mianserin has been researched along with Leukoencephalopathy, Progressive Multifocal in 33 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Leukoencephalopathy, Progressive Multifocal: An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Demonstration of survival and outcome of progressive multifocal leukoencephalopathy (PML) in a 56-year-old patient with common variable immunodeficiency, consisting of severe hypogammaglobulinemia and CD4+ T lymphocytopenia, during continuous treatment with mirtazapine (30 mg/day) and mefloquine (250 mg/week) over 23 months." | 7.81 | Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine. ( Bassetti, CL; Du Pasquier, R; Furrer, H; Hirsch, HH; Kardas, P; Krestel, H; Kurmann, R; Lämmle, B; Sturzenegger, M; Weisstanner, C; Wiest, R, 2015) |
| "Mirtazapine 15 mg was started while prednisone treatment was continued." | 5.43 | Clearance of cerebrospinal fluid JCV DNA with mirtazapine in a patient with progressive multifocal leukoencephalopathy and sarcoidosis. ( Atzori, C; Bonora, S; Busolli, P; Calcagno, A; Ghisetti, V; Imperiale, D; Trentalange, A, 2016) |
| "Demonstration of survival and outcome of progressive multifocal leukoencephalopathy (PML) in a 56-year-old patient with common variable immunodeficiency, consisting of severe hypogammaglobulinemia and CD4+ T lymphocytopenia, during continuous treatment with mirtazapine (30 mg/day) and mefloquine (250 mg/week) over 23 months." | 3.81 | Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine. ( Bassetti, CL; Du Pasquier, R; Furrer, H; Hirsch, HH; Kardas, P; Krestel, H; Kurmann, R; Lämmle, B; Sturzenegger, M; Weisstanner, C; Wiest, R, 2015) |
| "Mirtazapine use was safe and well tolerated." | 2.74 | Mirtazapine use in human immunodeficiency virus-infected patients with progressive multifocal leukoencephalopathy. ( Cettomai, D; McArthur, JC, 2009) |
| "Steroids were restarted and his ataxia stabilized." | 1.46 | JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7. ( Angeles, MR; Bucelli, RC; Clifford, DB; Dang, X; Koralnik, IJ; Kuhlmann, FM; Major, EO; Ryschkewitsch, CF; Schmidt, RE; Schwetye, KE; Soleimani-Meigooni, DN, 2017) |
| "Mirtazapine 15 mg was started while prednisone treatment was continued." | 1.43 | Clearance of cerebrospinal fluid JCV DNA with mirtazapine in a patient with progressive multifocal leukoencephalopathy and sarcoidosis. ( Atzori, C; Bonora, S; Busolli, P; Calcagno, A; Ghisetti, V; Imperiale, D; Trentalange, A, 2016) |
| "An 83-year-old man with chronic renal failure was referred to our hospital because of subacute progressive right hemiparesis." | 1.43 | A case of progressive multifocal leukoencephalopathy with chronic renal failure, whose JC virus in cerebrospinal fluid disappeared after mefloquine-mirtazapine dual therapy. ( Asayama, S; Asayama, T; Kosaka, S; Nakamichi, K; Ohnuki, E; Saijo, M, 2016) |
| "Treatment with mirtazapine 30 mg orally daily and mefloquine hydrochloride 250 mg orally for three days, then 250 mg weekly, was initiated." | 1.38 | Mirtazapine and mefloquine therapy for progressive multifocal leukoencephalopathy in a patient infected with human immunodeficiency virus. ( Jett, RA; Moenster, RP, 2012) |
| "A patient with multiple myeloma was treated with high-dose chemotherapy followed by two autologous bone marrow transplantations (ABMTs)." | 1.37 | Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: a treatment option. ( Brustia, D; Cantello, R; Comi, C; Conconi, A; De Paoli, L; Gaidano, G; Monaco, F; Mula, M; Nasuelli, N; Ripellino, P; Savio, K; Stecco, A; Varrasi, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (21.21) | 29.6817 |
