants; Apnea; Child; Child, Preschool; Emergency Medical Services; Fema | 2014 |
Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling.
Topics: Action Potentials; Animals; Anticonvulsants; Berberine Alkaloids; Carbamazepine; Convulsants; Diseas | 2014 |
[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase].
Topics: Anticonvulsants; Clonazepam; Epilepsy; Glioma; Humans; Midazolam; Seizures; Terminal Care | 2014 |
Emulsified isoflurane increases convulsive thresholds of lidocaine and produces neural protection after convulsion in rats.
Topics: Anesthesia, Conduction; Anesthetics, Inhalation; Anesthetics, Local; Animals; Cognition; Dose-Respon | 2014 |
Comparison between the effect of propofol and midazolam on picrotoxin-induced convulsions in rat.
Topics: Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug | 2014 |
Peri-ictal headache due to epileptiform activity in a disconnected hemisphere.
Topics: Anticonvulsants; Brain; Carbamazepine; Child, Preschool; Electroencephalography; Epilepsy; Female; F | 2014 |
Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospital; Female; | 2015 |
Exacerbation of benign familial neonatal epilepsy induced by massive doses of phenobarbital and midazolam.
Topics: Electroencephalography; Epilepsy, Benign Neonatal; Female; GABA Modulators; Humans; Midazolam; Pheno | 2014 |
Anticonvulsant effectiveness and hemodynamic safety of midazolam in full-term infants treated with hypothermia.
Topics: Anticonvulsants; Arterial Pressure; Asphyxia Neonatorum; Electroencephalography; Female; Hemodynamic | 2015 |
Exploring carer perceptions of training in out-of-hospital use of buccal midazolam for emergency management of seizures (2008-2012).
Topics: Administration, Buccal; Adolescent; Anticonvulsants; Attitude to Health; Child; Child, Preschool; Ed | 2015 |
Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors.
Topics: Animals; Anticonvulsants; Brain Chemistry; Female; Flumazenil; GABA Modulators; Hippocampus; Hypnoti | 2015 |
Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infusions, I | 2015 |
A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Female; Humans; Infant; Levetiracetam; Midazolam; Piracetam; | 2015 |
Intranasal midazolam during presurgical epilepsy monitoring is well tolerated, delays seizure recurrence, and protects from generalized tonic-clonic seizures.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Child; Electroencephalography; Female; GABA Mod | 2015 |
Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study.
Topics: Administration, Buccal; Administration, Intranasal; Aged; Brain Neoplasms; Clonazepam; Feasibility S | 2016 |
Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus.
Topics: Animals; Anticonvulsants; Apoptosis; Benzodiazepines; Convulsants; Exploratory Behavior; GABA Agonis | 2015 |
Physiological and biochemical variables in captive tigers (Panthera tigris) immobilised with dexmedetomidine and ketamine or dexmedetomidine, midazolam and ketamine.
Topics: Anesthetics, Combined; Animals; Animals, Zoo; Biochemical Phenomena; Blood Pressure; Dexmedetomidine | 2015 |
Lidocaine response rate in aEEG-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants.
Topics: Anticonvulsants; Central Nervous System Infections; Cohort Studies; Electroencephalography; Female; | 2016 |
A case of recurrent status epilepticus and successful management with progesterone.
Topics: Adult; Anti-Anxiety Agents; Female; Humans; Menstrual Cycle; Midazolam; Progesterone; Seizures; Stat | 2016 |
Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.
Topics: Animals; Anticonvulsants; Dentate Gyrus; GABA Agonists; GABA Modulators; In Vitro Techniques; Intern | 2016 |
Administration of anticonvulsive rescue medication in children-discrepancies between parents' self-reports and limited practical performance.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anticonvulsants; Child; Diazepam; | 2016 |
Intranasal midazolam for seizure cessation in the community setting.
Topics: Administration, Intranasal; Ambulatory Care Facilities; Anticonvulsants; Child; Diazepam; Humans; Mi | 2016 |
Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation.
Topics: Adamantane; Administration, Intravenous; Anti-Anxiety Agents; Cannabinoid Receptor Agonists; Citalop | 2016 |
Implementation of Intranasal Midazolam for Prolonged Seizures in a Child Neurology Practice.
