mianserin and Sexual Dysfunction, Physiological studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Sexual Dysfunction, Physiological: Physiological disturbances in normal sexual performance in either the male or the female.

Research Excerpts

Excerpt	Relevance	Reference
"Mirtazapine was administered in the newly developed fast dissolving, orally disintegrating tablet formulation."	2.71	Mirtazapine orally disintegrating tablet versus sertraline: a prospective onset of action study. ( Agren, H; Bäuml, J; Behnke, K; Martin, S; Ravindran, AV; Søgaard, J; Vester-Blokland, ED, 2003)
" Twenty-four men with an intravaginal ejaculation latency time (IELT) less than 1 minute were randomly assigned to paroxetine (20 mg/d) or mirtazapine (30 mg/d) for a period of 6 weeks; half the dosage was given in the first week."	2.71	Antidepressants and ejaculation: a double-blind, randomized, fixed-dose study with mirtazapine and paroxetine. ( Olivier, B; Waldinger, MD; Zwinderman, AH, 2003)
"Anecdotal reports have suggested that the long-term use of selective serotonin reuptake inhibitors (SSRIs) may be associated with significant weight gain, sexual dysfunction, drug interactions, and discontinuation symptoms."	2.41	Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine. ( Gupta, S; Masand, PS, 2002)
" The sexual symptoms resolved gradually after a few days and reappeared upon every dosage increase."	1.35	A case of mirtazapine-induced spontaneous orgasms in a female patient. ( Ben-Zion, I; Shalev, H; Shiber, A, 2009)

Research

Studies (10)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change in Frontostriatal Reactivity to Reward During MID fMRI Task

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (20.00)	18.7374
1990's	2 (20.00)	18.2507
2000's	6 (60.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Masand, PS	1
Gupta, S	1
Gupta, RK	1
Tiller, JW	1
Burrows, GD	2
Behnke, K	1
Søgaard, J	1
Martin, S	1
Bäuml, J	1
Ravindran, AV	1
Agren, H	1
Vester-Blokland, ED	1
Waldinger, MD	2
Zwinderman, AH	2
Olivier, B	2
Schweitzer, DH	1
Shalev, H	1
Ben-Zion, I	1
Shiber, A	1
Farah, A	1
Koutouvidis, N	1
Pratikakis, M	1
Fotiadou, A	1
Norman, TR	1
Dennerstein, L	2
Davies, BM	1
Kowalski, A	1
Stanley, RO	1
Burrows, G	1
Maguire, KP	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effects of a High Eicosapentaenoic Acid Multinutrient Supplement on Measures of Stress, Anxiety and Depression in Young Adults: a Randomised, Double-blind, Placebo-controlled Trial.[NCT04844034]		94 participants (Anticipated)	Interventional	2022-04-19	Recruiting
Effects of a Tissue Selective Estrogen Complex (TESC) on Depression and the Neural Reward System in the Perimenopause[NCT03740009]	Phase 4	20 participants (Actual)	Interventional	2019-01-02	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The primary outcome measure is functional magnetic resonance imaging (fMRI) data collected during a Monetary Incentive Delay (MID) Task. All participants will complete the fMRI Monetary Incentive Delay (MID) task at baseline and at 3 weeks. During the task, participants need to select the correct response during win and lose conditions by pressing a button on a button box in the MRI. Participant's blood-oxygen-level dependent (BOLD) activation response (A measurement of oxygen level that is released to neurons since areas of the brain that are thought to be more active or involved in certain tasks require more oxygen to perform the tasks.) is measured while they performed the task in MRI scanner." (NCT03740009)
Timeframe: Baseline to 3 weeks

Depressive Symptoms as Measured by the MASQ-AD

Intervention	percent signal change (Mean)
	Caudate Baseline	Caudate Posttreatment	Nucleus Accumbens Baseline	Nucleus Accumbens Posttreatment	Putamen Baseline	Putamen Posttreatment
Perimenopausal Women, Depressed	.0704	.0475	.0623	.0280	.0399	.0408

