mianserin has been researched along with Neuroblastoma in 4 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have assessed the ability of the serotonergic antagonist mianserin to modulate the number and functional activity of human 5-hydroxytryptamine2A (5-HT2A) and 5-HT2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y." | 7.69 | Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y. ( Elliott, JM; Newton, RA, 1997) |
| "We have assessed the ability of the serotonergic antagonist mianserin to modulate the number and functional activity of human 5-hydroxytryptamine2A (5-HT2A) and 5-HT2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y." | 3.69 | Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y. ( Elliott, JM; Newton, RA, 1997) |
| "NCB-20 cells (neuroblastoma X fetal Chinese hamster brain hybrids) are equipped with a [3H]5-hydroxytryptamine [( 3H]5-HT) uptake system and [3H]imipramine recognition sites." | 3.67 | 5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells. ( Chuang, DM; Costa, E; Nakaki, T; Roth, BL, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosen, T | 1 |
| Seeger, TF | 1 |
| McLean, S | 1 |
| Nagel, AA | 1 |
| Ives, JL | 1 |
| Guarino, KJ | 1 |
| Bryce, D | 1 |
| Furman, J | 1 |
| Roth, RW | 1 |
| Chalabi, PM | 1 |
| Levkovitz, Y | 1 |
| Gil-Ad, I | 1 |
| Zeldich, E | 1 |
| Dayag, M | 1 |
| Weizman, A | 1 |
| Newton, RA | 1 |
| Elliott, JM | 1 |
| Nakaki, T | 1 |
| Roth, BL | 1 |
| Chuang, DM | 1 |
| Costa, E | 1 |
4 other studies available for mianserin and Neuroblastoma
| Article | Year |
|---|---|
Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.
Topics: Animals; Blood-Brain Barrier; Brain; Chemical Phenomena; Chemistry; Glioma; Imidazoles; Mice; Molecu | 1990 |
Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement.
Topics: Animals; Antidepressive Agents; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Cyt | 2005 |
Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y.
Topics: Cell Membrane; DNA, Complementary; Down-Regulation; Ergolines; Humans; Ketanserin; Kinetics; Mianser | 1997 |
5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells.
Topics: Animals; Binding Sites; Brain; Clomipramine; Cricetinae; Cricetulus; Desipramine; Fluoxetine; Hybrid | 1985 |