mianserin and Drug Withdrawal Symptoms
mianserin has been researched along with Drug Withdrawal Symptoms in 42 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" We suspected that these symptoms were related to side effects caused by the milnacipran she was taking for depression, prior to hospitalization." | 7.83 | Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran. ( Koshiishi, T; Okuyama, K, 2016) |
"Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)." | 7.74 | Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008) |
"Seizures were observed following the withdrawal of mianserin 60 mg/day for 2 years." | 7.67 | Seizures following the withdrawal of long-term treatment with mianserin. ( Dalla Barba, G; De Leo, D; Zanchin, G, 1988) |
"A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine." | 5.43 | [Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016) |
"The objective of the present study was to determine whether a combined psychotherapeutic-psychopharmacological (with mirtazapine) treatment of collateral anxiety and depressive symptomatology during the post-withdrawal phase of alcoholism facilitates the process of alcohol detoxification, which is a decisive stage in the treatment of alcohol-dependent individuals." | 5.11 | Mirtazapine improves alcohol detoxification. ( Christodoulou, G; Liappas, J; Malitas, P; Paparrigopoulos, T; Tzavellas, E, 2004) |
" We suspected that these symptoms were related to side effects caused by the milnacipran she was taking for depression, prior to hospitalization." | 3.83 | Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran. ( Koshiishi, T; Okuyama, K, 2016) |
"Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)." | 3.74 | Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008) |
" Single doses of 5-HT2 antagonists, mianserin (5mg/kg) and ritanserin (1mg/kg), effectively ameliorated withdrawal anxiety in the rat, returning behavioural function in the social interaction test and elevated plus maze to levels comparable to vehicle-treated animals." | 3.73 | Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists. ( Begg, DP; Hallam, KT; Norman, TR, 2005) |
"The effects of the atypical antidepressant and serotonin antagonist mianserin on the expression of opiate withdrawal was examined using an acute and a chronic model of morphine dependence." | 3.67 | Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine. ( Neal, BS; Sparber, SB, 1986) |
"Seizures were observed following the withdrawal of mianserin 60 mg/day for 2 years." | 3.67 | Seizures following the withdrawal of long-term treatment with mianserin. ( Dalla Barba, G; De Leo, D; Zanchin, G, 1988) |
"Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine." | 2.73 | Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual. ( McGregor, C; Mitchell, A; Srisurapanont, M; White, JM; Wickes, W, 2008) |
"Mianserin (or placebo) was added to the routine medication protocol, during the 3-week in-patient phase of detoxification in a prospective, randomized, double blind, placebo controlled study." | 2.71 | The effect of mianserin add-on, on the intensity of opioid withdrawal symptoms during detoxification program--a randomized, double blind, placebo controlled, prospective study. ( Bar-Hamburger, R; Herman, I; Pick, CG; Schreiber, S; Shamir, D, 2005) |
"The drug also decreased alcohol addiction, had vegetostabilising and sedative effects." | 2.68 | [The efficacy and mechanisms of action of lerivon in alcoholism]. ( Anokhina, IP; Chirko, VV; Ivanets, NN; Kogan, BM; Nebarakova, TP; Rusinov, AV, 1996) |
"A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine." | 1.43 | [Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016) |
"Intensity of withdrawal symptoms was evaluated by tail-flick assay latencies and three behavioural measurements (rearing, jumping and grooming) in each group." | 1.32 | Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice. ( Backler, MM; Bar-Hamburger, R; Herman, I; Pick, CG; Rigai, T; Schreiber, S; Shamir, D, 2003) |
