midazolam has been researched along with Abnormality, Heart in 27 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate and compare the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery." | 9.15 | Comparison of the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery. ( Liu, Y; Tang, QZ; Xia, WF; Zhou, QS; Zou, HD, 2011) |
| "Midazolam sedation was estimated by Bayesian inference for generalized linear mixed models." | 5.56 | Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients. ( Enomoto, Y; Hiramatsu, Y; Hoshino, H; Inoue, Y; Mathis, BJ; Matsuishi, Y; Sakuramoto, H; Shimojo, N, 2020) |
| "This study was designed to determine whether transport of a paediatric inpatient in a children's ride-on toy car has an effect on perioperative levels of anxiety compared with transport on a hospital gurney with or without oral midazolam premedication." | 5.27 | The effectiveness of transport in a toy car for reducing preoperative anxiety in preschool children: a randomised controlled prospective trial. ( Chen, YQ; Huang, Y; Liu, PP; Sun, Y; Wu, C; Wu, JZ; Xu, WH; Zhang, MZ; Zhang, RD; Zheng, JJ, 2018) |
| "To investigate and compare the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery." | 5.15 | Comparison of the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery. ( Liu, Y; Tang, QZ; Xia, WF; Zhou, QS; Zou, HD, 2011) |
| "To compare the effectiveness of oral midazolam and chloral hydrate on anxiety and sedation at various stages of pre-operative period in congenital heart surgery patients." | 3.78 | Effectiveness of premedication at the time of separation from parent and mask induction in paediatric patients coming for congenital heart disease surgery. ( Akhtar, I; Hamid, M; Khan, MA; Khatri, A, 2012) |
| " In those aged from 3 to 6 years of age, dosage of midazolam was 2." | 2.73 | Can analysis of the bispectral index prove helpful when monitoring titration of doses of midazolam and ketamine for sedation during paediatric cardiac catheterization. ( Baysal, A; Celebi, A; Polat, TB; Yalcin, Y, 2008) |
| "Ninety patients undergoing repair of congenital heart defect with CPB were investigated in a prospective randomized study." | 2.71 | Effect of three different anaesthetic agents on the postoperative production of cardiac troponin T in paediatric cardiac surgery. ( Bovill, JG; Hazekamp, MG; Hogenbirk, K; Malagon, I; van Pelt, J, 2005) |
| "Midazolam sedation was estimated by Bayesian inference for generalized linear mixed models." | 1.56 | Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients. ( Enomoto, Y; Hiramatsu, Y; Hoshino, H; Inoue, Y; Mathis, BJ; Matsuishi, Y; Sakuramoto, H; Shimojo, N, 2020) |
| "Advances in the treatment of congenital heart disease have led to a new group of adolescents or adults patients with cardiac anomalies." | 1.31 | Anaesthetic management of an adolescent for scoliosis surgery with a Fontan circulation. ( Boutin, C; Fortier, LP; Labelle, H; Villeneuve, E; Vischoff, D, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 11 (40.74) | 29.6817 |
| 2010's | 9 (33.33) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuishi, Y | 1 |
| Sakuramoto, H | 1 |
| Hoshino, H | 1 |
| Shimojo, N | 1 |
| Enomoto, Y | 1 |
| Mathis, BJ | 1 |
| Hiramatsu, Y | 1 |
| Inoue, Y | 1 |
| Michel, J | 1 |
| Hofbeck, M | 1 |
| Gerbig, I | 1 |
| Icheva, V | 1 |
| Heimberg, E | 1 |
| Jost, W | 1 |
| Schlensak, C | 1 |
| Kumpf, M | 1 |
| Blumenstock, G | 1 |
| Neunhoeffer, F | 1 |
| Zeilmaker-Roest, GA | 1 |
| van Saet, A | 1 |
| van Rosmalen, J | 1 |
| Bahmany, S | 1 |
| van Dijk, A | 1 |
| Wildschut, ED | 1 |
| Tibboel, D | 1 |
| Bogers, AJJC | 1 |
| Liu, PP | 1 |
| Sun, Y | 1 |
| Wu, C | 1 |
| Xu, WH | 1 |
| Zhang, RD | 1 |
| Zheng, JJ | 1 |
| Huang, Y | 1 |
| Chen, YQ | 1 |
| Zhang, MZ | 1 |
| Wu, JZ | 1 |
| Jiang, L | 1 |
| Ding, S | 1 |
| Yan, H | 1 |
| Li, Y | 1 |
| Zhang, L | 1 |
| Chen, X | 1 |
| Yin, X | 1 |
| Liu, S | 1 |
| Tang, X | 1 |