| 2010's | 26 (78.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikeda, J | 2 |
| Matsushima, A | 1 |
| Ishii, W | 2 |
| Goto, T | 1 |
| Takahashi, K | 1 |
| Nakamichi, K | 3 |
| Saijo, M | 2 |
| Sekijima, Y | 2 |
| Ikeda, SI | 1 |
| Scholten, P | 1 |
| Kralt, P | 1 |
| Jacobs, B | 1 |
| Akagawa, Y | 1 |
| Ueno, A | 1 |
| Shishido-Hara, Y | 1 |
| Loyaga-Rendon, RY | 1 |
| Taylor, DO | 1 |
| Koval, CE | 1 |
| Iannetta, M | 1 |
| Bellizzi, A | 1 |
| Lo Menzo, S | 1 |
| Anzivino, E | 1 |
| D'Abramo, A | 1 |
| Oliva, A | 1 |
| D'Agostino, C | 1 |
| d'Ettorre, G | 1 |
| Pietropaolo, V | 1 |
| Vullo, V | 1 |
| Ciardi, MR | 1 |
| Yoshida, H | 1 |
| Ohshima, K | 1 |
| Toda, J | 1 |
| Kusakabe, S | 1 |
| Masaie, H | 1 |
| Yagi, T | 1 |
| Ishikawa, J | 1 |
| Di Pauli, F | 1 |
| Berger, T | 1 |
| Walder, A | 1 |
| Maier, H | 1 |
| Rhomberg, P | 1 |
| Uprimny, C | 1 |
| Steurer, M | 1 |
| Stockhammer, G | 1 |
| Meister, S | 1 |
| Benecke, R | 1 |
| König, FB | 1 |
| Großmann, A | 1 |
| Zettl, UK | 1 |
| Winkelmann, A | 1 |
| Epperla, N | 1 |
| Medina-Flores, R | 1 |
| Mazza, JJ | 1 |
| Yale, SH | 1 |
| Kurmann, R | 1 |
| Weisstanner, C | 1 |
| Kardas, P | 1 |
| Hirsch, HH | 1 |
| Wiest, R | 1 |
| Lämmle, B | 1 |
| Furrer, H | 1 |
| Du Pasquier, R | 1 |
| Bassetti, CL | 1 |
| Sturzenegger, M | 1 |
| Krestel, H | 1 |
| Loignon, M | 1 |
| Toma, E | 1 |
| Trentalange, A | 1 |
| Calcagno, A | 1 |
| Ghisetti, V | 1 |
| Atzori, C | 1 |
| Busolli, P | 1 |
| Bonora, S | 1 |
| Imperiale, D | 1 |
| Ito, D | 1 |
| Yasui, K | 1 |
| Hasegawa, Y | 1 |
| Katsuno, M | 1 |
| Takahashi, A | 1 |
| Jamilloux, Y | 1 |
| Kerever, S | 1 |
| Ferry, T | 1 |
| Broussolle, C | 1 |
| Honnorat, J | 1 |
| Sève, P | 1 |
| Soleimani-Meigooni, DN | 1 |
| Schwetye, KE | 1 |
| Angeles, MR | 1 |
| Ryschkewitsch, CF | 1 |
| Major, EO | 1 |
| Dang, X | 1 |
| Koralnik, IJ | 4 |
| Schmidt, RE | 1 |
| Clifford, DB | 1 |
| Kuhlmann, FM | 1 |
| Bucelli, RC | 1 |
| Lutz, M | 1 |
| Schulze, AB | 1 |
| Rebber, E | 1 |
| Wiebe, S | 1 |
| Zoubi, T | 1 |
| Grauer, OM | 1 |
| Keßler, T | 1 |
| Kerkhoff, A | 1 |
| Lenz, G | 1 |
| Berdel, WE | 1 |
| Ohnuki, E | 1 |
| Asayama, S | 1 |
| Asayama, T | 1 |
| Kosaka, S | 1 |
| Cettomai, D | 1 |
| McArthur, JC | 1 |
| Lanzafame, M | 1 |
| Ferrari, S | 1 |
| Lattuada, E | 1 |
| Corsini, F | 1 |
| Deganello, R | 1 |
| Vento, S | 1 |
| Concia, E | 1 |
| Rock, C | 1 |
| Bergin, C | 1 |
| Fernández-Ruiz, M | 1 |
| de la Serna, J | 1 |
| Ruiz, J | 1 |
| López-Medrano, F | 1 |
| McGuire, JL | 1 |
| Fridman, V | 1 |
| Wüthrich, C | 1 |
| Jacobs, D | 1 |
| Pallin, M | 1 |
| O'Sullivan, C | 1 |
| Dodd, JD | 1 |
| McCreery, K | 1 |
| Brett, F | 1 |
| Farrell, M | 1 |
| O'Brien, D | 1 |
| Hall, WW | 1 |
| Tubridy, NJ | 1 |
| Keane, MP | 1 |
| Damasceno, A | 1 |
| von Glehn, F | 1 |
| Martinez, AR | 1 |
| Longhini, AL | 1 |
| Deus-Silva, L | 1 |
| Brandão, CO | 1 |
| Santos, LM | 1 |
| Damasceno, BP | 1 |
| Moenster, RP | 1 |
| Jett, RA | 1 |
| Rath, T | 1 |
| Hackenbroch, M | 1 |
| Saech, J | 1 |
| Hallek, M | 2 |
| Rubbert, A | 2 |
| Lasso, M | 1 |
| Cerón, I | 1 |
| Ripellino, P | 1 |
| Comi, C | 1 |
| Mula, M | 1 |
| Varrasi, C | 1 |
| Conconi, A | 1 |
| Stecco, A | 1 |
| Brustia, D | 1 |
| Nasuelli, N | 1 |
| Savio, K | 1 |
| De Paoli, L | 1 |
| Cantello, R | 1 |
| Gaidano, G | 1 |
| Monaco, F | 1 |
| Hohlfeld, SK | 1 |
| Günthard, HF | 1 |
| Zeitz, J | 1 |
| Locher, P | 1 |
| Bachli, E | 1 |
| Vulliemoz, S | 1 |
| Lurati-Ruiz, F | 1 |
| Borruat, FX | 1 |
| Delavelle, J | 1 |
| Kuntzer, T | 1 |
| Bogousslavsky, J | 1 |
| Picard, F | 1 |
