Page last updated: 2024-08-24

mibefradil and Nerve Pain

mibefradil has been researched along with Nerve Pain in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's12 (92.31)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Back, SK; Choo, HY; Kam, YL; Na, HS; Rhee, HK; Rhim, H1
Chung, HJ; Lee, YS; Pae, AN; Roh, EJ; Seo, SH; Shin, KJ; Song, CM; Woo, HM1
Chung, H; Keum, G; Kim, JH; Nam, G1
Kim, JH; Nam, G1
Du Nguyen, H; Horaguchi, Y; Kasanami, Y; Kawabata, A; Kitamura, S; Nishikawa, H; Okada, T; Sekiguchi, F; Toyooka, N; Tsubota, M; Yamaoka, S; Yoshida, S1
Jeong, KS; Lim, SM; Pae, AN; Son, WS1
Wang, J; Wang, XW; Yin, CP; Yue, SW; Zhang, Y1
Kumamoto, N; Shibata, Y; Shimada, S; Ueda, T; Ugawa, S; Watanabe, M1
Chang, YF; Chen, YL; Cheng, JK; Hung, YC; Lin, CS; Shiue, SJ; Tsaur, ML; Wang, SW; Wang, TY; Wang, YC1
Chen, ZX; Li, H; Liang, H; Wen, XJ; Xu, SY; Yang, CX1
Aoki, Y; Kawabata, A; Maeda, Y; Mitani, K; Nishikawa, H; Okubo, K; Sekiguchi, F; Takahashi, T1
Liu, L; Liu, Z; Shu, B; Yue, J; Zhang, Y1
Dogrul, A; Gardell, LR; Lai, J; Ossipov, MH; Porreca, F; Tulunay, FC1

Other Studies

13 other study(ies) available for mibefradil and Nerve Pain

ArticleYear
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.
    Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

    Topics: Analgesics; Animals; Calcium Channels, T-Type; Humans; Neuralgia; Pain Measurement; Piperazines; Rats

2010
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Drug Stability; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Hyperalgesia; Inhibitory Concentration 50; Ligands; Mibefradil; Molecular Structure; Molecular Targeted Therapy; Neuralgia; Patch-Clamp Techniques; Piperidines; Quantitative Structure-Activity Relationship; Rats; Spinal Nerves; Structure-Activity Relationship

2011
Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment.
    European journal of medicinal chemistry, 2016, Nov-10, Volume: 123

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Chemistry Techniques, Synthetic; Drug Stability; Humans; Neuralgia; Rats; Sulfonamides

2016
Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain.
    Bioorganic & medicinal chemistry, 2016, 11-01, Volume: 24, Issue:21

    Topics: Administration, Oral; Animals; Azabicyclo Compounds; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; HEK293 Cells; Humans; Male; Neuralgia; Pyrazoles; Rats; Structure-Activity Relationship

2016
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
    Bioorganic & medicinal chemistry, 2018, 08-15, Volume: 26, Issue:15

    Topics: Action Potentials; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Flavonoids; HEK293 Cells; Humans; Inhibitory Concentration 50; Male; Mice; Neuralgia; Patch-Clamp Techniques; Structure-Activity Relationship

2018
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model.
    Bioorganic & medicinal chemistry letters, 2019, 05-15, Volume: 29, Issue:10

    Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Calcium Signaling; Disease Models, Animal; Gabapentin; Ganglia, Spinal; Humans; Ligation; Microsomes, Liver; Molecular Structure; Neuralgia; Pyrrolidines; Rats; Structure-Activity Relationship

2019
Ca(2+) influx mediates the TRPV4-NO pathway in neuropathic hyperalgesia following chronic compression of the dorsal root ganglion.
    Neuroscience letters, 2015, Feb-19, Volume: 588

    Topics: Animals; Calcium; Calcium Channel Blockers; Chronic Disease; Ganglia, Spinal; Hyperalgesia; Male; Mibefradil; Nerve Compression Syndromes; Neuralgia; NF-kappa B; Nitric Oxide; Phorbols; Rats, Wistar; RNA, Small Interfering; Signal Transduction; TRPV Cation Channels

2015
Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Analgesics; Animals; Benzimidazoles; Calcium Channels, T-Type; Cyclopropanes; Ganglia, Spinal; Hyperalgesia; Inflammation; Mibefradil; Mice; Naphthalenes; Neuralgia; Neurons

2015
Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats.
    British journal of anaesthesia, 2015, Volume: 115, Issue:1

    Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Ethosuximide; Ligation; Male; Mibefradil; Neuralgia; Nickel; Rats; Rats, Sprague-Dawley

2015
The roles of T-type calcium channel in the development of neuropathic pain following chronic compression of rat dorsal root ganglia.
    Pharmacology, 2010, Volume: 85, Issue:5

    Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, T-Type; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Lumbar Vertebrae; Male; Mibefradil; Nerve Compression Syndromes; Neuralgia; Protein Isoforms; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; RNA, Messenger; Time Factors; Touch

2010
Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain.
    Pain, 2010, Volume: 150, Issue:1

    Topics: Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, T-Type; Hydrogen Sulfide; Hyperalgesia; Immunohistochemistry; Male; Mibefradil; Neuralgia; Neurons, Afferent; Pain Threshold; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Spinal Nerves; Up-Regulation

2010
Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.
    Spine, 2013, Mar-15, Volume: 38, Issue:6

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Ganglia, Spinal; Injections, Spinal; Lumbar Vertebrae; Male; Membrane Potentials; Mibefradil; Neuralgia; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensory Receptor Cells; Spinal Nerves; Up-Regulation

2013
Reversal of experimental neuropathic pain by T-type calcium channel blockers.
    Pain, 2003, Volume: 105, Issue:1-2

    Topics: Administration, Topical; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Dose-Response Relationship, Drug; Ethosuximide; Foot; Hot Temperature; Injections, Intraperitoneal; Injections, Spinal; Ligation; Male; Mibefradil; Neuralgia; Rats; Rats, Sprague-Dawley; Spinal Nerves; Touch; Wounds, Nonpenetrating

2003