mianserin has been researched along with Pregnancy in 30 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This multicenter, observational prospective cohort study addresses the risk associated with exposure to mirtazapine during pregnancy." | 7.81 | Pregnancy outcome following maternal exposure to mirtazapine: a multicenter, prospective study. ( Arnon, J; Buclin, T; Clementi, M; Eleftheriou, G; Kaplan, YC; Klinger, G; Malm, H; Maňáková, E; Merlob, P; Panchaud, A; Pistelli, A; Rothuizen, LE; Stephens, S; Te Winkel, B; Winterfeld, U, 2015) |
| " This report presents the beneficial effect of low-dose mirtazapine added onto selective serotonin reuptake inhibitors in the treatment of the symptoms of severe nausea, insomnia and loss of appetite accompanying psychiatric disorders during pregnancy, which is an important problem in clinical practice." | 7.79 | Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. ( Uguz, F, 2013) |
| "We present a case of recurrent hypothermia in concordant monozygotic twins born to a mirtazapine treated mother." | 7.74 | Neonatal recurrent prolonged hypothermia associated with maternal mirtazapine treatment during pregnancy. ( Klinger, G; Merlob, P; Sokolover, N, 2008) |
| "Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)." | 7.74 | Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008) |
| "Mirtazapine seems to be an effective treatment modality in patients with severe hyperemesis gravidarum who do not respond to conventional anti-emesis treatment regimens." | 7.73 | Mirtazapine use in resistant hyperemesis gravidarum: report of three cases and review of the literature. ( Dogan, E; Gol, M; Guclu, S; Saygili, U, 2005) |
| " When the patient asked for termination of the pregnancy because of the unbearable symptoms, treatment with intravenous mirtazapine (Remergil) was started." | 7.72 | Mirtazapine (Remergil) for treatment resistant hyperemesis gravidarum: rescue of a twin pregnancy. ( Dembinski, J; Dorn, C; Rohde, A, 2003) |
| "Mirtazapine is a novel piperazinoazepine antidepressant, unrelated to any known class of antidepressants." | 5.33 | Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes. ( De Santis, M; Diav-Citrin, O; Djulus, J; Einarson, A; Einarson, TR; Kennedy, D; Koren, G; Shakir, S; Voyer Lavigne, S; Wilton, L, 2006) |
| "To assess whether the use of selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, mirtazapine, venlafaxine or other antidepressants is associated with late elective termination of pregnancy." | 3.81 | Use of antidepressants and association with elective termination of pregnancy: population based case-control study. ( Artama, M; Engeland, A; Furu, K; Gissler, M; Haglund, B; Kieler, H; Malm, H; Nørgaard, M; Stephansson, O; Valdimarsdottir, U; Zoega, H, 2015) |
| "This multicenter, observational prospective cohort study addresses the risk associated with exposure to mirtazapine during pregnancy." | 3.81 | Pregnancy outcome following maternal exposure to mirtazapine: a multicenter, prospective study. ( Arnon, J; Buclin, T; Clementi, M; Eleftheriou, G; Kaplan, YC; Klinger, G; Malm, H; Maňáková, E; Merlob, P; Panchaud, A; Pistelli, A; Rothuizen, LE; Stephens, S; Te Winkel, B; Winterfeld, U, 2015) |
| " This report presents the beneficial effect of low-dose mirtazapine added onto selective serotonin reuptake inhibitors in the treatment of the symptoms of severe nausea, insomnia and loss of appetite accompanying psychiatric disorders during pregnancy, which is an important problem in clinical practice." | 3.79 | Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. ( Uguz, F, 2013) |
