Page last updated: 2024-10-31

mianserin and Drug Withdrawal Symptoms

mianserin has been researched along with Drug Withdrawal Symptoms in 42 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Research Excerpts

ExcerptRelevanceReference
" We suspected that these symptoms were related to side effects caused by the milnacipran she was taking for depression, prior to hospitalization."7.83Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran. ( Koshiishi, T; Okuyama, K, 2016)
"Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)."7.74Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008)
"Seizures were observed following the withdrawal of mianserin 60 mg/day for 2 years."7.67Seizures following the withdrawal of long-term treatment with mianserin. ( Dalla Barba, G; De Leo, D; Zanchin, G, 1988)
"A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine."5.43[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016)
"The objective of the present study was to determine whether a combined psychotherapeutic-psychopharmacological (with mirtazapine) treatment of collateral anxiety and depressive symptomatology during the post-withdrawal phase of alcoholism facilitates the process of alcohol detoxification, which is a decisive stage in the treatment of alcohol-dependent individuals."5.11Mirtazapine improves alcohol detoxification. ( Christodoulou, G; Liappas, J; Malitas, P; Paparrigopoulos, T; Tzavellas, E, 2004)
" We suspected that these symptoms were related to side effects caused by the milnacipran she was taking for depression, prior to hospitalization."3.83Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran. ( Koshiishi, T; Okuyama, K, 2016)
"Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)."3.74Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008)
" Single doses of 5-HT2 antagonists, mianserin (5mg/kg) and ritanserin (1mg/kg), effectively ameliorated withdrawal anxiety in the rat, returning behavioural function in the social interaction test and elevated plus maze to levels comparable to vehicle-treated animals."3.73Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists. ( Begg, DP; Hallam, KT; Norman, TR, 2005)
"The effects of the atypical antidepressant and serotonin antagonist mianserin on the expression of opiate withdrawal was examined using an acute and a chronic model of morphine dependence."3.67Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine. ( Neal, BS; Sparber, SB, 1986)
"Seizures were observed following the withdrawal of mianserin 60 mg/day for 2 years."3.67Seizures following the withdrawal of long-term treatment with mianserin. ( Dalla Barba, G; De Leo, D; Zanchin, G, 1988)
"Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine."2.73Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual. ( McGregor, C; Mitchell, A; Srisurapanont, M; White, JM; Wickes, W, 2008)
"Mianserin (or placebo) was added to the routine medication protocol, during the 3-week in-patient phase of detoxification in a prospective, randomized, double blind, placebo controlled study."2.71The effect of mianserin add-on, on the intensity of opioid withdrawal symptoms during detoxification program--a randomized, double blind, placebo controlled, prospective study. ( Bar-Hamburger, R; Herman, I; Pick, CG; Schreiber, S; Shamir, D, 2005)
"The drug also decreased alcohol addiction, had vegetostabilising and sedative effects."2.68[The efficacy and mechanisms of action of lerivon in alcoholism]. ( Anokhina, IP; Chirko, VV; Ivanets, NN; Kogan, BM; Nebarakova, TP; Rusinov, AV, 1996)
"A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine."1.43[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016)
"Intensity of withdrawal symptoms was evaluated by tail-flick assay latencies and three behavioural measurements (rearing, jumping and grooming) in each group."1.32Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice. ( Backler, MM; Bar-Hamburger, R; Herman, I; Pick, CG; Rigai, T; Schreiber, S; Shamir, D, 2003)
") or saline during the second cocaine dosing regimen in the acute withdrawal period, 3."1.315-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization. ( Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH; Xiong, X, 2002)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199010 (23.81)18.7374
1990's12 (28.57)18.2507
2000's16 (38.10)29.6817
2010's4 (9.52)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arora, S1
Vohora, D1
de Witte, LD1
Dekker, D1
Veraart, J1
Kromkamp, M1
Kaasjager, K1
Vinkers, CH1
Koshiishi, T1
Okuyama, K1
Chandrasekaran, PK1
Kang, L1
Wang, D1
Li, B1
Hu, M1
Zhang, P1
Li, J1
Haney, M1
Hart, CL1
Vosburg, SK1
Comer, SD1
Reed, SC1
Cooper, ZD1
Foltin, RW1
Davidson, C1
Lazarus, C1
Xiong, X1
Lee, TH1
Ellinwood, EH1
Schreiber, S2
Backler, MM1
Herman, I2
Shamir, D2
Rigai, T1
Bar-Hamburger, R2
Pick, CG2
Liappas, J2
Paparrigopoulos, T2
Malitas, P1
Tzavellas, E2
Christodoulou, G1
Rabavilas, A1
Begg, DP1
Hallam, KT1
Norman, TR1
Zullino, DF1
Krenz, S1
Zimmerman, G1
Miozzari, A1
Rajeswaran, R1
Kolly, S1
Khazaal, Y1
Kitabayashi, Y1
Shibata, K1
Nakamae, T1
Narumoto, J1
Tani, N1
Fukui, K1
Schwarzer, V1
Heep, A1
Gembruch, U1
Rohde, A1
McGregor, C1
Srisurapanont, M1
Mitchell, A1
Wickes, W1
White, JM1
Benyamina, A1
Lecacheux, M1
Blecha, L1
Reynaud, M1
Lukasiewcz, M1
Cruickshank, CC1
Montebello, ME1
Dyer, KR1
Quigley, A1
Blaszczyk, J1
Tomkins, S1
Shand, D1
Einarson, TR1
Ivanets, NN1
Anokhina, IP1
Kogan, BM1
Chirko, VV1
Nebarakova, TP1
Rusinov, AV1
Uchimura, N1
Nakamura, J1
Bertschy, G1
Bryois, C1
Bondolfi, G1
Velardi, A1
Budry, P1
Dascal, D1
Martinet, C1
Baettig, D1
Baumann, P1
Bottlender, R1
Erfurth, A1
Hoff, P1
Möller, HJ1
Benazzi, F1
MacCall, C1
Callender, J1
Klesmer, J1
Sarcevic, A1
Fomari, V1
Roy, A1
Mittal, N1
Zhang, H1
Pandey, SC1
Lynch, MA1
Leonard, BE1
Mogilnicka, E1
Klimek, V1
Drust, EG1
Sloviter, RS1
Connor, JD1
Otani, K1
Sasa, H1
Kaneko, S1
Fukushima, Y1
Sansone, M1
Battaglia, M1
Ekblom, J1
Nalepa, I1
Vetulani, J1
Neal, BS3
Sparber, SB4
Messing, RB1
Prather, PL1
Rezazadeh, SM1
Lal, H1
Bell, A1
Kleven, MS1
Kuniyoshi, M1
Arikawa, K1
Miura, C1
Inanaga, K1
Muijen, M1
Jones, DP1
Roy, D1
Silverstone, T1
Mehmet, A1
De Leo, D1
Dalla Barba, G1
Zanchin, G1
Nabeshima, T1
Yamaguchi, K1
Yoshida, S1
Furukawa, H1
Kameyama, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Baclofen on Marijuana Withdrawal and Relapse[NCT00373295]Phase 213 participants (Actual)Interventional2006-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Measure of Relapse: Change in Money Spent Between Baseline and Relapse Phase

