mianserin has been researched along with Sensitivity and Specificity in 19 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This analytical method was applied in a relative bioavailability study in order to compare a test mirtazapine 30 mg single-dose formulation vs a reference formulation in 31 volunteers of both sexes." | 2.77 | A fast, sensitive and simple method for mirtazapine quantification in human plasma by HPLC-ESI-MS/MS. Application to a comparative bioavailability study. ( Barrientos-Astigarraga, RE; Borges, NC; Donato, JL; Felix, L; Galvinas, PA; Moreno, P; Moreno, RA; Sverdloff, CE, 2012) |
| "Mirtazapine is an antidepressant that acts specifically on noradrenergic and sertonergic receptors." | 2.71 | Chirality in the new generation of antidepressants: stereoselective analysis of the enantiomers of mirtazapine, N-demethylmirtazapine, and 8-hydroxymirtazapine by LC-MS. ( Baumann, P; Cochard, N; Eap, CB; Jonzier-Perey, M; Paus, E, 2004) |
| "For mirtazapine, no increase of SGF was observed when the column ID was decreased." | 1.33 | Evaluation of the sensitivity of miniaturized liquid chromatography-electrospray ionization-mass spectrometry for pharmaceutical analysis. ( de Jong, GJ; Kranendijk, M; Somsen, GW; Waterval, JC, 2005) |
| "Mirtazapine is a novel antidepressant that acts by enhancing serotonergic and noradrenergic neurotransmission." | 1.32 | Therapeutic drug monitoring of the antidepressant mirtazapine and its N-demethylated metabolite in human serum. ( Härtter, S; Hiemke, C; Shams, M, 2004) |
| " In addition to qualitative and quantitative validation data for the assay method, concentration measurements in samples from patients on mirtazapine therapy and the relevant dosing information are presented." | 1.32 | Therapeutic drug monitoring of mirtazapine and its metabolite desmethylmirtazapine by HPLC with fluorescence detection. ( Brockmöller, J; Kress, I; Meineke, I; Poser, W; Rüther, E, 2004) |
| "Mirtazapine is a recent noradrenergic and specific serotonergic antidepressant drug." | 1.32 | Enantioselective determination of the novel antidepressant mirtazapine and its active demethylated metabolite in human plasma by means of capillary electrophoresis. ( Bartoletti, C; Fanali, S; Mandrioli, R; Pucci, V; Raggi, MA; Sabbioni, C, 2004) |
| "Mirtazapine is a new centrally acting noradrenergic and specific serotonin antidepressant, with an active demethyl metabolite." | 1.31 | Determination of mirtazapine and its demethyl metabolite in plasma by high-performance liquid chromatography with ultraviolet detection. Application to management of acute intoxication. ( Begaud, B; Jarry, C; Matoga, M; Pehourcq, F; Romiguieres, T, 2002) |
| "The mianserin enantiomers were extracted from 0." | 1.31 | Liquid-phase microextraction combined with capillary electrophoresis, a promising tool for the determination of chiral drugs in biological matrices. ( Andersen, S; Halvorsen, TG; Pedersen-Bjergaard, S; Rasmussen, KE, 2002) |
| "Mirtazapine was analyzed by HPLC and gas chromatography with nitrogen-sensitive detection." | 1.31 | Determination of mirtazapine in tablets by UV spectrophotometric and derivative spectrophotometric methods. ( Altinöz, S; Karaşen, N, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 14 (73.68) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, P | 1 |
| Li, HD | 1 |
| Chen, BM | 1 |
| Ma, N | 1 |
| Yan, M | 1 |
| Zhu, YG | 1 |
| Rao, RN | 1 |
| Raju, AN | 1 |
| Hasselstrøm, J | 1 |
| Borges, NC | 1 |
| Barrientos-Astigarraga, RE | 1 |
| Sverdloff, CE | 1 |
| Donato, JL | 1 |
| Moreno, P | 1 |
| Felix, L | 1 |
| Galvinas, PA | 1 |
| Moreno, RA | 1 |
| Nielsen, MK | 1 |
| Johansen, SS | 1 |
| Sfair, LL | 1 |
| Gobetti, C | 1 |
| Sangoi, Mda S | 1 |
| Lange, AD | 1 |
| Steppe, M | 1 |
| Schapoval, EE | 1 |
| Romiguieres, T | 1 |
| Pehourcq, F | 1 |
| Matoga, M | 1 |
| Begaud, B | 1 |
| Jarry, C | 1 |
| Andersen, S | 1 |
| Halvorsen, TG | 1 |
| Pedersen-Bjergaard, S | 1 |
| Rasmussen, KE | 1 |
| Ptácek, P | 1 |
| Klíma, J | 1 |
| Macek, J | 1 |
| Morgan, PE | 1 |
| Tapper, J | 1 |
| Spencer, EP | 1 |
| Shams, M | 1 |
| Hiemke, C | 1 |
| Härtter, S | 1 |
| Meineke, I | 1 |
| Kress, I | 1 |
| Poser, W | 1 |
| Rüther, E | 1 |
| Brockmöller, J | 1 |
| Paus, E | 1 |
| Jonzier-Perey, M | 1 |
| Cochard, N | 1 |
| Eap, CB | 1 |
| Baumann, P | 1 |
| de Santana, FJ | 1 |
| Cesarino, EJ | 1 |
| Bonato, PS | 1 |
| Mandrioli, R | 1 |
| Pucci, V | 1 |
| Sabbioni, C | 1 |
| Bartoletti, C | 1 |
| Fanali, S | 1 |
| Raggi, MA | 1 |
| Kranendijk, M | 1 |
| Waterval, JC | 1 |
| Somsen, GW | 1 |
| de Jong, GJ | 1 |
| Waldinger, MD | 1 |
| Zwinderman, AH | 1 |
| Olivier, B | 1 |
| Schweitzer, DH | 1 |
| Karaşen, N | 1 |
| Altinöz, S | 1 |
| Durlach-Misteli, C | 1 |
| Van Ree, JM | 1 |
2 trials available for mianserin and Sensitivity and Specificity
| Article | Year |
|---|---|
A fast, sensitive and simple method for mirtazapine quantification in human plasma by HPLC-ESI-MS/MS. Application to a comparative bioavailability study.