| "Mirtazapine is a new antidepressant used in last years, however experience with it during pregnancy is unsatisfactory on the present." | 3.76 | Embryotoxicity of mirtazapine: a study using Chick Embryotoxicity Screening Test. ( Hubickova, L; Kostalova, J; Manakova, E; Zemanova, Z, 2010) |
| "We present a case of recurrent hypothermia in concordant monozygotic twins born to a mirtazapine treated mother." | 3.74 | Neonatal recurrent prolonged hypothermia associated with maternal mirtazapine treatment during pregnancy. ( Klinger, G; Merlob, P; Sokolover, N, 2008) |
| "Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)." | 3.74 | Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008) |
| "Mirtazapine seems to be an effective treatment modality in patients with severe hyperemesis gravidarum who do not respond to conventional anti-emesis treatment regimens." | 3.73 | Mirtazapine use in resistant hyperemesis gravidarum: report of three cases and review of the literature. ( Dogan, E; Gol, M; Guclu, S; Saygili, U, 2005) |
| " When the patient asked for termination of the pregnancy because of the unbearable symptoms, treatment with intravenous mirtazapine (Remergil) was started." | 3.72 | Mirtazapine (Remergil) for treatment resistant hyperemesis gravidarum: rescue of a twin pregnancy. ( Dembinski, J; Dorn, C; Rohde, A, 2003) |
| "Hyperemesis gravidarum is not uncommon." | 1.46 | Intractable hyperemesis gravidarum in a patient with type 1 diabetes. ( Arshad, MF; Bekhit, M; Javed, N, 2017) |
| "Mirtazapine was detected (1." | 1.34 | Transfer of the antidepressant mirtazapine into breast milk. ( Hackett, LP; Ilett, KF; Kohan, R; Kristensen, JH; Rampono, J, 2007) |
| "Mirtazapine is a novel piperazinoazepine antidepressant, unrelated to any known class of antidepressants." | 1.33 | Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes. ( De Santis, M; Diav-Citrin, O; Djulus, J; Einarson, A; Einarson, TR; Kennedy, D; Koren, G; Shakir, S; Voyer Lavigne, S; Wilton, L, 2006) |
| " To test the hypothesis that the 5-HT1C properties of these drugs are involved instead, dose-response and time-course studies of 5-HT1C and 5-HT2 receptors were performed using several different radioligands in rat brain after making neonatal 5,7-DHT lesions by intraperitoneal injection." | 1.29 | High and low affinity 5-HT2 and 5-HT1C binding sites: responses to neonatal 5,7-DHT lesions in rat brain. ( Gregory, CM; Pranzatelli, MR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.00) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arshad, MF | 1 |
| Javed, N | 1 |
| Bekhit, M | 1 |
| Kjaersgaard, MI | 1 |
| Parner, ET | 1 |
| Vestergaard, M | 1 |
| Sørensen, MJ | 1 |
| Olsen, J | 1 |
| Christensen, J | 1 |
| Bech, BH | 1 |
| Pedersen, LH | 1 |
| Kieler, H | 1 |
| Malm, H | 2 |
| Artama, M | 1 |
| Engeland, A | 1 |
| Furu, K | 1 |
| Gissler, M | 1 |
| Nørgaard, M | 1 |
| Stephansson, O | 1 |
| Valdimarsdottir, U | 1 |
| Zoega, H | 1 |
| Haglund, B | 1 |
| Smit, M | 2 |
| Wennink, H | 1 |
| Heres, M | 1 |
| Dolman, KM | 2 |
| Honig, A | 2 |
| Winterfeld, U | 1 |
| Klinger, G | 2 |
| Panchaud, A | 1 |
| Stephens, S | 1 |
| Arnon, J | 1 |
| Te Winkel, B | 1 |
| Clementi, M | 1 |
| Pistelli, A | 1 |
| Maňáková, E | 2 |
| Eleftheriou, G | 1 |
| Merlob, P | 2 |
| Kaplan, YC | 1 |
| Buclin, T | 1 |
| Rothuizen, LE | 1 |
| Gentile, S | 1 |
| Abramowitz, A | 1 |
| Miller, ES | 1 |
| Wisner, KL | 1 |
| Sokolover, N | 1 |
| Hubickova, L | 1 |
| Kostalova, J | 1 |
| Zemanova, Z | 1 |