The second primary outcome measure uses the Mood and Anxiety Symptoms Questionnaire - Anhedonic Depression Scale (MASQ-AD) to examine symptom change. All participants will complete the MASQ-AD at each study visit, which measures their current symptoms of depression and anxiety. Scores range from 22 to 110 with lower scores reflecting a better outcome. (NCT03740009)
Timeframe: Baseline, week 2, week 3, week 4 (post treatment)

Intervention	score on a scale (Mean)
	Baseline Week 1	Week 2	Week 3	Post Treatment Week 4
Perimenopausal Women, Depressed	72.1	62.4	57.2	54.5

Article	Year
Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2002, Volume: 14, Issue:3 Topics: Antidepressive Agents, Second-Generation; Bupropion; Cyclohexanols; Drug Interactions; Humans; Mians	2002
Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2002, Volume: 14, Issue:3 Topics: Antidepressive Agents, Second-Generation; Bupropion; Cyclohexanols; Drug Interactions; Humans; Mians	2002
Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2002, Volume: 14, Issue:3 Topics: Antidepressive Agents, Second-Generation; Bupropion; Cyclohexanols; Drug Interactions; Humans; Mians	2002
Long-term side effects of newer-generation antidepressants: SSRIS, venlafaxine, nefazodone, bupropion, and mirtazapine. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2002, Volume: 14, Issue:3 Topics: Antidepressive Agents, Second-Generation; Bupropion; Cyclohexanols; Drug Interactions; Humans; Mians	2002
Dual action antidepressants and some important considerations. The Australian and New Zealand journal of psychiatry, 2003, Volume: 37, Issue:2 Topics: Adrenergic alpha-Antagonists; Antidepressive Agents, Second-Generation; Cyclohexanols; Cyclopropanes	2003
Antidepressant therapy: benefits and risks in perspective. Acta psychiatrica Scandinavica. Supplementum, 1985, Volume: 320 Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Depressive Disorder; Dibenzazepines	1985

Article	Year
Mirtazapine orally disintegrating tablet versus sertraline: a prospective onset of action study. Journal of clinical psychopharmacology, 2003, Volume: 23, Issue:4 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorde	2003
Antidepressants and ejaculation: a double-blind, randomized, fixed-dose study with mirtazapine and paroxetine. Journal of clinical psychopharmacology, 2003, Volume: 23, Issue:5 Topics: Adolescent; Adult; Aged; Analysis of Variance; Antidepressive Agents; Chi-Square Distribution; Confi	2003
The use of mirtazapine in a group of 11 patients following poor compliance to selective serotonin reuptake inhibitor treatment due to sexual dysfunction. International clinical psychopharmacology, 1999, Volume: 14, Issue:4 Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Humans; Male; Mianserin; Mirta	1999
The sexual side-effects of antidepressant medication: a double-blind comparison of two antidepressants in a non-psychiatric population. The British journal of psychiatry : the journal of mental science, 1985, Volume: 147 Topics: Adolescent; Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Dou	1985

Article	Year
Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy. The journal of sexual medicine, 2008, Volume: 5, Issue:2 Topics: Antidepressive Agents; Coitus; Data Interpretation, Statistical; Ejaculation; Fluoxetine; Fluvoxamin	2008
A case of mirtazapine-induced spontaneous orgasms in a female patient. Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:1 Topics: Antidepressive Agents, Tricyclic; Anxiety; Depressive Disorder; Female; Hospitals, Psychiatric; Huma	2009
Lack of sexual adverse effects with mirtazapine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Oct-15, Volume: 55, Issue:20 Topics: Adult; Antidepressive Agents, Tricyclic; Female; Humans; Mianserin; Middle Aged; Mirtazapine; Sexual	1998

mianserin and Sexual Dysfunction, Physiological