mianserin has been researched along with Seizures in 20 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures." | 8.85 | Seizures associated with levofloxacin: case presentation and literature review. ( Bellon, A; Chacko, RC; Coverdale, JH; Perez-Garcia, G, 2009) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 7.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| "Seizures were observed following the withdrawal of mianserin 60 mg/day for 2 years." | 7.67 | Seizures following the withdrawal of long-term treatment with mianserin. ( Dalla Barba, G; De Leo, D; Zanchin, G, 1988) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 5.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "5 Factors that might predispose to seizures include relevant family and past medical history, starting treatment, a change in dose, benzodiazepine withdrawal and concomitant treatment with other drugs that have epileptogenic properties." | 5.27 | Mianserin and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1983) |
| "We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures." | 4.85 | Seizures associated with levofloxacin: case presentation and literature review. ( Bellon, A; Chacko, RC; Coverdale, JH; Perez-Garcia, G, 2009) |
| " We have investigated the effects of mirtazapine on pentylenetetrazole (PTZ)- and maximal electroconvulsive shock (MES)-induced seizures in mice." | 3.74 | Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice. ( Kayir, H; Sezer, Z; Uzbay, TI; Yilmaz, I, 2007) |
| "Seizures were observed following the withdrawal of mianserin 60 mg/day for 2 years." | 3.67 | Seizures following the withdrawal of long-term treatment with mianserin. ( Dalla Barba, G; De Leo, D; Zanchin, G, 1988) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 1.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "Mirtazapine is a commonly prescribed antidepressant drug, which is also metabolized through and may modulate the CYP4502D6 pathway leading to altered metabolism of propafenone and possible adverse effects." | 1.40 | Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction. ( Aryal, SR; Khan, MA; Rajpurohit, N; Stys, AT; Stys, TP, 2014) |
| "Audiogenic seizures can be induced in DBA/2J mice following intense auditory stimulation." | 1.30 | Correlation between 5-HT7 receptor affinity and protection against sound-induced seizures in DBA/2J mice. ( Boess, FG; Bourson, A; Kapps, V; Rudler, A; Sleight, AJ; Zwingelstein, C, 1997) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "5 Factors that might predispose to seizures include relevant family and past medical history, starting treatment, a change in dose, benzodiazepine withdrawal and concomitant treatment with other drugs that have epileptogenic properties." | 1.27 | Mianserin and convulsive seizures. ( Edwards, JG; Glen-Bott, M, 1983) |
| "Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants." | 1.27 | Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex. ( Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI, 1988) |
| "The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats." | 1.27 | Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats. ( Peterson, SL; St Mary, JS; Trzeciakowski, JP, 1985) |
| " It is concluded that all four drugs show the toxic effects classically associated with tricyclic antidepressants but the relative toxicity amongst these agents varies considerably and is in the order amitriptyline greater than imipramine greater than maprotiline greater than mianserin." | 1.26 | The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo. ( Hughes, IE; Radwan, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rajpurohit, N | 1 |
| Aryal, SR | 1 |
| Khan, MA | 1 |
| Stys, AT | 1 |
| Stys, TP | 1 |
| Bittolo, T | 1 |
| Raminelli, CA | 1 |
| Deiana, C | 1 |
| Baj, G | 1 |
| Vaghi, V | 1 |
| Ferrazzo, S | 1 |
| Bernareggi, A | 1 |
| Tongiorgi, E | 1 |
| Bellon, A | 1 |
| Perez-Garcia, G | 1 |
| Coverdale, JH | 1 |
| Chacko, RC | 1 |
| Brissos, S | 1 |
| Palhavã, F | 1 |
| Dias, VV | 1 |
| Paiva, T | 1 |
| Pericić, D | 1 |
| Strac, DS | 1 |
