mianserin has been researched along with Sleep Apnea, Obstructive in 5 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine is an a2A antagonist and mixed 5-HT2/5-HT3 antagonist that has been proposed as a potential treatment for obstructive sleep apnea (OSA)." | 2.73 | Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. ( Buchanan, PR; Crompton, R; Desai, AV; Gendreau, RM; Grunstein, RR; Kranzler, J; Marshall, NS; Melehan, KL; Rao, SG; Wong, KK; Yee, BJ; Zack, N, 2008) |
| "In an animal model of central apnea the use of mirtazapine produced a significant reduction of apneas." | 1.32 | Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS). ( Castillo, JL; Guilleminault, C; Menendez, P; Segovia, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marshall, NS | 1 |
| Yee, BJ | 1 |
| Desai, AV | 1 |
| Buchanan, PR | 1 |
| Wong, KK | 1 |
| Crompton, R | 1 |
| Melehan, KL | 1 |
| Zack, N | 2 |
| Rao, SG | 1 |
| Gendreau, RM | 1 |
| Kranzler, J | 2 |
| Grunstein, RR | 1 |
| Levendowski, DJ | 1 |
| Rao, S | 1 |
| Wong, K | 1 |
| Gendreau, M | 1 |
| Zavora, T | 1 |
| Westbrook, PR | 1 |
| Kohler, M | 1 |
| Bloch, KE | 1 |
| Stradling, JR | 1 |
| Castillo, JL | 1 |
| Menendez, P | 1 |
| Segovia, L | 1 |
| Guilleminault, C | 1 |
| Carley, DW | 1 |
| Olopade, C | 1 |
| Ruigt, GS | 1 |
| Radulovacki, M | 1 |
1 review available for mianserin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Pharmacological approaches to the treatment of obstructive sleep apnoea.
Topics: Animals; Cholinesterase Inhibitors; Humans; Mianserin; Mirtazapine; Protriptyline; Pulmonary Ventila | 2009 |
3 trials available for mianserin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Histamine H1 Antagonists; Hu | 2008 |
Assessment of the test-retest reliability of laboratory polysomnography.
Topics: Adrenergic alpha-Antagonists; Adult; Body Mass Index; Continuous Positive Airway Pressure; Female; H | 2009 |
Efficacy of mirtazapine in obstructive sleep apnea syndrome.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cross-Over Studies; Dose-Response Relationship, Drug; | 2007 |
1 other study available for mianserin and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS).
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Continuous Positive Airway Pressure; Disorders | 2004 |