Topics: Administration, Intranasal; Anticonvulsants; Health Personnel; Humans; Midazolam; Neurology; Pediatr | 2016 |
Case report: management of differential diagnosis and treatment of severe anaphylaxis in the setting of spinal anesthesia.
Topics: Anaphylaxis; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Arthroplasty, Replace | 2016 |
Pre-hospital midazolam for benzodiazepine-treated seizures before and after the Rapid Anticonvulsant Medication Prior to Arrival Trial: A national observational cohort study.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Cohort Studies; Female | 2017 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.
Topics: Animals; Anticonvulsants; Bacteria; Carboxylic Ester Hydrolases; Cocaine; Cocaine-Related Disorders; | 2009 |
Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for the control of soman-induced seizures.
Topics: Administration, Intranasal; Administration, Sublingual; Animals; Anticonvulsants; Chemical Warfare A | 2009 |
Intranasal midazolam.
Topics: Administration, Intranasal; Adult; Emergency Treatment; GABA Modulators; Humans; Male; Midazolam; Se | 2009 |
Ketogenic diet in Alpers-Huttenlocher syndrome.
Topics: Anticonvulsants; Brain; Child, Preschool; Cognition; Diet, Ketogenic; Diffuse Cerebral Sclerosis of | 2009 |
Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Malaria; Male; Midazolam | 2009 |
Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Cholinergic Antagonists; Cholinesterase Inhibitors; Disea | 2010 |
Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats.
Topics: Acetylcholine; Animals; Anticonvulsants; Electrodes, Implanted; Electroencephalography; gamma-Aminob | 2010 |
Unexpected postoperative seizure after mastoid surgery--a case report.
Topics: Anesthesia; Anticonvulsants; Female; Humans; Mastoid; Midazolam; Phenytoin; Postoperative Complicati | 2010 |
Limited clinical value of bacterial cocaine esterase in cocaine toxicity.
Topics: Animals; Anticonvulsants; Carboxylesterase; Cocaine; Cocaine-Related Disorders; Humans; Midazolam; R | 2010 |
Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures.
Topics: Animals; Anticonvulsants; Arginase; Behavior, Animal; Biogenic Polyamines; Brain; Convulsants; Male; | 2010 |
Survival after diphenhydramine ingestion with hemodialysis in a toddler.
Topics: Diphenhydramine; Humans; Hypnotics and Sedatives; Infant; Injections, Intramuscular; Male; Midazolam | 2011 |
Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology.
Topics: Animals; Anticonvulsants; Antigens, Nuclear; Benzodiazepines; Brain; Dose-Response Relationship, Dru | 2011 |
[Paroxysmal automatic movements mimicking neonatal seizures induced by midazolam].
Topics: Diagnosis, Differential; Dyskinesia, Drug-Induced; Female; Humans; Hypnotics and Sedatives; Infant, | 2011 |
Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Hippocam | 2012 |
Anaesthetic management of emergency caesarean section in a patient with seizures and likely raised intracranial pressure due to tuberculous meningitis.
Topics: Adult; Androstanols; Anesthesia, Obstetrical; Anesthetics, Inhalation; Anesthetics, Intravenous; Ant | 2011 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate.
Topics: Anticonvulsants; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Electrocardiography; Emerg | 2011 |
Benzodiazepines for acute management of seizures.
Topics: Diazepam; Female; Humans; Lorazepam; Male; Midazolam; Seizures | 2012 |
Effects of midazolam and lidocaine on spectral properties of the EEG in full-term neonates with stroke.
Topics: Anticonvulsants; Brain Ischemia; Data Interpretation, Statistical; Electroencephalography; Epilepsy; | 2012 |
Neuropharmacological specificity of brain structures involved in soman-induced seizures.
Topics: Animals; Anticonvulsants; Brain; Brain Mapping; Chemical Warfare Agents; Cholinergic Antagonists; Di | 2012 |
Oromucosal midazolam: a guide to its use in paediatric patients with prolonged acute convulsive seizures.
Topics: Administration, Buccal; Adolescent; Child; Child, Preschool; Diazepam; Humans; Infant; Midazolam; Se | 2012 |
Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity.
Topics: Animals; Cocaine; Disease Models, Animal; Etomidate; Ketamine; Mice; Midazolam; Phenytoin; Random Al | 2012 |
Prehospital transient airway management using the I-gel with sustained spontaneous breathing in different emergency situations.