| Vlainić, J | 1 |
| Solberg, DK | 1 |
| Koht, J | 1 |
| Refsum, H | 1 |
| Yilmaz, I | 1 |
| Sezer, Z | 1 |
| Kayir, H | 1 |
| Uzbay, TI | 1 |
| Borowicz, KK | 1 |
| Banach, M | 1 |
| Zarczuk, R | 1 |
| Lukasik, D | 1 |
| Luszczki, JJ | 1 |
| Czuczwar, SJ | 1 |
| Zia Ul Haq, M | 1 |
| Prakash, R | 1 |
| Akhtar, S | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Edwards, JG | 1 |
| Glen-Bott, M | 1 |
| Ashton, D | 1 |
| Leysen, JE | 1 |
| Wauquier, A | 1 |
| Evans, L | 1 |
| Lander, CM | 1 |
| Semenova, TP | 1 |
| Riku, MK | 1 |
| Bourson, A | 1 |
| Kapps, V | 1 |
| Zwingelstein, C | 1 |
| Rudler, A | 1 |
| Boess, FG | 1 |
| Sleight, AJ | 1 |
| Hughes, IE | 1 |
| Radwan, S | 1 |
| Malatynska, E | 1 |
| Knapp, RJ | 1 |
| Ikeda, M | 1 |
| Yamamura, HI | 1 |
| De Leo, D | 1 |
| Dalla Barba, G | 1 |
| Zanchin, G | 1 |
| Peterson, SL | 1 |
| Trzeciakowski, JP | 1 |
| St Mary, JS | 1 |
1 review available for mianserin and Seizures
| Article | Year |
|---|---|
Seizures associated with levofloxacin: case presentation and literature review.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Cytochrome | 2009 |
19 other studies available for mianserin and Seizures
| Article | Year |
|---|---|
Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction.
Topics: Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Atrial Fibrillation; Bradycardia; Di | 2014 |
Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.
Topics: Animals; Antidepressive Agents; Atrophy; Breath Tests; Cerebral Cortex; Desipramine; GABAergic Neuro | 2016 |
A case of crying seizures.
Topics: Adult; Crying; Female; Humans; Mianserin; Mirtazapine; Seizures | 2011 |
Mirtazapine: seizures and neutropenia.
Topics: Antidepressive Agents; Australia; Humans; Mianserin; Neutropenia; Seizures | 2004 |
Zimelidine decreases seizure susceptibility in stressed mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Ket | 2006 |
[A 74-year-old unconscious woman with myoclonia and seizures].
Topics: Aged; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Citalopram; F | 2006 |
Mirtazapine does not affect pentylenetetrazole- and maximal electroconvulsive shock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Depressive | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Car | 2007 |
Mirtazapine precipitated seizures: a case report.
Topics: Anticonvulsants; Antidepressive Agents; Drug Interactions; Electroencephalography; Epilepsies, Parti | 2008 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
Mianserin and convulsive seizures.
Topics: Adolescent; Adult; Aged; Aging; Child; Dibenzazepines; Female; Follow-Up Studies; Humans; Male; Mian | 1983 |
Neurotransmitters and receptor binding in amygdaloid kindled rats: serotonergic and noradrenergic modulatory effects.
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain; Clonidine; Dexetimide; Electric Stimulation; Male; Mi | 1980 |
Mianserin and epilepsy.
Topics: Adult; Depressive Disorder; Dibenzazepines; Epilepsy; Humans; Male; Mianserin; Phenytoin; Seizures | 1980 |
[The role of the interaction of various types of serotonin- and alpha 2-adrenoreceptors in regulating audiogenic seizures in DBA/2 mice].
Topics: Acoustic Stimulation; Adrenergic alpha-2 Receptor Antagonists; Animals; Cyproheptadine; Mianserin; M | 1995 |
Correlation between 5-HT7 receptor affinity and protection against sound-induced seizures in DBA/2J mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; CHO Cells; Cricetinae; Ergolines; Male; Methysergide | 1997 |
The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo.
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Behavior | 1979 |
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chlorides; Desipramine; gamma-Aminob | 1988 |
Seizures following the withdrawal of long-term treatment with mianserin.
Topics: Adult; Depressive Disorder; Female; Humans; Mianserin; Seizures; Substance Withdrawal Syndrome | 1988 |
Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats.
Topics: Amoxapine; Animals; Antidepressive Agents; Clomipramine; Convulsants; Desipramine; Electric Stimulat | 1985 |