microcystin and Liver-Cirrhosis

microcystin has been researched along with Liver-Cirrhosis* in 1 studies

Other Studies

1 other study(ies) available for microcystin and Liver-Cirrhosis

Article	Year
Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. American journal of physiology. Gastrointestinal and liver physiology, 2019, 10-01, Volume: 317, Issue:4 Nonalcoholic fatty liver disease (NAFLD) is an emerging global pandemic. Though significant progress has been made in unraveling the pathophysiology of the disease, the role of protein phosphatase 2A (PP2A) and its subsequent inhibition by environmental and genetic factors in NAFLD pathophysiology remains unclear. The present report tests the hypothesis that an exogenous PP2A inhibitor leads to hepatic inflammation and fibrogenesis via an NADPH oxidase 2 (NOX2)-dependent pathway in NAFLD. Results showed that microcystin (MC) administration, a potent PP2A inhibitor found in environmental exposure, led to an exacerbation of NAFLD pathology with increased Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cytokines; Enzyme Inhibitors; Hepatic Stellate Cells; Kupffer Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; MicroRNAs; NADPH Oxidase 2; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid; Protein Phosphatase 2	2019

Article

Year

Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.

American journal of physiology. Gastrointestinal and liver physiology, 2019, 10-01, Volume: 317, Issue:4

Nonalcoholic fatty liver disease (NAFLD) is an emerging global pandemic. Though significant progress has been made in unraveling the pathophysiology of the disease, the role of protein phosphatase 2A (PP2A) and its subsequent inhibition by environmental and genetic factors in NAFLD pathophysiology remains unclear. The present report tests the hypothesis that an exogenous PP2A inhibitor leads to hepatic inflammation and fibrogenesis via an NADPH oxidase 2 (NOX2)-dependent pathway in NAFLD. Results showed that microcystin (MC) administration, a potent PP2A inhibitor found in environmental exposure, led to an exacerbation of NAFLD pathology with increased

Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cytokines; Enzyme Inhibitors; Hepatic Stellate Cells; Kupffer Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; MicroRNAs; NADPH Oxidase 2; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid; Protein Phosphatase 2

2019