"This is a measure of marijuana self-administration and relapse since each initial puff costs $7 and is a burden to overcome just to smoke.~Over each 3 day period, the puffs chosen by each participant is averaged for a single value." (NCT00373295)
Timeframe: Days 1-3 (Baseline) and Days 6-8 (Relapse Phase)

Interventiondollars spent on marijuana (Mean)
Baclofen 60, Marijuana7.15
Placebo, Marijuana9.77
Baclofen 90, Marijuana7.25

Reviews

3 reviews available for mianserin and Drug Withdrawal Symptoms

ArticleYear
[Diagnosis, assessment, and treatment of alcohol withdrawal syndrome].
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2006, Volume: 41, Issue:6

    Topics: Alcohol-Related Disorders; Alcoholism; Antipsychotic Agents; Benzodiazepines; Diagnostic and Statist

2006
Pharmacotherapy and psychotherapy in cannabis withdrawal and dependence.
    Expert review of neurotherapeutics, 2008, Volume: 8, Issue:3

    Topics: Behavior Therapy; Buspirone; Cannabinoids; Cognitive Behavioral Therapy; Combined Modality Therapy;

2008
[Changes in metabolism of catecholamines and serotonin during alcohol withdrawal].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl

    Topics: Antidepressive Agents, Second-Generation; Dopamine; Ethanol; Homovanillic Acid; Humans; Hydroxyindol