Topics: Administration, Intranasal; Adult; Aged; Airway Management; Alcoholic Intoxication; Analgesics, Opio | 2013 |
Magnesium sulfate treatment against sarin poisoning: dissociation between overt convulsions and recorded cortical seizure activity.
Topics: Animals; Anticonvulsants; Antidotes; Brain Injuries; Cerebral Cortex; Chemical Warfare Agents; Cyclo | 2013 |
[Effects of pretreatment of lipid, midazolam and propofol on ropivacaine-induced convulsion and LD50 in rats].
Topics: Amides; Animals; Female; Lethal Dose 50; Lipids; Male; Midazolam; Propofol; Rats; Rats, Sprague-Dawl | 2012 |
Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Cocaine-Related Disorders; Disease Models, Animal; D | 2013 |
Controlling seizures in the prehospital setting: diazepam or midazolam?
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Medical Services; Female; GABA Modulat | 2002 |
Nasal midazolam as a novel anticonvulsive treatment against organophosphate-induced seizure activity in the guinea pig.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Cholinesterase Inhibitors; Electrophysiology; | 2003 |
Seizure after levobupivacaine for interscalene brachial plexus block.
Topics: Adult; Anesthetics, Local; Brachial Plexus; Bupivacaine; Female; Humans; Hypnotics and Sedatives; Mi | 2003 |
Postoperative pseudoepileptic seizures in a known epileptic: complications in recovery.
Topics: Anesthesia Recovery Period; Anesthesia, General; Epilepsy; Female; Humans; Hypnotics and Sedatives; | 2003 |
Nasal/buccal midazolam use in the community.
Topics: Administration, Buccal; Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Child; Child | 2004 |
[A case of treatment of convulsion caused by poison of tetramethylenedisulfotetramine with medazolam].
Topics: Anti-Anxiety Agents; Bridged-Ring Compounds; Child; Humans; Male; Midazolam; Seizures | 2003 |
Burst suppression on amplitude-integrated electroencephalogram may be induced by midazolam: a report on three cases.
Topics: Anesthetics, Intravenous; Asphyxia Neonatorum; Electroencephalography; Gestational Age; Humans; Infa | 2004 |
Pharmacokinetic studies of intramuscular midazolam in guinea pigs challenged with soman.
Topics: Animals; Anti-Anxiety Agents; Area Under Curve; Cholinesterase Inhibitors; Electroencephalography; G | 2004 |
[Withdrawal syndrome in a critically ill child after sedation with midazolam and fentanyl].
Topics: Child; Critical Illness; Esophageal Stenosis; Esophagoplasty; Female; Fentanyl; Humans; Hypnotics an | 2004 |
Midazolam and amplitude-integrated EEG.
Topics: Anticonvulsants; Asphyxia Neonatorum; Electroencephalography; Humans; Infant, Newborn; Midazolam; Se | 2004 |
Neonatal seizures: after all these years we still love what doesn't work.
Topics: Animals; Anticonvulsants; Brain; Clinical Trials as Topic; Drug Resistance; Electroencephalography; | 2005 |
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children.
Topics: Anticonvulsants; Child; Chromatography, High Pressure Liquid; Humans; Kenya; Malaria, Falciparum; Mi | 2005 |
Efficacy of the ketamine-atropine combination in the delayed treatment of soman-induced status epilepticus.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Dose-Response Relationship, Drug; Drug | 2005 |
[Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Female | 2005 |
Anticonvulsant treatment of sarin-induced seizures with nasal midazolam: an electrographic, behavioral, and histological study in freely moving rats.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Behavior, Animal; Body Weight; Brain; Cholines | 2005 |
Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chemical Warfare Agents; Cholinesterase Inhibitors; Cytok | 2006 |
[Etiology and management of neonatal seizures--successful treatment by midazolam].
Topics: Humans; Hypnotics and Sedatives; Hypotension; Infant, Newborn; Infusions, Intravenous; Injections, I | 2006 |
Clinical course and toxicokinetic data following isolated citalopram overdose in an infant.
