mianserin has been researched along with Sleep Wake Disorders in 13 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms." | 5.13 | Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008) |
| "Nineteen patients (12 women and 7 men), with SSRI-induced sexual dysfunction who were in remission from major depressive disorder (total Hamilton Rating Scale for Depression [HAM-D] score < or = 10), were switched to open-label mirtazapine for up to 6 weeks." | 5.09 | Mirtazapine substitution in SSRI-induced sexual dysfunction. ( Delgado, P; Gelenberg, AJ; Laukes, C; McGahuey, C; Moreno, F; Okayli, G; Zentner, L, 2000) |
| "Ninety-two outpatients with depressive disorders which met Research Diagnostic Criteria were treated either with mianserin or placebo in a 6-week controlled trial." | 5.05 | Placebo-controlled study of mianserin in depressed outpatients. ( Harrison, W; Markowitz, J; McGrath, PJ; Quitkin, FM; Rabkin, JG; Stewart, JW, 1985) |
| "Treatment with mirtazapine or placebo had no effect on cognitive and functional status as assessed by the Mini-Mental State Examination and the Katz scale, respectively." | 2.84 | Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study. ( Camargos, EF; Louzada, LL; Naves, JO; Nóbrega, OT; Quintas, JL; Scoralick, FM, 2017) |
| "Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine." | 2.73 | Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual. ( McGregor, C; Mitchell, A; Srisurapanont, M; White, JM; Wickes, W, 2008) |
| "Imipramine was more effective against the clusters related to core symptoms of depression: "depression and guilt", "retardation", and "melancholia", respectively." | 2.69 | Depressed in-patients respond differently to imipramine and mirtazapine. ( Bruijn, JA; Moleman, P; Mulder, PG; van den Broek, WW, 1999) |
| "Mirtazapine (MTZ) is an antidepressant, which is considered to enhance noradrenergic and serotonergic neurotransmission via antagonistic action at central α2-adrenergic autoreceptors and heteroreceptors." | 1.38 | Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. ( Enomoto, T; Hirayama, S; Horiuchi, H; Ikegami, D; Inada, E; Iseki, M; Nagase, H; Nakahara, K; Narita, M; Sakai, H; Suzuki, T; Torigoe, K; Yamashita, A; Yanase, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Sandahl, H | 2 |
| Jennum, P | 2 |
| Baandrup, L | 2 |
| Lykke Mortensen, E | 1 |
| Carlsson, J | 2 |
| Poschmann, IS | 1 |
| Künzel, H | 1 |
| Jeong, JH | 1 |
| Bahk, WM | 1 |
| Scoralick, FM | 1 |
| Louzada, LL | 1 |
| Quintas, JL | 2 |
| Naves, JO | 1 |
| Camargos, EF | 2 |
| Nóbrega, OT | 1 |
| Enomoto, T | 1 |
| Yamashita, A | 1 |
| Torigoe, K | 1 |
| Horiuchi, H | 1 |
| Hirayama, S | 1 |
| Nakahara, K | 1 |
| Yanase, M | 1 |
| Sakai, H | 1 |
| Ikegami, D | 1 |
| Nagase, H | 1 |
| Suzuki, T | 1 |
| Iseki, M | 1 |
| Inada, E | 1 |
| Narita, M | 1 |
| Oliveira, LF | 1 |
| Boaventura, TD | 1 |
| Cankurtaran, ES | 1 |
| Ozalp, E | 1 |
| Soygur, H | 1 |
| Akbiyik, DI | 1 |
| Turhan, L | 1 |
| Alkis, N | 1 |
| McGregor, C | 1 |
| Srisurapanont, M | 1 |
| Mitchell, A | 1 |
| Wickes, W | 1 |
| White, JM | 1 |
| Bruijn, JA | 1 |
| Moleman, P | 1 |
| Mulder, PG | 1 |
| van den Broek, WW | 1 |
| Gelenberg, AJ | 1 |
| McGahuey, C | 1 |
| Laukes, C | 1 |
| Okayli, G | 1 |
| Moreno, F | 1 |
| Zentner, L | 1 |
| Delgado, P | 1 |
| Thase, ME | 1 |
| McGrath, PJ | 1 |
| Rabkin, JG | 1 |
| Stewart, JW | 1 |
| Harrison, W | 1 |
| Quitkin, FM | 1 |
| Markowitz, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Sleep Disturbances in Trauma-affected Refugees: A Randomised Controlled Trial[NCT02761161] | Phase 4 | 241 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mianserin and Sleep Wake Disorders
| Article | Year |
|---|---|
Treatment issues related to sleep and depression.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder; Humans; M | 2000 |
8 trials available for mianserin and Sleep Wake Disorders
| Article | Year |
|---|---|
Imagery rehearsal therapy and/or mianserin in treatment of refugees diagnosed with PTSD: Results from a randomized controlled trial.
Topics: Adult; Female; Humans; Imagery, Psychotherapy; Male; Mianserin; Middle Aged; Refugees; Sleep Wake Di | 2021 |
Treatment of sleep disturbances in trauma-affected refugees: Study protocol for a randomised controlled trial.
Topics: Clinical Protocols; Combined Modality Therapy; Denmark; Humans; Imagery, Psychotherapy; Mianserin; R | 2017 |
Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double-blind, placebo-controlled pilot study.
Topics: Actigraphy; Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents, Tricyclic; Brazil; Do | 2017 |
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive | 2008 |
Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual.
Topics: Adult; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Centra | 2008 |
Depressed in-patients respond differently to imipramine and mirtazapine.
Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Anxiety | 1999 |
Mirtazapine substitution in SSRI-induced sexual dysfunction.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Depressive Disorder; Female; Humans; Irritable Mood; Male | 2000 |
Placebo-controlled study of mianserin in depressed outpatients.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Dizziness; F | 1985 |
4 other studies available for mianserin and Sleep Wake Disorders
| Article | Year |
|---|---|
[Use of psychotropic drugs in patients with chronic pain].
Topics: Chronic Pain; Cortisone; Depression; Guillain-Barre Syndrome; Humans; Mianserin; Middle Aged; Mirtaz | 2014 |
Sleep-related eating disorder associated with mirtazapine.
Topics: Antidepressive Agents, Tricyclic; Feeding and Eating Disorders; Female; Humans; Mianserin; Mirtazapi | 2014 |
Effects of mirtazapine on sleep disturbance under neuropathic pain-like state.
Topics: Animals; Disease Models, Animal; Histamine H1 Antagonists; Hyperalgesia; Male; Mianserin; Mice; Mice | 2012 |
Mianserin for the treatment of sleep disorders in patients with dementia: a retrospective open-label study.
Topics: Aged; Aged, 80 and over; Dementia; Humans; Hypnotics and Sedatives; Mianserin; Retrospective Studies | 2012 |