| Zhang, J | 1 |
| Kerai, S | 1 |
| Saxena, KN | 1 |
| Sehrawat, L | 1 |
| Taneja, B | 1 |
| Soriano, A | 1 |
| Salmerón, J | 1 |
| Quitantes, A | 1 |
| Navarro, I | 1 |
| Bernet, V | 1 |
| Latal, B | 1 |
| Natalucci, G | 1 |
| Doell, C | 1 |
| Ziegler, A | 1 |
| Wohlrab, G | 1 |
| Xia, WF | 2 |
| Liu, Y | 1 |
| Zhou, QS | 2 |
| Tang, QZ | 1 |
| Zou, HD | 2 |
| Hamid, M | 1 |
| Khan, MA | 1 |
| Khatri, A | 1 |
| Akhtar, I | 1 |
| Laird, TH | 1 |
| Stayer, SA | 2 |
| Rivenes, SM | 2 |
| Lewin, MB | 2 |
| McKenzie, ED | 2 |
| Fraser, CD | 2 |
| Andropoulos, DB | 2 |
| Odegard, KC | 1 |
| Schure, A | 1 |
| Saiki, Y | 1 |
| Hansen, DD | 1 |
| Jonas, RA | 1 |
| Laussen, PC | 1 |
| Chauhan, S | 1 |
| Ingole, P | 1 |
| Kale, S | 1 |
| Kiran, U | 1 |
| Malagon, I | 1 |
| Hogenbirk, K | 1 |
| van Pelt, J | 1 |
| Hazekamp, MG | 1 |
| Bovill, JG | 1 |
| Subramaniam, B | 1 |
| Soriano, SG | 1 |
| Michael Scott, R | 1 |
| Kussman, BD | 1 |
| Wu, LX | 1 |
| Cheng, BC | 1 |
| Baysal, A | 2 |
| Polat, TB | 2 |
| Yalcin, Y | 2 |
| Celebi, A | 2 |
| Pohl-Schickinger, A | 1 |
| Lemmer, J | 1 |
| Hübler, M | 1 |
| Alexi-Meskishvili, V | 1 |
| Redlin, M | 1 |
| Berger, F | 1 |
| Stiller, B | 1 |
| Lévêque, C | 1 |
| Hamza, J | 1 |
| Berg, AE | 1 |
| Barbotin-Larrieu, F | 1 |
| Laguenie, G | 1 |
| Goutail-Flaud, F | 1 |
| Couturier, C | 1 |
| Egu, JF | 1 |
| Mekouar, R | 1 |
| Saint-Maurice, C | 1 |
| Alswang, M | 1 |
| Friesen, RH | 1 |
| Bangert, P | 1 |
| Chhangani, SV | 1 |
| Shenoy, K | 1 |
| Freeman, JE | 1 |
| Hofstra, J | 1 |
| Deleon, SY | 1 |
| Levine, MF | 1 |
| Hartley, EJ | 1 |
| Macpherson, BA | 1 |
| Burrows, FA | 1 |
| Lerman, J | 1 |
| van der Bijl, P | 1 |
| Roelofse, JA | 1 |
| Bent, ST | 1 |
| Schoenig, HM | 1 |
| Vischoff, D | 1 |
| Fortier, LP | 1 |
| Villeneuve, E | 1 |
| Boutin, C | 1 |
| Labelle, H | 1 |
| Schlünder, C | 1 |
| Houben, F | 1 |
| Hartwig, S | 1 |
| Theisohn, M | 1 |
| Roth, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Clonidine in Reducing Iatrogenic-induced Opioid Dependence in Infants:[NCT01360450] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2011-07-31 | Terminated (stopped due to The study was treminated because of low accural) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time to complete detoxification is defined as 48 hrs off all opioids/benzodiazepines and study drug with acceptable withdrawal scores of <9 (on average we expect the infant to be enrolled in the study for 2-4 weeks). The scale used to assess withdrawal was the Modified Finnegan Neonatal Withdrawal Scale, which ranges from 0-41, 0 represents no withdrawal and 41 represent maximum withdrawal. (NCT01360450)
Timeframe: up to 4 weeks
| Intervention | days (Mean) | |
|---|---|---|
| total days on narcotics | duration on study drug in days | |
| Control | 37.2 | 14.2 |
| Treatment | 89.5 | 21 |
10 trials available for midazolam and Abnormality, Heart
| Article | Year |
|---|---|
The effectiveness of transport in a toy car for reducing preoperative anxiety in preschool children: a randomised controlled prospective trial.
Topics: Anesthesia, General; Anxiety; Cardiac Surgical Procedures; Child, Preschool; Female; Heart Defects, | 2018 |
Comparison of the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Cardiac Surgical Procedures; Child; Female; Heart | 2011 |
Pulmonary-to-systemic blood flow ratio effects of sevoflurane, isoflurane, halothane, and fentanyl/midazolam with 100% oxygen in children with congenital heart disease.
Topics: Adolescent; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind | 2002 |
Effect of three different anaesthetic agents on the postoperative production of cardiac troponin T in paediatric cardiac surgery.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Child, Preschool; Female; Heart Defec | 2005 |
[Cardioprotective effects of propofol and midazolam in children with congenital heart diseases undergoing open heart surgery].