") or saline during the second cocaine dosing regimen in the acute withdrawal period, 3." | 1.31 | 5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization. ( Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH; Xiong, X, 2002) |
Research
Studies (42)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 10 (23.81) | 18.7374 |
1990's | 12 (28.57) | 18.2507 |
2000's | 16 (38.10) | 29.6817 |
2010's | 4 (9.52) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Arora, S | 1 |
Vohora, D | 1 |
de Witte, LD | 1 |
Dekker, D | 1 |
Veraart, J | 1 |
Kromkamp, M | 1 |
Kaasjager, K | 1 |
Vinkers, CH | 1 |
Koshiishi, T | 1 |
Okuyama, K | 1 |
Chandrasekaran, PK | 1 |
Kang, L | 1 |
Wang, D | 1 |
Li, B | 1 |
Hu, M | 1 |
Zhang, P | 1 |
Li, J | 1 |
Haney, M | 1 |
Hart, CL | 1 |
Vosburg, SK | 1 |
Comer, SD | 1 |
Reed, SC | 1 |
Cooper, ZD | 1 |
Foltin, RW | 1 |
Davidson, C | 1 |
Lazarus, C | 1 |
Xiong, X | 1 |
Lee, TH | 1 |
Ellinwood, EH | 1 |
Schreiber, S | 2 |
Backler, MM | 1 |
Herman, I | 2 |
Shamir, D | 2 |
Rigai, T | 1 |
Bar-Hamburger, R | 2 |
Pick, CG | 2 |
Liappas, J | 2 |
Paparrigopoulos, T | 2 |
Malitas, P | 1 |
Tzavellas, E | 2 |
Christodoulou, G | 1 |
Rabavilas, A | 1 |
Begg, DP | 1 |
Hallam, KT | 1 |
Norman, TR | 1 |
Zullino, DF | 1 |
Krenz, S | 1 |
Zimmerman, G | 1 |
Miozzari, A | 1 |
Rajeswaran, R | 1 |
Kolly, S | 1 |
Khazaal, Y | 1 |
Kitabayashi, Y | 1 |
Shibata, K | 1 |
Nakamae, T | 1 |
Narumoto, J | 1 |
Tani, N | 1 |
Fukui, K | 1 |
Schwarzer, V | 1 |
Heep, A | 1 |
Gembruch, U | 1 |
Rohde, A | 1 |
McGregor, C | 1 |
Srisurapanont, M | 1 |
Mitchell, A | 1 |
Wickes, W | 1 |
White, JM | 1 |
Benyamina, A | 1 |
Lecacheux, M | 1 |
Blecha, L | 1 |
Reynaud, M | 1 |
Lukasiewcz, M | 1 |
Cruickshank, CC | 1 |
Montebello, ME | 1 |
Dyer, KR | 1 |
Quigley, A | 1 |
Blaszczyk, J | 1 |
Tomkins, S | 1 |
Shand, D | 1 |
Einarson, TR | 1 |
Ivanets, NN | 1 |
Anokhina, IP | 1 |
Kogan, BM | 1 |
Chirko, VV | 1 |
Nebarakova, TP | 1 |
Rusinov, AV | 1 |
Uchimura, N | 1 |
Nakamura, J | 1 |
Bertschy, G | 1 |
Bryois, C | 1 |
Bondolfi, G | 1 |
Velardi, A | 1 |
Budry, P | 1 |
Dascal, D | 1 |
Martinet, C | 1 |
Baettig, D | 1 |
Baumann, P | 1 |
Bottlender, R | 1 |
Erfurth, A | 1 |
Hoff, P | 1 |
Möller, HJ | 1 |
Benazzi, F | 1 |
MacCall, C | 1 |
Callender, J | 1 |
Klesmer, J | 1 |
Sarcevic, A | 1 |
Fomari, V | 1 |
Roy, A | 1 |
Mittal, N | 1 |
Zhang, H | 1 |
Pandey, SC | 1 |
Lynch, MA | 1 |
Leonard, BE | 1 |
Mogilnicka, E | 1 |
Klimek, V | 1 |
Drust, EG | 1 |
Sloviter, RS | 1 |
Connor, JD | 1 |
Otani, K | 1 |
Sasa, H | 1 |
Kaneko, S | 1 |
Fukushima, Y | 1 |
Sansone, M | 1 |
Battaglia, M | 1 |
Ekblom, J | 1 |
Nalepa, I | 1 |
Vetulani, J | 1 |
Neal, BS | 3 |
Sparber, SB | 4 |
Messing, RB | 1 |
Prather, PL | 1 |
Rezazadeh, SM | 1 |
Lal, H | 1 |
Bell, A | 1 |
Kleven, MS | 1 |
Kuniyoshi, M | 1 |
Arikawa, K | 1 |
Miura, C | 1 |
Inanaga, K | 1 |
Muijen, M | 1 |
Jones, DP | 1 |
Roy, D | 1 |
Silverstone, T | 1 |
Mehmet, A | 1 |
De Leo, D | 1 |
Dalla Barba, G | 1 |
Zanchin, G | 1 |
Nabeshima, T | 1 |
Yamaguchi, K | 1 |
Yoshida, S | 1 |
Furukawa, H | 1 |
Kameyama, T | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effect of Baclofen on Marijuana Withdrawal and Relapse[NCT00373295] | Phase 2 | 13 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Measure of Relapse: Change in Money Spent Between Baseline and Relapse Phase
"This is a measure of marijuana self-administration and relapse since each initial puff costs $7 and is a burden to overcome just to smoke.~Over each 3 day period, the puffs chosen by each participant is averaged for a single value." (NCT00373295)
Timeframe: Days 1-3 (Baseline) and Days 6-8 (Relapse Phase)
Intervention | dollars spent on marijuana (Mean) |
---|---|
Baclofen 60, Marijuana | 7.15 |
Placebo, Marijuana | 9.77 |
Baclofen 90, Marijuana | 7.25 |
Reviews
3 reviews available for mianserin and Drug Withdrawal Symptoms
Article | Year |
---|---|
[Diagnosis, assessment, and treatment of alcohol withdrawal syndrome].