Topics: Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over S | 2012 |
Chirality in the new generation of antidepressants: stereoselective analysis of the enantiomers of mirtazapine, N-demethylmirtazapine, and 8-hydroxymirtazapine by LC-MS.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liqu | 2004 |
17 other studies available for mianserin and Sensitivity and Specificity
| Article | Year |
|---|---|
Determination of mianserin in human plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI/MS): application to a bioequivalence study in Chinese volunteers.
Topics: Acetonitriles; Antidepressive Agents, Second-Generation; Area Under Curve; Biological Assay; Calibra | 2008 |
Development and validation of a reversed-phase HPLC method for separation and simultaneous determination of process-related substances of mirtazapine in bulk drugs and formulations.
Topics: Acetonitriles; Antidepressive Agents, Tricyclic; Buffers; Chromatography, High Pressure Liquid; Drug | 2009 |
Quantification of antidepressants and antipsychotics in human serum by precipitation and ultra high pressure liquid chromatography-tandem mass spectrometry.
Topics: Antidepressive Agents; Antipsychotic Agents; Chemical Precipitation; Chromatography, High Pressure L | 2011 |
Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Analgesics; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Chromatography, Hi | 2012 |
Micellar electrokinetic chromatographic method for mianserin hydrochloride and analysis of degradation products by mass spectrometry.
Topics: Antidepressive Agents, Second-Generation; Chromatography, Micellar Electrokinetic Capillary; Mianser | 2012 |
Determination of mirtazapine and its demethyl metabolite in plasma by high-performance liquid chromatography with ultraviolet detection. Application to management of acute intoxication.
Topics: Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Mianserin; Mirtazapine; Repr | 2002 |
Liquid-phase microextraction combined with capillary electrophoresis, a promising tool for the determination of chiral drugs in biological matrices.
Topics: Calibration; Electrophoresis, Capillary; Humans; Mianserin; Reproducibility of Results; Sensitivity | 2002 |
Determination of mirtazapine in human plasma by liquid chromatography.
Topics: Antidepressive Agents, Tricyclic; Area Under Curve; Humans; Male; Mianserin; Mirtazapine; Reference | 2003 |
Measurement of total mirtazapine and normirtazapine in plasma/serum by liquid chromatography with fluorescence detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Mianserin; Mirtazapine; Reproducibility of Result | 2003 |
Therapeutic drug monitoring of the antidepressant mirtazapine and its N-demethylated metabolite in human serum.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Histamine H1 Antagonists | 2004 |
Therapeutic drug monitoring of mirtazapine and its metabolite desmethylmirtazapine by HPLC with fluorescence detection.
Topics: Adrenergic alpha-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid | 2004 |
New method for the chiral evaluation of mirtazapine in human plasma by liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Mianserin; Mirtazapine; Reproducibility of Results; Se | 2004 |
Enantioselective determination of the novel antidepressant mirtazapine and its active demethylated metabolite in human plasma by means of capillary electrophoresis.
Topics: Antidepressive Agents; Electrophoresis, Capillary; Humans; Mianserin; Mirtazapine; Reproducibility o | 2004 |
Evaluation of the sensitivity of miniaturized liquid chromatography-electrospray ionization-mass spectrometry for pharmaceutical analysis.
Topics: Chromatography, High Pressure Liquid; Desogestrel; Mianserin; Miniaturization; Mirtazapine; Pharmace | 2005 |
Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy.
Topics: Antidepressive Agents; Coitus; Data Interpretation, Statistical; Ejaculation; Fluoxetine; Fluvoxamin | 2008 |
Determination of mirtazapine in tablets by UV spectrophotometric and derivative spectrophotometric methods.
Topics: Antidepressive Agents, Tricyclic; Calibration; Mianserin; Mirtazapine; Sensitivity and Specificity; | 2000 |
Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs.
Topics: Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Desipramine; Dopamine; Dose-Response | 1992 |