Page last updated: 2024-10-31

mianserin and Neutropenia

mianserin has been researched along with Neutropenia in 15 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
"Two cases of mianserin induced neutropenia associated with prolonged elimination of the drug were studied."7.67Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics. ( Begg, EJ; Colls, BM; Moller, PW; O'Donnell, JL; Sharman, JR, 1985)
"Four episodes of neutropenia or agranulocytosis possibly caused by the tetracyclic antidepressant drug, mianserin hydrochloride, were reported to the Australian Adverse Drug Reactions Advisory Committee during the first year of the drug's general availability in Australia."7.66Mianserin: a possible cause of neutropenia and agranulocytosis. Adverse Drug Reactions Advisory Committee. ( , 1980)
"A 40-year old woman with a history of acute psychotic symptoms developed agranulocytosis and neutropenia after starting therapy that included lamotrigine, mirtazapine, quetiapine, and venlafaxine."3.78Fatal agranulocytosis associated with psychotropic medication use. ( Al-Najjar, T; Ali, BA; Nazer, LH; Shankar, G, 2012)
"Two cases of mianserin induced neutropenia associated with prolonged elimination of the drug were studied."3.67Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics. ( Begg, EJ; Colls, BM; Moller, PW; O'Donnell, JL; Sharman, JR, 1985)
"Four episodes of neutropenia or agranulocytosis possibly caused by the tetracyclic antidepressant drug, mianserin hydrochloride, were reported to the Australian Adverse Drug Reactions Advisory Committee during the first year of the drug's general availability in Australia."3.66Mianserin: a possible cause of neutropenia and agranulocytosis. Adverse Drug Reactions Advisory Committee. ( , 1980)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19908 (53.33)18.7374
1990's0 (0.00)18.2507
2000's5 (33.33)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Khan, AY1
Golewale, MH1
Kahn, DA1
Nazer, LH1
Shankar, G1
Ali, BA1
Al-Najjar, T1
Estabrook, KR1
Pheister, M1
Ahmed, A1
Anghelescu, I1
Klawe, C1
Dahmen, N1
Ozcanli, T1
Unsalver, B1
Ozdemir, S1
Ozmen, M1
Braye, SG1
Copplestone, JA1
Gartell, PC1
Adams, PC1
Robinson, A1
Reid, MM1
Vishu, MC1
Livingston, M1
Wilcox, JB1
Edwards, IR1
O'Donnell, JL1
Sharman, JR1
Begg, EJ1
Colls, BM1
Moller, PW1
Forgan-Smith, J1
Leslie, P1

Other Studies

15 other studies available for mianserin and Neutropenia

ArticleYear
A case of chronic drug-induced neutropenia.
    Journal of psychiatric practice, 2008, Volume: 14, Issue:4

    Topics: Anti-Anxiety Agents; Anti-Infective Agents; Anxiety Disorders; Chronic Disease; Female; Humans; Metr

2008
Fatal agranulocytosis associated with psychotropic medication use.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2012, May-15, Volume: 69, Issue:10

    Topics: Adult; Agranulocytosis; Antidepressive Agents, Second-Generation; Antimanic Agents; Antipsychotic Ag

2012
A case of quetiapine XR and divalproex-associated neutropenia followed by successful use of ziprasidone.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Antimanic Agents; Antipsychotic Agents; Anxiety Disorders; Bipolar Disor

2012
Neutropenia associated with mirtazapine use: is a drop in the neutrophil count in a symptomatic older adults a cause for concern?
    Journal of the American Geriatrics Society, 2002, Volume: 50, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents, Tricyclic; Depression; Female; Hu

2002
Venlafaxine in a patient with idiopathic leukopenia and mirtazapine-induced severe neutropenia.
    The Journal of clinical psychiatry, 2002, Volume: 63, Issue:9

    Topics: Agranulocytosis; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Comorbi

2002
Mirtazapine: seizures and neutropenia.
    Prescrire international, 2004, Volume: 13, Issue:70

    Topics: Antidepressive Agents; Australia; Humans; Mianserin; Neutropenia; Seizures

2004
Sertraline- and mirtazapine-induced severe neutropenia.
    The American journal of psychiatry, 2005, Volume: 162, Issue:7

    Topics: Adult; Agranulocytosis; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Female; Humans

2005
Adverse Drug Reactions Advisory Committee: ADRAC report for 1980.
    The Medical journal of Australia, 1982, May-15, Volume: 1, Issue:10

    Topics: Adolescent; Adult; Aged; Agranulocytosis; Australia; Bronchial Spasm; Chemical and Drug Induced Live

1982
Neutropenic enterocolitis during mianserin-induced agranulocytosis.
    British medical journal (Clinical research ed.), 1982, Oct-16, Volume: 285, Issue:6348

    Topics: Aged; Agranulocytosis; Dibenzazepines; Enterocolitis, Pseudomembranous; Female; Humans; Mianserin; N

1982
Blood dyscrasias and mianserin.
    Postgraduate medical journal, 1983, Volume: 59, Issue:687

    Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Dibenzazepines; Female; Humans; Mianserin; Middle Ag

1983
Neutropenia following mianserin.
    The New Zealand medical journal, 1982, Jul-28, Volume: 95, Issue:712

    Topics: Adult; Agranulocytosis; Dibenzazepines; Female; Humans; Mianserin; Neutropenia

1982
Mianserin: a possible cause of neutropenia and agranulocytosis. Adverse Drug Reactions Advisory Committee.
    The Medical journal of Australia, 1980, Dec-13, Volume: 2, Issue:12

    Topics: Adult; Aged; Agranulocytosis; Depressive Disorder; Dibenzazepines; Female; Humans; Male; Mianserin;

1980
Agranulocytosis and mianserin.
    The New Zealand medical journal, 1985, Feb-13, Volume: 98, Issue:772

    Topics: Adult; Aged; Agranulocytosis; Dibenzazepines; Female; Humans; Male; Mianserin; Middle Aged; Neutrope

1985
Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics.
    British medical journal (Clinical research ed.), 1985, Nov-16, Volume: 291, Issue:6506

    Topics: Aged; Agranulocytosis; Bone Marrow; Dibenzazepines; Female; Humans; Kinetics; Leukocyte Count; Metab

1985
Neutropenia and mianserin.
    The Medical journal of Australia, 1985, Oct-28, Volume: 143, Issue:9

    Topics: Aged; Agranulocytosis; Dibenzazepines; Humans; Male; Mianserin; Neutropenia

1985