mibefradil has been researched along with Disease Models, Animal in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 16 (59.26) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, HK; Lee, JY; Lee, YS; Rhim, H; Roh, EJ; Shin, KJ | 1 |
| Chung, HJ; Lee, YS; Pae, AN; Roh, EJ; Seo, SH; Shin, KJ; Song, CM; Woo, HM | 1 |
| Kim, JH; Nam, G | 1 |
| Du Nguyen, H; Horaguchi, Y; Kasanami, Y; Kawabata, A; Kitamura, S; Nishikawa, H; Okada, T; Sekiguchi, F; Toyooka, N; Tsubota, M; Yamaoka, S; Yoshida, S | 1 |
| Jeong, KS; Lim, SM; Pae, AN; Son, WS | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chitaley, K; Jiang, X; Luttrell, I; Yang, CC | 1 |
| Duker, G; Fjellstrom, O; Giordanetto, F; Iwasaki, YK; Kato, T; Nattel, S; Sundqvist, M; Wallin, A; Wang, QD | 1 |
| Hu, F; Li, M; Long, M; Lu, Y; Xu, Z; Zhou, S | 1 |
| Chang, YF; Chen, YL; Cheng, JK; Hung, YC; Lin, CS; Shiue, SJ; Tsaur, ML; Wang, SW; Wang, TY; Wang, YC | 1 |
| Chen, LH; Huang, Y; Li, JC; Liu, T; Peng, XY; Tian, B; Wang, XL | 1 |
| Casarez, EV; Dziegielewska, B; Dziegielewski, J; Gray, LS; Slack-Davis, JK; Yang, WZ | 1 |
| Aoki, Y; Kawabata, A; Maeda, Y; Matsunami, M; Nishikawa, H; Sekiguchi, F; Takahashi, T | 1 |
| Arai, Y; Fujiwara, M; Harada, M; Kinoshita, H; Kuwabara, Y; Kuwahara, K; Murakami, M; Nakagawa, Y; Nakanishi, M; Nakao, K; Takano, M; Ueshima, K; Yasuno, S | 1 |
| Bui, PH; Handforth, A; Hankinson, O; Homanics, GE; Quesada, A | 1 |
| Huang, CS; Kuo, CC; Pan, MK; Tai, CH; Yang, YC | 1 |
| Hayashi, Y; Kawabata, A; Kubo, L; Matsunami, M; Miki, T; Nishikawa, H; Nishiura, K; Okawa, Y; Ozaki, T; Sekiguchi, F; Tsujiuchi, T | 1 |
| Bigner, DD; Friedman, HS; Gray, LA; Keir, ST; Reardon, DA | 1 |
| Kowalski, L; Popp, B; Schlesinger, D; Sheehan, JP; Xu, Z | 1 |
| Gezici, A; Ozturk, H | 1 |
| Duran, H; Ozturk, H; Uzunlar, AK | 1 |
| Chen, CC; Cheng, JK; Chiou, LC; Lin, CS; Yang, JR | 1 |
| Broicher, T; Budde, T; Kanyshkova, T; Meuth, P; Meuth, SG; Munsch, T; Pape, HC; Seidenbecher, T | 1 |
| Bohle, RM; Dreyer, T; Sandmann, S; Unger, T | 1 |
| Meissner, A; Min, JY; Morgan, JP; Wang, J | 1 |
| Dogrul, A; Tulunay, FC; Zagli, U | 1 |
27 other study(ies) available for mibefradil and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels, T-Type; Combinatorial Chemistry Techniques; Disease Models, Animal; Drug Design; Mibefradil; Mice; Molecular Structure; Phenylacetates; Piperazines | 2008 |
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Drug Stability; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Hyperalgesia; Inhibitory Concentration 50; Ligands; Mibefradil; Molecular Structure; Molecular Targeted Therapy; Neuralgia; Patch-Clamp Techniques; Piperidines; Quantitative Structure-Activity Relationship; Rats; Spinal Nerves; Structure-Activity Relationship | 2011 |
Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; HEK293 Cells; Humans; Male; Neuralgia; Pyrazoles; Rats; Structure-Activity Relationship | 2016 |
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
Topics: Action Potentials; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Drug Design; Flavonoids; HEK293 Cells; Humans; Inhibitory Concentration 50; Male; Mice; Neuralgia; Patch-Clamp Techniques; Structure-Activity Relationship | 2018 |
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model.
Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Calcium Signaling; Disease Models, Animal; Gabapentin; Ganglia, Spinal; Humans; Ligation; Microsomes, Liver; Molecular Structure; Neuralgia; Pyrrolidines; Rats; Structure-Activity Relationship | 2019 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
T- and L-type voltage-gated calcium channels: their role in diabetic bladder dysfunction.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mibefradil; Mice; Mice, Inbred C57BL; Muscle Contraction; Myocytes, Smooth Muscle; Nifedipine; RNA, Messenger; Urinary Bladder; Urinary Bladder Diseases | 2014 |
Inefficacy of a highly selective T-type calcium channel blocker in preventing atrial fibrillation related remodeling.
Topics: Action Potentials; Animals; Atrial Fibrillation; Atrial Remodeling; Calcium Channel Blockers; Calcium Channels, T-Type; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Heart Atria; Mibefradil; Refractory Period, Electrophysiological; Time Factors | 2014 |
Mibefradil reduces blood glucose concentration in db/db mice.