| Landis, T | 1 |
| Du Pasquier, RA | 1 |
| Owczarczyk, K | 1 |
| Hilker, R | 1 |
| Brunn, A | 1 |
| Verma, S | 1 |
| Cikurel, K | 1 |
| Morgello, S | 1 |
| Cunningham-Rundles, C | 1 |
| Weinstein, ZR | 1 |
| Bergmann, C | 1 |
| Simpson, DM | 1 |
| Focosi, D | 1 |
| Kast, RE | 1 |
| Maggi, F | 1 |
| Lauria, G | 1 |
| Ceccherini-Nelli, L | 1 |
| Petrini, M | 1 |
3 reviews available for mianserin and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Treatment options for progressive multifocal leukoencephalopathy in HIV-infected persons: current status and future directions.
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Cidofovir; Coinfection; Cy | 2016 |
Treatment of Progressive Multifocal Leukoencephalopathy With Mirtazapine.
Topics: Humans; Immunosuppressive Agents; JC Virus; Leukoencephalopathy, Progressive Multifocal; Mianserin; | 2016 |
[Mirtazapine and antiretroviral therapy in the treatment of progressive multifocal leukoencephalopathy associated with HIV-1 infection: report of a case and review of literature].
Topics: Adult; AIDS Dementia Complex; Antidepressive Agents, Tricyclic; Antiretroviral Therapy, Highly Activ | 2012 |
1 trial available for mianserin and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Mirtazapine use in human immunodeficiency virus-infected patients with progressive multifocal leukoencephalopathy.
Topics: Adult; Blood-Brain Barrier; Brain; Drug Administration Schedule; Early Diagnosis; Female; HIV Infect | 2009 |
29 other studies available for mianserin and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy.
Topics: Adrenergic alpha-Antagonists; Adult; Antimalarials; Biopsy; Brain; DNA, Viral; Female; Humans; JC Vi | 2017 |
Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease.
Topics: Adrenergic alpha-Antagonists; Cerebellar Ataxia; Disease Progression; Dysarthria; Fatal Outcome; Hum | 2017 |
[Two patients with progressive multifocal leukoencephalopathy with immune response against JC virus showing good long-term outcome by combination therapy of mefloquine, mirtazapine, and risperidone].
Topics: Adult; Brain; Drug Therapy, Combination; Female; Humans; Immunity, Cellular; JC Virus; Leukoencephal | 2018 |
Progressive multifocal leukoencephalopathy in a heart transplant recipient following rituximab therapy for antibody-mediated rejection.
Topics: Antibodies, Monoclonal, Murine-Derived; Cognition Disorders; Fatal Outcome; Graft Rejection; Heart F | 2013 |
HIV-associated progressive multifocal leukoencephalopathy: longitudinal study of JC virus non-coding control region rearrangements and host immunity.
Topics: Adrenal Cortex Hormones; Antiretroviral Therapy, Highly Active; Antiviral Agents; Coinfection; Fatal | 2013 |
Significant improvement following combination treatment with mefloquine and mirtazapine in a patient with progressive multifocal leukoencephalopathy after allogeneic peripheral blood stem cell transplantation.
Topics: Adult; Antiviral Agents; Brain; Drug Therapy, Combination; Female; Humans; Leukoencephalopathy, Prog | 2014 |
Progressive multifocal leukoencephalopathy complicating untreated chronic lymphatic leukemia: case report and review of the literature.
Topics: Cytarabine; Disease Progression; Female; Humans; JC Virus; Leukemia, Lymphocytic, Chronic, B-Cell; L | 2014 |
Progressive multifocal leukoencephalopathy in a patient with pre-clinical primary biliary cirrhosis.
Topics: Aged; Brain; Disease Progression; Female; Humans; JC Virus; Leukoencephalopathy, Progressive Multifo | 2014 |
Mirtazapine and mefloquine therapy for non-AIDS-related progressive multifocal leukoencephalopathy.