| Lieb, M | 1 |
| Palm, U | 1 |
| Jacoby, D | 1 |
| Baghai, TC | 1 |
| Severus, E | 1 |
| Uguz, F | 1 |
| Kesim, M | 2 |
| Yaris, F | 2 |
| Kadioglu, M | 2 |
| Yaris, E | 2 |
| Kalyoncu, NI | 2 |
| Ulku, C | 2 |
| Biswas, PN | 1 |
| Wilton, LV | 1 |
| Shakir, SA | 1 |
| Rohde, A | 2 |
| Dembinski, J | 1 |
| Dorn, C | 1 |
| Unsal, M | 1 |
| Guclu, S | 1 |
| Gol, M | 1 |
| Dogan, E | 1 |
| Saygili, U | 1 |
| Djulus, J | 1 |
| Koren, G | 1 |
| Einarson, TR | 1 |
| Wilton, L | 1 |
| Shakir, S | 1 |
| Diav-Citrin, O | 1 |
| Kennedy, D | 1 |
| Voyer Lavigne, S | 1 |
| De Santis, M | 1 |
| Einarson, A | 1 |
| Kristensen, JH | 1 |
| Ilett, KF | 1 |
| Rampono, J | 1 |
| Kohan, R | 1 |
| Hackett, LP | 1 |
| Klier, CM | 1 |
| Mossaheb, N | 1 |
| Lee, A | 1 |
| Zernig, G | 1 |
| Schwarzer, V | 1 |
| Heep, A | 1 |
| Gembruch, U | 1 |
| Lennestål, R | 1 |
| Källén, B | 1 |
| Hoekstra, A | 1 |
| Yih, TD | 1 |
| Joosten, HF | 1 |
| Waalkens, DH | 1 |
| Pranzatelli, MR | 1 |
| Gregory, CM | 1 |
| Moiseiwitsch, JR | 1 |
| Lauder, JM | 1 |
| Bal, AK | 1 |
| Bird, MM | 2 |
| Shimizu, M | 1 |
| Nishida, A | 1 |
| Yamawaki, S | 1 |
| Bal-Klara, A | 1 |
| De Ceballos, ML | 1 |
| Benedi, A | 1 |
| Urdin, C | 1 |
| Del Rio, J | 1 |
| Vandeputte-Van Messon, G | 1 |
| Burvenich, C | 1 |
| Peeters, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Endeavor to Stop Nausea/Vomiting Associated With Pregnancy (E-SNAP)[NCT05452174] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2022-06-13 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mianserin and Pregnancy
| Article | Year |
|---|---|
Mirtazapine in pregnancy and lactation - A systematic review.
Topics: Antidepressive Agents, Tricyclic; Breast Feeding; Depressive Disorder; Female; Humans; Lactation; Mi | 2016 |
Treatment options for hyperemesis gravidarum.
Topics: Adrenergic alpha-Antagonists; Adult; Antiemetics; Dopamine Agonists; Female; Humans; Hyperemesis Gra | 2017 |
28 other studies available for mianserin and Pregnancy
| Article | Year |
|---|---|
Intractable hyperemesis gravidarum in a patient with type 1 diabetes.
Topics: Antiemetics; Cesarean Section; Diabetes Mellitus, Type 1; Female; Gestational Age; Humans; Hyperemes | 2017 |
Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study.
Topics: Abortion, Spontaneous; Adult; Antidepressive Agents; Cyclohexanols; Depression; Duloxetine Hydrochlo | 2013 |
Use of antidepressants and association with elective termination of pregnancy: population based case-control study.
Topics: Abortion, Induced; Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Case-Control Stud | 2015 |
Mirtazapine in pregnancy and lactation: data from a case series.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents, Tricyclic; Breast Feeding; Cohort Studies | 2015 |
Pregnancy outcome following maternal exposure to mirtazapine: a multicenter, prospective study.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents; Birth Weight; Case-Control Studies; Depre | 2015 |
Pharmacological management of borderline personality disorder in a pregnant woman with a previous history of alcohol addiction: a case report.
Topics: Adult; Alcoholism; Borderline Personality Disorder; Diagnosis, Dual (Psychiatry); Female; Humans; Mi | 2015 |
Neonatal recurrent prolonged hypothermia associated with maternal mirtazapine treatment during pregnancy.
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety Disorders; Body Temperature Regulation; Female; Fol | 2008 |
Embryotoxicity of mirtazapine: a study using Chick Embryotoxicity Screening Test.
