midazolam has been researched along with Abnormalities, Congenital in 1 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of midazolam in early stages of pregnancy has resulted in a high incidence of birth defects; however, the underlying reason is unknown." | 3.88 | Relationship between low midazolam metabolism by cytochrome P450 3A in mice and the high incidence of birth defects. ( Hatogai, J; Iimura, R; Kitaoka, S; Kusunoki, Y; Nakai, M; Oba, K; Ochiai, W; Sugiyama, K; Yamamoto, Y, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kitaoka, S | 1 |
| Hatogai, J | 1 |
| Iimura, R | 1 |
| Yamamoto, Y | 1 |
| Oba, K | 1 |
| Nakai, M | 1 |
| Kusunoki, Y | 1 |
| Ochiai, W | 1 |
| Sugiyama, K | 1 |
1 other study available for midazolam and Abnormalities, Congenital
| Article | Year |
|---|---|
Relationship between low midazolam metabolism by cytochrome P450 3A in mice and the high incidence of birth defects.
Topics: Animals; Congenital Abnormalities; Cytochrome P-450 CYP3A; Female; Humans; Hypnotics and Sedatives; | 2018 |