Topics: Charcoal; Citalopram; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Infant; Intensive Care | 2006 |
Community use of intranasal midazolam for managing prolonged seizures.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Adult; Aged; Anticonvulsants; Attitu | 2006 |
[Prolonged convulsions treated with buccal midazolam in a setting of mentally retarded patients with refractory epilepsy].
Topics: Administration, Oral; Adult; Epilepsy; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Mid | 2006 |
Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Dose-Response Relationship, D | 2007 |
The birth of the NETT: NIH-funded network will launch emergency neurological trials.
Topics: Anticonvulsants; Clinical Trials as Topic; Emergency Medical Services; Humans; Informed Consent; Lor | 2006 |
Serial-probe recognition in rhesus macaques: effects of midazolam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Macaca mulatta; Male; Memory, Short-Term; Midaz | 2006 |
Efficacy of the bone injection gun in the treatment of organophosphate poisoning.
Topics: Animals; Anticonvulsants; Antidotes; Biological Availability; Dose-Response Relationship, Drug; Infu | 2007 |
Prehospital intranasal midazolam for the treatment of pediatric seizures.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Presc | 2007 |
Intra-arterial verapamil-induced seizures: case report and review of the literature.
Topics: Adult; Anticonvulsants; Aphasia, Broca; Carotid Artery, Internal; Female; Functional Laterality; Hum | 2007 |
Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus).
Topics: Acinonyx; Anesthetics, Combined; Animals; Blood Gas Analysis; Heart Rate; Hypertension; Immobilizati | 2006 |
Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction.
Topics: Action Potentials; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Cortical Spreading D | 2007 |
Repetitive generalized seizure-like activity during emergence from sevoflurane anesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Humans; Hypnotic | 2007 |
Practice of palliative sedation in children with brain tumors and sarcomas at the end of life.
Topics: Adolescent; Bone Neoplasms; Brain Neoplasms; Child; Combined Modality Therapy; Consciousness; Glioma | 2007 |
The interaction of the beta-carboline derivative DMCM with inhibitory amino acid responses on cultured mouse neurones.
Topics: Animals; Benzodiazepines; Carbolines; Central Nervous System; Culture Techniques; Evoked Potentials; | 1983 |
[Midazolam. Chemical data and experimental neuropharmacology].
Topics: Anesthetics; Animals; Benzodiazepines; Central Nervous System Agents; Chemical Phenomena; Chemistry; | 1984 |
Benzodiazepines protect mice from local anesthetic convulsions and deaths.
Topics: Anesthetics; Animals; Benzodiazepines; Bupivacaine; Diazepam; Drug Interactions; Etidocaine; Female; | 1981 |
Withdrawal syndrome following midazolam infusion.
Topics: Adult; Amitriptyline; Drug Overdose; Female; Humans; Midazolam; Seizures; Substance Withdrawal Syndr | 1995 |
Stable anticonvulsant action of benzodiazepines during development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Electric Stimulation; Electroencephal | 1993 |
Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain; Diazepam; Drug Tolerance | 1994 |
Recurrent hypotension immediately after seizures in nortriptyline overdose.
Topics: Biological Availability; Blood Pressure; Drug Overdose; Female; Heart; Humans; Hypotension; Midazola | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female | 1993 |
Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine.
Topics: Animals; Disease Models, Animal; Injections, Intramuscular; Injections, Intravenous; Midazolam; Pent | 1994 |
Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Drug To | 1993 |
Subcutaneous midazolam, diamorphine and hyoscine infusion in palliative care of a child with neurodegenerative disease.
Topics: Fatal Outcome; Female; Heroin; Humans; Hypnotics and Sedatives; Infant; Midazolam; Muscarinic Antago | 1995 |
Nasal benzodiazepines for management of acute childhood seizures?
Topics: Absorption; Administration, Intranasal; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschoo | 1997 |
A case report or a cautionary tale?
Topics: Anesthesia, Dental; Dental Care for Chronically Ill; Epilepsy; Female; Humans; Midazolam; Seizures | 1997 |
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation; | 1996 |
Strychnine-like multifocal myoclonus and seizures in extremely high-dose opioid administration: treatment strategies.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Intravenous; Drug Administration Sc | 1997 |
Antagonism of soman-induced convulsions by midazolam, diazepam and scopolamine.