Topics: Adrenergic alpha-Antagonists; Aged; Drug Therapy, Combination; Humans; Leukoencephalopathy, Progress | 2014 |
Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine.
Topics: Antiviral Agents; Common Variable Immunodeficiency; DNA, Viral; Humans; JC Virus; Leukoencephalopath | 2015 |
Clearance of cerebrospinal fluid JCV DNA with mirtazapine in a patient with progressive multifocal leukoencephalopathy and sarcoidosis.
Topics: Aged; DNA, Viral; Female; Humans; Immunosuppressive Agents; JC Virus; Leukoencephalopathy, Progressi | 2016 |
Progressive multifocal leukoencephalopathy with bilateral middle cerebellar peduncle lesions confirmed by repeated CSF-JC virus tests and coexistence of JC virus granule cell neuronopathy. Report of a case.
Topics: Aged; Cerebellum; Cerebrospinal Fluid; Corneal Dystrophies, Hereditary; Diagnosis, Differential; DNA | 2016 |
JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7.
Topics: Aged; Ataxia; Chronic Disease; Hamartoma Syndrome, Multiple; Humans; Immunocompromised Host; Immunog | 2017 |
Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia.
Topics: Adenine; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain; Disease | 2017 |
A case of progressive multifocal leukoencephalopathy with chronic renal failure, whose JC virus in cerebrospinal fluid disappeared after mefloquine-mirtazapine dual therapy.
Topics: Aged, 80 and over; Astrocytes; Brain; Cerebrospinal Fluid; Drug Therapy, Combination; Humans; Immuno | 2016 |
Mirtazapine in an HIV-1 infected patient with progressive multifocal leukoencephalopathy.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, H | 2009 |
Progressive multifocal leukoencephalopathy - experimental options.
Topics: Humans; Leukoencephalopathy, Progressive Multifocal; Mianserin; Mirtazapine; Selective Serotonin Reu | 2009 |
[Progressive multifocal leukoencephalopathy in a patient with acute myeloid leukaemia after allogeneic hematopoietic-cell transplantation].
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fatal Outcome; Graft vs H | 2011 |
Progressive multifocal leukoencephalopathy associated with isolated CD8+ T-lymphocyte deficiency mimicking tumefactive MS.
Topics: Aged; Brain; CD8-Positive T-Lymphocytes; Female; Humans; JC Virus; Leukoencephalopathy, Progressive | 2011 |
A case of progressive multifocal leukoencephalopathy in a patient with sarcoidosis.
Topics: Antimalarials; Antiviral Agents; Biopsy; Brain; Hemianopsia; Histamine H1 Antagonists; Histological | 2012 |
Early onset of natalizumab-related progressive multifocal leukoencephalopathy.
Topics: Antibodies, Monoclonal, Humanized; Glatiramer Acetate; Humans; Immunologic Factors; Immunosuppressiv | 2011 |
Mirtazapine and mefloquine therapy for progressive multifocal leukoencephalopathy in a patient infected with human immunodeficiency virus.
Topics: Cognition Disorders; Histamine H1 Antagonists; HIV Infections; Humans; JC Virus; Leukoencephalopathy | 2012 |
Longterm remission of more than 5 years in a patient with progressive multifocal leucoencephalopathy and sarcoidosis.
Topics: Anti-Inflammatory Agents; Antiviral Agents; Brain; Cidofovir; Cytosine; Female; Gait Disorders, Neur | 2012 |
Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: a treatment option.
Topics: Antidepressive Agents, Tricyclic; Antiviral Agents; Bone Marrow Transplantation; Cidofovir; Cytosine | 2011 |
Progressive multi-focal leukoencephalopathy as a rare lethal complication in untreated sarcoidosis.
Topics: Adrenergic alpha-Antagonists; Adult; DNA, Viral; Fatal Outcome; Humans; JC Virus; Leukoencephalopath | 2012 |
Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis.
Topics: Adrenergic alpha-Antagonists; Cytarabine; Dermatomyositis; Female; Humans; Immunosuppressive Agents; | 2006 |
Progressive multifocal leucoencephalopathy in a patient with sarcoidosis--successful treatment with cidofovir and mirtazapine.
Topics: Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Female; Humans; Leukoencephalopath | 2007 |
Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera.
Topics: Female; Humans; Leukoencephalopathy, Progressive Multifocal; Mianserin; Middle Aged; Mirtazapine; Po | 2007 |
5-HT2a inhibitors for progressive multifocal leukoencephalopathy: old drugs for an old disease.
Topics: Adult; Female; Humans; JC Virus; Leukoencephalopathy, Progressive Multifocal; Male; Mianserin; Middl | 2008 |