mianserin has been researched along with Spinal Cord Injuries in 6 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| " To probe the role of 5-HT2R in this increased amplitude, dose-response studies were done with the selective antagonists mianserin or LY53857 and the 5-HT2R agonist (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)." | 1.34 | Up-regulation of 5-HT2 receptors is involved in the increased H-reflex amplitude after contusive spinal cord injury. ( Johnson, CS; Lee, JK; Wrathall, JR, 2007) |
| " dosage again displayed significant efficacy when administered at 15 min delaying treatment to 30 min resulted in only marginal therapeutic actions." | 1.29 | Characterization of mianserin neuroprotection in experimental spinal trauma: dose/route response and late treatment. ( Agresta, CA; Azim, S; Chavin, J; Kelly, G; Puniak, MA; Salzman, SK; Wang, L, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saruhashi, Y | 2 |
| Matsusue, Y | 1 |
| Hukuda, S | 1 |
| Lee, JK | 1 |
| Johnson, CS | 1 |
| Wrathall, JR | 1 |
| Young, W | 1 |
| Salzman, SK | 3 |
| Kelly, G | 1 |
| Chavin, J | 1 |
| Wang, L | 1 |
| Puniak, MA | 3 |
| Agresta, CA | 3 |
| Azim, S | 1 |
| Liu, ZJ | 1 |
| Maitland-Heriot, RP | 1 |
| Freeman, GM | 2 |
| Van Newkirk, L | 1 |
| Barone, CA | 1 |
6 other studies available for mianserin and Spinal Cord Injuries
| Article | Year |
|---|---|
Effects of serotonin 1A agonist on acute spinal cord injury.
Topics: Action Potentials; Analysis of Variance; Animals; In Vitro Techniques; Isoindoles; Male; Mianserin; | 2002 |
Up-regulation of 5-HT2 receptors is involved in the increased H-reflex amplitude after contusive spinal cord injury.
Topics: Amphetamines; Animals; Contusions; Ergolines; Female; H-Reflex; Immunohistochemistry; Injections, Sp | 2007 |
Effect of mianserin on locomotory function after thoracic spinal cord hemisection in rats.
Topics: Analysis of Variance; Animals; Hindlimb; Immunohistochemistry; Laminectomy; Mianserin; Motor Activit | 1994 |
Characterization of mianserin neuroprotection in experimental spinal trauma: dose/route response and late treatment.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Edema; Ketanserin; Male; Mian | 1994 |
The serotonin antagonist mianserin improves functional recovery following experimental spinal trauma.
Topics: Analysis of Variance; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Ketanserin; Male; M | 1991 |
Comparison of a serotonin antagonist, opioid antagonist, and TRH analog for the acute treatment of experimental spinal trauma.
Topics: Animals; Azetidines; Dipeptides; Evoked Potentials, Somatosensory; Male; Mianserin; Naltrexone; Narc | 1991 |