mianserin has been researched along with Muscle Contraction in 25 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mood depression was evaluated at 0, 4 and 8 weeks by using Zung's Self-Rating Depression Scale and Hamilton Rating Scale for Depression." | 6.67 | Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine. ( Bolino, F; Di Cicco, L; Manna, V, 1994) |
| "Mood depression was evaluated at 0, 4 and 8 weeks by using Zung's Self-Rating Depression Scale and Hamilton Rating Scale for Depression." | 2.67 | Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine. ( Bolino, F; Di Cicco, L; Manna, V, 1994) |
| "5 Mianserin has optimal efficacy as the racemate." | 2.65 | The potential therapeutic role of the enantiomers and metabolites of mianserin. ( Pinder, RM; Van Delft, AM, 1983) |
| "3." | 1.28 | Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors. ( Banner, SE; Cattell, KJ; Osborne, RH; Wood, SJ, 1990) |
| " These results show that the adaptative changes of alpha-adrenoceptors in the rat anococcygeus muscle following long-term administration may depend on the efficiency to inhibit the neuronal uptake and the ability to antagonize alpha 1-adrenoceptors." | 1.28 | Effects of chronic antidepressant treatment on alpha 1- and alpha 2-adrenoceptors in the rat anococcygeus muscle. ( Badia, A; Sallés, J; Vila, E, 1990) |
| "4) Amineptin was the only compound that increased blood pressure." | 1.26 | [A study of three potential antidepressants (amineptin, mianserin and nomifensin) on the cardiovascular system and isolated intestine (author's transl)]. ( Bourin, M; Delaigue, R; Schaff, G, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (48.00) | 18.7374 |
| 1990's | 11 (44.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wentland, MP | 1 |
| Bailey, DM | 1 |
| Alexander, EJ | 1 |
| Castaldi, MJ | 1 |
| Ferrari, RA | 1 |
| Haubrich, DR | 1 |
| Luttinger, DA | 1 |
| Perrone, MH | 1 |
| Saari, WS | 1 |
| Halczenko, W | 1 |
| King, SW | 1 |
| Huff, JR | 1 |
| Guare, JP | 1 |
| Hunt, CA | 1 |
| Randall, WC | 1 |
| Anderson, PS | 1 |
| Lotti, VJ | 1 |
| Taylor, DA | 1 |
| Wainscott, DB | 1 |
| Cohen, ML | 1 |
| Schenck, KW | 1 |
| Audia, JE | 1 |
| Nissen, JS | 1 |
| Baez, M | 1 |
| Kursar, JD | 1 |
| Lucaites, VL | 1 |
| Nelson, DL | 1 |
| Bonhaus, DW | 1 |
| Flippin, LA | 1 |
| Greenhouse, RJ | 1 |
| Jaime, S | 1 |
| Rocha, C | 1 |
| Dawson, M | 1 |
| Van Natta, K | 1 |
| Chang, LK | 1 |
| Pulido-Rios, T | 1 |
| Webber, A | 1 |
| Leung, E | 1 |
| Eglen, RM | 1 |
| Martin, GR | 1 |
| Sood, S | 1 |
| Liu, X | 1 |
| Liu, H | 1 |
| Nolan, P | 1 |
| Horner, RL | 1 |
| Becker, B | 1 |
| Morel, N | 1 |
| Vanbellinghen, AM | 1 |
| Lebrun, P | 1 |
| Doggrell, SA | 4 |
| Pommier, Y | 1 |
| Andréjak, M | 1 |
| Mouillé, P | 1 |
| Dabiré, H | 1 |
| Lucet, B | 1 |
| Schmitt, H | 1 |
| Bourin, M | 1 |
| Delaigue, R | 1 |
| Schaff, G | 1 |
| Pinder, RM | 1 |
| Van Delft, AM | 1 |
| Leitch, IM | 3 |
| Temple, DM | 1 |
| Wei, H | 1 |
| Boura, AL | 3 |
| Rawlow, A | 1 |
| King, RG | 2 |
| Bremner, JB | 1 |
| Browne, EJ | 1 |
| Manna, V | 1 |
| Bolino, F | 1 |
| Di Cicco, L | 1 |
| Okoro, EO | 1 |
| Marwood, JF | 1 |
| Hill, JM | 1 |
| Kaufman, MP | 1 |
| Banner, SE | 1 |
| Wood, SJ | 1 |
| Osborne, RH | 1 |
| Cattell, KJ | 1 |
| Vila, E | 1 |
| Sallés, J | 1 |
| Badia, A | 1 |
| Szarek, JL | 1 |
| Schmidt, NL | 1 |
| Tuncer, M | 2 |
| Doğan, N | 1 |
| Ilhan, M | 1 |
| Kayaalp, SO | 2 |
| Vandeputte-Van Messon, G | 1 |
| Burvenich, C | 1 |
| Peeters, G | 1 |
| Uma, S | 1 |
2 trials available for mianserin and Muscle Contraction
| Article | Year |
|---|---|
The potential therapeutic role of the enantiomers and metabolites of mianserin.