Topics: Alcohol-Related Disorders; Alcoholism; Antipsychotic Agents; Benzodiazepines; Diagnostic and Statist | 2006 |
Pharmacotherapy and psychotherapy in cannabis withdrawal and dependence.
Topics: Behavior Therapy; Buspirone; Cannabinoids; Cognitive Behavioral Therapy; Combined Modality Therapy; | 2008 |
[Changes in metabolism of catecholamines and serotonin during alcohol withdrawal].
Topics: Antidepressive Agents, Second-Generation; Dopamine; Ethanol; Homovanillic Acid; Humans; Hydroxyindol | 1997 |
Trials
8 trials available for mianserin and Drug Withdrawal Symptoms
Article | Year |
---|---|
Effects of baclofen and mirtazapine on a laboratory model of marijuana withdrawal and relapse.
Topics: Adrenergic alpha-Antagonists; Adult; Affect; Baclofen; Cognition; Dose-Response Relationship, Drug; | 2010 |
Mirtazapine improves alcohol detoxification.
Topics: Adolescent; Adult; Alcoholism; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Female; | 2004 |
Mirtazapine and venlafaxine in the management of collateral psychopathology during alcohol detoxification.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Anxiety; Central Nervous System Depressants; | 2005 |
The effect of mianserin add-on, on the intensity of opioid withdrawal symptoms during detoxification program--a randomized, double blind, placebo controlled, prospective study.
Topics: Analysis of Variance; Antidepressive Agents, Second-Generation; Anxiety; Depressive Disorder; Double | 2005 |
Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual.
Topics: Adult; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Centra | 2008 |
A placebo-controlled trial of mirtazapine for the management of methamphetamine withdrawal.
Topics: Adult; Ambulatory Care; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Central Ner | 2008 |
[The efficacy and mechanisms of action of lerivon in alcoholism].
Topics: Adolescent; Adult; Alcohol Deterrents; Alcoholism; Amitriptyline; Anti-Anxiety Agents; Antidepressiv | 1996 |
The association carbamazepine-mianserin in opiate withdrawal: a double blind pilot study versus clonidine.
Topics: Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Second-Generation; Carbamazepine; Clonidine; | 1997 |
Other Studies
31 other studies available for mianserin and Drug Withdrawal Symptoms
Article | Year |
---|---|
Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Anxiety; Be | 2016 |
[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms].
Topics: Adult; Aggression; Alcoholism; Baclofen; Delirium; Drug Overdose; GABA-B Receptor Agonists; Humans; | 2016 |
Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran.
Topics: Aged; Antidepressive Agents; Cerebral Hemorrhage; Cyclopropanes; Depression; Drug Substitution; Fema | 2016 |
Employing mirtazapine to aid benzodiazepine withdrawal.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Humans; Male; Mianserin; Midazolam; Mi | 2008 |
Mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuates morphine dependence and withdrawal in Sprague-Dawley rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Dose-Response Relationship, Drug; | 2008 |
5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization.
Topics: Animals; Behavior, Animal; Clozapine; Cocaine; Injections; Ketanserin; Male; Mianserin; Rats; Rats, | 2002 |
Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Disease Models, An | 2003 |
Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Interpers | 2005 |
Topiramate in opiate withdrawal- comparison with clonidine and with carbamazepine/mianserin.
