micafungin and Brain-Abscess

Topics: Abscess; Adult; Antifungal Agents; beta-Glucans; Brain Abscess; Central Nervous System Infections; Dexamethasone; Fresh Water; Humans; Invasive Fungal Infections; Lung Abscess; Magnetic Resonance Imaging; Male; Micafungin; Near Drowning; Pneumonia, Aspiration; Scedosporium; Spinal Cord Diseases; Tomography, X-Ray Computed; Voriconazole

Micafungin and caspofungin, which are both echinocandins, elicit their antifungal effects by suppressing the synthesis of β-D-glucan, an essential component of fungal cell walls. If micafungin is not effective against a fungal infection, is it unreasonable to switch to caspofungin?. An 80-year-old Asian man presented to our hospital with brain and lung abscesses. Klebsiella pneumonia and Escherichia coli were identified by sputa culture and Streptococcus mitis was identified in the brain abscess culture obtained by drainage surgery. He was treated with antibiotics and both abscesses shrank after the treatment. But he continued to have a high fever and Candida glabrata was identified by blood culture. The origin of the infection was not clarified and micafungin was administered intravenously. The fungus showed poor susceptibility to micafungin; we then switched the antifungal from micafungin to caspofungin. After caspofungin treatment, his body temperature remained below 37 °C and his β-D-glucan levels decreased remarkably.. In vitro, micafungin is considered more effective against C. glabrata because its minimum inhibitory concentration against C. glabrata is lower than that of caspofungin. However, in vivo, there is no significantly different effect between the two drugs. When micafungin is not effective against candidiasis, a switch to caspofungin might be applicable because the pharmacokinetics in each echinocandin is slightly different.

Topics: Aged, 80 and over; Antifungal Agents; Brain Abscess; Candida glabrata; Candidiasis; Caspofungin; Echinocandins; Fever; Humans; Lipopeptides; Lung Abscess; Male; Micafungin; Treatment Outcome