1997

Trials

8 trials available for mianserin and Drug Withdrawal Symptoms

ArticleYear
Effects of baclofen and mirtazapine on a laboratory model of marijuana withdrawal and relapse.
    Psychopharmacology, 2010, Volume: 211, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Affect; Baclofen; Cognition; Dose-Response Relationship, Drug;

2010
Mirtazapine improves alcohol detoxification.
    Journal of psychopharmacology (Oxford, England), 2004, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Alcoholism; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Female;

2004
Mirtazapine and venlafaxine in the management of collateral psychopathology during alcohol detoxification.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:1

    Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Anxiety; Central Nervous System Depressants;

2005
The effect of mianserin add-on, on the intensity of opioid withdrawal symptoms during detoxification program--a randomized, double blind, placebo controlled, prospective study.
    Addictive behaviors, 2005, Volume: 30, Issue:6

    Topics: Analysis of Variance; Antidepressive Agents, Second-Generation; Anxiety; Depressive Disorder; Double

2005
Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual.
    Journal of substance abuse treatment, 2008, Volume: 35, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Centra

2008
A placebo-controlled trial of mirtazapine for the management of methamphetamine withdrawal.
    Drug and alcohol review, 2008, Volume: 27, Issue:3

    Topics: Adult; Ambulatory Care; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Central Ner

2008
[The efficacy and mechanisms of action of lerivon in alcoholism].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1996, Volume: 96, Issue:5

    Topics: Adolescent; Adult; Alcohol Deterrents; Alcoholism; Amitriptyline; Anti-Anxiety Agents; Antidepressiv

1996
The association carbamazepine-mianserin in opiate withdrawal: a double blind pilot study versus clonidine.
    Pharmacological research, 1997, Volume: 35, Issue:5

    Topics: Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Second-Generation; Carbamazepine; Clonidine;

1997

Other Studies

31 other studies available for mianserin and Drug Withdrawal Symptoms

ArticleYear
Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 119, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Anxiety; Be

2016
[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms].
    Nederlands tijdschrift voor geneeskunde, 2016, Volume: 160

    Topics: Adult; Aggression; Alcoholism; Baclofen; Delirium; Drug Overdose; GABA-B Receptor Agonists; Humans;

2016
Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:12

    Topics: Aged; Antidepressive Agents; Cerebral Hemorrhage; Cyclopropanes; Depression; Drug Substitution; Fema

2016
Employing mirtazapine to aid benzodiazepine withdrawal.
    Singapore medical journal, 2008, Volume: 49, Issue:6

    Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Humans; Male; Mianserin; Midazolam; Mi

2008
Mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuates morphine dependence and withdrawal in Sprague-Dawley rats.
    The American journal of drug and alcohol abuse, 2008, Volume: 34, Issue:5

    Topics: Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Dose-Response Relationship, Drug;

2008
5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization.
    European journal of pharmacology, 2002, Oct-25, Volume: 453, Issue:2-3

    Topics: Animals; Behavior, Animal; Clozapine; Cocaine; Injections; Ketanserin; Male; Mianserin; Rats; Rats,

2002
Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice.
    Addiction biology, 2003, Volume: 8, Issue:1

    Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Disease Models, An

2003
Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists.
    Behavioural brain research, 2005, Jun-20, Volume: 161, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Interpers

2005
Topiramate in opiate withdrawal- comparison with clonidine and with carbamazepine/mianserin.
    Substance abuse, 2004, Volume: 25, Issue:4

    Topics: Adrenergic alpha-Agonists; Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Carbama

2004
Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine.
    Archives of gynecology and obstetrics, 2008, Volume: 277, Issue:1

    Topics: Adult; Antidepressive Agents, Tricyclic; Diabetes Mellitus, Type 1; Drug Resistance; Female; Humans;

2008
Lorazepam withdrawal seizures.
    Lancet (London, England), 1980, Jan-19, Volume: 1, Issue:8160

    Topics: Anti-Anxiety Agents; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Male; Mia

1980
[Mianserin-induced hypertension 2 weeks after discontinuation of tranylcypromine].
    Der Nervenarzt, 1997, Volume: 68, Issue:7

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Cardiomyopathy, Dilated; Depressive

1997
Mirtazapine withdrawal symptoms.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:5

    Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combination; Humans; Mal

1998
Mirtazapine withdrawal causing hypomania.
    The British journal of psychiatry : the journal of mental science, 1999, Volume: 175

    Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Female; Humans; Mianserin; Mirtazapine; Su

1999
Panic attacks during discontinuation of mirtazepine.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2000, Volume: 45, Issue:6

    Topics: Antidepressive Agents, Tricyclic; Appendectomy; Dysthymic Disorder; Hernia, Umbilical; Humans; Male;

2000
Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2

    Topics: Adaptation, Biological; Alcohol Drinking; Animals; Cerebral Cortex; Disease Models, Animal; DNA; Eth

2002
Effect of chronic amphetamine administration on the behaviour of rats in the open field apparatus: reversal of post-withdrawal depression by two antidepressants.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:12

    Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Dextroamphetamine; Huma

1978
Mianserin, danitracen and amitriptyline withdrawal increases the behavioural responses of rats to L-5-HTP.
    The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:10

    Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Behavior, Animal; Dibenzazepines; Humans; Male; Mianser

1979
Effect of morphine on 'wet-dog' shakes caused by cerebroventricular injection of serotonin.
    Pharmacology, 1979, Volume: 18, Issue:6

    Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Dopamine; Dose-Response Relationship, Drug; Humans; Injecti

1979
Lack of withdrawal symptoms after discontinuation of mianserin.
    Lancet (London, England), 1991, Mar-16, Volume: 337, Issue:8742

    Topics: Acute Disease; Adult; Aged; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Mianserin; M

1991
Avoidance learning during antidepressant withdrawal in mice.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:1

    Topics: Animals; Avoidance Learning; Brain; Desipramine; Injections, Intraperitoneal; Male; Mianserin; Mice;

1991
The serotonin2 antagonist ritanserin blocks quasi-morphine withdrawal at a time when mianserin is no longer effective.
    Psychopharmacology, 1990, Volume: 100, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Conditioning, Operant; Male; Mianserin; Morphine Dependence; N

1990
Long-term effects of neonatal exposure to isobutylmethylxanthine. II. Attenuation of acute morphine withdrawal in mature rats.
    Psychopharmacology, 1991, Volume: 103, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Body Temperature; Conditioning, Operant; Dos

1991
Mianserin in the treatment of ethanol withdrawal in the rat: prevention of behaviors indicative of anxiety.
    Psychopharmacology bulletin, 1991, Volume: 27, Issue:3

    Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Male; Mianserin; Rats; Substance Withdrawal Syndrome

1991
Calcium channel blockers.
    The Australian and New Zealand journal of psychiatry, 1990, Volume: 24, Issue:4

    Topics: Aged; Atrial Fibrillation; Bipolar Disorder; Combined Modality Therapy; Electroconvulsive Therapy; H

1990
Modification of quasi-morphine withdrawal with serotonin agonists and antagonists: evidence for a role of serotonin in the expression of opiate withdrawal.
    Psychopharmacology, 1989, Volume: 98, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 5-Hydroxytryptophan; Animals; Fluoxetine; Male; Methysergide; Mianserin

1989
Panic anxiety after abrupt discontinuation of mianserin.
    The Japanese journal of psychiatry and neurology, 1989, Volume: 43, Issue:2

    Topics: Adult; Anxiety Disorders; Depressive Disorder; Fear; Female; Humans; Mianserin; Panic; Substance Wit

1989
Mianserin withdrawal and the pupil response of depressed and recovered patients: a preliminary report.
    Biological psychiatry, 1989, Mar-15, Volume: 25, Issue:6

    Topics: Adult; Arousal; Depressive Disorder; Female; Humans; Male; Mianserin; Middle Aged; Phenylephrine; Ps

1989
Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1

    Topics: Animals; Body Temperature; Clonidine; Corticosterone; Dibenzazepines; Male; Mianserin; Morphine Depe

1986
Seizures following the withdrawal of long-term treatment with mianserin.
    Italian journal of neurological sciences, 1988, Volume: 9, Issue:2

    Topics: Adult; Depressive Disorder; Female; Humans; Mianserin; Seizures; Substance Withdrawal Syndrome

1988
Phencyclidine-induced wet-dog shakes observed in rats after withdrawal from reserpine treatment.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:5

    Topics: Animals; Behavior, Animal; Imipramine; Male; Mianserin; p-Chloroamphetamine; Phencyclidine; Rats; Ra

1986
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