Topics: Animals; Behavior, Animal; Binding, Competitive; Dibenzazepines; Humans; Mianserin; Muscle Contracti | 1983 |
Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine.
Topics: Adult; Chronic Disease; Depression; Double-Blind Method; Female; Fluvoxamine; Headache; Humans; Male | 1994 |
23 other studies available for mianserin and Muscle Contraction
| Article | Year |
|---|---|
Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives.
Topics: Animals; Antidepressive Agents; Blepharoptosis; Brain; Chemical Phenomena; Chemistry; Dioxanes; Dopa | 1987 |
Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Male; Muscle Contraction; Piperazines; Pupil | 1983 |
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; | 1993 |
RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Humans; Male; Muscle Contraction; Pyrimidines; Radioligand | 1999 |
5-HT at hypoglossal motor nucleus and respiratory control of genioglossus muscle in anesthetized rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Carbon Dioxide; Diaphragm; Dose-Response Relationship | 2003 |
Blockade of calcium entry in smooth muscle cells by the antidepressant imipramine.
Topics: Animals; Antidepressive Agents; Aorta; Calcium; Calcium Channel Blockers; Calcium Channels; Colon; D | 2004 |
Effect of mianserin on noradrenergic transmission in the rat anococcygeus muscle.
Topics: Animals; Dibenzazepines; Hydroxydopamines; In Vitro Techniques; Male; Mianserin; Muscle Contraction; | 1980 |
Interaction between mianserin and clonidine at alpha 2-adrenoceptors.
Topics: Animals; Blood Pressure; Chickens; Clonidine; Desipramine; Dibenzazepines; Dogs; Drug Interactions; | 1982 |
[A study of three potential antidepressants (amineptin, mianserin and nomifensin) on the cardiovascular system and isolated intestine (author's transl)].
Topics: Animals; Antidepressive Agents; Dibenzocycloheptenes; Dogs; Duodenum; Hemodynamics; In Vitro Techniq | 1982 |
Some anti-allergic and anti-inflammatory actions of 2-N-carboxamidinonormianserin (FCC5).
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug | 1995 |
The action of 1,2,3,5,6,11b-hexahydro-[1]benzothieno [3,2-g]indolizine hydrochloride (ADT 16) on peripheral and central responses mediated by 5-hydroxytryptaminergic and adrenergic systems of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Guinea Pigs; In Vitro Techniques; Indolizines; Male | 1994 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female | 1997 |
Mianserin potentiates responses to acetylcholine in the rat anococcygeus muscle.
Topics: Acetylcholine; Animals; Carbachol; Dibenzazepines; Drug Synergism; Hydroxydopamines; In Vitro Techni | 1979 |
Pharmacological evaluation of the histamine H1 and 5-HT blocking properties of 2-N-(carboxamidinonormianserin) (FCC5): in-vitro studies.
Topics: Animals; Electric Stimulation; Guinea Pigs; Heart Rate; Histamine; Histamine H1 Antagonists; Ileum; | 1992 |
Intrathecal serotonin attenuates the pressor response to static contraction.
Topics: Animals; Blood Pressure; Cats; Heart Rate; Injections, Spinal; Mianserin; Muscle Contraction; Recept | 1991 |
Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors.
Topics: Animals; Caffeine; Digestive System; Digestive System Physiological Phenomena; Dose-Response Relatio | 1990 |
Effects of chronic antidepressant treatment on alpha 1- and alpha 2-adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Antidepressive Agents; Cocaine; Desipramine; Electric Stimulation; Male; Mianserin; Muscle | 1990 |
Hydrogen peroxide-induced potentiation of contractile responses in isolated rat airways.
Topics: Acetylcholine; Animals; Bronchi; Catalase; Electric Stimulation; Hydrogen Peroxide; In Vitro Techniq | 1990 |
Postjunctional effects of mianserin and its metabolites on the rat isolated anococcygeus muscle.
Topics: Animals; Dibenzazepines; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Male; | 1985 |
Serotonin-induced contraction of canine saphenous vein: mediation by 5-HT1 receptors.
Topics: Animals; Clonidine; Dogs; Drug Interactions; Emetics; In Vitro Techniques; Ketanserin; Mianserin; Mu | 1985 |
Effect of serotonin on the motility of smooth muscles in teats of lactating cows.
Topics: Animals; Cattle; Female; Ketanserin; Lactation; Mammary Glands, Animal; Methysergide; Mianserin; Mil | 1985 |
Differential antagonism of the initial fast and secondary slow contractile responses of the rat isolated aorta to 5-hydroxytryptamine by mianserin and ketanserin.
Topics: Animals; Drug Interactions; In Vitro Techniques; Ketanserin; Male; Mianserin; Muscle Contraction; Mu | 1987 |
The subtype of serotonin (5-HT) receptors in the rat pulmonary artery.
Topics: Animals; Female; In Vitro Techniques; Ketanserin; Male; Methysergide; Mianserin; Muscle Contraction; | 1987 |