midazolam has been researched along with 2019 Novel Coronavirus Disease in 12 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Management of drug-drug interactions (DDIs) for ensitrelvir, a novel 3-chymotrypsin-like protease inhibitor of SARS-CoV-2 infection is crucial." | 3.30 | Evaluation of the Drug-Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults. ( Fukuhara, T; Kubota, R; Kuwata, A; Matsuo, Y; Matsuzaki, T; Shimizu, R; Sonoyama, T, 2023) |
| "Phenobarbital was trialed for possible propofol withdrawal syndrome, allowing for a dose reduction of 10 μg/kg/min within 2 hours of the first dose without any corresponding symptoms." | 1.91 | Successful management of suspected propofol dependence with phenobarbital in an adult patient with COVID-19. ( Feeney, ME; Steiling, K, 2023) |
| " We used physiologically-based pharmacokinetic (PBPK) modeling to simulate the effect of inflammation on the pharmacokinetics of CYP3A metabolized drugs." | 1.72 | Physiologically Based Pharmacokinetic Modelling to Investigate the Impact of the Cytokine Storm on CYP3A Drug Pharmacokinetics in COVID-19 Patients. ( Battegay, M; Marzolini, C; Sendi, P; Stader, F, 2022) |
| "The incidence of PTSD was 16." | 1.72 | COVID-19 induced PTSD: Stressors for trauma and acute care surgeons. ( Esposito, TJ; James, MK; McKenzie, K; Robitsek, RJ; Valenzuela, JY, 2022) |
| "The most prevalent symptoms were: breathlessness, weakness/lack of energy, drowsiness, anxiety, agitation, confusion/delirium, and pain." | 1.72 | Symptom Control and Survival for People Severely ill With COVID: A Multicentre Cohort Study (CovPall-Symptom). ( Bajwah, S; Bradshaw, A; Chambers, RL; Dunleavy, L; Fraser, LK; Higginson, IJ; Hocaoglu, MB; Maddocks, M; Murtagh, FEM; Oluyase, AO; Preston, N; Sleeman, KE; Walshe, C, 2022) |
| "Pneumonia caused by coronavirus disease 2019 (COVID-19) is a highly contagious disease." | 1.62 | A Case Report of Sedation Strategy for a Patient With Coronavirus Disease 2019 Supported by Extracorporeal Membrane Oxygenation After Cesarean Section. ( Cheng, Z; Li, B; Liao, X; Wen, J, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 12 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stader, F | 1 |
| Battegay, M | 1 |
| Sendi, P | 1 |
| Marzolini, C | 1 |
| Shudofsky, KN | 1 |
| Janssen, PKC | 1 |
| Foudraine, N | 1 |
| le Noble, JLML | 1 |
| James, MK | 1 |
| Robitsek, RJ | 1 |
| McKenzie, K | 1 |
| Valenzuela, JY | 1 |
| Esposito, TJ | 1 |
| Higginson, IJ | 1 |
| Hocaoglu, MB | 1 |
| Fraser, LK | 1 |
| Maddocks, M | 1 |
| Sleeman, KE | 1 |
| Oluyase, AO | 1 |
| Chambers, RL | 1 |
| Preston, N | 1 |
| Dunleavy, L | 1 |
| Bradshaw, A | 1 |
| Bajwah, S | 1 |
| Murtagh, FEM | 1 |
| Walshe, C | 1 |
| Rijpstra, M | 1 |
| Kuip, E | 1 |
| Hasselaar, J | 1 |
| Vissers, K | 1 |
| Shimizu, R | 1 |
| Sonoyama, T | 1 |
| Fukuhara, T | 1 |
| Kuwata, A | 1 |
| Matsuzaki, T | 1 |
| Matsuo, Y | 1 |
| Kubota, R | 1 |
| Feeney, ME | 1 |
| Steiling, K | 1 |
| Kiserud, Y | 1 |
| Rosland, JH | 1 |
| Jackson, T | 1 |
| Hobson, K | 1 |
| Clare, H | 1 |
| Weegmann, D | 1 |
| Moloughney, C | 1 |
| McManus, S | 1 |
| Zombori, L | 1 |
| Bacon, M | 1 |
| Wood, H | 1 |
| Chatterjee, F | 1 |
| Venkateswaran, R | 1 |
| Lampariello, S | 1 |
| Yoong, M | 1 |
| Liao, X | 1 |
| Cheng, Z | 1 |
| Wen, J | 1 |
| Li, B | 1 |
| Gutierrez, J | 1 |
| Sepulveda, W | 1 |
| Ramirez, R | 1 |
| Acosta, G | 1 |
| Ambiado, S | 1 |
1 trial available for midazolam and 2019 Novel Coronavirus Disease
| Article | Year |
|---|---|
Evaluation of the Drug-Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults.
Topics: Adult; Area Under Curve; COVID-19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexame | 2023 |
11 other studies available for midazolam and 2019 Novel Coronavirus Disease
| Article | Year |
|---|---|
Physiologically Based Pharmacokinetic Modelling to Investigate the Impact of the Cytokine Storm on CYP3A Drug Pharmacokinetics in COVID-19 Patients.
Topics: Adult; COVID-19; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; | 2022 |
Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome.
Topics: Aged; Continuous Renal Replacement Therapy; COVID-19; COVID-19 Drug Treatment; Critical Illness; Dee | 2022 |
COVID-19 induced PTSD: Stressors for trauma and acute care surgeons.
Topics: Adult; COVID-19; Female; Hospitals, University; Humans; Male; Midazolam; Pandemics; Stress Disorders | 2022 |
Symptom Control and Survival for People Severely ill With COVID: A Multicentre Cohort Study (CovPall-Symptom).
Topics: Aged; Cohort Studies; COVID-19; Delirium; Dyspnea; Humans; Midazolam; Morphine; Pain; Palliative Car | 2022 |
The clinical practice of palliative sedation in patients dying from COVID-19: a retrospective chart review.
Topics: Adult; COVID-19; Humans; Hypnotics and Sedatives; Midazolam; Neoplasms; Palliative Care; Pandemics; | 2023 |
Successful management of suspected propofol dependence with phenobarbital in an adult patient with COVID-19.
Topics: Adult; COVID-19; Dexmedetomidine; Fentanyl; Humans; Hypertension; Hypnotics and Sedatives; Male; Mid | 2023 |
Relieving the sensation of suffocation in patients dying with COVID-19.
Topics: Algorithms; Analgesics, Opioid; Asphyxia; Betacoronavirus; Coronavirus Infections; COVID-19; Fear; H | 2020 |
End-of-life care in COVID-19: An audit of pharmacological management in hospital inpatients.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Betacoronavirus; Biopharmaceutics; Coronavirus I | 2020 |
Severe cortical damage associated with COVID-19 case report.
Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo | 2021 |
A Case Report of Sedation Strategy for a Patient With Coronavirus Disease 2019 Supported by Extracorporeal Membrane Oxygenation After Cesarean Section.
Topics: Cesarean Section; Combined Modality Therapy; COVID-19; Dexmedetomidine; Extracorporeal Membrane Oxyg | 2021 |
Fetal Bladder Rupture as a Complication of Adjunctive Therapy in Severe Maternal SARS-CoV-2 Pneumonia.
Topics: Adult; Analgesics, Opioid; COVID-19; Dexmedetomidine; Female; Fentanyl; Humans; Midazolam; Pregnancy | 2022 |