Topics: Adrenergic alpha-Agonists; Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Carbama | 2004 |
Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine.
Topics: Adult; Antidepressive Agents, Tricyclic; Diabetes Mellitus, Type 1; Drug Resistance; Female; Humans; | 2008 |
Lorazepam withdrawal seizures.
Topics: Anti-Anxiety Agents; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Male; Mia | 1980 |
[Mianserin-induced hypertension 2 weeks after discontinuation of tranylcypromine].
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Cardiomyopathy, Dilated; Depressive | 1997 |
Mirtazapine withdrawal symptoms.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combination; Humans; Mal | 1998 |
Mirtazapine withdrawal causing hypomania.
Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Female; Humans; Mianserin; Mirtazapine; Su | 1999 |
Panic attacks during discontinuation of mirtazepine.
Topics: Antidepressive Agents, Tricyclic; Appendectomy; Dysthymic Disorder; Hernia, Umbilical; Humans; Male; | 2000 |
Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal.
Topics: Adaptation, Biological; Alcohol Drinking; Animals; Cerebral Cortex; Disease Models, Animal; DNA; Eth | 2002 |
Effect of chronic amphetamine administration on the behaviour of rats in the open field apparatus: reversal of post-withdrawal depression by two antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Dextroamphetamine; Huma | 1978 |
Mianserin, danitracen and amitriptyline withdrawal increases the behavioural responses of rats to L-5-HTP.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Behavior, Animal; Dibenzazepines; Humans; Male; Mianser | 1979 |
Effect of morphine on 'wet-dog' shakes caused by cerebroventricular injection of serotonin.
Topics: 5,7-Dihydroxytryptamine; Animals; Brain; Dopamine; Dose-Response Relationship, Drug; Humans; Injecti | 1979 |
Lack of withdrawal symptoms after discontinuation of mianserin.
Topics: Acute Disease; Adult; Aged; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Mianserin; M | 1991 |
Avoidance learning during antidepressant withdrawal in mice.
Topics: Animals; Avoidance Learning; Brain; Desipramine; Injections, Intraperitoneal; Male; Mianserin; Mice; | 1991 |
The serotonin2 antagonist ritanserin blocks quasi-morphine withdrawal at a time when mianserin is no longer effective.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Conditioning, Operant; Male; Mianserin; Morphine Dependence; N | 1990 |
Long-term effects of neonatal exposure to isobutylmethylxanthine. II. Attenuation of acute morphine withdrawal in mature rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Body Temperature; Conditioning, Operant; Dos | 1991 |
Mianserin in the treatment of ethanol withdrawal in the rat: prevention of behaviors indicative of anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Male; Mianserin; Rats; Substance Withdrawal Syndrome | 1991 |
Calcium channel blockers.
Topics: Aged; Atrial Fibrillation; Bipolar Disorder; Combined Modality Therapy; Electroconvulsive Therapy; H | 1990 |
Modification of quasi-morphine withdrawal with serotonin agonists and antagonists: evidence for a role of serotonin in the expression of opiate withdrawal.
Topics: 1-Methyl-3-isobutylxanthine; 5-Hydroxytryptophan; Animals; Fluoxetine; Male; Methysergide; Mianserin | 1989 |
Panic anxiety after abrupt discontinuation of mianserin.
Topics: Adult; Anxiety Disorders; Depressive Disorder; Fear; Female; Humans; Mianserin; Panic; Substance Wit | 1989 |
Mianserin withdrawal and the pupil response of depressed and recovered patients: a preliminary report.
Topics: Adult; Arousal; Depressive Disorder; Female; Humans; Male; Mianserin; Middle Aged; Phenylephrine; Ps | 1989 |
Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine.
Topics: Animals; Body Temperature; Clonidine; Corticosterone; Dibenzazepines; Male; Mianserin; Morphine Depe | 1986 |
Seizures following the withdrawal of long-term treatment with mianserin.
Topics: Adult; Depressive Disorder; Female; Humans; Mianserin; Seizures; Substance Withdrawal Syndrome | 1988 |
Phencyclidine-induced wet-dog shakes observed in rats after withdrawal from reserpine treatment.
Topics: Animals; Behavior, Animal; Imipramine; Male; Mianserin; p-Chloroamphetamine; Phencyclidine; Rats; Ra | 1986 |