Topics: Animals; Blood Glucose; Blotting, Western; Brain; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Disease Models, Animal; Eating; Hypoglycemic Agents; Immunohistochemistry; Injections, Intraperitoneal; Liver; Male; Medical Illustration; Mibefradil; Mice; Reproducibility of Results; Time Factors; Treatment Outcome | 2014 |
Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Ethosuximide; Ligation; Male; Mibefradil; Neuralgia; Nickel; Rats; Rats, Sprague-Dawley | 2015 |
Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
Topics: Acetanilides; Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Diterpenes; Male; Mibefradil; Mice; Pruritus; Purines; Receptors, Opioid; RNA Interference; Sensory Receptor Cells; Sulfides; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2015 |
T-Type Ca2+ Channel Inhibition Sensitizes Ovarian Cancer to Carboplatin.
Topics: Animals; Antineoplastic Agents; Apoptosis; Calcium Channel Blockers; Calcium Channels, T-Type; Carboplatin; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Forkhead Transcription Factors; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Inhibitor of Apoptosis Proteins; Mibefradil; Mice; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Survivin; Transcription, Genetic; Xenograft Model Antitumor Assays | 2016 |
Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cerebellum; Disease Models, Animal; Ganglia, Spinal; Hydrogen Sulfide; Hyperalgesia; Male; Mibefradil; Oligodeoxyribonucleotides, Antisense; Pain Threshold; Rats; Rats, Wistar; Spinal Cord | 2009 |
T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiomyopathy, Dilated; Death, Sudden, Cardiac; Dihydropyridines; Disease Models, Animal; Female; Mibefradil; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Infarction; Myocytes, Cardiac; Nitrendipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques | 2009 |
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor.
Topics: Animals; Behavior, Animal; Benzimidazoles; Cyclopropanes; Cytochrome P-450 Enzyme System; Disease Models, Animal; Essential Tremor; Gene Deletion; Harmaline; Hydroxylation; Methylation; Mibefradil; Mice; Naphthalenes; Receptors, GABA-A; Structure-Activity Relationship; Testosterone | 2011 |
Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.
Topics: Animals; Benzimidazoles; Cadmium; Calcium; Calcium Channels, T-Type; Cyclopropanes; Dihydropyridines; Disease Models, Animal; Electrophysiology; Male; Mibefradil; Movement; Naphthalenes; Neurons; Nickel; Nitrophenols; Organophosphorus Compounds; Parkinson Disease; Rats; Rats, Wistar | 2011 |
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.
Topics: Acetanilides; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclophosphamide; Cyclopropanes; Cystathionine gamma-Lyase; Cystitis; Disease Models, Animal; Female; Ganglia, Spinal; Hydrogen Sulfide; Mibefradil; Mice; Naphthalenes; Organ Size; Pain; Purines; Transient Receptor Potential Channels; TRPA1 Cation Channel; Urinary Bladder; Verapamil | 2012 |
Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Calcium Channel Blockers; Cell Cycle; Dacarbazine; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Glioblastoma; Humans; Kaplan-Meier Estimate; Mibefradil; Mice; Neoplasm Transplantation; Skin Neoplasms; Temozolomide; Time Factors; Xenograft Model Antitumor Assays | 2013 |
Inhibition of glioblastoma and enhancement of survival via the use of mibefradil in conjunction with radiosurgery.
Topics: Animals; Brain Neoplasms; Calcium Channel Blockers; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Glioblastoma; Magnetic Resonance Imaging; Mibefradil; Proportional Hazards Models; Radiosurgery; Rats; Rats, Sprague-Dawley; Retrospective Studies; Survival Rate; Treatment Outcome | 2013 |
The effects of mibefradil, a T-type Ca2+ channels blocker, on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Blood Urea Nitrogen; Calcium Channel Blockers; Creatinine; Disease Models, Animal; Immunohistochemistry; Kidney; Kidney Diseases; Kidney Function Tests; Male; Mibefradil; Nephrectomy; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion Injury; Risk Factors; Sensitivity and Specificity | 2005 |
Mibefradil, a T-type Ca2+ channel blocker, protects against mesenteric ischemia-reperfusion-induced oxidative injury and histologic alterations in intestinal mucosa in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Glutathione Peroxidase; Intestinal Mucosa; Lipid Peroxidation; Mesentery; Mibefradil; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Superoxide Dismutase; Treatment Outcome | 2006 |
Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Ethosuximide; Formaldehyde; Hindlimb; Injections, Spinal; Long-Term Potentiation; Male; Mibefradil; Neural Inhibition; Neuronal Plasticity; Nickel; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Electroencephalography; Epilepsy, Absence; Ethosuximide; Interneurons; Membrane Potentials; Mibefradil; Patch-Clamp Techniques; Rats; Rats, Inbred ACI; Thalamus | 2007 |
The T-type calcium channel blocker mibefradil reduced interstitial and perivascular fibrosis and improved hemodynamic parameters in myocardial infarction-induced cardiac failure in rats.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Fibrosis; Heart; Heart Failure; Hemodynamics; Male; Mibefradil; Myocardial Infarction; Myocardium; Organ Size; Rats; Rats, Wistar; Ventricular Remodeling | 2000 |
Mibefradil improves beta-adrenergic responsiveness and intracellular Ca(2+) handling in hypertrophied rat myocardium.
Topics: Adrenergic beta-Agonists; Aequorin; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; In Vitro Techniques; Injections; Intracellular Fluid; Isometric Contraction; Male; Mibefradil; Myocardial Contraction; Myocardium; Papillary Muscles; Rats; Rats, Inbred Lew; Verapamil | 2002 |
The role of T-type calcium channels in morphine analgesia, development of antinociceptive tolerance and dependence to morphine, and morphine abstinence syndrome.
Topics: Analgesia; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mibefradil; Mice; Morphine; Morphine Dependence; Pain; Substance Withdrawal Syndrome | 2002 |