Topics: Animals; Anticonvulsants; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Di | 1997 |
Opisthotonos after flumazenil administered to antagonize midazolam previously administered to treat developing local anesthetic toxicity.
Topics: Adolescent; Flumazenil; Humans; Male; Midazolam; Seizures | 1998 |
Unexplained physical symptoms in dental patients.
Topics: Adult; Anesthesia, Dental; Anticonvulsants; Conscious Sedation; Dental Care; Diagnosis, Differential | 1998 |
Kainic acid causes redox changes in cerebral cortex extracellular fluid: NMDA receptor activity increases ascorbic acid whereas seizure activity increases uric acid.
Topics: Animals; Antioxidants; Ascorbic Acid; Cerebral Cortex; Excitatory Amino Acid Agonists; Extracellular | 1998 |
Intranasal midazolam for childhood seizures.
Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; M | 1998 |
Buccal route for benzodiazepines in treatment of seizures?
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsa | 1999 |
The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Anta | 1999 |
Midazolam suppresses spike-and-wave rhythm accompanying three different models of epileptic seizures.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalogra | 1999 |
Intranasal midazolam for prolonged convulsive seizures.
Topics: Administration, Intranasal; Child; Child, Preschool; Female; Humans; Infant; Male; Midazolam; Prospe | 2000 |
Bilateral frontal haemorrhages associated with continuous spinal analgesia.
Topics: Adjuvants, Anesthesia; Aged; Analgesia, Epidural; Cerebral Hemorrhage; Fatal Outcome; Humans; Male; | 2001 |
Intranasal midazolam. An alternative in childhood seizures.
Topics: Administration, Intranasal; Humans; Hypnotics and Sedatives; Infant; Male; Midazolam; Seizures | 2001 |
Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; | 2001 |
Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam.
Topics: Amino Acids; Animals; Convulsants; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GAB | 2002 |
Temporary bilateral blindness after acute lidocaine toxicity.
Topics: Acute Disease; Adult; Anesthetics, Local; Blindness; Female; Fractures, Bone; GABA Modulators; Hand | 2002 |
Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem.
Topics: Animals; Drug Tolerance; Electroshock; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoniaz | 1992 |
The use of intramuscular midazolam for acute seizure cessation or behavioral emergencies in patients with traumatic brain injury.
Topics: Adult; Brain Injuries; Child; Emergencies; Female; Humans; Injections, Intramuscular; Male; Mental D | 1992 |
Intramuscular midazolam for treatment of acute seizures or behavioral episodes in patients with brain injuries.
Topics: Adult; Aggression; Brain Injuries; Epilepsy, Post-Traumatic; Humans; Injections, Intramuscular; Male | 1992 |
Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drug Overdose; Electrocardiog | 1992 |
The effect of ontogenetic development on the anticonvulsant activity of midazolam.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Female; Growth; Injections, Intra | 1992 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Substantia nigra regulates action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Ethosuximide; Ma | 1990 |
Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated.
Topics: Animals; Carbolines; Clonazepam; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Elect | 1990 |
Effect of midazolam pretreatment on the intravenous toxicity of lidocaine with and without epinephrine in rats.
Topics: Animals; Drug Interactions; Epinephrine; Injections, Intraperitoneal; Injections, Intravenous; Lidoc | 1989 |
Injection of benzodiazepines but not GABA or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures.
Topics: Animals; Benzodiazepines; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Muscimol; Pentylenet | 1989 |
A complication associated with the use of midazolam.
Topics: Adult; Female; Humans; Midazolam; Seizures | 1989 |
Comparative effects of diazepam and midazolam on paraoxon toxicity in rats.
Topics: Animals; Atropine; Benzodiazepines; Diazepam; Drug Interactions; Injections, Subcutaneous; Lethal Do | 1985 |
Comparative seizure inducing properties of various cholinesterase inhibitors: antagonism by diazepam and midazolam.
Topics: Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Diazepam; Isoflurophate; Male; Midaz | 1987 |
Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures.
Topics: Animals; Cysteamine; Kindling, Neurologic; Male; Midazolam; Myoclonus; Neural Inhibition; Rats; Rats | 1987 |
Midazolam: an effective intravenous agent for seizure control.
Topics: Adult; Aged; Female; Humans; Injections, Intravenous; Male; Midazolam; Middle Aged; Seizures; Status | 1987 |