mianserin has been researched along with Morphine Abuse in 5 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the atypical antidepressant and serotonin antagonist mianserin on the expression of opiate withdrawal was examined using an acute and a chronic model of morphine dependence." | 3.67 | Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine. ( Neal, BS; Sparber, SB, 1986) |
| "Pretreatment with mirtazapine 24h prior to the CPP test had no effect on CPP expression." | 1.38 | The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization. ( Graves, SM; Napier, TC; Persons, AL; Riddle, JL, 2012) |
| "Intensity of withdrawal symptoms was evaluated by tail-flick assay latencies and three behavioural measurements (rearing, jumping and grooming) in each group." | 1.32 | Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice. ( Backler, MM; Bar-Hamburger, R; Herman, I; Pick, CG; Rigai, T; Schreiber, S; Shamir, D, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, L | 1 |
| Wang, D | 1 |
| Li, B | 1 |
| Hu, M | 1 |
| Zhang, P | 1 |
| Li, J | 1 |
| Graves, SM | 1 |
| Persons, AL | 1 |
| Riddle, JL | 1 |
| Napier, TC | 1 |
| Schreiber, S | 1 |
| Backler, MM | 1 |
| Herman, I | 1 |
| Shamir, D | 1 |
| Rigai, T | 1 |
| Bar-Hamburger, R | 1 |
| Pick, CG | 1 |
| Neal, BS | 2 |
| Sparber, SB | 2 |
5 other studies available for mianserin and Morphine Abuse
| Article | Year |
|---|---|
Mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuates morphine dependence and withdrawal in Sprague-Dawley rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Dose-Response Relationship, Drug; | 2008 |
The atypical antidepressant mirtazapine attenuates expression of morphine-induced place preference and motor sensitization.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Conditionin | 2012 |
Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Disease Models, An | 2003 |
The serotonin2 antagonist ritanserin blocks quasi-morphine withdrawal at a time when mianserin is no longer effective.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Conditioning, Operant; Male; Mianserin; Morphine Dependence; N | 1990 |
Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine.
Topics: Animals; Body Temperature; Clonidine; Corticosterone; Dibenzazepines; Male; Mianserin; Morphine Depe | 1986 |