Topics: Adolescent; Anesthetics, Intravenous; Body Temperature; Cardiac Surgical Procedures; Cardiotonic Age | 2007 |
Can analysis of the bispectral index prove helpful when monitoring titration of doses of midazolam and ketamine for sedation during paediatric cardiac catheterization.
Topics: Adjuvants, Anesthesia; Adolescent; Age Factors; Anesthetics, Dissociative; Blood Pressure; Body Weig | 2008 |
The use of basic parameters for monitoring the haemodynamic effects of midazolam and ketamine as opposed to propofol during cardiac catheterization.
Topics: Adolescent; Arterial Pressure; Cardiac Catheterization; Child; Child, Preschool; Female; Heart Defec | 2014 |
Effect of preanesthetic medication on carbon dioxide tension in children with congenital heart disease.
Topics: Blood Gas Monitoring, Transcutaneous; Blood Pressure; Carbon Dioxide; Child; Child, Preschool; Consc | 1994 |
Oral midazolam premedication for children with congenital cyanotic heart disease undergoing cardiac surgery: a comparative study.
Topics: Administration, Oral; Administration, Rectal; Anxiety, Separation; Atropine; Awareness; Child; Child | 1993 |
Cardiovascular effects of sevoflurane, isoflurane, halothane, and fentanyl-midazolam in children with congenital heart disease: an echocardiographic study of myocardial contractility and hemodynamics.
Topics: Adolescent; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Echocardiogr | 2001 |
17 other studies available for midazolam and Abnormality, Heart
| Article | Year |
|---|---|
Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients.
Topics: Bayes Theorem; Benzodiazepines; Cardiovascular System; Deep Sedation; Down Syndrome; Female; Heart D | 2020 |
Nurse-driven analgesia and sedation in pediatric patients with univentricular hearts requiring extracorporeal life support after first-stage palliation surgery: A pilot study.
Topics: Advanced Cardiac Life Support; Analgesia; Analgesics, Opioid; Cardiac Surgical Procedures; Conscious | 2017 |
Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery.
Topics: Adolescent; Anesthetics, Intravenous; Anti-Bacterial Agents; Blood Transfusion, Autologous; Cardiac | 2018 |
A retrospective comparison of dexmedetomidine versus midazolam for pediatric patients with congenital heart disease requiring postoperative sedation.
Topics: Anesthetics, Intravenous; Child, Preschool; Delirium; Dexmedetomidine; Dose-Response Relationship, D | 2015 |
Anesthesia for noncardiac intervention in a patient with total anomalous systemic venous return.
Topics: Anesthesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Child, Preschool; Cystoscopy; Fenta | 2016 |
[Sedation-analgesia to provide topical anesthesia on the eye in Holt-Oram syndrome].
Topics: Abnormalities, Multiple; Administration, Intranasal; Administration, Topical; Anesthetics, Local; Co | 2009 |
Effect of sedation and analgesia on postoperative amplitude-integrated EEG in newborn cardiac patients.
Topics: Analgesics, Opioid; Brain; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child Development; C | 2010 |
Effectiveness of premedication at the time of separation from parent and mask induction in paediatric patients coming for congenital heart disease surgery.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Cardiac Surgical Procedures; Chi-Square Distribution; Child; Ch | 2012 |
Anesthetic considerations during caval inflow occlusion in children with congenital heart disease.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child, Preschool; Constricti | 2004 |
Correlation of BIS with Tet spells.
Topics: Analgesics; Anti-Anxiety Agents; Child; Cyanosis; Electroencephalography; Heart Defects, Congenital; | 2004 |
Anesthetic management of pial synangiosis and intracranial hemorrhage with a Fontan circulation.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Craniotomy; Female; Fontan Procedure; Hear | 2006 |
Intravenous clonidine infusion in infants after cardiovascular surgery.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Blood Pressure; Body Temperature; Clonidine; Female; Fent | 2008 |
Successful repair of a severe left congenital diaphragmatic hernia during continuous inhalation of nitric oxide.
Topics: Administration, Inhalation; Alfentanil; Anesthesia, General; Birth Weight; Dobutamine; Epoprostenol; | 1994 |
Monitored anesthesia care for closure of adjustable atrial fenestrations following the Fontan procedure.
Topics: Anastomosis, Surgical; Anesthesia, Intravenous; Blood Pressure; Child, Preschool; Fentanyl; Heart At | 1994 |
Propofol and midazolam for conscious sedation in a mentally retarded dental patient.
Topics: Adult; Conscious Sedation; Dental Care for Disabled; Female; Heart Defects, Congenital; Humans; Infu | 1992 |
Anaesthetic management of an adolescent for scoliosis surgery with a Fontan circulation.
Topics: Adolescent; Androstanols; Anesthesia, Intravenous; Anesthetics, Combined; Fentanyl; Fontan Procedure | 2001 |
[Analgesia and sedation in neonatal-pediatric intensive care].
Topics: Analgesia; Analgesics, Opioid; Child, Preschool; Conscious Sedation; Dose-Response Relationship, Dru | 1991 |