Topics: Abnormalities, Drug-Induced; Animals; Antidepressive Agents, Tricyclic; Chick Embryo; Depression; Do | 2010 |
[Mirtazapine and hyperemesis gravidarum].
Topics: Adult; Antidepressive Agents, Tricyclic; Female; Humans; Hyperemesis Gravidarum; Mianserin; Mirtazap | 2012 |
Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases.
Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Dose-Response Relationship, Drug; Feeding and E | 2013 |
Mirtazapine use in two pregnant women: is it safe?
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Depression; Drug Therapy, Combination; Female; Fol | 2002 |
The pharmacovigilance of mirtazapine: results of a prescription event monitoring study on 13554 patients in England.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tri | 2003 |
Mirtazapine (Remergil) for treatment resistant hyperemesis gravidarum: rescue of a twin pregnancy.
Topics: Abortion, Induced; Adult; Antidepressive Agents, Tricyclic; Cesarean Section; Female; Humans; Hypere | 2003 |
Newer antidepressants in pregnancy: prospective outcome of a case series.
Topics: Abnormalities, Drug-Induced; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, | 2004 |
Mirtazapine use in resistant hyperemesis gravidarum: report of three cases and review of the literature.
Topics: Adult; Antiemetics; Female; Humans; Hyperemesis Gravidarum; Infant, Newborn; Mianserin; Mirtazapine; | 2005 |
Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Abortion, Therapeutic; Adult; Antidepressive Age | 2006 |
Transfer of the antidepressant mirtazapine into breast milk.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Breast Feeding; Depressi | 2007 |
Mirtazapine and breastfeeding: maternal and infant plasma levels.
Topics: Adult; Antidepressive Agents, Tricyclic; Breast Feeding; Depressive Disorder; Female; Humans; Infant | 2007 |
Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine.
Topics: Adult; Antidepressive Agents, Tricyclic; Diabetes Mellitus, Type 1; Drug Resistance; Female; Humans; | 2008 |
Delivery outcome in relation to maternal use of some recently introduced antidepressants.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adrenergic Uptake Inhibitors; Antidepressive Age | 2007 |
The effects of chlorpromazine, mianserin and Org GC94 on reproductive function in the rat.
Topics: Animals; Chlorpromazine; Dibenzazepines; Dibenzoxazepines; Estrus; Female; Male; Mianserin; Ovulatio | 1984 |
High and low affinity 5-HT2 and 5-HT1C binding sites: responses to neonatal 5,7-DHT lesions in rat brain.
Topics: 5,7-Dihydroxytryptamine; Analysis of Variance; Animals; Animals, Newborn; Binding Sites; Brain Neopl | 1993 |
Regulation of gene expression in cultured embryonic mouse mandibular mesenchyme by serotonin antagonists.
Topics: Aggrecans; Animals; Calcium-Binding Proteins; Chondroitin Sulfate Proteoglycans; Culture Techniques; | 1997 |
Changes in the amount and distribution of neuronal alkaline and acid phosphatase after chronic exposure of cultures of cingulate cortex to antidepressant drugs.
Topics: Acid Phosphatase; Alkaline Phosphatase; Amitriptyline; Animals; Antidepressive Agents; Cells, Cultur | 1992 |
Antidepressants inhibit spontaneous oscillations of intracellular Ca2+ concentration in rat cortical cultured neurons.
Topics: Amitriptyline; Animals; Antidepressive Agents; Calcium; Cerebral Cortex; Dose-Response Relationship, | 1992 |
The effects of various antidepressant drugs on the fine-structure of neurons of the cingulate cortex in culture.
Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Cytoskeleton; Desipramine; Female; Gyrus | 1990 |
Prenatal exposure of rats to antidepressant drugs down-regulates beta-adrenoceptors and 5-HT2 receptors in cerebral cortex. Lack of correlation between 5-HT2 receptors and serotonin-mediated behaviour.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Clomipramine; Female; Iprindole; Mianserin; Nomifen | 1985 |
Effect of serotonin on the motility of smooth muscles in teats of lactating cows.
Topics: Animals; Cattle; Female; Ketanserin; Lactation; Mammary Glands, Animal; Methysergide; Mianserin; Mil | 1985 |